PubMed

Hypogonadotropic hypogonadism due to a novel missense mutation in the first extracellular loop of the neurokinin B receptor.

Guran T, Tolhurst G, Bereket A, Rocha N, Porter K, Turan S, Gribble FM, Kotan LD, Akcay T, Atay Z, Canan H, Serin A, O'Rahilly S, Reimann F, Semple RK, Topaloglu AK.

J Clin Endocrinol Metab. 2009 Oct;94(10):3633-9. Epub 2009 Sep 15.PMID: 19755480 [PubMed - indexed for MEDLINE]Related articles

Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants.

Nicolson TJ, Bellomo EA, Wijesekara N, Loder MK, Baldwin JM, Gyulkhandanyan AV, Koshkin V, Tarasov AI, Carzaniga R, Kronenberger K, Taneja TK, da Silva Xavier G, Libert S, Froguel P, Scharfmann R, Stetsyuk V, Ravassard P, Parker H, Gribble FM, Reimann F, Sladek R, Hughes SJ, Johnson PR, Masseboeuf M, Burcelin R, Baldwin SA, Liu M, Lara-Lemus R, Arvan P, Schuit FC, Wheeler MB, Chimienti F, Rutter GA.

Diabetes. 2009 Sep;58(9):2070-83. Epub 2009 Jun 19.PMID: 19542200 [PubMed - indexed for MEDLINE]Related articles

The role of the PDE4D cAMP phosphodiesterase in the regulation of glucagon-like peptide-1 release.

Ong WK, Gribble FM, Reimann F, Lynch MJ, Houslay MD, Baillie GS, Furman BL, Pyne NJ.

Br J Pharmacol. 2009 Jun;157(4):633-44. Epub 2009 Apr 9.PMID: 19371330 [PubMed - indexed for MEDLINE]Related articles

Intolerant of glucose and gasping for oxygen.

Gribble FM.

Nat Med. 2009 Mar;15(3):247-9. No abstract available. PMID: 19265823 [PubMed - indexed for MEDLINE]Related articles

Nutrient-dependent secretion of glucose-dependent insulinotropic polypeptide from primary murine K cells.

Parker HE, Habib AM, Rogers GJ, Gribble FM, Reimann F.

Diabetologia. 2009 Feb;52(2):289-98. Epub 2008 Dec 11.PMID: 19082577 [PubMed - indexed for MEDLINE]Related articles

Oral glutamine increases circulating glucagon-like peptide 1, glucagon, and insulin concentrations in lean, obese, and type 2 diabetic subjects.

Greenfield JR, Farooqi IS, Keogh JM, Henning E, Habib AM, Blackwood A, Reimann F, Holst JJ, Gribble FM.

Am J Clin Nutr. 2009 Jan;89(1):106-13. Epub 2008 Dec 3.PMID: 19056578 [PubMed - indexed for MEDLINE]Related articles

Glucose sensing in L cells: a primary cell study.

Reimann F, Habib AM, Tolhurst G, Parker HE, Rogers GJ, Gribble FM.

Cell Metab. 2008 Dec;8(6):532-9.PMID: 19041768 [PubMed - indexed for MEDLINE]Related articlesFree article

Nutritional regulation of glucagon-like peptide-1 secretion.

Tolhurst G, Reimann F, Gribble FM.

J Physiol. 2009 Jan 15;587(Pt 1):27-32. Epub 2008 Nov 10. Review.PMID: 19001044 [PubMed - indexed for MEDLINE]Related articles

RD Lawrence Lecture 2008: Targeting GLP-1 release as a potential strategy for the therapy of Type 2 diabetes.

Gribble FM.

Diabet Med. 2008 Aug;25(8):889-94. Review.PMID: 18959599 [PubMed - indexed for MEDLINE]Related articlesFree article

Calcium elevation in mouse pancreatic beta cells evoked by extracellular human islet amyloid polypeptide involves activation of the mechanosensitive ion channel TRPV4.

