PubMed

The Tpl2 kinase is up-regulated in adipose tissue in obesity and may mediate IL-1{beta} and TNF-{alpha} effects on ERK activation and lipolysis.

Jager J, Grémeaux T, Gonzalez T, Bonnafous S, Debard C, Laville M, Vidal H, Tran A, Gual P, Le Marchand-Brustel Y, Cormont M, Tanti JF.

Diabetes. 2009 Oct 6. [Epub ahead of print]PMID: 19808894 [PubMed - as supplied by publisher]Related articles

Rab4b is a small GTPase involved in the control of the glucose transporter GLUT4 localization in adipocyte.

Kaddai V, Gonzalez T, Keslair F, Grémeaux T, Bonnafous S, Gugenheim J, Tran A, Gual P, Le Marchand-Brustel Y, Cormont M.

PLoS One. 2009 Apr 17;4(4):e5257.PMID: 19590752 [PubMed - indexed for MEDLINE]Related articlesFree article

Cannabinoid CB2 receptor potentiates obesity-associated inflammation, insulin resistance and hepatic steatosis.

Deveaux V, Cadoudal T, Ichigotani Y, Teixeira-Clerc F, Louvet A, Manin S, Nhieu JT, Belot MP, Zimmer A, Even P, Cani PD, Knauf C, Burcelin R, Bertola A, Le Marchand-Brustel Y, Gual P, Mallat A, Lotersztajn S.

PLoS One. 2009 Jun 9;4(6):e5844.PMID: 19513120 [PubMed - indexed for MEDLINE]Related articlesFree article

Involvement of TNF-alpha in abnormal adipocyte and muscle sortilin expression in obese mice and humans.

Kaddai V, Jager J, Gonzalez T, Najem-Lendom R, Bonnafous S, Tran A, Le Marchand-Brustel Y, Gual P, Tanti JF, Cormont M.

Diabetologia. 2009 May;52(5):932-40. Epub 2009 Feb 14.PMID: 19219422 [PubMed - indexed for MEDLINE]Related articles

Impact of laparoscopic Roux-en-Y gastric bypass on metabolic syndrome, inflammation, and insulin resistance in super versus morbidly obese women.

Iannelli A, Anty R, Piche T, Dahman M, Gual P, Tran A, Gugenheim J.

Obes Surg. 2009 May;19(5):577-82. Epub 2008 Nov 19.PMID: 19018603 [PubMed - indexed for MEDLINE]Related articles

Elevated expression of osteopontin may be related to adipose tissue macrophage accumulation and liver steatosis in morbid obesity.

Bertola A, Deveaux V, Bonnafous S, Rousseau D, Anty R, Wakkach A, Dahman M, Tordjman J, Clément K, McQuaid SE, Frayn KN, Huet PM, Gugenheim J, Lotersztajn S, Le Marchand-Brustel Y, Tran A, Gual P.

Diabetes. 2009 Jan;58(1):125-33. Epub 2008 Oct 24.PMID: 18952835 [PubMed - indexed for MEDLINE]Related articlesFree article

Informal caregiving: perceived needs.

Zabalegui A, Bover A, Rodriquez E, Cabrera E, Diaz M, Gallart A, González A, Gual P, Izquierdo MD, López L, Pulpón AM, Ramírez A.

Nurs Sci Q. 2008 Apr;21(2):166-72.PMID: 18378827 [PubMed - indexed for MEDLINE]Related articles

Bariatric surgery can correct iron depletion in morbidly obese women: a link with chronic inflammation.

Anty R, Dahman M, Iannelli A, Gual P, Staccini-Myx A, Amor IB, Luciani N, Saint-Paul MC, Huet PM, Sadoul JL, Srai SK, Unwin R, Gugenheim J, Le Marchand-Brustel Y, Tran A, Bekri S.

Obes Surg. 2008 Jun;18(6):709-14. Epub 2008 Mar 11.PMID: 18330662 [PubMed - indexed for MEDLINE]Related articles

HMGA2 is the partner of MDM2 in well-differentiated and dedifferentiated liposarcomas whereas CDK4 belongs to a distinct inconsistent amplicon.

Italiano A, Bianchini L, Keslair F, Bonnafous S, Cardot-Leccia N, Coindre JM, Dumollard JM, Hofman P, Leroux A, Mainguené C, Peyrottes I, Ranchere-Vince D, Terrier P, Tran A, Gual P, Pedeutour F.

Int J Cancer. 2008 May 15;122(10):2233-41.PMID: 18214854 [PubMed - indexed for MEDLINE]Related articles

[Metabolic fatty liver diseases: hepatic consequences of the metabolic syndrome]

Anty R, Gual P, Huet PM, Marchand-Brustel YL, Tran A.

Gastroenterol Clin Biol. 2007 Dec;31(12):1127-34. Review. French. PMID: 18176372 [PubMed - indexed for MEDLINE]Related articles

Osmotic regulation of cellular glucose uptake.

Gual P, Gonzalez T, Gremeaux T, Le Marchand-Brustel Y, Tanti JF.

Methods Enzymol. 2007;428:343-54.PMID: 17875428 [PubMed - indexed for MEDLINE]Related articles

Glucose intolerance and hypoadiponectinemia are already present in lean patients with chronic hepatitis C infected with genotype non-3 viruses.

Anty R, Gelsi E, Giudicelli J, Mariné-Barjoan E, Gual P, Benzaken S, Saint-Paul MC, Sadoul JL, Huet PM, Tran A.

Eur J Gastroenterol Hepatol. 2007 Aug;19(8):671-7.PMID: 17625437 [PubMed - indexed for MEDLINE]Related articles

Self-oriented perfectionism in eating disorders.

Castro-Fornieles J, Gual P, Lahortiga F, Gila A, Casulà V, Fuhrmann C, Imirizaldu M, Saura B, Martínez E, Toro J.

Int J Eat Disord. 2007 Sep;40(6):562-8.PMID: 17510925 [PubMed - indexed for MEDLINE]Related articles

C3H/HeJ mice carrying a toll-like receptor 4 mutation are protected against the development of insulin resistance in white adipose tissue in response to a high-fat diet.

Poggi M, Bastelica D, Gual P, Iglesias MA, Gremeaux T, Knauf C, Peiretti F, Verdier M, Juhan-Vague I, Tanti JF, Burcelin R, Alessi MC.

Diabetologia. 2007 Jun;50(6):1267-76. Epub 2007 Apr 11.PMID: 17426960 [PubMed - indexed for MEDLINE]Related articles

Hepatocyte growth factor induces glucose uptake in 3T3-L1 adipocytes through A Gab1/phosphatidylinositol 3-kinase/Glut4 pathway.

Bertola A, Bonnafous S, Cormont M, Anty R, Tanti JF, Tran A, Le Marchand-Brustel Y, Gual P.

J Biol Chem. 2007 Apr 6;282(14):10325-32. Epub 2007 Feb 6.PMID: 17284447 [PubMed - indexed for MEDLINE]Related articlesFree article

[Obesity, diabetes and insulin resistance. Alterations of insulin signalling]

Le Marchand-Brustel Y, Gual P, Aouadi M, Grémeaux T, Binétruy B, Bost F, Tanti JF.

J Soc Biol. 2006;200(1):93-7. Review. French. PMID: 17144167 [PubMed - indexed for MEDLINE]Related articles

Increased adipose tissue expression of hepcidin in severe obesity is independent from diabetes and NASH.

Bekri S, Gual P, Anty R, Luciani N, Dahman M, Ramesh B, Iannelli A, Staccini-Myx A, Casanova D, Ben Amor I, Saint-Paul MC, Huet PM, Sadoul JL, Gugenheim J, Srai SK, Tran A, Le Marchand-Brustel Y.

Gastroenterology. 2006 Sep;131(3):788-96.PMID: 16952548 [PubMed - indexed for MEDLINE]Related articles

Differential effects of IRS1 phosphorylated on Ser307 or Ser632 in the induction of insulin resistance by oxidative stress.

Bloch-Damti A, Potashnik R, Gual P, Le Marchand-Brustel Y, Tanti JF, Rudich A, Bashan N.

Diabetologia. 2006 Oct;49(10):2463-73. Epub 2006 Aug 3.PMID: 16896943 [PubMed - indexed for MEDLINE]Related articles

Enigma interacts with adaptor protein with PH and SH2 domains to control insulin-induced actin cytoskeleton remodeling and glucose transporter 4 translocation.

Barrès R, Grémeaux T, Gual P, Gonzalez T, Gugenheim J, Tran A, Le Marchand-Brustel Y, Tanti JF.

Mol Endocrinol. 2006 Nov;20(11):2864-75. Epub 2006 Jun 27.PMID: 16803868 [PubMed - indexed for MEDLINE]Related articlesFree article

The inflammatory C-reactive protein is increased in both liver and adipose tissue in severely obese patients independently from metabolic syndrome, Type 2 diabetes, and NASH.

Anty R, Bekri S, Luciani N, Saint-Paul MC, Dahman M, Iannelli A, Amor IB, Staccini-Myx A, Huet PM, Gugenheim J, Sadoul JL, Le Marchand-Brustel Y, Tran A, Gual P.

Am J Gastroenterol. 2006 Aug;101(8):1824-33. Epub 2006 Jun 22.PMID: 16790033 [PubMed - indexed for MEDLINE]Related articles

Positive and negative regulation of insulin signaling through IRS-1 phosphorylation.

Gual P, Le Marchand-Brustel Y, Tanti JF.

Biochimie. 2005 Jan;87(1):99-109. Review.PMID: 15733744 [PubMed - indexed for MEDLINE]Related articles

Perfectionism dimensions in children and adolescents with anorexia nervosa.

Castro J, Gila A, Gual P, Lahortiga F, Saura B, Toro J.

J Adolesc Health. 2004 Nov;35(5):392-8.PMID: 15488433 [PubMed - indexed for MEDLINE]Related articles

Alteration in insulin action: role of IRS-1 serine phosphorylation in the retroregulation of insulin signalling.

Tanti JF, Gual P, Grémeaux T, Gonzalez T, Barrès R, Le Marchand-Brustel Y.

Ann Endocrinol (Paris). 2004 Feb;65(1):43-8. Review.PMID: 15122091 [PubMed - indexed for MEDLINE]Related articles

Positive and negative regulation of glucose uptake by hyperosmotic stress.

Gual P, Le Marchand-Brustel Y, Tanti J.

Diabetes Metab. 2003 Dec;29(6):566-75. Review.PMID: 14707885 [PubMed - indexed for MEDLINE]Related articlesFree article

Fatty acid-induced insulin resistance: role of insulin receptor substrate 1 serine phosphorylation in the retroregulation of insulin signalling.

Le Marchand-Brustel Y, Gual P, Grémeaux T, Gonzalez T, Barrès R, Tanti JF.

Biochem Soc Trans. 2003 Dec;31(Pt 6):1152-6. Review.PMID: 14641015 [PubMed - indexed for MEDLINE]Related articles

MAP kinases and mTOR mediate insulin-induced phosphorylation of insulin receptor substrate-1 on serine residues 307, 612 and 632.

Gual P, Grémeaux T, Gonzalez T, Le Marchand-Brustel Y, Tanti JF.

Diabetologia. 2003 Nov;46(11):1532-42. Epub 2003 Oct 25.PMID: 14579029 [PubMed - indexed for MEDLINE]Related articles

Reduced activation of phosphatidylinositol-3 kinase and increased serine 636 phosphorylation of insulin receptor substrate-1 in primary culture of skeletal muscle cells from patients with type 2 diabetes.

Bouzakri K, Roques M, Gual P, Espinosa S, Guebre-Egziabher F, Riou JP, Laville M, Le Marchand-Brustel Y, Tanti JF, Vidal H.

Diabetes. 2003 Jun;52(6):1319-25.PMID: 12765939 [PubMed - indexed for MEDLINE]Related articlesFree article

Hyperosmotic stress inhibits insulin receptor substrate-1 function by distinct mechanisms in 3T3-L1 adipocytes.

Gual P, Gonzalez T, Grémeaux T, Barres R, Le Marchand-Brustel Y, Tanti JF.

J Biol Chem. 2003 Jul 18;278(29):26550-7. Epub 2003 May 1.PMID: 12730242 [PubMed - indexed for MEDLINE]Related articlesFree article

Neuroticism and low self-esteem as risk factors for incident eating disorders in a prospective cohort study.

Cervera S, Lahortiga F, Martínez-González MA, Gual P, de Irala-Estévez J, Alonso Y.

Int J Eat Disord. 2003 Apr;33(3):271-80.PMID: 12655623 [PubMed - indexed for MEDLINE]Related articles

Parental factors, mass media influences, and the onset of eating disorders in a prospective population-based cohort.

Martínez-González MA, Gual P, Lahortiga F, Alonso Y, de Irala-Estévez J, Cervera S.

Pediatrics. 2003 Feb;111(2):315-20.PMID: 12563057 [PubMed - indexed for MEDLINE]Related articlesFree article

A Crk-II/TC10 signaling pathway is required for osmotic shock-stimulated glucose transport.

Gual P, Shigematsu S, Kanzaki M, Grémeaux T, Gonzalez T, Pessin JE, Le Marchand-Brustel Y, Tanti JF.

J Biol Chem. 2002 Nov 15;277(46):43980-6. Epub 2002 Sep 4.PMID: 12215429 [PubMed - indexed for MEDLINE]Related articlesFree article

Self-esteem, personality, and eating disorders: baseline assessment of a prospective population-based cohort.

Gual P, Pérez-Gaspar M, Martínez-González MA, Lahortiga F, de Irala-Estévez J, Cervera-Enguix S.

