PubMed

Activated polyamine catabolism leads to low cholesterol levels by enhancing bile acid synthesis.

Pirinen E, Gylling H, Itkonen P, Yaluri N, Heikkinen S, Pietilä M, Kuulasmaa T, Tusa M, Cerrada-Gimenez M, Pihlajamäki J, Alhonen L, Jänne J, Miettinen TA, Laakso M.

Amino Acids. 2009 Dec 3. [Epub ahead of print]PMID: 19956992 [PubMed - as supplied by publisher]Related articles

Pandemic influenza: human rights, ethics and duty to treat.

Pahlman I, Tohmo H, Gylling H.

Acta Anaesthesiol Scand. 2009 Nov 16. [Epub ahead of print]PMID: 19919583 [PubMed - as supplied by publisher]Related articles

Very high plant stanol intake and serum plant stanols and non-cholesterol sterols.

Gylling H, Hallikainen M, Nissinen MJ, Simonen P, Miettinen TA.

Eur J Nutr. 2009 Sep 23. [Epub ahead of print]PMID: 19774436 [PubMed - as supplied by publisher]Related articles

The effect of a very high daily plant stanol ester intake on serum lipids, carotenoids, and fat-soluble vitamins.

Gylling H, Hallikainen M, Nissinen MJ, Miettinen TA.

Clin Nutr. 2009 Aug 25. [Epub ahead of print]PMID: 19709787 [PubMed - as supplied by publisher]Related articles

Applicability of non-cholesterol sterols in predicting response in cholesterol metabolism to simvastatin and fluvastatin treatment among hypercholesterolemic men.

Nissinen MJ, Miettinen TE, Gylling H, Miettinen TA.

Nutr Metab Cardiovasc Dis. 2009 Aug 18. [Epub ahead of print]PMID: 19695854 [PubMed - as supplied by publisher]Related articles

Cholesterol, non-cholesterol sterols and bile acids in paediatric gallstones.

Koivusalo AI, Pakarinen MP, Sittiwet C, Gylling H, Miettinen TA, Miettinen TE, Nissinen MJ.

Dig Liver Dis. 2009 Jul 23. [Epub ahead of print]PMID: 19632165 [PubMed - as supplied by publisher]Related articles

Dietary carbohydrate modification alters serum metabolic profiles in individuals with the metabolic syndrome.

Lankinen M, Schwab U, Gopalacharyulu PV, Seppänen-Laakso T, Yetukuri L, Sysi-Aho M, Kallio P, Suortti T, Laaksonen DE, Gylling H, Poutanen K, Kolehmainen M, Orešič M.

Nutr Metab Cardiovasc Dis. 2009 Jun 22. [Epub ahead of print]PMID: 19553094 [PubMed - as supplied by publisher]Related articles

Fatty fish intake decreases lipids related to inflammation and insulin signaling--a lipidomics approach.

Lankinen M, Schwab U, Erkkilä A, Seppänen-Laakso T, Hannila ML, Mussalo H, Lehto S, Uusitupa M, Gylling H, Oresic M.

PLoS One. 2009;4(4):e5258. Epub 2009 Apr 23.PMID: 19390588 [PubMed - indexed for MEDLINE]Related articlesFree article

The metabolism of plant sterols is disturbed in postmenopausal women with coronary artery disease.

Gylling H, Hallikainen M, Rajaratnam RA, Simonen P, Pihlajamäki J, Laakso M, Miettinen TA.

Metabolism. 2009 Mar;58(3):401-7.PMID: 19217458 [PubMed - indexed for MEDLINE]Related articles

Increased exposure to estrogens disturbs maturation, steroidogenesis, and cholesterol homeostasis via estrogen receptor alpha in adult mouse Leydig cells.

Strauss L, Kallio J, Desai N, Pakarinen P, Miettinen T, Gylling H, Albrecht M, Mäkelä S, Mayerhofer A, Poutanen M.

Endocrinology. 2009 Jun;150(6):2865-72. Epub 2009 Feb 5.PMID: 19196801 [PubMed - indexed for MEDLINE]Related articles

Twenty-one year tracking of serum non-cholesterol sterols. The Cardiovascular Risk in Young Finns study.

