PubMed

Endoplasmic reticulum stress in beta-cells and development of diabetes.

Fonseca SG, Burcin M, Gromada J, Urano F.

Curr Opin Pharmacol. 2009 Dec;9(6):763-70. Epub 2009 Aug 6.PMID: 19665428 [PubMed - in process]Related articles

The insulin receptor talks to glucagon?

Gromada J, Duttaroy A, Rorsman P.

Cell Metab. 2009 Apr;9(4):303-5.PMID: 19356709 [PubMed - indexed for MEDLINE]Related articles

Reduced insulin secretion and content in VEGF-a deficient mouse pancreatic islets.

Jabs N, Franklin I, Brenner MB, Gromada J, Ferrara N, Wollheim CB, Lammert E.

Exp Clin Endocrinol Diabetes. 2008 Sep;116 Suppl 1:S46-9. Epub 2008 Sep 5.PMID: 18777454 [PubMed - indexed for MEDLINE]Related articles

Requirement of inositol pyrophosphates for full exocytotic capacity in pancreatic beta cells.

Illies C, Gromada J, Fiume R, Leibiger B, Yu J, Juhl K, Yang SN, Barma DK, Falck JR, Saiardi A, Barker CJ, Berggren PO.

Science. 2007 Nov 23;318(5854):1299-302.PMID: 18033884 [PubMed - indexed for MEDLINE]Related articlesFree article

Alpha-cells of the endocrine pancreas: 35 years of research but the enigma remains.

Gromada J, Franklin I, Wollheim CB.

Endocr Rev. 2007 Feb;28(1):84-116. Epub 2007 Jan 16. Review.PMID: 17261637 [PubMed - indexed for MEDLINE]Related articlesFree article

Activation of liver X receptors and retinoid X receptors induces growth arrest and apoptosis in insulin-secreting cells.

Wente W, Brenner MB, Zitzer H, Gromada J, Efanov AM.

Endocrinology. 2007 Apr;148(4):1843-9. Epub 2006 Dec 28.PMID: 17194744 [PubMed - indexed for MEDLINE]Related articlesFree article

C16:0 sulfatide inhibits insulin secretion in rat beta-cells by reducing the sensitivity of KATP channels to ATP inhibition.

Buschard K, Blomqvist M, Månsson JE, Fredman P, Juhl K, Gromada J.

Diabetes. 2006 Oct;55(10):2826-34.PMID: 17003349 [PubMed - indexed for MEDLINE]Related articlesFree article

Fibroblast growth factor-21 improves pancreatic beta-cell function and survival by activation of extracellular signal-regulated kinase 1/2 and Akt signaling pathways.

Wente W, Efanov AM, Brenner M, Kharitonenkov A, Köster A, Sandusky GE, Sewing S, Treinies I, Zitzer H, Gromada J.

Diabetes. 2006 Sep;55(9):2470-8.PMID: 16936195 [PubMed - indexed for MEDLINE]Related articlesFree article

Ringing the dinner bell for insulin: muscarinic M3 receptor activity in the control of pancreatic beta cell function.

Gromada J, Hughes TE.

Cell Metab. 2006 Jun;3(6):390-2. Review.PMID: 16753574 [PubMed - indexed for MEDLINE]Related articles

Sterol regulatory element-binding protein 1 mediates liver X receptor-beta-induced increases in insulin secretion and insulin messenger ribonucleic acid levels.

Zitzer H, Wente W, Brenner MB, Sewing S, Buschard K, Gromada J, Efanov AM.

Endocrinology. 2006 Aug;147(8):3898-905. Epub 2006 Apr 27.PMID: 16644917 [PubMed - indexed for MEDLINE]Related articlesFree article

Tomosyn is expressed in beta-cells and negatively regulates insulin exocytosis.

Zhang W, Lilja L, Mandic SA, Gromada J, Smidt K, Janson J, Takai Y, Bark C, Berggren PO, Meister B.

Diabetes. 2006 Mar;55(3):574-81.PMID: 16505218 [PubMed - indexed for MEDLINE]Related articlesFree article

The free fatty acid receptor GPR40 generates excitement in pancreatic beta-cells.