Int J Eat Disord. 2002 Apr;31(3):261-73.PMID: 11920987 [PubMed - indexed for MEDLINE]Related articles

Differential requirement of the last C-terminal tail of Met receptor for cell transformation and invasiveness.

Gual P, Giordano S, Anguissola S, Comoglio PM.

Oncogene. 2001 Sep 6;20(39):5493-502.PMID: 11571647 [PubMed - indexed for MEDLINE]Related articlesFree article

Gab1 phosphorylation: a novel mechanism for negative regulation of HGF receptor signaling.

Gual P, Giordano S, Anguissola S, Parker PJ, Comoglio PM.

Oncogene. 2001 Jan 11;20(2):156-66.PMID: 11313945 [PubMed - indexed for MEDLINE]Related articlesFree article

[Reply] [In Process Citation]

A Martinez-Gonzalez M, Gual P, de Irala-Estevez J, Cervera S.

Med Clin (Barc). 2000 Sep 9;115(7):279. Spanish. No abstract available. PMID: 11013156 [PubMed - as supplied by publisher]Related articles

Cross-talk between the proto-oncogenes Met and Ron.

Follenzi A, Bakovic S, Gual P, Stella MC, Longati P, Comoglio PM.

Oncogene. 2000 Jun 22;19(27):3041-9.PMID: 10871856 [PubMed - indexed for MEDLINE]Related articlesFree article

[Prevalence of eating disorders in a representative sample of female adolescents from Navarra (Spain)]

Pérez-Gaspar M, Gual P, de Irala-Estévez J, Martínez-González MA, Lahortiga F, Cervera S.

Med Clin (Barc). 2000 Apr 8;114(13):481-6. Spanish. PMID: 10846651 [PubMed - indexed for MEDLINE]Related articles

[Abstinence is better]

Martínez-González MA, de Irala-Estévez J, Pérez-Gaspar M, Gual P.

Med Clin (Barc). 2000 Feb 19;114(6):237-8. Spanish. No abstract available. PMID: 10757109 [PubMed - indexed for MEDLINE]Related articles

Sustained recruitment of phospholipase C-gamma to Gab1 is required for HGF-induced branching tubulogenesis.

Gual P, Giordano S, Williams TA, Rocchi S, Van Obberghen E, Comoglio PM.

Oncogene. 2000 Mar 16;19(12):1509-18.PMID: 10734310 [PubMed - indexed for MEDLINE]Related articlesFree article

Different point mutations in the met oncogene elicit distinct biological properties.

Giordano S, Maffe A, Williams TA, Artigiani S, Gual P, Bardelli A, Basilico C, Michieli P, Comoglio PM.

FASEB J. 2000 Feb;14(2):399-406.PMID: 10657996 [PubMed - indexed for MEDLINE]Related articlesFree article

MET(PRC) mutations in the Ron receptor result in upregulation of tyrosine kinase activity and acquisition of oncogenic potential.

Williams TA, Longati P, Pugliese L, Gual P, Bardelli A, Michieli P.

J Cell Physiol. 1999 Dec;181(3):507-14.PMID: 10528237 [PubMed - indexed for MEDLINE]Related articles

Interaction of Janus kinases JAK-1 and JAK-2 with the insulin receptor and the insulin-like growth factor-1 receptor.

Gual P, Baron V, Lequoy V, Van Obberghen E.

Endocrinology. 1998 Mar;139(3):884-93.PMID: 9492017 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of the insulin receptor C-terminal acidic domain in the modulation of the receptor kinase by polybasic effectors.

Baron V, Gual P, Alengrin F, Van Obberghen E.

Eur J Biochem. 1996 Oct 1;241(1):186-92.PMID: 8898905 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin receptor-induced phosphorylation of cellular and synthetic substrates is regulated by the receptor beta-subunit C-terminus.

Gual P, Baron V, Alengrin F, Mothe I, Van Obberghen E.

Endocrinology. 1996 Aug;137(8):3416-23.PMID: 8754769 [PubMed - indexed for MEDLINE]Related articles

A conformational change in the beta-subunit of the insulin-like growth factor I receptor identified by antipeptide antibodies.

Gual P, Baron V, Alengrin F, Van Obberghen E.

Endocrinology. 1995 Dec;136(12):5298-304.PMID: 7588274 [PubMed - indexed for MEDLINE]Related articles

[Anorexia nervosa: study method and sleep analysis]

Cervera S, Zapata R, Gual P, Quintanilla B.

Rev Esp Fisiol. 1989;45 Suppl:265-78. Spanish. PMID: 2641824 [PubMed - indexed for MEDLINE]Related articles