Miettinen TA, Hallikainen M, Raitakari OT, Viikari J, Gylling H.

Nutr Metab Cardiovasc Dis. 2009 Oct;19(8):525-31. Epub 2009 Jan 29.PMID: 19185477 [PubMed - in process]Related articles

The common variant in the FTO gene did not modify the effect of lifestyle changes on body weight: the Finnish Diabetes Prevention Study.

Lappalainen TJ, Tolppanen AM, Kolehmainen M, Schwab U, Lindström J, Tuomilehto J, Pulkkinen L, Eriksson JG, Laakso M, Gylling H, Uusitupa M; Finnish Diabetes Prevention Study Group.

Obesity (Silver Spring). 2009 Apr;17(4):832-6. Epub 2009 Jan 29.PMID: 19180072 [PubMed - indexed for MEDLINE]Related articles

The effects of statins and sitosterols: benefit or not?

Miettinen TA, Gylling H.

Curr Atheroscler Rep. 2009 Jan;11(1):23-7.PMID: 19080724 [PubMed - indexed for MEDLINE]Related articles

Long-term consumption of plant stanol and sterol esters, vascular function and genetic regulation.

Gylling H, Hallikainen M, Raitakari OT, Laakso M, Vartiainen E, Salo P, Korpelainen V, Sundvall J, Miettinen TA.

Br J Nutr. 2009 Jun;101(11):1688-95. Epub 2008 Nov 19.PMID: 19019257 [PubMed - indexed for MEDLINE]Related articles

Plant stanol ester spreads as components of a balanced diet for pregnant and breast-feeding women: evaluation of clinical safety.

Laitinen K, Isolauri E, Kaipiainen L, Gylling H, Miettinen TA.

Br J Nutr. 2009 Jun;101(12):1797-804. Epub 2008 Nov 19.PMID: 19017423 [PubMed - indexed for MEDLINE]Related articles

Lifestyle intervention with weight reduction: first-line treatment in mild obstructive sleep apnea.

Tuomilehto HP, Seppä JM, Partinen MM, Peltonen M, Gylling H, Tuomilehto JO, Vanninen EJ, Kokkarinen J, Sahlman JK, Martikainen T, Soini EJ, Randell J, Tukiainen H, Uusitupa M; Kuopio Sleep Apnea Group.

Am J Respir Crit Care Med. 2009 Feb 15;179(4):320-7. Epub 2008 Nov 14.PMID: 19011153 [PubMed - indexed for MEDLINE]Related articles

Serum sterols in patients with primary biliary cirrhosis and acute liver failure before and after liver transplantation.

Nikkilä K, Nissinen MJ, Gylling H, Isoniemi H, Miettinen TA.

J Hepatol. 2008 Dec;49(6):936-45. Epub 2008 Sep 26.PMID: 18926587 [PubMed - indexed for MEDLINE]Related articles

Polymorphism of the hepatic influx transporter organic anion transporting polypeptide 1B1 is associated with increased cholesterol synthesis rate.

Pasanen MK, Miettinen TA, Gylling H, Neuvonen PJ, Niemi M.

Pharmacogenet Genomics. 2008 Oct;18(10):921-6.PMID: 18794729 [PubMed - indexed for MEDLINE]Related articles

Downregulation of genes involved in NFkappaB activation in peripheral blood mononuclear cells after weight loss is associated with the improvement of insulin sensitivity in individuals with the metabolic syndrome: the GENOBIN study.

de Mello VD, Kolehmainen M, Pulkkinen L, Schwab U, Mager U, Laaksonen DE, Niskanen L, Gylling H, Atalay M, Rauramaa R, Uusitupa M.

Diabetologia. 2008 Nov;51(11):2060-7. Epub 2008 Aug 30.PMID: 18758745 [PubMed - indexed for MEDLINE]Related articles

Effect of weight reduction on rhinometric measurements in overweight patients with obstructive sleep apnea.

Kemppainen T, Ruoppi P, Seppä J, Sahlman J, Peltonen M, Tukiainen H, Gylling H, Vanninen E, Tuomilehto H.

