PubMed

Novel Obesity Risk Loci Do Not Determine Distribution of Body Fat Depots: A Whole-body MRI/MRS study.

Haupt A, Thamer C, Heni M, Machicao F, Machann J, Schick F, Stefan N, Fritsche A, Häring HU, Staiger H.

Obesity (Silver Spring). 2009 Nov 12. [Epub ahead of print]PMID: 19910938 [PubMed - as supplied by publisher]Related articles

Circulating Palmitoleate strongly and independently predicts Insulin Sensitivity in Humans.

Stefan N, Kantartzis K, Celebi N, Staiger H, Machann J, Schick F, Cegan A, Elcnerova M, Schleicher E, Fritsche A, Häring HU.

Diabetes Care. 2009 Nov 4. [Epub ahead of print]PMID: 19889804 [PubMed - as supplied by publisher]Related articles

Medical antihyperglycaemic treatment of type 2 diabetes mellitus: update of the evidence-based guideline of the German Diabetes Association.

Matthaei S, Bierwirth R, Fritsche A, Gallwitz B, Häring HU, Joost HG, Kellerer M, Kloos Ch, Kunt T, Nauck M, Schernthaner G, Siegel E, Thienel F.

Exp Clin Endocrinol Diabetes. 2009 Oct;117(9):522-57. Epub 2009 Oct 29. No abstract available. PMID: 19876795 [PubMed - in process]Related articles

Hepatic Lipid Composition and Stearoyl-Coenzyme A Desaturase 1 mRNA Expression Can Be Estimated from Plasma VLDL Fatty Acid Ratios.

Peter A, Cegan A, Wagner S, Lehmann R, Stefan N, Königsrainer A, Königsrainer I, Häring HU, Schleicher E.

Clin Chem. 2009 Oct 22. [Epub ahead of print]PMID: 19850634 [PubMed - as supplied by publisher]Related articles

Over-expression of kinase negative protein kinase C{delta} in pancreatic {beta}-cells protects mice from diet-induced glucose intolerance and {beta}-cell dysfunction.

Hennige AM, Ranta F, Heinzelmann I, Düfer M, Michael D, Braumüller H, Lutz SZ, Lammers R, Drews G, Bosch F, Häring HU, Ullrich S.

Diabetes. 2009 Oct 13. [Epub ahead of print]PMID: 19826167 [PubMed - as supplied by publisher]Related articles

The insulin effect on cerebrocortical theta activity is associated with serum concentrations of saturated nonesterified Fatty acids.

Tschritter O, Preissl H, Hennige AM, Sartorius T, Grichisch Y, Stefan N, Guthoff M, Düsing S, Machann J, Schleicher E, Cegan A, Birbaumer N, Fritsche A, Häring HU.

J Clin Endocrinol Metab. 2009 Nov;94(11):4600-7. Epub 2009 Oct 9.PMID: 19820026 [PubMed - in process]Related articles

A Combined Risk Allele Score of Eight Type 2 Diabetes Genes Is Associated With Reduced First Phase Glucose Stimulated Insulin Secretion During Hyperglycemic Clamps.

't Hart LM, Simonis-Bik AM, Nijpels G, van Haeften TW, Schäfer SA, Houwing-Duistermaat JJ, Boomsma DI, Groenewoud MJ, Reiling E, van Hove EC, Diamant M, Kramer MH, Heine RJ, Maassen JA, Kirchhoff K, Machicao F, Häring HU, Slagboom PE, Willemsen G, Eekhoff EM, de Geus EJ, Dekker JM, Fritsche A.

Diabetes. 2009 Oct 6. [Epub ahead of print]PMID: 19808892 [PubMed - as supplied by publisher]Related articles

Variant near ADAMTS9 known to associate with type 2 diabetes is related to insulin resistance in offspring of type 2 diabetes patients--EUGENE2 study.

Boesgaard TW, Gjesing AP, Grarup N, Rutanen J, Jansson PA, Hribal ML, Sesti G, Fritsche A, Stefan N, Staiger H, Häring H, Smith U, Laakso M, Pedersen O, Hansen T; EUGENE2 Consortium.

PLoS One. 2009 Sep 30;4(9):e7236.PMID: 19789630 [PubMed - in process]Related articlesFree article

Autoimmune thyroid disease: arterial spin-labeling perfusion MR imaging.

