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Mind the gap: bringing scientists and society together.

Guinovart JJ.

Cell. 2009 May 29;137(5):793-5.PMID: 19490884 [PubMed - indexed for MEDLINE]Related articles

Control of liver glycogen synthase activity and intracellular distribution by phosphorylation.

Ros S, García-Rocha M, Domínguez J, Ferrer JC, Guinovart JJ.

J Biol Chem. 2009 Mar 6;284(10):6370-8. Epub 2009 Jan 5.PMID: 19124463 [PubMed - indexed for MEDLINE]Related articles

Tyrosine phosphorylation of vitreous inflammatory and angiogenic peptides and proteins in diabetic retinopathy.

Reverter JL, Nadal J, Fernández-Novell JM, Ballester J, Ramió-Lluch L, Rivera MM, Elizalde J, Abengoechea S, Guinovart JJ, Rodríguez-Gil JE.

Invest Ophthalmol Vis Sci. 2009 Mar;50(3):1378-82. Epub 2008 Oct 31.PMID: 18978347 [PubMed - indexed for MEDLINE]Related articles

Sodium tungstate decreases sucrase and Na+/D-glucose cotransporter in the jejunum of diabetic rats.

Miró-Queralt M, Guinovart JJ, Planas JM.

Am J Physiol Gastrointest Liver Physiol. 2008 Sep;295(3):G479-84. Epub 2008 Jul 10.PMID: 18617558 [PubMed - indexed for MEDLINE]Related articlesFree article

The glucose-lowering agent sodium tungstate increases the levels and translocation of GLUT4 in L6 myotubes through a mechanism associated with ERK1/2 and MEF2D.

Girón MD, Sevillano N, Vargas AM, Domínguez J, Guinovart JJ, Salto R.

Diabetologia. 2008 Jul;51(7):1285-95. Epub 2008 May 16.PMID: 18483800 [PubMed - indexed for MEDLINE]Related articles

IUBMB and the Mediterranean.

Guinovart JJ.

IUBMB Life. 2008 May;60(5):249. No abstract available. PMID: 18421777 [PubMed - indexed for MEDLINE]Related articles

Hepatic glycogen synthesis in the absence of glucokinase: the case of embryonic liver.

Cifuentes D, Martínez-Pons C, García-Rocha M, Galina A, Ribas de Pouplana L, Guinovart JJ.

J Biol Chem. 2008 Feb 29;283(9):5642-9. Epub 2007 Dec 28.PMID: 18165236 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of glycogen synthesis by the laforin-malin complex is modulated by the AMP-activated protein kinase pathway.

Solaz-Fuster MC, Gimeno-Alcañiz JV, Ros S, Fernandez-Sanchez ME, Garcia-Fojeda B, Criado Garcia O, Vilchez D, Dominguez J, Garcia-Rocha M, Sanchez-Piris M, Aguado C, Knecht E, Serratosa J, Guinovart JJ, Sanz P, Rodriguez de Córdoba S.

Hum Mol Genet. 2008 Mar 1;17(5):667-78. Epub 2007 Nov 20.PMID: 18029386 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanism suppressing glycogen synthesis in neurons and its demise in progressive myoclonus epilepsy.

Vilchez D, Ros S, Cifuentes D, Pujadas L, Vallès J, García-Fojeda B, Criado-García O, Fernández-Sánchez E, Medraño-Fernández I, Domínguez J, García-Rocha M, Soriano E, Rodríguez de Córdoba S, Guinovart JJ.

Nat Neurosci. 2007 Nov;10(11):1407-13. Epub 2007 Oct 21.PMID: 17952067 [PubMed - indexed for MEDLINE]Related articles

Tungstate administration improves the sexual and reproductive function in female rats with streptozotocin-induced diabetes.

Ballester J, Muñoz MC, Domínguez J, Palomo MJ, Rivera M, Rigau T, Guinovart JJ, Rodríguez-Gil JE.

