PubMed

MBX-102/JNJ39659100, a novel peroxisome proliferator-activated receptor-ligand with weak transactivation activity retains antidiabetic properties in the absence of weight gain and edema.

Gregoire FM, Zhang F, Clarke HJ, Gustafson TA, Sears DD, Favelyukis S, Lenhard J, Rentzeperis D, Clemens LE, Mu Y, Lavan BE.

Mol Endocrinol. 2009 Jul;23(7):975-88. Epub 2009 Apr 23.PMID: 19389808 [PubMed - indexed for MEDLINE]Related articles

Halofenate is a selective peroxisome proliferator-activated receptor gamma modulator with antidiabetic activity.

Allen T, Zhang F, Moodie SA, Clemens LE, Smith A, Gregoire F, Bell A, Muscat GE, Gustafson TA.

Diabetes. 2006 Sep;55(9):2523-33.PMID: 16936200 [PubMed - indexed for MEDLINE]Related articlesFree article

The BPS domain of Grb10 inhibits the catalytic activity of the insulin and IGF1 receptors.

Stein EG, Gustafson TA, Hubbard SR.

FEBS Lett. 2001 Mar 30;493(2-3):106-11.PMID: 11287005 [PubMed - indexed for MEDLINE]Related articles

Functional inactivation of the IGF-I receptor delays differentiation of skeletal muscle cells.

Cheng ZQ, Adi S, Wu NY, Hsiao D, Woo EJ, Filvaroff EH, Gustafson TA, Rosenthal SM.

J Endocrinol. 2000 Oct;167(1):175-82.PMID: 11018765 [PubMed - indexed for MEDLINE]Related articlesFree article

Interaction of the PA2G4 (EBP1) protein with ErbB-3 and regulation of this binding by heregulin.

Yoo JY, Wang XW, Rishi AK, Lessor T, Xia XM, Gustafson TA, Hamburger AW.

Br J Cancer. 2000 Feb;82(3):683-90.PMID: 10682683 [PubMed - indexed for MEDLINE]Related articlesFree article

Alternative splicing, gene localization, and binding of SH2-B to the insulin receptor kinase domain.

Nelms K, O'Neill TJ, Li S, Hubbard SR, Gustafson TA, Paul WE.

Mamm Genome. 1999 Dec;10(12):1160-7.PMID: 10594240 [PubMed - indexed for MEDLINE]Related articles

Age-related adipose tissue mRNA expression of ADD1/SREBP1, PPARgamma, lipoprotein lipase, and GLUT4 glucose transporter in rhesus monkeys.

Hotta K, Bodkin NL, Gustafson TA, Yoshioka S, Ortmeyer HK, Hansen BC.

J Gerontol A Biol Sci Med Sci. 1999 May;54(5):B183-8.PMID: 10361996 [PubMed - indexed for MEDLINE]Related articles

Insulin receptor substrate-1 enhances growth hormone-induced proliferation.

Liang L, Zhou T, Jiang J, Pierce JH, Gustafson TA, Frank SJ.

Endocrinology. 1999 May;140(5):1972-83.PMID: 10218944 [PubMed - indexed for MEDLINE]Related articlesFree article

The insulin receptor and metabolic signaling.

Gustafson TA, Moodie SA, Lavan BE.

Rev Physiol Biochem Pharmacol. 1999;137:71-190. Review. No abstract available. PMID: 10207305 [PubMed - indexed for MEDLINE]Related articles

Identification of the APS protein as a novel insulin receptor substrate.

Moodie SA, Alleman-Sposeto J, Gustafson TA.

J Biol Chem. 1999 Apr 16;274(16):11186-93.PMID: 10196204 [PubMed - indexed for MEDLINE]Related articlesFree article

Relationships of PPARgamma and PPARgamma2 mRNA levels to obesity, diabetes and hyperinsulinaemia in rhesus monkeys.

Hotta K, Gustafson TA, Yoshioka S, Ortmeyer HK, Bodkin NL, Hansen BC.