Schraml C, Müssig K, Martirosian P, Schwenzer NF, Claussen CD, Häring HU, Balletshofer BM, Schick F.

Radiology. 2009 Nov;253(2):435-42. Epub 2009 Sep 29.PMID: 19789231 [PubMed - in process]Related articles

Future perspectives for insulinotropic agents in the treatment of type 2 diabetes-DPP-4 inhibitors and sulphonylureas.

Gallwitz B, Häring HU.

Diabetes Obes Metab. 2009 Sep 24. [Epub ahead of print]PMID: 19788431 [PubMed - as supplied by publisher]Related articles

Insulin-mediated cortical activity in the slow frequency range is diminished in obese mice and promotes physical inactivity.

Hennige AM, Sartorius T, Lutz SZ, Tschritter O, Preissl H, Hopp S, Fritsche A, Rammensee HG, Ruth P, Häring HU.

Diabetologia. 2009 Sep 15. [Epub ahead of print]PMID: 19756482 [PubMed - as supplied by publisher]Related articles

Pathomechanisms of type 2 diabetes genes.

Staiger H, Machicao F, Fritsche A, Häring HU.

Endocr Rev. 2009 Oct;30(6):557-85. Epub 2009 Sep 11.PMID: 19749172 [PubMed - in process]Related articles

Use of multiple metabolic and genetic markers to improve the prediction of type 2 diabetes: the EPIC-Potsdam Study.

Schulze MB, Weikert C, Pischon T, Bergmann MM, Al-Hasani H, Schleicher E, Fritsche A, Häring HU, Boeing H, Joost HG.

Diabetes Care. 2009 Nov;32(11):2116-9. Epub 2009 Aug 31.PMID: 19720844 [PubMed - in process]Related articles

High baseline vitamin C levels do not prevent a positive outcome of a lifestyle intervention.

Thamer C, Machicao F, Stefan N, Fritsche A, Häring HU.

Diabetes Care. 2009 Sep;32(9):e112. No abstract available. PMID: 19717817 [PubMed - indexed for MEDLINE]Related articles

Preliminary report: genetic variation within the GPBAR1 gene is not associated with metabolic traits in white subjects at an increased risk for type 2 diabetes mellitus.

Müssig K, Staiger H, Machicao F, Machann J, Schick F, Schäfer SA, Claussen CD, Holst JJ, Gallwitz B, Stefan N, Fritsche A, Häring HU.

Metabolism. 2009 Dec;58(12):1809-11. Epub 2009 Aug 28.PMID: 19716570 [PubMed - in process]Related articles

Epinephrine-induced hyperpolarization of pancreatic islet cells is sensitive to PI3K-PDK1 signaling.

Zhang Y, Shumilina E, Häring HU, Lang F, Ullrich S.

FEBS Lett. 2009 Sep 17;583(18):3101-6. Epub 2009 Aug 27.PMID: 19716369 [PubMed - indexed for MEDLINE]Related articles

Common polymorphisms within the NR4A3 locus, encoding the orphan nuclear receptor Nor-1, are associated with enhanced beta-cell function in non-diabetic subjects.

Weyrich P, Staiger H, Stancáková A, Schäfer SA, Kirchhoff K, Ullrich S, Ranta F, Gallwitz B, Stefan N, Machicao F, Kuusisto J, Laakso M, Fritsche A, Häring HU.

BMC Med Genet. 2009 Aug 14;10:77.PMID: 19682370 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of the UBP1 locus as a critical blood pressure determinant using a combination of mouse and human genetics.

Koutnikova H, Laakso M, Lu L, Combe R, Paananen J, Kuulasmaa T, Kuusisto J, Häring HU, Hansen T, Pedersen O, Smith U, Hanefeld M, Williams RW, Auwerx J.

PLoS Genet. 2009 Aug;5(8):e1000591. Epub 2009 Aug 7.PMID: 19662162 [PubMed - indexed for MEDLINE]Related articlesFree article

Dissociation between fatty liver and insulin resistance in humans carrying a variant of the patatin-like phospholipase 3 gene.

Kantartzis K, Peter A, Machicao F, Machann J, Wagner S, Königsrainer I, Königsrainer A, Schick F, Fritsche A, Häring HU, Stefan N.

Diabetes. 2009 Nov;58(11):2616-23. Epub 2009 Aug 3.PMID: 19651814 [PubMed - in process]Related articles

Insulin detemir causes increased symptom awareness during hypoglycaemia compared to human insulin.