Am J Rhinol. 2008 Jul-Aug;22(4):410-5.PMID: 18702908 [PubMed - indexed for MEDLINE]Related articles

Effect of parenteral serum plant sterols on liver enzymes and cholesterol metabolism in a patient with short bowel syndrome.

Hallikainen M, Huikko L, Kontra K, Nissinen M, Piironen V, Miettinen T, Gylling H.

Nutr Clin Pract. 2008 Aug-Sep;23(4):429-35.PMID: 18682596 [PubMed - indexed for MEDLINE]Related articles

Triacylglycerol fatty acid composition in diet-induced weight loss in subjects with abnormal glucose metabolism--the GENOBIN study.

Schwab U, Seppänen-Laakso T, Yetukuri L, Agren J, Kolehmainen M, Laaksonen DE, Ruskeepää AL, Gylling H, Uusitupa M, Oresic M; GENOBIN Study Group.

PLoS One. 2008 Jul 9;3(7):e2630.PMID: 18612464 [PubMed - indexed for MEDLINE]Related articlesFree article

Adolescent cholesterol metabolism predicts coronary risk factors at middle age: the Cardiovascular Risk in Young Finns Study.

Miettinen TA, Gylling H, Raitakari OT, Hallikainen M, Viikari J.

Transl Res. 2008 May;151(5):260-6. Epub 2008 Mar 27.PMID: 18433708 [PubMed - indexed for MEDLINE]Related articles

Vascular effects of diets, especially plant sterol ester consumption.

Miettinen TA, Gylling H.

J Am Coll Cardiol. 2008 Apr 22;51(16):1562-3. No abstract available. PMID: 18420098 [PubMed - indexed for MEDLINE]Related articles

Accumulation of cholesterol precursors and plant sterols in human stenotic aortic valves.

Helske S, Miettinen T, Gylling H, Mäyränpää M, Lommi J, Turto H, Werkkala K, Kupari M, Kovanen PT.

J Lipid Res. 2008 Jul;49(7):1511-8. Epub 2008 Apr 8.PMID: 18398220 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression of ghrelin gene in peripheral blood mononuclear cells and plasma ghrelin concentrations in patients with metabolic syndrome.

Mager U, Kolehmainen M, de Mello VD, Schwab U, Laaksonen DE, Rauramaa R, Gylling H, Atalay M, Pulkkinen L, Uusitupa M.

Eur J Endocrinol. 2008 Apr;158(4):499-510.PMID: 18362297 [PubMed - indexed for MEDLINE]Related articlesFree article

Serum concentrations and expressions of serum amyloid A and leptin in adipose tissue are interrelated: the Genobin Study.

Lappalainen T, Kolehmainen M, Schwab U, Pulkkinen L, Laaksonen DE, Rauramaa R, Uusitupa M, Gylling H.

Eur J Endocrinol. 2008 Mar;158(3):333-41.PMID: 18299466 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of dietary cholesterol and fat on serum non-cholesterol sterols according to different apolipoprotein E subgroups among healthy men.

Nissinen MJ, Gylling H, Miettinen TA.

Br J Nutr. 2008 Aug;100(2):373-9. Epub 2008 Feb 18.PMID: 18279555 [PubMed - indexed for MEDLINE]Related articles

Plant stanol ester consumption and arterial elasticity and endothelial function.

Raitakari OT, Salo P, Gylling H, Miettinen TA.

Br J Nutr. 2008 Sep;100(3):603-8. Epub 2008 Feb 18.PMID: 18279553 [PubMed - indexed for MEDLINE]Related articles

Effect of weight loss on cytokine messenger RNA expression in peripheral blood mononuclear cells of obese subjects with the metabolic syndrome.

de Mello VD, Kolehmainen M, Schwab U, Mager U, Laaksonen DE, Pulkkinen L, Niskanen L, Gylling H, Atalay M, Rauramaa R, Uusitupa M.

Metabolism. 2008 Feb;57(2):192-9.PMID: 18191048 [PubMed - indexed for MEDLINE]Related articles

Synthesis and absorption of cholesterol in Finnish boys by serum non-cholesterol sterols: the cardiovascular risk in Young Finns Study.

Miettinen TA, Gylling H, Viikari J, Lehtimäki T, Raitakari OT.