Int J Obes Relat Metab Disord. 1998 Oct;22(10):1000-10.PMID: 9806316 [PubMed - indexed for MEDLINE]Related articles

Monkey leptin receptor mRNA: sequence, tissue distribution, and mRNA expression in the adipose tissue of normal, hyperinsulinemic, and type 2 diabetic rhesus monkeys.

Hotta K, Gustafson TA, Ortmeyer HK, Bodkin NL, Hansen BC.

Obes Res. 1998 Sep;6(5):353-60.PMID: 9738551 [PubMed - indexed for MEDLINE]Related articles

Grb10 interacts differentially with the insulin receptor, insulin-like growth factor I receptor, and epidermal growth factor receptor via the Grb10 Src homology 2 (SH2) domain and a second novel domain located between the pleckstrin homology and SH2 domains.

He W, Rose DW, Olefsky JM, Gustafson TA.

J Biol Chem. 1998 Mar 20;273(12):6860-7.PMID: 9506989 [PubMed - indexed for MEDLINE]Related articlesFree article

Adenovirus-mediated overexpression of IRS-1 interacting domains abolishes insulin-stimulated mitogenesis without affecting glucose transport in 3T3-L1 adipocytes.

Sharma PM, Egawa K, Gustafson TA, Martin JL, Olefsky JM.

Mol Cell Biol. 1997 Dec;17(12):7386-97.PMID: 9372969 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of SH2-Bbeta as a substrate of the tyrosine kinase JAK2 involved in growth hormone signaling.

Rui L, Mathews LS, Hotta K, Gustafson TA, Carter-Su C.

Mol Cell Biol. 1997 Nov;17(11):6633-44.PMID: 9343427 [PubMed - indexed for MEDLINE]Related articlesFree article

14-3-3 (epsilon) interacts with the insulin-like growth factor I receptor and insulin receptor substrate I in a phosphoserine-dependent manner.

Craparo A, Freund R, Gustafson TA.

J Biol Chem. 1997 Apr 25;272(17):11663-9.PMID: 9111084 [PubMed - indexed for MEDLINE]Related articlesFree article

Interaction of MAD2 with the carboxyl terminus of the insulin receptor but not with the IGFIR. Evidence for release from the insulin receptor after activation.

O'Neill TJ, Zhu Y, Gustafson TA.

J Biol Chem. 1997 Apr 11;272(15):10035-40.PMID: 9092546 [PubMed - indexed for MEDLINE]Related articlesFree article

The anti-cancer agent distamycin A displaces essential transcription factors and selectively inhibits myogenic differentiation.

Taylor A, Webster KA, Gustafson TA, Kedes L.

Mol Cell Biochem. 1997 Apr;169(1-2):61-72.PMID: 9089632 [PubMed - indexed for MEDLINE]Related articles

Protein-tyrosine phosphatase 1B complexes with the insulin receptor in vivo and is tyrosine-phosphorylated in the presence of insulin.

Bandyopadhyay D, Kusari A, Kenner KA, Liu F, Chernoff J, Gustafson TA, Kusari J.

J Biol Chem. 1997 Jan 17;272(3):1639-45.PMID: 8999839 [PubMed - indexed for MEDLINE]Related articlesFree article

Three new toxins from the scorpion Pandinus imperator selectively block certain voltage-gated K+ channels.

Rogowski RS, Collins JH, O'Neill TJ, Gustafson TA, Werkman TR, Rogawski MA, Tenenholz TC, Weber DJ, Blaustein MP.

Mol Pharmacol. 1996 Nov;50(5):1167-77.PMID: 8913348 [PubMed - indexed for MEDLINE]Related articles

Regulation of obese (ob) mRNA and plasma leptin levels in rhesus monkeys. Effects of insulin, body weight, and non-insulin-dependent diabetes mellitus.

Hotta K, Gustafson TA, Ortmeyer HK, Bodkin NL, Nicolson MA, Hansen BC.

J Biol Chem. 1996 Oct 11;271(41):25327-31.PMID: 8810296 [PubMed - indexed for MEDLINE]Related articlesFree article

Interaction of a GRB-IR splice variant (a human GRB10 homolog) with the insulin and insulin-like growth factor I receptors. Evidence for a role in mitogenic signaling.