Tschritter O, Schäfer SA, Klett J, Pfäfflin A, Häring HU, Hennige AM, Fritsche A.

Diabetes Obes Metab. 2009 Nov;11(11):1017-26. Epub 2009 Jul 23.PMID: 19650876 [PubMed - in process]Related articles

Younger age is a good predictor of better executive function after surgery for pituitary adenoma in adults.

Müssig K, Leyhe T, Besemer B, Saur R, Häring HU, Gallwitz B, Klingberg S.

J Int Neuropsychol Soc. 2009 Sep;15(5):803-6. Epub 2009 Jul 29.PMID: 19638252 [PubMed - indexed for MEDLINE]Related articles

The importance of brown adipose tissue.

Stefan N, Pfannenberg C, Häring HU.

N Engl J Med. 2009 Jul 23;361(4):416-7; author reply 418-21. No abstract available. PMID: 19630141 [PubMed - indexed for MEDLINE]Related articles

Impact of variation near MC4R on whole-body fat distribution, liver fat, and weight loss.

Haupt A, Thamer C, Heni M, Tschritter O, Machann J, Schick F, Machicao F, Häring HU, Staiger H, Fritsche A.

Obesity (Silver Spring). 2009 Oct;17(10):1942-5. Epub 2009 Jul 30.PMID: 19629057 [PubMed - in process]Related articles

[Individualized prevention of type 2 diabetes]

Stefan N, Fritsche A, Häring HU.

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2009 Jul;52(7):677-82. German. PMID: 19626284 [PubMed - indexed for MEDLINE]Related articles

High plasma fetuin-A is associated with increased carotid intima-media thickness in a middle-aged population.

Rittig K, Thamer C, Haupt A, Machann J, Peter A, Balletshofer B, Fritsche A, Haring HU, Stefan N.

Atherosclerosis. 2009 May 22. [Epub ahead of print] No abstract available. PMID: 19615685 [PubMed - as supplied by publisher]Related articles

Urinary free cortisone, but not cortisol, is associated with urine volume in severe obesity.

Müssig K, Remer T, Fritsche A, Häring HU, Maser-Gluth C.

Steroids. 2009 Sep;74(9):742-5. Epub 2009 Apr 2.PMID: 19541001 [PubMed - indexed for MEDLINE]Related articles

Sphingomyelinase dependent apoptosis following treatment of pancreatic beta-cells with amyloid peptides Abeta(1-42) or IAPP.

Zhang Y, Ranta F, Tang C, Shumilina E, Mahmud H, Föller M, Ullrich S, Häring HU, Lang F.

Apoptosis. 2009 Jul;14(7):878-89.PMID: 19488858 [PubMed - indexed for MEDLINE]Related articles

Individual stearoyl-coa desaturase 1 expression modulates endoplasmic reticulum stress and inflammation in human myotubes and is associated with skeletal muscle lipid storage and insulin sensitivity in vivo.

Peter A, Weigert C, Staiger H, Machicao F, Schick F, Machann J, Stefan N, Thamer C, Häring HU, Schleicher E.

Diabetes. 2009 Aug;58(8):1757-65. Epub 2009 May 28.PMID: 19478146 [PubMed - indexed for MEDLINE]Related articlesFree article

High cardiovascular event rates in patients with asymptomatic carotid stenosis: the REACH Registry.

Aichner FT, Topakian R, Alberts MJ, Bhatt DL, Haring HP, Hill MD, Montalescot G, Goto S, Touzé E, Mas JL, Steg PG, Röther J; REACH Registry Investigators.

Eur J Neurol. 2009 Aug;16(8):902-8. Epub 2009 Mar 31.PMID: 19473362 [PubMed - indexed for MEDLINE]Related articles

Intermuscular adipose tissue (IMAT): association with other adipose tissue compartments and insulin sensitivity.

Boettcher M, Machann J, Stefan N, Thamer C, Häring HU, Claussen CD, Fritsche A, Schick F.

J Magn Reson Imaging. 2009 Jun;29(6):1340-5.PMID: 19422021 [PubMed - indexed for MEDLINE]Related articles

Enforced expression of protein kinase C in skeletal muscle causes physical inactivity, fatty liver and insulin resistance in the brain.