Atherosclerosis. 2008 Sep;200(1):177-83. Epub 2008 Feb 21.PMID: 18178213 [PubMed - indexed for MEDLINE]Related articles

SREBP-1c gene polymorphism is associated with increased inhibition of cholesterol-absorption in response to ezetimibe treatment.

Berthold HK, Laaksonen R, Lehtimäki T, Gylling H, Krone W, Gouni-Berthold I.

Exp Clin Endocrinol Diabetes. 2008 May;116(5):262-7. Epub 2007 Dec 10.PMID: 18072016 [PubMed - indexed for MEDLINE]Related articles

Effects of plant stanol esters on serum cholesterol concentrations, relative markers of cholesterol metabolism and endothelial function in type 1 diabetes.

Hallikainen M, Lyyra-Laitinen T, Laitinen T, Moilanen L, Miettinen TA, Gylling H.

Atherosclerosis. 2008 Aug;199(2):432-9. Epub 2007 Dec 11.PMID: 18062976 [PubMed - indexed for MEDLINE]Related articles

Effects of ezetimibe and/or simvastatin on LDL receptor protein expression and on LDL receptor and HMG-CoA reductase gene expression: a randomized trial in healthy men.

Gouni-Berthold I, Berthold HK, Gylling H, Hallikainen M, Giannakidou E, Stier S, Ko Y, Patel D, Soutar AK, Seedorf U, Mantzoros CS, Plat J, Krone W.

Atherosclerosis. 2008 May;198(1):198-207. Epub 2007 Nov 5.PMID: 17980884 [PubMed - indexed for MEDLINE]Related articles

The validity of serum squalene and non-cholesterol sterols as surrogate markers of cholesterol synthesis and absorption in type 2 diabetes.

Simonen P, Gylling H, Miettinen TA.

Atherosclerosis. 2008 Apr;197(2):883-8. Epub 2007 Sep 17.PMID: 17875306 [PubMed - indexed for MEDLINE]Related articles

Weight reduction modulates expression of genes involved in extracellular matrix and cell death: the GENOBIN study.

Kolehmainen M, Salopuro T, Schwab US, Kekäläinen J, Kallio P, Laaksonen DE, Pulkkinen L, Lindi VI, Sivenius K, Mager U, Siitonen N, Niskanen L, Gylling H, Rauramaa R, Uusitupa M.

Int J Obes (Lond). 2008 Feb;32(2):292-303. Epub 2007 Sep 11.PMID: 17848939 [PubMed - indexed for MEDLINE]Related articles

Responses of surrogate markers of cholesterol absorption and synthesis to changes in cholesterol metabolism during various amounts of fat and cholesterol feeding among healthy men.

Nissinen MJ, Gylling H, Miettinen TA.

Br J Nutr. 2008 Feb;99(2):370-8. Epub 2007 Aug 15.PMID: 17697430 [PubMed - indexed for MEDLINE]Related articles

Serum adipokines are associated with cholesterol metabolism in the metabolic syndrome.

Hallikainen M, Kolehmainen M, Schwab U, Laaksonen DE, Niskanen L, Rauramaa R, Pihlajamäki J, Uusitupa M, Miettinen TA, Gylling H.

Clin Chim Acta. 2007 Aug;383(1-2):126-32. Epub 2007 May 18.PMID: 17573060 [PubMed - indexed for MEDLINE]Related articles

Respective hydrolysis and esterification of esterified and free plant stanols occur rapidly in human intestine after their duodenal infusion in triacyl- or diacylglycerol.

Nissinen MJ, Vuoristo M, Gylling H, Miettinen TA.

Lipids. 2007 Jul;42(7):603-12. Epub 2007 Jun 6.PMID: 17551763 [PubMed - indexed for MEDLINE]Related articles

Cholesterol synthesis prevails over absorption in metabolic syndrome.

Gylling H, Hallikainen M, Kolehmainen M, Toppinen L, Pihlajamäki J, Mykkänen H, Agren JJ, Rauramaa R, Laakso M, Miettinen TA.