Casas S, Novials A, Reimann F, Gomis R, Gribble FM.

Diabetologia. 2008 Dec;51(12):2252-62. Epub 2008 Aug 28.PMID: 18751967 [PubMed - indexed for MEDLINE]Related articles

No differences in mortality between users of pancreatic-specific and non-pancreatic-specific sulphonylureas: a cohort analysis.

Evans JM, Ogston SA, Reimann F, Gribble FM, Morris AD, Pearson ER.

Diabetes Obes Metab. 2008 Apr;10(4):350-2. Epub 2007 Dec 17.PMID: 18093208 [PubMed - indexed for MEDLINE]Related articles

Cyclic AMP triggers glucagon-like peptide-1 secretion from the GLUTag enteroendocrine cell line.

Simpson AK, Ward PS, Wong KY, Collord GJ, Habib AM, Reimann F, Gribble FM.

Diabetologia. 2007 Oct;50(10):2181-9. Epub 2007 Jul 21.PMID: 17643200 [PubMed - indexed for MEDLINE]Related articles

Impairment of the ubiquitin-proteasome pathway is a downstream endoplasmic reticulum stress response induced by extracellular human islet amyloid polypeptide and contributes to pancreatic beta-cell apoptosis.

Casas S, Gomis R, Gribble FM, Altirriba J, Knuutila S, Novials A.

Diabetes. 2007 Sep;56(9):2284-94. Epub 2007 Jun 11.PMID: 17563070 [PubMed - indexed for MEDLINE]Related articlesFree article

TCF7L2 polymorphisms modulate proinsulin levels and beta-cell function in a British Europid population.

Loos RJ, Franks PW, Francis RW, Barroso I, Gribble FM, Savage DB, Ong KK, O'Rahilly S, Wareham NJ.

Diabetes. 2007 Jul;56(7):1943-7. Epub 2007 Apr 6.PMID: 17416797 [PubMed - indexed for MEDLINE]Related articlesFree article

An SCN9A channelopathy causes congenital inability to experience pain.

Cox JJ, Reimann F, Nicholas AK, Thornton G, Roberts E, Springell K, Karbani G, Jafri H, Mannan J, Raashid Y, Al-Gazali L, Hamamy H, Valente EM, Gorman S, Williams R, McHale DP, Wood JN, Gribble FM, Woods CG.

Nature. 2006 Dec 14;444(7121):894-8.PMID: 17167479 [PubMed - indexed for MEDLINE]Related articles

Sodium-coupled glucose cotransporters contribute to hypothalamic glucose sensing.

O'Malley D, Reimann F, Simpson AK, Gribble FM.

Diabetes. 2006 Dec;55(12):3381-6.PMID: 17130483 [PubMed - indexed for MEDLINE]Related articlesFree article

Mucolipin-1 is a lysosomal membrane protein required for intracellular lactosylceramide traffic.

Pryor PR, Reimann F, Gribble FM, Luzio JP.

Traffic. 2006 Oct;7(10):1388-98.PMID: 16978393 [PubMed - indexed for MEDLINE]Related articles

The neurotransmitters glycine and GABA stimulate glucagon-like peptide-1 release from the GLUTag cell line.

Gameiro A, Reimann F, Habib AM, O'Malley D, Williams L, Simpson AK, Gribble FM.

J Physiol. 2005 Dec 15;569(Pt 3):761-72. Epub 2005 Oct 13.PMID: 16223757 [PubMed - indexed for MEDLINE]Related articlesFree article

Metabolism: a higher power for insulin.

Gribble FM.

Nature. 2005 Apr 21;434(7036):965-6. No abstract available. PMID: 15846327 [PubMed - indexed for MEDLINE]Related articles

Relapsing diabetes can result from moderately activating mutations in KCNJ11.