Hennige AM, Heni M, Machann J, Staiger H, Sartorius T, Hoene M, Lehmann R, Weigert C, Peter A, Bornemann A, Kroeber S, Pujol A, Franckhauser S, Bosch F, Schick F, Lammers R, Håring HU.

J Cell Mol Med. 2008 Dec 24. [Epub ahead of print]PMID: 19413892 [PubMed - as supplied by publisher]Related articles

Increased prevalence of antibodies to central nervous system tissue and gangliosides in Hashimoto's thyroiditis compared to other thyroid illnesses.

Müssig K, Leyhe T, Holzmüller S, Klein R, Weinert C, Saur R, Klingberg S, Häring HU, Gallwitz B.

Psychoneuroendocrinology. 2009 Sep;34(8):1252-6. Epub 2009 Apr 17.PMID: 19375868 [PubMed - indexed for MEDLINE]Related articles

Enhanced insulin sensitivity of gene-targeted mice lacking functional KCNQ1.

Boini KM, Graf D, Hennige AM, Koka S, Kempe DS, Wang K, Ackermann TF, Föller M, Vallon V, Pfeifer K, Schleicher E, Ullrich S, Häring HU, Häussinger D, Lang F.

Am J Physiol Regul Integr Comp Physiol. 2009 Jun;296(6):R1695-701. Epub 2009 Apr 15.PMID: 19369585 [PubMed - indexed for MEDLINE]Related articles

Association of type 2 diabetes candidate polymorphisms in KCNQ1 with incretin and insulin secretion.

Müssig K, Staiger H, Machicao F, Kirchhoff K, Guthoff M, Schäfer SA, Kantartzis K, Silbernagel G, Stefan N, Holst JJ, Gallwitz B, Häring HU, Fritsche A.

Diabetes. 2009 Jul;58(7):1715-20. Epub 2009 Apr 14.PMID: 19366866 [PubMed - indexed for MEDLINE]Related articlesFree article

AHSG gene variation is not associated with regional body fat distribution--a magnetic resonance study.

Müssig K, Staiger H, Machicao F, Machann J, Hennige AM, Schick F, Claussen CD, Fritsche A, Häring HU, Stefan N.

Exp Clin Endocrinol Diabetes. 2009 Sep;117(8):432-7. Epub 2009 Apr 8.PMID: 19358088 [PubMed - in process]Related articles

A common genetic variant in WFS1 determines impaired glucagon-like peptide-1-induced insulin secretion.

Schäfer SA, Müssig K, Staiger H, Machicao F, Stefan N, Gallwitz B, Häring HU, Fritsche A.

Diabetologia. 2009 Jun;52(6):1075-82. Epub 2009 Mar 28.PMID: 19330314 [PubMed - indexed for MEDLINE]Related articles

Protein kinase C iota mediates lipid-induced apoptosis of human coronary artery endothelial cells.

Staiger K, Schatz U, Staiger H, Weyrich P, Haas C, Guirguis A, Machicao F, Häring HU, Kellerer M.

Microvasc Res. 2009 Jun;78(1):40-4. Epub 2009 Mar 25.PMID: 19327373 [PubMed - indexed for MEDLINE]Related articles

RARRES2, encoding the novel adipokine chemerin, is a genetic determinant of disproportionate regional body fat distribution: a comparative magnetic resonance imaging study.

Müssig K, Staiger H, Machicao F, Thamer C, Machann J, Schick F, Claussen CD, Stefan N, Fritsche A, Häring HU.

Metabolism. 2009 Apr;58(4):519-24.PMID: 19303973 [PubMed - indexed for MEDLINE]Related articles

The inhibitory effect of recent type 2 diabetes risk loci on insulin secretion is modulated by insulin sensitivity.

Haupt A, Guthoff M, Schäfer SA, Kirchhoff K, Machicao F, Gallwitz B, Staiger H, Stefan N, Fritsche A, Häring HU.

J Clin Endocrinol Metab. 2009 May;94(5):1775-80. Epub 2009 Mar 3.PMID: 19258404 [PubMed - indexed for MEDLINE]Related articles

[A rare cause of hypoglycaemia in a patient with type 2 diabetes]

Heni M, Schott S, Horger M, Dudziak K, Thamer C, Häring HU, Fritsche A, Müssig K.

Dtsch Med Wochenschr. 2009;134 Suppl Falldatenbank:F2. Epub 2009 Feb 23. German. PMID: 19235687 [PubMed - indexed for MEDLINE]Related articles

The risk allele load accelerates the age-dependent decline in beta cell function.

