PubMed

Interferon regulatory factor-1 is a key transcription factor in murine beta cells under immune attack.

Gysemans C, Callewaert H, Moore F, Nelson-Holte M, Overbergh L, Eizirik DL, Mathieu C.

Diabetologia. 2009 Sep 8. [Epub ahead of print]PMID: 19756487 [PubMed - as supplied by publisher]Related articles

Molecular evolution of a novel hyperactive Sleeping Beauty transposase enables robust stable gene transfer in vertebrates.

Mátés L, Chuah MK, Belay E, Jerchow B, Manoj N, Acosta-Sanchez A, Grzela DP, Schmitt A, Becker K, Matrai J, Ma L, Samara-Kuko E, Gysemans C, Pryputniewicz D, Miskey C, Fletcher B, Vandendriessche T, Ivics Z, Izsvák Z.

Nat Genet. 2009 Jun;41(6):753-61. Epub 2009 May 3.PMID: 19412179 [PubMed - in process]Related articles

Regulation of vitamin D homeostasis: implications for the immune system.

van Etten E, Stoffels K, Gysemans C, Mathieu C, Overbergh L.

Nutr Rev. 2008 Oct;66(10 Suppl 2):S125-34. Review.PMID: 18844839 [PubMed - indexed for MEDLINE]Related articles

Vitamin D signaling in immune-mediated disorders: Evolving insights and therapeutic opportunities.

Baeke F, van Etten E, Gysemans C, Overbergh L, Mathieu C.

Mol Aspects Med. 2008 Dec;29(6):376-87. Epub 2008 Jul 14. Review.PMID: 18621414 [PubMed - indexed for MEDLINE]Related articles

Late CD8+ T cell-dependent xenoantibody production in innate tolerant nude rats after hamster islet grafting but not after hamster heart grafting.

Devos T, Shengqiao L, Gysemans C, Yan Y, Damme BV, Nelson-Holte M, Billiau AD, Waer M, Mathieu C.

Transplantation. 2008 May 27;85(10):1489-95.PMID: 18497691 [PubMed - indexed for MEDLINE]Related articles

Pancreatic duct cells in human islet cell preparations are a source of angiogenic cytokines interleukin-8 and vascular endothelial growth factor.

Movahedi B, Gysemans C, Jacobs-Tulleneers-Thevissen D, Mathieu C, Pipeleers D.

Diabetes. 2008 Aug;57(8):2128-36. Epub 2008 May 20.PMID: 18492788 [PubMed - indexed for MEDLINE]Related articlesFree article

Cytokine signalling in the beta-cell: a dual role for IFNgamma.

Gysemans C, Callewaert H, Overbergh L, Mathieu C.

Biochem Soc Trans. 2008 Jun;36(Pt 3):328-33. Review.PMID: 18481951 [PubMed - indexed for MEDLINE]Related articles

Identification of discrete tumor-induced myeloid-derived suppressor cell subpopulations with distinct T cell-suppressive activity.

Movahedi K, Guilliams M, Van den Bossche J, Van den Bergh R, Gysemans C, Beschin A, De Baetselier P, Van Ginderachter JA.

Blood. 2008 Apr 15;111(8):4233-44. Epub 2008 Feb 13.PMID: 18272812 [PubMed - indexed for MEDLINE]Related articlesFree article

Double-stranded RNA induces pancreatic beta-cell apoptosis by activation of the toll-like receptor 3 and interferon regulatory factor 3 pathways.

Dogusan Z, García M, Flamez D, Alexopoulou L, Goldman M, Gysemans C, Mathieu C, Libert C, Eizirik DL, Rasschaert J.

Diabetes. 2008 May;57(5):1236-45. Epub 2008 Jan 25.PMID: 18223009 [PubMed - indexed for MEDLINE]Related articlesFree article

Unaltered diabetes presentation in NOD mice lacking the vitamin D receptor.

Gysemans C, van Etten E, Overbergh L, Giulietti A, Eelen G, Waer M, Verstuyf A, Bouillon R, Mathieu C.

Diabetes. 2008 Jan;57(1):269-75. Epub 2007 Oct 24.PMID: 17959935 [PubMed - indexed for MEDLINE]Related articlesFree article

Proteomics analysis of cytokine-induced dysfunction and death in insulin-producing INS-1E cells: new insights into the pathways involved.