Hum Reprod. 2007 Aug;22(8):2128-35. Epub 2007 Jun 22.PMID: 17588954 [PubMed - indexed for MEDLINE]Related articlesFree article

Phosphorylation events implicating p38 and PI3K mediate tungstate-effects in MIN6 beta cells.

Piquer S, Barceló-Batllori S, Julià M, Marzo N, Nadal B, Guinovart JJ, Gomis R.

Biochem Biophys Res Commun. 2007 Jun 29;358(2):385-91. Epub 2007 Apr 30.PMID: 17490618 [PubMed - indexed for MEDLINE]Related articles

Lithium ions increase hepatic glycogen synthase stability through a proteasome-related mechanism.

Fernández-Novell JM, Rodríguez-Gil JE, Barberà A, Guinovart JJ.

Arch Biochem Biophys. 2007 Jan 1;457(1):29-34. Epub 2006 Nov 10.PMID: 17125726 [PubMed - indexed for MEDLINE]Related articles

Inhibition of GSK3 dependent tau phosphorylation by metals.

Gómez-Ramos A, Domínguez J, Zafra D, Corominola H, Gomis R, Guinovart JJ, Avila J.

Curr Alzheimer Res. 2006 Apr;3(2):123-7. Review.PMID: 16611012 [PubMed - indexed for MEDLINE]Related articles

Sodium tungstate decreases the phosphorylation of tau through GSK3 inactivation.

Gómez-Ramos A, Domínguez J, Zafra D, Corominola H, Gomis R, Guinovart JJ, Avila J.

J Neurosci Res. 2006 Feb 1;83(2):264-73.PMID: 16397900 [PubMed - indexed for MEDLINE]Related articles

Utilization of citrate and lactate through a lactate dehydrogenase and ATP-regulated pathway in boar spermatozoa.

Medrano A, Fernández-Novell JM, Ramió L, Alvarez J, Goldberg E, Montserrat Rivera M, Guinovart JJ, Rigau T, Rodríguez-Gil JE.

Mol Reprod Dev. 2006 Mar;73(3):369-78.PMID: 16362974 [PubMed - indexed for MEDLINE]Related articles

Crystal structure of an archaeal glycogen synthase: insights into oligomerization and substrate binding of eukaryotic glycogen synthases.

Horcajada C, Guinovart JJ, Fita I, Ferrer JC.

J Biol Chem. 2006 Feb 3;281(5):2923-31. Epub 2005 Nov 29.PMID: 16319074 [PubMed - indexed for MEDLINE]Related articlesFree article

Tungstate treatment improves Leydig cell function in streptozotocin-diabetic rats.

Ballester J, Domínguez J, Muñoz MC, Sensat M, Rigau T, Guinovart JJ, Rodríguez-Gil JE.

J Androl. 2005 Nov-Dec;26(6):706-15.PMID: 16291965 [PubMed - indexed for MEDLINE]Related articlesFree article

Tungstate decreases weight gain and adiposity in obese rats through increased thermogenesis and lipid oxidation.

Claret M, Corominola H, Canals I, Saura J, Barcelo-Batllori S, Guinovart JJ, Gomis R.

Endocrinology. 2005 Oct;146(10):4362-9. Epub 2005 Jul 7.PMID: 16002523 [PubMed - indexed for MEDLINE]Related articlesFree article

Determinants of the nucleocytoplasmic shuttling of muscle glycogen synthase.

Cid E, Cifuentes D, Baqué S, Ferrer JC, Guinovart JJ.

FEBS J. 2005 Jun;272(12):3197-213.PMID: 15955076 [PubMed - indexed for MEDLINE]Related articlesFree article

Subcellular localization of liver FBPase is modulated by metabolic conditions.

Yáñez AJ, Garcia-Rocha M, Bertinat R, Droppelmann C, Concha II, Guinovart JJ, Slebe JC.