Haupt A, Staiger H, Schäfer SA, Kirchhoff K, Guthoff M, Machicao F, Gallwitz B, Stefan N, Häring HU, Fritsche A.

Diabetologia. 2009 Mar;52(3):457-62. Epub 2009 Jan 27.PMID: 19172244 [PubMed - indexed for MEDLINE]Related articles

Adiponectin oligomers and ectopic fat in liver and skeletal muscle in humans.

Kantartzis K, Staiger H, Machann J, Schick F, Claussen CD, Machicao F, Fritsche A, Häring HU, Stefan N.

Obesity (Silver Spring). 2009 Feb;17(2):390-2. Epub 2008 Oct 30.PMID: 19169222 [PubMed - indexed for MEDLINE]Related articles

Psychological effects of prevention: do participants of a type 2 diabetes prevention program experience increased mental distress?

Giel KE, Enck P, Zipfel S, Schrauth M, Bury A, Graf M, Kümmerle S, Guthoff M, Stefan N, Häring HU, Fritsche A.

Diabetes Metab Res Rev. 2009 Jan;25(1):83-8.PMID: 19145589 [PubMed - indexed for MEDLINE]Related articles

Association of common genetic variation in the FOXO1 gene with beta-cell dysfunction, impaired glucose tolerance, and type 2 diabetes.

Müssig K, Staiger H, Machicao F, Stancáková A, Kuusisto J, Laakso M, Thamer C, Machann J, Schick F, Claussen CD, Stefan N, Fritsche A, Häring HU.

J Clin Endocrinol Metab. 2009 Apr;94(4):1353-60. Epub 2009 Jan 13.PMID: 19141580 [PubMed - indexed for MEDLINE]Related articles

Polymorphisms within the novel type 2 diabetes risk locus MTNR1B determine beta-cell function.

Staiger H, Machicao F, Schäfer SA, Kirchhoff K, Kantartzis K, Guthoff M, Silbernagel G, Stefan N, Häring HU, Fritsche A.

PLoS One. 2008;3(12):e3962. Epub 2008 Dec 17.PMID: 19088850 [PubMed - indexed for MEDLINE]Related articlesFree article

Muscle-derived angiopoietin-like protein 4 is induced by fatty acids via peroxisome proliferator-activated receptor (PPAR)-delta and is of metabolic relevance in humans.

Staiger H, Haas C, Machann J, Werner R, Weisser M, Schick F, Machicao F, Stefan N, Fritsche A, Häring HU.

Diabetes. 2009 Mar;58(3):579-89. Epub 2008 Dec 15.PMID: 19074989 [PubMed - indexed for MEDLINE]Related articlesFree article

High cardiorespiratory fitness is an independent predictor of the reduction in liver fat during a lifestyle intervention in non-alcoholic fatty liver disease.

Kantartzis K, Thamer C, Peter A, Machann J, Schick F, Schraml C, Königsrainer A, Königsrainer I, Kröber S, Niess A, Fritsche A, Häring HU, Stefan N.

Gut. 2009 Sep;58(9):1281-8. Epub 2008 Dec 11.PMID: 19074179 [PubMed - indexed for MEDLINE]Related articles

Development and validation of a Daphnia magna four-day survival and growth test method.

Lazorchak JM, Smith ME, Haring HJ.

Environ Toxicol Chem. 2009 May;28(5):1028-34.PMID: 19067494 [PubMed - indexed for MEDLINE]Related articles

Changes of the plasma metabolome during an oral glucose tolerance test: is there more than glucose to look at?

Zhao X, Peter A, Fritsche J, Elcnerova M, Fritsche A, Häring HU, Schleicher ED, Xu G, Lehmann R.

Am J Physiol Endocrinol Metab. 2009 Feb;296(2):E384-93. Epub 2008 Dec 9.PMID: 19066319 [PubMed - indexed for MEDLINE]Related articles

Selective association of plasma non-esterified fatty acid species with circulating interleukin-8 concentrations in humans.

Staiger H, Wöll J, Haas C, Machicao F, Schleicher ED, Fritsche A, Stefan N, Häring HU.

Exp Clin Endocrinol Diabetes. 2009 Jan;117(1):21-7. Epub 2008 Dec 3.PMID: 19053024 [PubMed - indexed for MEDLINE]Related articles