Gromada J.

Endocrinology. 2006 Feb;147(2):672-3. No abstract available. PMID: 16418431 [PubMed - indexed for MEDLINE]Related articlesFree article

The PDZ/coiled-coil domain containing protein PIST modulates insulin secretion in MIN6 insulinoma cells by interacting with somatostatin receptor subtype 5.

Wente W, Efanov AM, Treinies I, Zitzer H, Gromada J, Richter D, Kreienkamp HJ.

FEBS Lett. 2005 Nov 21;579(28):6305-10. Epub 2005 Oct 21.PMID: 16263117 [PubMed - indexed for MEDLINE]Related articles

Glucose stimulates glucagon release in single rat alpha-cells by mechanisms that mirror the stimulus-secretion coupling in beta-cells.

Olsen HL, Theander S, Bokvist K, Buschard K, Wollheim CB, Gromada J.

Endocrinology. 2005 Nov;146(11):4861-70. Epub 2005 Aug 4.PMID: 16081632 [PubMed - indexed for MEDLINE]Related articlesFree article

Neuronal calcium sensor-1 potentiates glucose-dependent exocytosis in pancreatic beta cells through activation of phosphatidylinositol 4-kinase beta.

Gromada J, Bark C, Smidt K, Efanov AM, Janson J, Mandic SA, Webb DL, Zhang W, Meister B, Jeromin A, Berggren PO.

Proc Natl Acad Sci U S A. 2005 Jul 19;102(29):10303-8. Epub 2005 Jul 12.PMID: 16014415 [PubMed - indexed for MEDLINE]Related articlesFree article

Beta-cell secretory products activate alpha-cell ATP-dependent potassium channels to inhibit glucagon release.

Franklin I, Gromada J, Gjinovci A, Theander S, Wollheim CB.

Diabetes. 2005 Jun;54(6):1808-15.PMID: 15919803 [PubMed - indexed for MEDLINE]Related articlesFree article

A novel glucokinase activator modulates pancreatic islet and hepatocyte function.

Efanov AM, Barrett DG, Brenner MB, Briggs SL, Delaunois A, Durbin JD, Giese U, Guo H, Radloff M, Gil GS, Sewing S, Wang Y, Weichert A, Zaliani A, Gromada J.

Endocrinology. 2005 Sep;146(9):3696-701. Epub 2005 May 26.PMID: 15919746 [PubMed - indexed for MEDLINE]Related articlesFree article

FGF-21 as a novel metabolic regulator.

Kharitonenkov A, Shiyanova TL, Koester A, Ford AM, Micanovic R, Galbreath EJ, Sandusky GE, Hammond LJ, Moyers JS, Owens RA, Gromada J, Brozinick JT, Hawkins ED, Wroblewski VJ, Li DS, Mehrbod F, Jaskunas SR, Shanafelt AB.

J Clin Invest. 2005 Jun;115(6):1627-35. Epub 2005 May 2.PMID: 15902306 [PubMed - indexed for MEDLINE]Related articlesFree article

New insights into the regulation of glucagon secretion by glucagon-like peptide-1.

Gromada J, Rorsman P.

Horm Metab Res. 2004 Nov-Dec;36(11-12):822-9. Review.PMID: 15655714 [PubMed - indexed for MEDLINE]Related articles

Incretin hormones and insulin secretion.

Ahrén B, Gromada J, Schmitz O.

Horm Metab Res. 2004 Nov-Dec;36(11-12):733-4. No abstract available. PMID: 15655700 [PubMed - indexed for MEDLINE]Related articles

Glucagon-like peptide-1: regulation of insulin secretion and therapeutic potential.

Gromada J, Brock B, Schmitz O, Rorsman P.

Basic Clin Pharmacol Toxicol. 2004 Dec;95(6):252-62. Review.PMID: 15569269 [PubMed - indexed for MEDLINE]Related articles

Liver X receptor activation stimulates insulin secretion via modulation of glucose and lipid metabolism in pancreatic beta-cells.