O'Neill TJ, Rose DW, Pillay TS, Hotta K, Olefsky JM, Gustafson TA.

J Biol Chem. 1996 Sep 13;271(37):22506-13.PMID: 8798417 [PubMed - indexed for MEDLINE]Related articlesFree article

Evidence for an insulin receptor substrate 1 independent insulin signaling pathway that mediates insulin-responsive glucose transporter (GLUT4) translocation.

Morris AJ, Martin SS, Haruta T, Nelson JG, Vollenweider P, Gustafson TA, Mueckler M, Rose DW, Olefsky JM.

Proc Natl Acad Sci U S A. 1996 Aug 6;93(16):8401-6.PMID: 8710883 [PubMed - indexed for MEDLINE]Related articlesFree article

Interaction of insulin receptor substrate-2 (IRS-2) with the insulin and insulin-like growth factor I receptors. Evidence for two distinct phosphotyrosine-dependent interaction domains within IRS-2.

He W, Craparo A, Zhu Y, O'Neill TJ, Wang LM, Pierce JH, Gustafson TA.

J Biol Chem. 1996 May 17;271(20):11641-5.PMID: 8662806 [PubMed - indexed for MEDLINE]Related articlesFree article

Distinct modes of interaction of SHC and insulin receptor substrate-1 with the insulin receptor NPEY region via non-SH2 domains.

He W, O'Neill TJ, Gustafson TA.

J Biol Chem. 1995 Oct 6;270(40):23258-62.PMID: 7559478 [PubMed - indexed for MEDLINE]Related articlesFree article

Non-SH2 domains within insulin receptor substrate-1 and SHC mediate their phosphotyrosine-dependent interaction with the NPEY motif of the insulin-like growth factor I receptor.

Craparo A, O'Neill TJ, Gustafson TA.

J Biol Chem. 1995 Jun 30;270(26):15639-43.PMID: 7541045 [PubMed - indexed for MEDLINE]Related articlesFree article

Phosphotyrosine-dependent interaction of SHC and insulin receptor substrate 1 with the NPEY motif of the insulin receptor via a novel non-SH2 domain.

Gustafson TA, He W, Craparo A, Schaub CD, O'Neill TJ.

Mol Cell Biol. 1995 May;15(5):2500-8.PMID: 7537849 [PubMed - indexed for MEDLINE]Related articlesFree article

Characterization of an interaction between insulin receptor substrate 1 and the insulin receptor by using the two-hybrid system.

O'Neill TJ, Craparo A, Gustafson TA.

Mol Cell Biol. 1994 Oct;14(10):6433-42.PMID: 7935368 [PubMed - indexed for MEDLINE]Related articlesFree article

Positively charged side chains in the insulin-like growth factor-1 C- and D-regions determine receptor binding specificity.

Zhang W, Gustafson TA, Rutter WJ, Johnson JD.

J Biol Chem. 1994 Apr 8;269(14):10609-13.PMID: 8144650 [PubMed - indexed for MEDLINE]Related articlesFree article

Mutually exclusive exon splicing of type III brain sodium channel alpha subunit RNA generates developmentally regulated isoforms in rat brain.

Gustafson TA, Clevinger EC, O'Neill TJ, Yarowsky PJ, Krueger BK.

J Biol Chem. 1993 Sep 5;268(25):18648-53.PMID: 8395514 [PubMed - indexed for MEDLINE]Related articlesFree article

Tityustoxin-K alpha, a structurally novel and highly potent K+ channel peptide toxin, interacts with the alpha-dendrotoxin binding site on the cloned Kv1.2 K+ channel.

Werkman TR, Gustafson TA, Rogowski RS, Blaustein MP, Rogawski MA.

Mol Pharmacol. 1993 Aug;44(2):430-6.PMID: 8355670 [PubMed - indexed for MEDLINE]Related articles

The cysteine-rich domains of the insulin and insulin-like growth factor I receptors are primary determinants of hormone binding specificity. Evidence from receptor chimeras.