FEBS Lett. 2004 Nov 5;577(1-2):154-8.PMID: 15527777 [PubMed - indexed for MEDLINE]Related articles

Insulin-dependent diabetes affects testicular function by FSH- and LH-linked mechanisms.

Ballester J, Muñoz MC, Domínguez J, Rigau T, Guinovart JJ, Rodríguez-Gil JE.

J Androl. 2004 Sep-Oct;25(5):706-19.PMID: 15292100 [PubMed - indexed for MEDLINE]Related articlesFree article

The presence of a high-Km hexokinase activity in dog, but not in boar, sperm.

Fernández-Novell JM, Ballester J, Medrano A, Otaegui PJ, Rigau T, Guinovart JJ, Rodríguez-Gil JE.

FEBS Lett. 2004 Jul 16;570(1-3):211-6.PMID: 15251466 [PubMed - indexed for MEDLINE]Related articles

Gluconeogenesis-linked glycogen metabolism is important in the achievement of in vitro capacitation of dog spermatozoa in a medium without glucose.

Albarracín JL, Fernández-Novell JM, Ballester J, Rauch MC, Quintero-Moreno A, Peña A, Mogas T, Rigau T, Yañez A, Guinovart JJ, Slebe JC, Concha II, Rodríguez-Gil JE.

Biol Reprod. 2004 Nov;71(5):1437-45. Epub 2004 Jun 23.PMID: 15215203 [PubMed - indexed for MEDLINE]Related articlesFree article

[The future of Spain it depends on the science]

Guinovart JJ.

Biol Res. 2004;37(1):5. Spanish. No abstract available. PMID: 15174300 [PubMed - indexed for MEDLINE]Related articles

Dynamic profiling of the glucose metabolic network in fasted rat hepatocytes using [1,2-13C2]glucose.

Marin S, Lee WN, Bassilian S, Lim S, Boros LG, Centelles JJ, FernAndez-Novell JM, Guinovart JJ, Cascante M.

Biochem J. 2004 Jul 1;381(Pt 1):287-94.PMID: 15032751 [PubMed - indexed for MEDLINE]Related articlesFree article

Stable and functional regeneration of pancreatic beta-cell population in nSTZ-rats treated with tungstate.

Fernández-Alvarez J, Barberà A, Nadal B, Barceló-Batllori S, Piquer S, Claret M, Guinovart JJ, Gomis R.

Diabetologia. 2004 Mar;47(3):470-7. Epub 2004 Feb 14.PMID: 14968293 [PubMed - indexed for MEDLINE]Related articles

Regulation of glycogen metabolism in cultured human muscles by the glycogen phosphorylase inhibitor CP-91149.

Lerín C, Montell E, Nolasco T, García-Rocha M, Guinovart JJ, Gómez-Foix AM.

Biochem J. 2004 Mar 15;378(Pt 3):1073-7.PMID: 14651477 [PubMed - indexed for MEDLINE]Related articlesFree article

Crystallization and preliminary X-ray analysis of the glycogen synthase from Pyrococcus abyssi.

Horcajada C, Cid E, Guinovart JJ, Verdaguer N, Ferrer JC.

Acta Crystallogr D Biol Crystallogr. 2003 Dec;59(Pt 12):2322-4. Epub 2003 Nov 27.PMID: 14646108 [PubMed - indexed for MEDLINE]Related articles

Alternative splicing of the human proto-oncogene c-H-ras renders a new Ras family protein that trafficks to cytoplasm and nucleus.

Guil S, de La Iglesia N, Fernández-Larrea J, Cifuentes D, Ferrer JC, Guinovart JJ, Bach-Elias M.

Cancer Res. 2003 Sep 1;63(17):5178-87.PMID: 14500341 [PubMed - indexed for MEDLINE]Related articlesFree article

The antidiabetic agent sodium tungstate activates glycogen synthesis through an insulin receptor-independent pathway.