Efanov AM, Sewing S, Bokvist K, Gromada J.

Diabetes. 2004 Dec;53 Suppl 3:S75-8.PMID: 15561926 [PubMed - indexed for MEDLINE]Related articlesFree article

ATP-sensitive K+ channel-dependent regulation of glucagon release and electrical activity by glucose in wild-type and SUR1-/- mouse alpha-cells.

Gromada J, Ma X, Høy M, Bokvist K, Salehi A, Berggren PO, Rorsman P.

Diabetes. 2004 Dec;53 Suppl 3:S181-9.PMID: 15561909 [PubMed - indexed for MEDLINE]Related articlesFree article

Removal of Ca2+ channel beta3 subunit enhances Ca2+ oscillation frequency and insulin exocytosis.

Berggren PO, Yang SN, Murakami M, Efanov AM, Uhles S, Köhler M, Moede T, Fernström A, Appelskog IB, Aspinwall CA, Zaitsev SV, Larsson O, de Vargas LM, Fecher-Trost C, Weissgerber P, Ludwig A, Leibiger B, Juntti-Berggren L, Barker CJ, Gromada J, Freichel M, Leibiger IB, Flockerzi V.

Cell. 2004 Oct 15;119(2):273-84.PMID: 15479643 [PubMed - indexed for MEDLINE]Related articles

Glucagon stimulates exocytosis in mouse and rat pancreatic alpha-cells by binding to glucagon receptors.

Ma X, Zhang Y, Gromada J, Sewing S, Berggren PO, Buschard K, Salehi A, Vikman J, Rorsman P, Eliasson L.

Mol Endocrinol. 2005 Jan;19(1):198-212. Epub 2004 Sep 30.PMID: 15459251 [PubMed - indexed for MEDLINE]Related articlesFree article

Beta-cell mass plasticity in type 2 diabetes.

Del Prato S, Wishner WJ, Gromada J, Schluchter BJ.

Diabetes Obes Metab. 2004 Sep;6(5):319-31. Review. No abstract available. PMID: 15287924 [PubMed - indexed for MEDLINE]Related articles

Role of incretin hormones in the regulation of insulin secretion in diabetic and nondiabetic humans.

Holst JJ, Gromada J.

Am J Physiol Endocrinol Metab. 2004 Aug;287(2):E199-206. Review.PMID: 15271645 [PubMed - indexed for MEDLINE]Related articlesFree article

GABAB receptor activation inhibits exocytosis in rat pancreatic beta-cells by G-protein-dependent activation of calcineurin.

Braun M, Wendt A, Buschard K, Salehi A, Sewing S, Gromada J, Rorsman P.

J Physiol. 2004 Sep 1;559(Pt 2):397-409. Epub 2004 Jul 2.PMID: 15235087 [PubMed - indexed for MEDLINE]Related articlesFree article

Hepatic and glucagon-like peptide-1-mediated reversal of diabetes by glucagon receptor antisense oligonucleotide inhibitors.

Sloop KW, Cao JX, Siesky AM, Zhang HY, Bodenmiller DM, Cox AL, Jacobs SJ, Moyers JS, Owens RA, Showalter AD, Brenner MB, Raap A, Gromada J, Berridge BR, Monteith DK, Porksen N, McKay RA, Monia BP, Bhanot S, Watts LM, Michael MD.

J Clin Invest. 2004 Jun;113(11):1571-81.PMID: 15173883 [PubMed - indexed for MEDLINE]Related articlesFree article

Cyclin-dependent kinase 5 associated with p39 promotes Munc18-1 phosphorylation and Ca(2+)-dependent exocytosis.

Lilja L, Johansson JU, Gromada J, Mandic SA, Fried G, Berggren PO, Bark C.

J Biol Chem. 2004 Jul 9;279(28):29534-41. Epub 2004 Apr 26.PMID: 15123626 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose inhibition of glucagon secretion from rat alpha-cells is mediated by GABA released from neighboring beta-cells.

Wendt A, Birnir B, Buschard K, Gromada J, Salehi A, Sewing S, Rorsman P, Braun M.