Gustafson TA, Rutter WJ.

J Biol Chem. 1990 Oct 25;265(30):18663-7.PMID: 2170418 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of multiple proteins that interact with functional regions of the human cardiac alpha-actin promoter.

Gustafson TA, Kedes L.

Mol Cell Biol. 1989 Aug;9(8):3269-83.PMID: 2796988 [PubMed - indexed for MEDLINE]Related articlesFree article

DNA bending is induced by a transcription factor that interacts with the human c-FOS and alpha-actin promoters.

Gustafson TA, Taylor A, Kedes L.

Proc Natl Acad Sci U S A. 1989 Apr;86(7):2162-6.PMID: 2494661 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification and characterization of a factor that binds to two human sarcomeric actin promoters.

Boxer LM, Miwa T, Gustafson TA, Kedes L.

J Biol Chem. 1989 Jan 15;264(2):1284-92.PMID: 2910853 [PubMed - indexed for MEDLINE]Related articlesFree article

A common factor regulates skeletal and cardiac alpha-actin gene transcription in muscle.

Muscat GE, Gustafson TA, Kedes L.

Mol Cell Biol. 1988 Oct;8(10):4120-33.PMID: 3185543 [PubMed - indexed for MEDLINE]Related articlesFree article

Interaction of nuclear proteins with muscle-specific regulatory sequences of the human cardiac alpha-actin promoter.

Gustafson TA, Miwa T, Boxer LM, Kedes L.

Mol Cell Biol. 1988 Oct;8(10):4110-9.PMID: 3185542 [PubMed - indexed for MEDLINE]Related articlesFree article

Hormonal regulation of myosin heavy chain and alpha-actin gene expression in cultured fetal rat heart myocytes.

Gustafson TA, Bahl JJ, Markham BE, Roeske WR, Morkin E.

J Biol Chem. 1987 Sep 25;262(27):13316-22.PMID: 2888758 [PubMed - indexed for MEDLINE]Related articlesFree article

Interaction of a protein factor within a thyroid hormone-sensitive region of rat alpha-myosin heavy chain gene.

Markham BE, Bahl JJ, Gustafson TA, Morkin E.

J Biol Chem. 1987 Sep 15;262(26):12856-62.PMID: 3624281 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of L-thyroxine in rats with chronic heart failure after myocardial infarction.

Gay R, Gustafson TA, Goldman S, Morkin E.

Am J Physiol. 1987 Aug;253(2 Pt 2):H341-6.PMID: 3618809 [PubMed - indexed for MEDLINE]Related articles

Thyroid hormone regulates expression of a transfected alpha-myosin heavy-chain fusion gene in fetal heart cells.

Gustafson TA, Markham BE, Bahl JJ, Morkin E.

Proc Natl Acad Sci U S A. 1987 May;84(10):3122-6.PMID: 3472199 [PubMed - indexed for MEDLINE]Related articlesFree article

Complete amino acid sequence of human thyroxine-binding globulin deduced from cloned DNA: close homology to the serine antiproteases.

Flink IL, Bailey TJ, Gustafson TA, Markham BE, Morkin E.

Proc Natl Acad Sci U S A. 1986 Oct;83(20):7708-12.PMID: 3094014 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of thyroid hormone on alpha-actin and myosin heavy chain gene expression in cardiac and skeletal muscles of the rat: measurement of mRNA content using synthetic oligonucleotide probes.

Gustafson TA, Markham BE, Morkin E.

Circ Res. 1986 Aug;59(2):194-201.PMID: 3742743 [PubMed - indexed for MEDLINE]Related articlesFree article

Analysis of thyroid hormone effects on myosin heavy chain gene expression in cardiac and soleus muscles using a novel dot-blot mRNA assay.

Gustafson TA, Markham BE, Morkin E.

Biochem Biophys Res Commun. 1985 Aug 15;130(3):1161-7.PMID: 4026863 [PubMed - indexed for MEDLINE]Related articles