Domínguez JE, Muñoz MC, Zafra D, Sanchez-Perez I, Baqué S, Caron M, Mercurio C, Barberà A, Perona R, Gomis R, Guinovart JJ.

J Biol Chem. 2003 Oct 31;278(44):42785-94. Epub 2003 Aug 18.PMID: 12925525 [PubMed - indexed for MEDLINE]Related articlesFree article

Control of glycogen deposition.

Ferrer JC, Favre C, Gomis RR, Fernández-Novell JM, García-Rocha M, de la Iglesia N, Cid E, Guinovart JJ.

FEBS Lett. 2003 Jul 3;546(1):127-32. Review.PMID: 12829248 [PubMed - indexed for MEDLINE]Related articles

Modulation of glucose transporters in rat diaphragm by sodium tungstate.

Girón MD, Caballero JJ, Vargas AM, Suárez MD, Guinovart JJ, Salto R.

FEBS Lett. 2003 May 8;542(1-3):84-8.PMID: 12729903 [PubMed - indexed for MEDLINE]Related articles

Glucose- and fructose-induced dog-sperm glycogen synthesis shows specific changes in the location of the sperm glycogen deposition.

Palomo MJ, FernAndez-Novell JM, Peña A, Guinovart JJ, Rigau T, Rodríguez-Gil JE.

Mol Reprod Dev. 2003 Mar;64(3):349-59.PMID: 12548667 [PubMed - indexed for MEDLINE]Related articles

Glucose 6-phosphate produced by gluconeogenesis and by glucokinase is equally effective in activating hepatic glycogen synthase.

Gomis RR, Favre C, García-Rocha M, Fernández-Novell JM, Ferrer JC, Guinovart JJ.

J Biol Chem. 2003 Mar 14;278(11):9740-6. Epub 2003 Jan 7.PMID: 12519761 [PubMed - indexed for MEDLINE]Related articlesFree article

Zonal distribution of glycogen synthesis in isolated rat hepatocytes.

Fernández-Novell JM, López-Iglesias C, Ferrer JC, Guinovart JJ.

FEBS Lett. 2002 Nov 6;531(2):222-8.PMID: 12417316 [PubMed - indexed for MEDLINE]Related articles

Expression of a green fluorescence protein-carrier protein into mouse spermatozoa.

Mogas T, Fernández-Novell JM, Palomo MJ, Otaegui PJ, Gomis RR, Ballester J, Izquierdo D, Guinovart JJ, Ferrer JC, Rigau T, Rodríguez-Gil JE.

Biochem Biophys Res Commun. 2002 Oct 4;297(4):841-6.PMID: 12359229 [PubMed - indexed for MEDLINE]Related articles

Glycogen synthase: towards a minimum catalytic unit?

Cid E, Geremia RA, Guinovart JJ, Ferrer JC.

FEBS Lett. 2002 Sep 25;528(1-3):5-11. Review.PMID: 12297270 [PubMed - indexed for MEDLINE]Related articles

Differential effects of glucose and fructose on hexose metabolism in dog spermatozoa.

Rigau T, Rivera M, Palomo MJ, Fernández-Novell JM, Mogas T, Ballester J, Peña A, Otaegui PJ, Guinovart JJ, Rodríguez-Gil JE.

Reproduction. 2002 Apr;123(4):579-91.PMID: 11914120 [PubMed - indexed for MEDLINE]Related articlesFree article

Liver glycogen synthase but not the muscle isoform differentiates between glucose 6-phosphate produced by glucokinase or hexokinase.

Gomis RR, Cid E, García-Rocha M, Ferrer JC, Guinovart JJ.

J Biol Chem. 2002 Jun 28;277(26):23246-52. Epub 2002 Mar 6.PMID: 11882651 [PubMed - indexed for MEDLINE]Related articlesFree article

Intracellular distribution of glycogen synthase and glycogen in primary cultured rat hepatocytes.