Transl Res. 2007 Jun;149(6):310-6. Epub 2007 May 23.PMID: 17543849 [PubMed - indexed for MEDLINE]Related articles

Serum high sensitivity C-reactive protein and cognitive function in elderly women.

Komulainen P, Lakka TA, Kivipelto M, Hassinen M, Penttilä IM, Helkala EL, Gylling H, Nissinen A, Rauramaa R.

Age Ageing. 2007 Jul;36(4):443-8. Epub 2007 May 30.PMID: 17537742 [PubMed - indexed for MEDLINE]Related articlesFree article

Plant stanol esters are potentially cost-effective in the prevention of coronary heart disease in men: Bayesian modelling approach.

Martikainen JA, Ottelin AM, Kiviniemi V, Gylling H.

Eur J Cardiovasc Prev Rehabil. 2007 Apr;14(2):265-72.PMID: 17446806 [PubMed - indexed for MEDLINE]Related articles

Costs of a self-selected, health-promoting diet among the participants of the Finnish Diabetes Prevention Study.

Ottelin AM, Lindström J, Peltonen M, Martikainen J, Uusitupa M, Gylling H, Poutanen K, Louheranta A, Mannelin M, Paturi M, Salminen V, Tuomilehto J; Finnish Diabetes Prevention Study Group.

Diabetes Care. 2007 May;30(5):1275-7. Epub 2007 Feb 26. No abstract available. PMID: 17325262 [PubMed - indexed for MEDLINE]Related articlesFree article

Blood glucose and the metabolism of cholesterol in coronary patients with and without simvastatin treatment.

Miettinen TA, Gylling H; Subgroup analysis of Scandinavian Simvastatin Survival Study (4S).

Clin Chim Acta. 2007 Apr;379(1-2):53-8. Epub 2006 Dec 22.PMID: 17258182 [PubMed - indexed for MEDLINE]Related articles

Moderate increase in dietary sucrose does not influence fasting or postprandial serum lipids regardless of the presence of apolipoprotein E2 allele in healthy subjects.

Erkkilä AT, Schwab US, Agren JJ, Hallikainen M, Gylling H, Uusitupa MI.

Eur J Clin Nutr. 2007 Sep;61(9):1094-101. Epub 2007 Jan 17.PMID: 17228342 [PubMed - indexed for MEDLINE]Related articles

Interaction between cholesterol and glucose metabolism during dietary carbohydrate modification in subjects with the metabolic syndrome.

Hallikainen M, Toppinen L, Mykkänen H, Agren JJ, Laaksonen DE, Miettinen TA, Niskanen L, Poutanen KS, Gylling H.

Am J Clin Nutr. 2006 Dec;84(6):1385-92.PMID: 17158421 [PubMed - indexed for MEDLINE]Related articlesFree article

Markers of absorption and synthesis of cholesterol in men with type 1 diabetes.

Gylling H, Laaksonen DE, Atalay M, Hallikainen M, Niskanen L, Miettinen TA.

Diabetes Metab Res Rev. 2007 Jul;23(5):372-7.PMID: 17080398 [PubMed - indexed for MEDLINE]Related articles

Cholesterol absorption and synthesis in children with type 1 diabetes.

Järvisalo M, Raitakari O, Gylling H, Miettinen TA.

Diabetes Care. 2006 Oct;29(10):2300-4.PMID: 17003310 [PubMed - indexed for MEDLINE]Related articlesFree article

Cholesterol metabolism and non-cholesterol sterol distribution in lipoproteins of type 1 diabetes: the effect of improved glycemic control.

Sittiwet C, Gylling H, Hallikainen M, Pihlajamäki J, Moilanen L, Laaksonen DE, Niskanen L, Agren JJ, Laakso M, Miettinen TA.

Atherosclerosis. 2007 Oct;194(2):465-72. Epub 2006 Sep 25.PMID: 16996519 [PubMed - indexed for MEDLINE]Related articles

The distribution of squalene and non-cholesterol sterols in lipoproteins in type 2 diabetes.

Simonen PP, Gylling H, Miettinen TA.

Atherosclerosis. 2007 Sep;194(1):222-9. Epub 2006 Sep 11.PMID: 16963050 [PubMed - indexed for MEDLINE]Related articles