D'Hertog W, Overbergh L, Lage K, Ferreira GB, Maris M, Gysemans C, Flamez D, Cardozo AK, Van den Bergh G, Schoofs L, Arckens L, Moreau Y, Hansen DA, Eizirik DL, Waelkens E, Mathieu C.

Mol Cell Proteomics. 2007 Dec;6(12):2180-99. Epub 2007 Oct 5.PMID: 17921177 [PubMed - indexed for MEDLINE]Related articlesFree article

Cell loss during pseudoislet formation hampers profound improvements in islet lentiviral transduction efficacy for transplantation purposes.

Callewaert H, Gysemans C, Cardozo AK, Elsner M, Tiedge M, Eizirik DL, Mathieu C.

Cell Transplant. 2007;16(5):527-37.PMID: 17708342 [PubMed - indexed for MEDLINE]Related articles

Mechanism and potential of the growth-inhibitory actions of vitamin D and ana-logs.

Eelen G, Gysemans C, Verlinden L, Vanoirbeek E, De Clercq P, Van Haver D, Mathieu C, Bouillon R, Verstuyf A.

Curr Med Chem. 2007;14(17):1893-910. Review.PMID: 17627525 [PubMed - indexed for MEDLINE]Related articles

Deletion of STAT-1 pancreatic islets protects against streptozotocin-induced diabetes and early graft failure but not against late rejection.

Callewaert HI, Gysemans CA, Ladrière L, D'Hertog W, Hagenbrock J, Overbergh L, Eizirik DL, Mathieu C.

Diabetes. 2007 Aug;56(8):2169-73. Epub 2007 May 1.PMID: 17473223 [PubMed - indexed for MEDLINE]Related articlesFree article

Novel insights in the immune function of the vitamin D system: synergism with interferon-beta.

van Etten E, Gysemans C, Branisteanu DD, Verstuyf A, Bouillon R, Overbergh L, Mathieu C.

J Steroid Biochem Mol Biol. 2007 Mar;103(3-5):546-51. Epub 2006 Dec 23.PMID: 17254771 [PubMed - indexed for MEDLINE]Related articles

Protective role of IFN-gamma in collagen-induced arthritis conferred by inhibition of mycobacteria-induced granulocyte chemotactic protein-2 production.

Kelchtermans H, Struyf S, De Klerck B, Mitera T, Alen M, Geboes L, Van Balen M, Dillen C, Put W, Gysemans C, Billiau A, Van Damme J, Matthys P.

J Leukoc Biol. 2007 Apr;81(4):1044-53. Epub 2007 Jan 2.PMID: 17200147 [PubMed - indexed for MEDLINE]Related articlesFree article

Quantification of chemokines by real-time reverse transcriptase PCR: applications in type 1 diabetes.

Overbergh L, Gysemans C, Mathieu C.

Expert Rev Mol Diagn. 2006 Jan;6(1):51-64. Review.PMID: 16359267 [PubMed - indexed for MEDLINE]Related articles

Disruption of the gamma-interferon signaling pathway at the level of signal transducer and activator of transcription-1 prevents immune destruction of beta-cells.

Gysemans CA, Ladrière L, Callewaert H, Rasschaert J, Flamez D, Levy DE, Matthys P, Eizirik DL, Mathieu C.

Diabetes. 2005 Aug;54(8):2396-403.PMID: 16046307 [PubMed - indexed for MEDLINE]Related articlesFree article

Toll-like receptor 3 and STAT-1 contribute to double-stranded RNA+ interferon-gamma-induced apoptosis in primary pancreatic beta-cells.

Rasschaert J, Ladrière L, Urbain M, Dogusan Z, Katabua B, Sato S, Akira S, Gysemans C, Mathieu C, Eizirik DL.

J Biol Chem. 2005 Oct 7;280(40):33984-91. Epub 2005 Jul 15.PMID: 16027122 [PubMed - indexed for MEDLINE]Related articlesFree article

Vitamin D and diabetes.

Mathieu C, Gysemans C, Giulietti A, Bouillon R.

Diabetologia. 2005 Jul;48(7):1247-57. Epub 2005 Jun 22. Review.PMID: 15971062 [PubMed - indexed for MEDLINE]Related articles

Role of CD4+ and CD8+ T cells in the rejection of heart or islet xenografts in recipients with xenotolerance in the innate immune compartment.