Gloyn AL, Reimann F, Girard C, Edghill EL, Proks P, Pearson ER, Temple IK, Mackay DJ, Shield JP, Freedenberg D, Noyes K, Ellard S, Ashcroft FM, Gribble FM, Hattersley AT.

Hum Mol Genet. 2005 Apr 1;14(7):925-34. Epub 2005 Feb 17.PMID: 15718250 [PubMed - indexed for MEDLINE]Related articlesFree article

Characterization and functional role of voltage gated cation conductances in the glucagon-like peptide-1 secreting GLUTag cell line.

Reimann F, Maziarz M, Flock G, Habib AM, Drucker DJ, Gribble FM.

J Physiol. 2005 Feb 15;563(Pt 1):161-75. Epub 2004 Dec 20.PMID: 15611035 [PubMed - indexed for MEDLINE]Related articlesFree article

Glutamine potently stimulates glucagon-like peptide-1 secretion from GLUTag cells.

Reimann F, Williams L, da Silva Xavier G, Rutter GA, Gribble FM.

Diabetologia. 2004 Sep;47(9):1592-601. Epub 2004 Sep 9.PMID: 15365617 [PubMed - indexed for MEDLINE]Related articles

Open to control--new hope for patients with neonatal diabetes.

Gribble FM, Reimann F.

N Engl J Med. 2004 Apr 29;350(18):1817-8. No abstract available. PMID: 15115828 [PubMed - indexed for MEDLINE]Related articles

Genetic cause of hyperglycaemia and response to treatment in diabetes.

Pearson ER, Starkey BJ, Powell RJ, Gribble FM, Clark PM, Hattersley AT.

Lancet. 2003 Oct 18;362(9392):1275-81.PMID: 14575972 [PubMed - indexed for MEDLINE]Related articles

Sulphonylurea action revisited: the post-cloning era.

Gribble FM, Reimann F.

Diabetologia. 2003 Jul;46(7):875-91. Epub 2003 Jun 18. Review.PMID: 12819907 [PubMed - indexed for MEDLINE]Related articles

A novel glucose-sensing mechanism contributing to glucagon-like peptide-1 secretion from the GLUTag cell line.

Gribble FM, Williams L, Simpson AK, Reimann F.

Diabetes. 2003 May;52(5):1147-54.PMID: 12716745 [PubMed - indexed for MEDLINE]Related articlesFree article

Characterisation of new KATP-channel mutations associated with congenital hyperinsulinism in the Finnish population.

Reimann F, Huopio H, Dabrowski M, Proks P, Gribble FM, Laakso M, Otonkoski T, Ashcroft FM.

Diabetologia. 2003 Feb;46(2):241-9. Epub 2003 Jan 9. Erratum in: Diabetologia. 2004 Jan;47(1):155. PMID: 12627323 [PubMed - indexed for MEDLINE]Related articles

Differential selectivity of insulin secretagogues: mechanisms, clinical implications, and drug interactions.

Gribble FM, Reimann F.

J Diabetes Complications. 2003 Mar-Apr;17(2 Suppl):11-5. Review.PMID: 12623163 [PubMed - indexed for MEDLINE]Related articles

Analysis of the differential modulation of sulphonylurea block of beta-cell and cardiac ATP-sensitive K+ (K(ATP)) channels by Mg-nucleotides.

Reimann F, Dabrowski M, Jones P, Gribble FM, Ashcroft FM.

J Physiol. 2003 Feb 15;547(Pt 1):159-68. Epub 2003 Jan 10.PMID: 12562963 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose-sensing in glucagon-like peptide-1-secreting cells.

Reimann F, Gribble FM.

Diabetes. 2002 Sep;51(9):2757-63.PMID: 12196469 [PubMed - indexed for MEDLINE]Related articlesFree article

Pharmacological modulation of K(ATP) channels.

Gribble FM, Reimann F.

Biochem Soc Trans. 2002 Apr;30(2):333-9. