PubMed

Role of Epidermal Growth Factor Inhibition in Experimental Pulmonary Hypertension.

Dahal BK, Cornitescu T, Tretyn A, Pullamsetti SS, Kosanovic D, Dumitrascu R, Ghofrani HA, Weissmann N, Voswinckel R, Banat GA, Seeger W, Grimminger F, Schermuly RT.

Am J Respir Crit Care Med. 2009 Oct 22. [Epub ahead of print]PMID: 19850946 [PubMed - as supplied by publisher]Related articles

Amplification of lipopolysaccharide-induced cytokine synthesis in non-small cell lung cancer/neutrophil cocultures.

Grandel U, Heygster D, Sibelius U, Fink L, Sigel S, Seeger W, Grimminger F, Hattar K.

Mol Cancer Res. 2009 Oct;7(10):1729-35. Epub 2009 Oct 13.PMID: 19825995 [PubMed - in process]Related articles

Expression and activity of phosphodiesterase isoforms during epithelial mesenchymal transition: the role of phosphodiesterase 4.

Kolosionek E, Savai R, Ghofrani HA, Weissmann N, Guenther A, Grimminger F, Seeger W, Banat GA, Schermuly RT, Pullamsetti SS.

Mol Biol Cell. 2009 Nov;20(22):4751-65. Epub 2009 Sep 16.PMID: 19759179 [PubMed - in process]Related articles

[Pulmonary hypertension in COPD and interstitial lung diseases]

Markart P, Ghofrani HA, Grimminger F, Günther A.

Dtsch Med Wochenschr. 2009 Aug;134 Suppl 5:S164-6. Epub 2009 Aug 28. Review. German. PMID: 19718606 [PubMed - indexed for MEDLINE]Related articles

[Update: Current clinical developments in pulmonary hypertension]

Dumitrescu D, Ghofrani HA, Grimminger F, Hoeper MM, Rosenkranz S.

Dtsch Med Wochenschr. 2009 Aug;134 Suppl 5:S160-3. Epub 2009 Aug 28. Review. German. PMID: 19718605 [PubMed - indexed for MEDLINE]Related articles

[Update: Preclinical developments for the treatment of pulmonary arterial hypertension]

Janssen W, Ghofrani HA, Weissmann N, Grimminger F, Schermuly RT.

Dtsch Med Wochenschr. 2009 Aug;134 Suppl 5:S157-9. Epub 2009 Aug 28. Review. German. PMID: 19718604 [PubMed - indexed for MEDLINE]Related articles

Effects of hypercapnia with and without acidosis on hypoxic pulmonary vasoconstriction.

Ketabchi F, Egemnazarov B, Schermuly RT, Ghofrani HA, Seeger W, Grimminger F, Shid-Moosavi M, Dehghani GA, Weissmann N, Sommer N.

Am J Physiol Lung Cell Mol Physiol. 2009 Nov;297(5):L977-83. Epub 2009 Aug 28.PMID: 19717554 [PubMed - indexed for MEDLINE]Related articles

[Therapy of pulmonary arterial hypertension]

Voswinckel R, Reichenberger F, Gall H, Seeger W, Grimminger F, Ghofrani HA.

Internist (Berl). 2009 Sep;50(9):1101-2, 1104-9. German. PMID: 19690823 [PubMed - in process]Related articles

The soluble guanylate cyclase activator HMR1766 reverses hypoxia-induced experimental pulmonary hypertension in mice.

Weissmann N, Hackemack S, Dahal BK, Pullamsetti SS, Savai R, Mittal M, Fuchs B, Medebach T, Dumitrascu R, Eickels M, Ghofrani HA, Seeger W, Grimminger F, Schermuly RT.

Am J Physiol Lung Cell Mol Physiol. 2009 Oct;297(4):L658-65. Epub 2009 Jul 17.PMID: 19617308 [PubMed - indexed for MEDLINE]Related articles

Macrophage tumor necrosis factor-alpha induces epithelial expression of granulocyte-macrophage colony-stimulating factor: impact on alveolar epithelial repair.

Cakarova L, Marsh LM, Wilhelm J, Mayer K, Grimminger F, Seeger W, Lohmeyer J, Herold S.

Am J Respir Crit Care Med. 2009 Sep 15;180(6):521-32. Epub 2009 Jul 9.PMID: 19590023 [PubMed - indexed for MEDLINE]Related articles

Future perspectives for the treatment of pulmonary arterial hypertension.

Ghofrani HA, Barst RJ, Benza RL, Champion HC, Fagan KA, Grimminger F, Humbert M, Simonneau G, Stewart DJ, Ventura C, Rubin LJ.

J Am Coll Cardiol. 2009 Jun 30;54(1 Suppl):S108-17. Review.PMID: 19555854 [PubMed - indexed for MEDLINE]Related articles

Inflammation, growth factors, and pulmonary vascular remodeling.

Hassoun PM, Mouthon L, Barberà JA, Eddahibi S, Flores SC, Grimminger F, Jones PL, Maitland ML, Michelakis ED, Morrell NW, Newman JH, Rabinovitch M, Schermuly R, Stenmark KR, Voelkel NF, Yuan JX, Humbert M.

J Am Coll Cardiol. 2009 Jun 30;54(1 Suppl):S10-9. Review.PMID: 19555853 [PubMed - indexed for MEDLINE]Related articles

Heme oxygenase-2 and large-conductance Ca2+-activated K+ channels: lung vascular effects of hypoxia.

Roth M, Rupp M, Hofmann S, Mittal M, Fuchs B, Sommer N, Parajuli N, Quanz K, Schubert D, Dony E, Schermuly RT, Ghofrani HA, Sausbier U, Rutschmann K, Wilhelm S, Seeger W, Ruth P, Grimminger F, Sausbier M, Weissmann N.

Am J Respir Crit Care Med. 2009 Aug 15;180(4):353-64. Epub 2009 Jun 4.PMID: 19498059 [PubMed - indexed for MEDLINE]Related articles

Staphylococcus aureus alpha-toxin and Escherichia coli hemolysin impair cardiac regional perfusion and contractile function by activating myocardial eicosanoid metabolism in isolated rat hearts.

Grandel U, Bennemann U, Buerke M, Hattar K, Seeger W, Grimminger F, Sibelius U.

Crit Care Med. 2009 Jun;37(6):2025-32.PMID: 19384217 [PubMed - indexed for MEDLINE]Related articles

A functional single-nucleotide polymorphism in the TRPC6 gene promoter associated with idiopathic pulmonary arterial hypertension.

Yu Y, Keller SH, Remillard CV, Safrina O, Nicholson A, Zhang SL, Jiang W, Vangala N, Landsberg JW, Wang JY, Thistlethwaite PA, Channick RN, Robbins IM, Loyd JE, Ghofrani HA, Grimminger F, Schermuly RT, Cahalan MD, Rubin LJ, Yuan JX.

Circulation. 2009 May 5;119(17):2313-22. Epub 2009 Apr 20.PMID: 19380626 [PubMed - indexed for MEDLINE]Related articlesFree article

The science of endothelin-1 and endothelin receptor antagonists in the management of pulmonary arterial hypertension: current understanding and future studies.

Davie NJ, Schermuly RT, Weissmann N, Grimminger F, Ghofrani HA.

Eur J Clin Invest. 2009 Jun;39 Suppl 2:38-49. Review. Erratum in: Eur J Clin Invest. 2009 Jul;39(7):630. PMID: 19335746 [PubMed - indexed for MEDLINE]Related articles

First acute haemodynamic study of soluble guanylate cyclase stimulator riociguat in pulmonary hypertension.

Grimminger F, Weimann G, Frey R, Voswinckel R, Thamm M, Bölkow D, Weissmann N, Mück W, Unger S, Wensing G, Schermuly RT, Ghofrani HA.

Eur Respir J. 2009 Apr;33(4):785-92. Epub 2009 Jan 7.PMID: 19129292 [PubMed - indexed for MEDLINE]Related articles

Evaluation of angiogenesis using micro-computed tomography in a xenograft mouse model of lung cancer.

Savai R, Langheinrich AC, Schermuly RT, Pullamsetti SS, Dumitrascu R, Traupe H, Rau WS, Seeger W, Grimminger F, Banat GA.

Neoplasia. 2009 Jan;11(1):48-56.PMID: 19107231 [PubMed - indexed for MEDLINE]Related articlesFree article

Modulating cGMP to treat lung diseases.

Ghofrani HA, Grimminger F.

Handb Exp Pharmacol. 2009;(191):469-83. Review.PMID: 19089341 [PubMed - indexed for MEDLINE]Related articles

Characterization of a murine model of monocrotaline pyrrole-induced acute lung injury.

Dumitrascu R, Koebrich S, Dony E, Weissmann N, Savai R, Pullamsetti SS, Ghofrani HA, Samidurai A, Traupe H, Seeger W, Grimminger F, Schermuly RT.

BMC Pulm Med. 2008 Dec 17;8:25.PMID: 19087359 [PubMed - indexed for MEDLINE]Related articlesFree article

Novel soluble guanylyl cyclase stimulator BAY 41-2272 attenuates ischemia-reperfusion-induced lung injury.

Egemnazarov B, Sydykov A, Schermuly RT, Weissmann N, Stasch JP, Sarybaev AS, Seeger W, Grimminger F, Ghofrani HA.

Am J Physiol Lung Cell Mol Physiol. 2009 Mar;296(3):L462-9. Epub 2008 Dec 12.PMID: 19074557 [PubMed - indexed for MEDLINE]Related articles

Metered dose inhaler delivery of treprostinil for the treatment of pulmonary hypertension.

Voswinckel R, Reichenberger F, Gall H, Schmehl T, Gessler T, Schermuly RT, Grimminger F, Rubin LJ, Seeger W, Ghofrani HA, Olschewski H.

Pulm Pharmacol Ther. 2009 Feb;22(1):50-6. Epub 2008 Nov 30.PMID: 19071225 [PubMed - indexed for MEDLINE]Related articles

Regulation of hypoxic pulmonary vasoconstriction: basic mechanisms.

Sommer N, Dietrich A, Schermuly RT, Ghofrani HA, Gudermann T, Schulz R, Seeger W, Grimminger F, Weissmann N.

Eur Respir J. 2008 Dec;32(6):1639-51. Review.PMID: 19043010 [PubMed - indexed for MEDLINE]Related articles

The noncanonical WNT pathway is operative in idiopathic pulmonary arterial hypertension.

Laumanns IP, Fink L, Wilhelm J, Wolff JC, Mitnacht-Kraus R, Graef-Hoechst S, Stein MM, Bohle RM, Klepetko W, Hoda MA, Schermuly RT, Grimminger F, Seeger W, Voswinckel R.

Am J Respir Cell Mol Biol. 2009 Jun;40(6):683-91. Epub 2008 Nov 21.PMID: 19029018 [PubMed - indexed for MEDLINE]Related articles

Inhibition of phosphodiesterase 4 enhances lung alveolarisation in neonatal mice exposed to hyperoxia.

Woyda K, Koebrich S, Reiss I, Rudloff S, Pullamsetti SS, Rühlmann A, Weissmann N, Ghofrani HA, Günther A, Seeger W, Grimminger F, Morty RE, Schermuly RT.

Eur Respir J. 2009 Apr;33(4):861-70. Epub 2008 Nov 14.PMID: 19010982 [PubMed - indexed for MEDLINE]Related articles

Combined tyrosine and serine/threonine kinase inhibition by sorafenib prevents progression of experimental pulmonary hypertension and myocardial remodeling.

Klein M, Schermuly RT, Ellinghaus P, Milting H, Riedl B, Nikolova S, Pullamsetti SS, Weissmann N, Dony E, Savai R, Ghofrani HA, Grimminger F, Busch AE, Schäfer S.

Circulation. 2008 Nov 11;118(20):2081-90. Epub 2008 Oct 27.PMID: 18955668 [PubMed - indexed for MEDLINE]Related articlesFree article

Pulmonary vascular disease in the developing world.

Butrous G, Ghofrani HA, Grimminger F.

Circulation. 2008 Oct 21;118(17):1758-66. Review. No abstract available. PMID: 18936338 [PubMed - indexed for MEDLINE]Related articlesFree article

[Dana Point: what is new in the treatment of pulmonary hypertension?]

Hoeper MM, Ghofrani HA, Grimminger F, Rosenkranz S.

Dtsch Med Wochenschr. 2008 Oct;133 Suppl 6:S191-5. Epub 2008 Sep 23. Review. German. PMID: 18814094 [PubMed - indexed for MEDLINE]Related articles

[Update in basic research in the therapy of pulmonary arterial hypertension]

Schermuly R, Grimminger F.

Dtsch Med Wochenschr. 2008 Oct;133 Suppl 6:S170-2. Epub 2008 Sep 23. Review. German. PMID: 18814088 [PubMed - indexed for MEDLINE]Related articles

Intravenous injection of siRNA directed against hypoxia-inducible factors prolongs survival in a Lewis lung carcinoma cancer model.

Kamlah F, Eul BG, Li S, Lang N, Marsh LM, Seeger W, Grimminger F, Rose F, Hänze J.

Cancer Gene Ther. 2009 Mar;16(3):195-205. Epub 2008 Sep 26.PMID: 18818708 [PubMed - indexed for MEDLINE]Related articles

Fhl-1, a new key protein in pulmonary hypertension.

Kwapiszewska G, Wygrecka M, Marsh LM, Schmitt S, Trösser R, Wilhelm J, Helmus K, Eul B, Zakrzewicz A, Ghofrani HA, Schermuly RT, Bohle RM, Grimminger F, Seeger W, Eickelberg O, Fink L, Weissmann N.

Circulation. 2008 Sep 9;118(11):1183-94. Epub 2008 Aug 25.PMID: 18725486 [PubMed - indexed for MEDLINE]Related articlesFree article

Direct and simultaneous profiling of epoxyeicosatrienoic acid enantiomers by capillary tandem column chiral-phase liquid chromatography with dual online photodiode array and tandem mass spectrometric detection.

Kiss L, Bier J, Röder Y, Weissmann N, Grimminger F, Seeger W.

Anal Bioanal Chem. 2008 Oct;392(4):717-26. Epub 2008 Aug 19.PMID: 18712367 [PubMed - indexed for MEDLINE]Related articles

Acute effects of the combination of sildenafil and inhaled treprostinil on haemodynamics and gas exchange in pulmonary hypertension.

Voswinckel R, Reichenberger F, Enke B, Kreckel A, Krick S, Gall H, Schermuly RT, Grimminger F, Rubin LJ, Olschewski H, Seeger W, Ghofrani HA.

Pulm Pharmacol Ther. 2008 Oct;21(5):824-32. Epub 2008 Jul 9.PMID: 18657627 [PubMed - indexed for MEDLINE]Related articles

Apoptosis contributes to septic cardiomyopathy and is improved by simvastatin therapy.

Buerke U, Carter JM, Schlitt A, Russ M, Schmidt H, Sibelius U, Grandel U, Grimminger F, Seeger W, Mueller-Werdan U, Werdan K, Buerke M.

Shock. 2008 Apr;29(4):497-503.PMID: 18598004 [PubMed - indexed for MEDLINE]Related articles

NOX4 regulates ROS levels under normoxic and hypoxic conditions, triggers proliferation, and inhibits apoptosis in pulmonary artery adventitial fibroblasts.

Li S, Tabar SS, Malec V, Eul BG, Klepetko W, Weissmann N, Grimminger F, Seeger W, Rose F, Hänze J.

Antioxid Redox Signal. 2008 Oct;10(10):1687-98.PMID: 18593227 [PubMed - indexed for MEDLINE]Related articles

Phosphodiesterase inhibitors for the treatment of pulmonary hypertension.

Wilkins MR, Wharton J, Grimminger F, Ghofrani HA.

Eur Respir J. 2008 Jul;32(1):198-209.PMID: 18591337 [PubMed - indexed for MEDLINE]Related articles

Expression and function of soluble guanylate cyclase in pulmonary arterial hypertension.

Schermuly RT, Stasch JP, Pullamsetti SS, Middendorff R, Müller D, Schlüter KD, Dingendorf A, Hackemack S, Kolosionek E, Kaulen C, Dumitrascu R, Weissmann N, Mittendorf J, Klepetko W, Seeger W, Ghofrani HA, Grimminger F.

Eur Respir J. 2008 Oct;32(4):881-91. Epub 2008 Jun 11.PMID: 18550612 [PubMed - indexed for MEDLINE]Related articles

Role of the prostanoid EP4 receptor in iloprost-mediated vasodilatation in pulmonary hypertension.

Lai YJ, Pullamsetti SS, Dony E, Weissmann N, Butrous G, Banat GA, Ghofrani HA, Seeger W, Grimminger F, Schermuly RT.

Am J Respir Crit Care Med. 2008 Jul 15;178(2):188-96. Epub 2008 May 8.PMID: 18467507 [PubMed - indexed for MEDLINE]Related articlesFree article

The lectin-like domain of tumor necrosis factor-alpha improves alveolar fluid balance in injured isolated rabbit lungs.

Vadász I, Schermuly RT, Ghofrani HA, Rummel S, Wehner S, Mühldorfer I, Schäfer KP, Seeger W, Morty RE, Grimminger F, Weissmann N.

Crit Care Med. 2008 May;36(5):1543-50.PMID: 18434905 [PubMed - indexed for MEDLINE]Related articles

Spatiotemporal expression of flk-1 in pulmonary epithelial cells during lung development.

Ahlbrecht K, Schmitz J, Seay U, Schwarz C, Mittnacht-Kraus R, Gaumann A, Haberberger RV, Herold S, Breier G, Grimminger F, Seeger W, Voswinckel R.