García-Rocha M, Roca A, De La Iglesia N, Baba O, Fernández-Novell JM, Ferrer JC, Guinovart JJ.

Biochem J. 2001 Jul 1;357(Pt 1):17-24.PMID: 11415431 [PubMed - indexed for MEDLINE]Related articlesFree article

Tungstate is an effective antidiabetic agent in streptozotocin-induced diabetic rats: a long-term study.

Barberà A, Gomis RR, Prats N, Rodríguez-Gil JE, Domingo M, Gomis R, Guinovart JJ.

Diabetologia. 2001 Apr;44(4):507-13.PMID: 11357483 [PubMed - indexed for MEDLINE]Related articles

Occurrence of paradoxical or sustained control by an enzyme when overexpressed: necessary conditions and experimental evidence with regard to hepatic glucokinase.

De Atauri P, Acerenza L, Kholodenko BN, De La Iglesia N, Guinovart JJ, Agius L, Cascante M.

Biochem J. 2001 May 1;355(Pt 3):787-93.PMID: 11311143 [PubMed - indexed for MEDLINE]Related articlesFree article

Hepatic glycogen synthesis is highly sensitive to phosphorylase activity: evidence from metabolic control analysis.

Aiston S, Hampson L, Gómez-Foix AM, Guinovart JJ, Agius L.

J Biol Chem. 2001 Jun 29;276(26):23858-66. Epub 2001 Apr 17.PMID: 11309391 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of tungstate, a new potential oral antidiabetic agent, in Zucker diabetic fatty rats.

Muñoz MC, Barberà A, Domínguez J, Fernàndez-Alvarez J, Gomis R, Guinovart JJ.

Diabetes. 2001 Jan;50(1):131-8.PMID: 11147778 [PubMed - indexed for MEDLINE]Related articlesFree article

Shared control of hepatic glycogen synthesis by glycogen synthase and glucokinase.

Gomis RR, Ferrer JC, Guinovart JJ.

Biochem J. 2000 Nov 1;351 Pt 3:811-6.PMID: 11042138 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of two essential glutamic acid residues in glycogen synthase.

Cid E, Gomis RR, Geremia RA, Guinovart JJ, Ferrer JC.

J Biol Chem. 2000 Oct 27;275(43):33614-21.PMID: 10924520 [PubMed - indexed for MEDLINE]Related articlesFree article

Evidence for a functional glycogen metabolism in mature mammalian spermatozoa.

Ballester J, Fernández-Novell JM, Rutllant J, García-Rocha M, Jesús Palomo M, Mogas T, Peña A, Rigau T, Guinovart JJ, Rodríguez-Gil JE.

Mol Reprod Dev. 2000 Jun;56(2):207-19.PMID: 10813853 [PubMed - indexed for MEDLINE]Related articles

The role of the regulatory protein of glucokinase in the glucose sensory mechanism of the hepatocyte.

de la Iglesia N, Mukhtar M, Seoane J, Guinovart JJ, Agius L.

J Biol Chem. 2000 Apr 7;275(14):10597-603.PMID: 10744755 [PubMed - indexed for MEDLINE]Related articlesFree article

Lithium's effects on rat liver glucose metabolism in vivo.

Rodriguez-Gil JE, Fernández-Novell JM, Barberá A, Guinovart JJ.

Arch Biochem Biophys. 2000 Mar 15;375(2):377-84.PMID: 10700396 [PubMed - indexed for MEDLINE]Related articles

Glucokinase overexpression restores glucose utilization and storage in cultured hepatocytes from male Zucker diabetic fatty rats.

Seoane J, Barberà A, Télémaque-Potts S, Newgard CB, Guinovart JJ.

J Biol Chem. 1999 Nov 5;274(45):31833-8.PMID: 10542207 [PubMed - indexed for MEDLINE]Related articlesFree article