Devos T, Yan Y, Segers C, Rutgeerts O, Laureys J, Gysemans C, Mathieu C, Waer M.

Transplant Proc. 2005 Jan-Feb;37(1):516-7.PMID: 15808695 [PubMed - indexed for MEDLINE]Related articles

1,25-Dihydroxyvitamin D3 alters the profile of bone marrow-derived dendritic cells of NOD mice.

van Etten E, Dardenne O, Gysemans C, Overbergh L, Mathieu C.

Ann N Y Acad Sci. 2004 Dec;1037:186-92.PMID: 15699515 [PubMed - indexed for MEDLINE]Related articles

1,25-Dihydroxyvitamin D3 modulates expression of chemokines and cytokines in pancreatic islets: implications for prevention of diabetes in nonobese diabetic mice.

Gysemans CA, Cardozo AK, Callewaert H, Giulietti A, Hulshagen L, Bouillon R, Eizirik DL, Mathieu C.

Endocrinology. 2005 Apr;146(4):1956-64. Epub 2005 Jan 6.PMID: 15637289 [PubMed - indexed for MEDLINE]Related articlesFree article

NOD macrophages produce high levels of inflammatory cytokines upon encounter of apoptotic or necrotic cells.

Stoffels K, Overbergh L, Giulietti A, Kasran A, Bouillon R, Gysemans C, Mathieu C.

J Autoimmun. 2004 Aug;23(1):9-15.PMID: 15236748 [PubMed - indexed for MEDLINE]Related articles

Vitamin D and 1,25-dihydroxyvitamin D3 as modulators in the immune system.

Mathieu C, van Etten E, Decallonne B, Guilietti A, Gysemans C, Bouillon R, Overbergh L.

J Steroid Biochem Mol Biol. 2004 May;89-90(1-5):449-52. Review.PMID: 15225818 [PubMed - indexed for MEDLINE]Related articles

Vitamin D deficiency in early life accelerates Type 1 diabetes in non-obese diabetic mice.

Giulietti A, Gysemans C, Stoffels K, van Etten E, Decallonne B, Overbergh L, Bouillon R, Mathieu C.

Diabetologia. 2004 Mar;47(3):451-62. Epub 2004 Jan 31.PMID: 14758446 [PubMed - indexed for MEDLINE]Related articles

Prevention of primary non-function of islet xenografts in autoimmune diabetic NOD mice by anti-inflammatory agents.

Gysemans C, Stoffels K, Giulietti A, Overbergh L, Waer M, Lannoo M, Feige U, Mathieu C.

Diabetologia. 2003 Aug;46(8):1115-23. Epub 2003 Jul 17.PMID: 12879250 [PubMed - indexed for MEDLINE]Related articles

IL-1beta and IFN-gamma induce the expression of diverse chemokines and IL-15 in human and rat pancreatic islet cells, and in islets from pre-diabetic NOD mice.

Cardozo AK, Proost P, Gysemans C, Chen MC, Mathieu C, Eizirik DL.

Diabetologia. 2003 Feb;46(2):255-66. Epub 2003 Feb 12.PMID: 12627325 [PubMed - indexed for MEDLINE]Related articles

Treatment of autoimmune diabetes recurrence in non-obese diabetic mice by mouse interferon-beta in combination with an analogue of 1alpha,25-dihydroxyvitamin-D3.

Gysemans C, Van Etten E, Overbergh L, Verstuyf A, Waer M, Bouillon R, Mathieu C.

Clin Exp Immunol. 2002 May;128(2):213-20.PMID: 11985511 [PubMed - indexed for MEDLINE]Related articlesFree article

Seasonality of birth in patients with type 1 diabetes.

Mathieu C, van Etten E, Gysemans C, Decallonne B, Bouillon R.

Lancet. 2002 Apr 6;359(9313):1248. No abstract available. PMID: 11955565 [PubMed - indexed for MEDLINE]Related articles

In vitro and in vivo analysis of the immune system of vitamin D receptor knockout mice.

Mathieu C, Van Etten E, Gysemans C, Decallonne B, Kato S, Laureys J, Depovere J, Valckx D, Verstuyf A, Bouillon R.

J Bone Miner Res. 2001 Nov;16(11):2057-65.PMID: 11697802 [PubMed - indexed for MEDLINE]Related articles

Dual role of interferon-gamma signalling pathway in sensitivity of pancreatic beta cells to immune destruction.

Gysemans CA, Pavlovic D, Bouillon R, Eizirik DL, Mathieu C.

Diabetologia. 2001 May;44(5):567-74.PMID: 11380074 [PubMed - indexed for MEDLINE]Related articles

A combination of KH1060, a vitamin D(3) analogue, and cyclosporin prevents early graft failure and prolongs graft survival of xenogeneic islets in nonobese diabetic mice.

Gysemans C, Waer M, Laureys J, Bouillon R, Mathieu C.

Transplant Proc. 2001 May;33(3):2365. No abstract available. PMID: 11377560 [PubMed - indexed for MEDLINE]Related articles

Immunomodulatory properties of a 1,25(OH)(2) vitamin D(3) analog combined with IFNbeta in an animal model of syngeneic islet transplantation.

van Etten E, Gysemans C, Verstuyf A, Bouillon R, Mathieu C.

Transplant Proc. 2001 May;33(3):2319. No abstract available. PMID: 11377545 [PubMed - indexed for MEDLINE]Related articles

Leflunomide and its analogue X920715 synergize with cyclosporin A in preventing early graft failure and delaying graft rejection of xenogeneic islets in nonobese diabetic mice.

Gysemans C, Waer M, Laureys J, Bouillon R, Mathieu C.

Transplant Proc. 2001 May;33(3):2094-5. No abstract available. PMID: 11377464 [PubMed - indexed for MEDLINE]Related articles

Monocyte chemoattractant protein-1 is expressed in pancreatic islets from prediabetic NOD mice and in interleukin-1 beta-exposed human and rat islet cells.

Chen MC, Proost P, Gysemans C, Mathieu C, Eizirik DL.

Diabetologia. 2001 Mar;44(3):325-32.PMID: 11317664 [PubMed - indexed for MEDLINE]Related articles

Early graft failure of xenogeneic islets in NOD mice is accompanied by high levels of interleukin-1 and low levels of transforming growth factor-beta mRNA in the grafts.

Gysemans CA, Waer M, Valckx D, Laureys JM, Mihkalsky D, Bouillon R, Mathieu C.

Diabetes. 2000 Dec;49(12):1992-7.PMID: 11117999 [PubMed - indexed for MEDLINE]Related articlesFree article

Streptococcal wall component OK432 restores sensitivity of non-obese diabetic (NOD) thymocytes to apoptotic signals.

Decallonne B, Overbergh L, Casteels KM, Gysemans C, Bouillon R, Mathieu C.

Diabetologia. 2000 Oct;43(10):1302-8.PMID: 11079749 [PubMed - indexed for MEDLINE]Related articles

Islet xenograft destruction in the hu-PBL-severe combined immunodeficient (SCID) mouse necessitates anti-CD3 preactivation of human immune cells.

Gysemans C, Waer M, Laureys J, Depovere J, Pipeleers D, Bouillon R, Mathieu C.

Clin Exp Immunol. 2000 Sep;121(3):557-65.PMID: 10971525 [PubMed - indexed for MEDLINE]Related articlesFree article

The role of interferon regulatory factor-1 in cytokine-induced mRNA expression and cell death in murine pancreatic beta-cells.

Pavlovic D, Chen MC, Gysemans CA, Mathieu C, Eizirik DL.

Eur Cytokine Netw. 1999 Sep;10(3):403-12.PMID: 10477397 [PubMed - indexed for MEDLINE]Related articles

Sex difference in resistance to dexamethasone-induced apoptosis in NOD mice: treatment with 1,25(OH)2D3 restores defect.

Casteels KM, Gysemans CA, Waer M, Bouillon R, Laureys JM, Depovere J, Mathieu C.

Diabetes. 1998 Jul;47(7):1033-7.PMID: 9648825 [PubMed - indexed for MEDLINE]Related articlesFree article

The use of intermittent lighting in broiler raising. 2. Effects on the somatotrophic and thyroid axes and on plasma testosterone levels.

Kühn ER, Darras VM, Gysemans C, Decuypere E, Berghman LR, Buyse J.

Poult Sci. 1996 May;75(5):595-600.PMID: 8722907 [PubMed - indexed for MEDLINE]Related articles