Diabetes. 2004 Apr;53(4):1038-45.PMID: 15047619 [PubMed - indexed for MEDLINE]Related articlesFree article

Restoration of first-phase insulin secretion by the imidazoline compound LY374284 in pancreatic islets of diabetic db/db mice.

Brenner MB, Gromada J, Efanov AM, Bokvist K, Mest HJ.

Ann N Y Acad Sci. 2003 Dec;1009:332-40.PMID: 15028607 [PubMed - indexed for MEDLINE]Related articles

Regulated exocytosis of GABA-containing synaptic-like microvesicles in pancreatic beta-cells.

Braun M, Wendt A, Birnir B, Broman J, Eliasson L, Galvanovskis J, Gromada J, Mulder H, Rorsman P.

J Gen Physiol. 2004 Mar;123(3):191-204. Epub 2004 Feb 9.PMID: 14769845 [PubMed - indexed for MEDLINE]Related articlesFree article

Secretory phospholipase A2 is released from pancreatic beta-cells and stimulates insulin secretion via inhibition of ATP-dependent K+ channels.

Juhl K, Efanov AM, Olsen HL, Gromada J.

Biochem Biophys Res Commun. 2003 Oct 17;310(2):274-9.PMID: 14521906 [PubMed - indexed for MEDLINE]Related articles

The imidazoline NNC77-0020 affects glucose-dependent insulin, glucagon and somatostatin secretion in mouse pancreatic islets.

Høy M, Olsen HL, Bokvist K, Petersen JS, Gromada J.

Naunyn Schmiedebergs Arch Pharmacol. 2003 Oct;368(4):284-93. Epub 2003 Sep 6.PMID: 13680090 [PubMed - indexed for MEDLINE]Related articles

Rapid association of protein kinase C-epsilon with insulin granules is essential for insulin exocytosis.

Mendez CF, Leibiger IB, Leibiger B, Høy M, Gromada J, Berggren PO, Bertorello AM.

J Biol Chem. 2003 Nov 7;278(45):44753-7. Epub 2003 Aug 25.PMID: 12941947 [PubMed - indexed for MEDLINE]Related articlesFree article

Involvement of protein kinase C-epsilon in inositol hexakisphosphate-induced exocytosis in mouse pancreatic beta-cells.

Høy M, Berggren PO, Gromada J.

J Biol Chem. 2003 Sep 12;278(37):35168-71. Epub 2003 Jul 1.PMID: 12837755 [PubMed - indexed for MEDLINE]Related articlesFree article

Repaglinide at a cellular level.

Krogsgaard Thomsen M, Bokvist K, Høy M, Buschard K, Holst JJ, Lindström P, Gromada J.

Diabetes Nutr Metab. 2002 Dec;15(6 Suppl):15-8.PMID: 12702003 [PubMed - indexed for MEDLINE]Related articles

Phosphatidylinositol 4-kinase serves as a metabolic sensor and regulates priming of secretory granules in pancreatic beta cells.

Olsen HL, Hoy M, Zhang W, Bertorello AM, Bokvist K, Capito K, Efanov AM, Meister B, Thams P, Yang SN, Rorsman P, Berggren PO, Gromada J.

Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5187-92. Epub 2003 Apr 16.PMID: 12700357 [PubMed - indexed for MEDLINE]Related articlesFree article

Imidazoline NNC77-0074 stimulates Ca2+-evoked exocytosis in INS-1E cells by a phospholipase A2-dependent mechanism.

Olsen HL, Nørby PL, Høy M, Spee P, Thams P, Capito K, Petersen JS, Gromada J.

Biochem Biophys Res Commun. 2003 Apr 18;303(4):1148-51.PMID: 12684056 [PubMed - indexed for MEDLINE]Related articles

Imidazoline NNC77-0074 stimulates insulin secretion and inhibits glucagon release by control of Ca(2+)-dependent exocytosis in pancreatic alpha- and beta-cells.

Høy M, Olsen HL, Andersen HS, Bokvist K, Buschard K, Hansen J, Jacobsen P, Petersen JS, Rorsman P, Gromada J.

