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    Results: 18

    1.

    Discovery of a new class of 4-anilinopyrimidines as potent c-Jun N-terminal kinase inhibitors: Synthesis and SAR studies.

    Liu M, Wang S, Clampit JE, Gum RJ, Haasch DL, Rondinone CM, Trevillyan JM, Abad-Zapatero C, Fry EH, Sham HL, Liu G.

    Bioorg Med Chem Lett. 2007 Feb 1;17(3):668-72. Epub 2006 Nov 2.PMID: 17107797 [PubMed - indexed for MEDLINE]Related articles

    2.

    Aminopyridine carboxamides as c-Jun N-terminal kinase inhibitors: targeting the gatekeeper residue and beyond.

    Liu G, Zhao H, Liu B, Xin Z, Liu M, Kosogof C, Szczepankiewicz BG, Wang S, Clampit JE, Gum RJ, Haasch DL, Trevillyan JM, Sham HL.

    Bioorg Med Chem Lett. 2006 Nov 15;16(22):5723-30. Epub 2006 Sep 12.PMID: 16971120 [PubMed - indexed for MEDLINE]Related articles

    3.

    Discovery of potent, highly selective, and orally bioavailable pyridine carboxamide c-Jun NH2-terminal kinase inhibitors.

    Zhao H, Serby MD, Xin Z, Szczepankiewicz BG, Liu M, Kosogof C, Liu B, Nelson LT, Johnson EF, Wang S, Pederson T, Gum RJ, Clampit JE, Haasch DL, Abad-Zapatero C, Fry EH, Rondinone C, Trevillyan JM, Sham HL, Liu G.

    J Med Chem. 2006 Jul 27;49(15):4455-8.PMID: 16854050 [PubMed - indexed for MEDLINE]Related articles

    4.

    Aminopyridine-based c-Jun N-terminal kinase inhibitors with cellular activity and minimal cross-kinase activity.

    Szczepankiewicz BG, Kosogof C, Nelson LT, Liu G, Liu B, Zhao H, Serby MD, Xin Z, Liu M, Gum RJ, Haasch DL, Wang S, Clampit JE, Johnson EF, Lubben TH, Stashko MA, Olejniczak ET, Sun C, Dorwin SA, Haskins K, Abad-Zapatero C, Fry EH, Hutchins CW, Sham HL, Rondinone CM, Trevillyan JM.

    J Med Chem. 2006 Jun 15;49(12):3563-80.PMID: 16759099 [PubMed - indexed for MEDLINE]Related articles

    5.

    Synthesis and SAR of 1,9-dihydro-9-hydroxypyrazolo[3,4-b]quinolin-4-ones as novel, selective c-Jun N-terminal kinase inhibitors.

    Liu M, Xin Z, Clampit JE, Wang S, Gum RJ, Haasch DL, Trevillyan JM, Abad-Zapatero C, Fry EH, Sham HL, Liu G.

    Bioorg Med Chem Lett. 2006 May 15;16(10):2590-4. Epub 2006 Mar 9.PMID: 16527482 [PubMed - indexed for MEDLINE]Related articles

    6.

    Benzoxazole benzenesulfonamides as allosteric inhibitors of fructose-1,6-bisphosphatase.

    Lai C, Gum RJ, Daly M, Fry EH, Hutchins C, Abad-Zapatero C, von Geldern TW.

    Bioorg Med Chem Lett. 2006 Apr 1;16(7):1807-10. Epub 2006 Jan 30.PMID: 16446092 [PubMed - indexed for MEDLINE]Related articles

    7.

    Benzoxazole benzenesulfonamides are novel allosteric inhibitors of fructose-1,6-bisphosphatase with a distinct binding mode.

    von Geldern TW, Lai C, Gum RJ, Daly M, Sun C, Fry EH, Abad-Zapatero C.

    Bioorg Med Chem Lett. 2006 Apr 1;16(7):1811-5. Epub 2006 Jan 25.PMID: 16442285 [PubMed - indexed for MEDLINE]Related articles

    8.

    Reduction of PTP1B induces differential expression of PI3-kinase (p85alpha) isoforms.

    Rondinone CM, Clampit J, Gum RJ, Zinker BA, Jirousek MR, Trevillyan JM.

    Biochem Biophys Res Commun. 2004 Oct 15;323(2):652-9.PMID: 15369800 [PubMed - indexed for MEDLINE]Related articles

    9.

    PTP1B antisense-treated mice show regulation of genes involved in lipogenesis in liver and fat.

    Waring JF, Ciurlionis R, Clampit JE, Morgan S, Gum RJ, Jolly RA, Kroeger P, Frost L, Trevillyan J, Zinker BA, Jirousek M, Ulrich RG, Rondinone CM.

    Mol Cell Endocrinol. 2003 May 30;203(1-2):155-68.PMID: 12782412 [PubMed - indexed for MEDLINE]Related articles

    10.

    Antisense protein tyrosine phosphatase 1B reverses activation of p38 mitogen-activated protein kinase in liver of ob/ob mice.

    Gum RJ, Gaede LL, Heindel MA, Waring JF, Trevillyan JM, Zinker BA, Stark ME, Wilcox D, Jirousek MR, Rondinone CM, Ulrich RG.

    Mol Endocrinol. 2003 Jun;17(6):1131-43. Epub 2003 Mar 20.PMID: 12649327 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    Reduction of protein tyrosine phosphatase 1B increases insulin-dependent signaling in ob/ob mice.

    Gum RJ, Gaede LL, Koterski SL, Heindel M, Clampit JE, Zinker BA, Trevillyan JM, Ulrich RG, Jirousek MR, Rondinone CM.

    Diabetes. 2003 Jan;52(1):21-8.PMID: 12502489 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    PTP1B antisense oligonucleotide lowers PTP1B protein, normalizes blood glucose, and improves insulin sensitivity in diabetic mice.

    Zinker BA, Rondinone CM, Trevillyan JM, Gum RJ, Clampit JE, Waring JF, Xie N, Wilcox D, Jacobson P, Frost L, Kroeger PE, Reilly RM, Koterski S, Opgenorth TJ, Ulrich RG, Crosby S, Butler M, Murray SF, McKay RA, Bhanot S, Monia BP, Jirousek MR.

    Proc Natl Acad Sci U S A. 2002 Aug 20;99(17):11357-62. Epub 2002 Aug 8.PMID: 12169659 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    Protein tyrosine phosphatase 1B reduction regulates adiposity and expression of genes involved in lipogenesis.

    Rondinone CM, Trevillyan JM, Clampit J, Gum RJ, Berg C, Kroeger P, Frost L, Zinker BA, Reilly R, Ulrich R, Butler M, Monia BP, Jirousek MR, Waring JF.

    Diabetes. 2002 Aug;51(8):2405-11.PMID: 12145151 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    Analysis of two matrix metalloproteinase inhibitors and their metabolites for induction of phospholipidosis in rat and human hepatocytes(1).

    Gum RJ, Hickman D, Fagerland JA, Heindel MA, Gagne GD, Schmidt JM, Michaelides MR, Davidsen SK, Ulrich RG.

    Biochem Pharmacol. 2001 Dec 15;62(12):1661-73.PMID: 11755120 [PubMed - indexed for MEDLINE]Related articles

    15.

    Identification of two distinct regions of p38 MAPK required for substrate binding and phosphorylation.

    Gum RJ, Young PR.

    Biochem Biophys Res Commun. 1999 Dec 9;266(1):284-9.PMID: 10581204 [PubMed - indexed for MEDLINE]Related articles

    16.

    Inhibitors of the p38 mitogen-activated kinase modulate IL-4 induction of low affinity IgE receptor (CD23) in human monocytes.

    Marshall LA, Hansbury MJ, Bolognese BJ, Gum RJ, Young PR, Mayer RJ.

    J Immunol. 1998 Dec 1;161(11):6005-13.PMID: 9834082 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    Acquisition of sensitivity of stress-activated protein kinases to the p38 inhibitor, SB 203580, by alteration of one or more amino acids within the ATP binding pocket.

    Gum RJ, McLaughlin MM, Kumar S, Wang Z, Bower MJ, Lee JC, Adams JL, Livi GP, Goldsmith EJ, Young PR.

    J Biol Chem. 1998 Jun 19;273(25):15605-10.PMID: 9624152 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    Novel homologues of CSBP/p38 MAP kinase: activation, substrate specificity and sensitivity to inhibition by pyridinyl imidazoles.

    Kumar S, McDonnell PC, Gum RJ, Hand AT, Lee JC, Young PR.

    Biochem Biophys Res Commun. 1997 Jun 27;235(3):533-8.PMID: 9207191 [PubMed - indexed for MEDLINE]Related articles

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