Am J Respir Cell Mol Biol. 2008 Aug;39(2):163-70. Epub 2008 Mar 6.PMID: 18323533 [PubMed - indexed for MEDLINE]Related articlesFree article

Direct eicosanoid profiling of the hypoxic lung by comprehensive analysis via capillary liquid chromatography with dual online photodiode-array and tandem mass-spectrometric detection.

Kiss L, Röder Y, Bier J, Weissmann N, Seeger W, Grimminger F.

Anal Bioanal Chem. 2008 Jan;390(2):697-714. Epub 2007 Dec 14.PMID: 18080119 [PubMed - indexed for MEDLINE]Related articles

Partial reversal of experimental pulmonary hypertension by phosphodiesterase-3/4 inhibition.

Dony E, Lai YJ, Dumitrascu R, Pullamsetti SS, Savai R, Ghofrani HA, Weissmann N, Schudt C, Flockerzi D, Seeger W, Grimminger F, Schermuly RT.

Eur Respir J. 2008 Mar;31(3):599-610. Epub 2007 Nov 21.PMID: 18032446 [PubMed - indexed for MEDLINE]Related articlesFree article

Functional role and species-specific contribution of arginases in pulmonary fibrosis.

Kitowska K, Zakrzewicz D, Königshoff M, Chrobak I, Grimminger F, Seeger W, Bulau P, Eickelberg O.

Am J Physiol Lung Cell Mol Physiol. 2008 Jan;294(1):L34-45. Epub 2007 Oct 12.PMID: 17934065 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of sildenafil on hypoxia-induced changes in pulmonary circulation and right ventricular function.

Reichenberger F, Kohstall MG, Seeger T, Olschewski H, Grimminger F, Seeger W, Ghofrani HA.

Respir Physiol Neurobiol. 2007 Nov 15;159(2):196-201. Epub 2007 Jul 27.PMID: 17851140 [PubMed - indexed for MEDLINE]Related articles

Long-term treatment with sildenafil in chronic thromboembolic pulmonary hypertension.

Reichenberger F, Voswinckel R, Enke B, Rutsch M, El Fechtali E, Schmehl T, Olschewski H, Schermuly R, Weissmann N, Ghofrani HA, Grimminger F, Mayer E, Seeger W.

Eur Respir J. 2007 Nov;30(5):922-7. Epub 2007 Aug 9.PMID: 17690123 [PubMed - indexed for MEDLINE]Related articlesFree article

Sildenafil in hypoxic pulmonary hypertension potentiates a compensatory up-regulation of NO-cGMP signaling.

Kirsch M, Kemp-Harper B, Weissmann N, Grimminger F, Schmidt HH.

FASEB J. 2008 Jan;22(1):30-40. Epub 2007 Aug 6.PMID: 17679609 [PubMed - indexed for MEDLINE]Related articlesFree article

Hypoxia-induced pulmonary hypertension: different impact of iloprost, sildenafil, and nitric oxide.

Weissmann N, Gerigk B, Kocer O, Nollen M, Hackemack S, Ghofrani HA, Schermuly RT, Butrous G, Schulz A, Roth M, Seeger W, Grimminger F.

Respir Med. 2007 Oct;101(10):2125-32. Epub 2007 Jul 20.PMID: 17643279 [PubMed - indexed for MEDLINE]Related articles

Hypoxia-dependent regulation of nonphagocytic NADPH oxidase subunit NOX4 in the pulmonary vasculature.

Mittal M, Roth M, König P, Hofmann S, Dony E, Goyal P, Selbitz AC, Schermuly RT, Ghofrani HA, Kwapiszewska G, Kummer W, Klepetko W, Hoda MA, Fink L, Hänze J, Seeger W, Grimminger F, Schmidt HH, Weissmann N.

Circ Res. 2007 Aug 3;101(3):258-67. Epub 2007 Jun 21.PMID: 17585072 [PubMed - indexed for MEDLINE]Related articlesFree article

A combination hybrid-based vaccination/adoptive cellular therapy to prevent tumor growth by involvement of T cells.

Savai R, Schermuly RT, Pullamsetti SS, Schneider M, Greschus S, Ghofrani HA, Traupe H, Grimminger F, Banat GA.

Cancer Res. 2007 Jun 1;67(11):5443-53.PMID: 17545626 [PubMed - indexed for MEDLINE]Related articlesFree article

Cellular and molecular mechanisms of hypoxia-inducible factor driven vascular remodeling.

Hänze J, Weissmann N, Grimminger F, Seeger W, Rose F.

Thromb Haemost. 2007 May;97(5):774-87. Review.PMID: 17479188 [PubMed - indexed for MEDLINE]Related articles