Eur J Pharmacol. 2003 Apr 11;466(1-2):213-21.PMID: 12679159 [PubMed - indexed for MEDLINE]Related articles

cPLA2alpha-evoked formation of arachidonic acid and lysophospholipids is required for exocytosis in mouse pancreatic beta-cells.

Juhl K, Høy M, Olsen HL, Bokvist K, Efanov AM, Hoffmann EK, Gromada J.

Am J Physiol Endocrinol Metab. 2003 Jul;285(1):E73-81. Epub 2003 Mar 18.PMID: 12644445 [PubMed - indexed for MEDLINE]Related articlesFree article

SUR1 regulates PKA-independent cAMP-induced granule priming in mouse pancreatic B-cells.

Eliasson L, Ma X, Renström E, Barg S, Berggren PO, Galvanovskis J, Gromada J, Jing X, Lundquist I, Salehi A, Sewing S, Rorsman P.

J Gen Physiol. 2003 Mar;121(3):181-97.PMID: 12601083 [PubMed - indexed for MEDLINE]Related articlesFree article

Increase in cellular glutamate levels stimulates exocytosis in pancreatic beta-cells.

Høy M, Maechler P, Efanov AM, Wollheim CB, Berggren PO, Gromada J.

FEBS Lett. 2002 Nov 6;531(2):199-203.PMID: 12417312 [PubMed - indexed for MEDLINE]Related articles

Neodymium alkoxides: synthesis, characterization and their combinations with dialkylmagnesiums as unique systems for polymerization and block copolymerization of ethylene and methyl methacrylate.

Gromada J, Mortreux A, Chenal T, Ziller JW, Leising F, Carpentier JF.

Chemistry. 2002 Aug 16;8(16):3773-88.PMID: 12203304 [PubMed]Related articles

Sulfonylurea receptor type 1 knock-out mice have intact feeding-stimulated insulin secretion despite marked impairment in their response to glucose.

Shiota C, Larsson O, Shelton KD, Shiota M, Efanov AM, Hoy M, Lindner J, Kooptiwut S, Juntti-Berggren L, Gromada J, Berggren PO, Magnuson MA.

J Biol Chem. 2002 Oct 4;277(40):37176-83. Epub 2002 Jul 30.PMID: 12149271 [PubMed - indexed for MEDLINE]Related articlesFree article

Sulfatide controls insulin secretion by modulation of ATP-sensitive K(+)-channel activity and Ca(2+)-dependent exocytosis in rat pancreatic beta-cells.

Buschard K, Høy M, Bokvist K, Olsen HL, Madsbad S, Fredman P, Gromada J.

Diabetes. 2002 Aug;51(8):2514-21.PMID: 12145165 [PubMed - indexed for MEDLINE]Related articlesFree article

Nateglinide, but not repaglinide, stimulates growth hormone release in rat pituitary cells by inhibition of K channels and stimulation of cyclic AMP-dependent exocytosis.

Gromada J, Bokvist K, Høy M, Olsen HL, Lindström P, Hansen BS, Gotfredsen CF, Rorsman P, Thomsen MK.

Eur J Endocrinol. 2002 Jul;147(1):133-42.PMID: 12088930 [PubMed - indexed for MEDLINE]Related articlesFree article

Inositol hexakisphosphate promotes dynamin I- mediated endocytosis.

Høy M, Efanov AM, Bertorello AM, Zaitsev SV, Olsen HL, Bokvist K, Leibiger B, Leibiger IB, Zwiller J, Berggren PO, Gromada J.

Proc Natl Acad Sci U S A. 2002 May 14;99(10):6773-7.PMID: 12011438 [PubMed - indexed for MEDLINE]Related articlesFree article

Clonidine-displacing substance reduces glucagon secretion from mouse pancreatic alpha-cells by K(ATP)-channel-independent inhibition of exocytosis.

Høy M, Chan SL, Weng XG, Gromada J.

Biochem Biophys Res Commun. 2001 Oct 26;288(2):309-12.PMID: 11606044 [PubMed - indexed for MEDLINE]Related articles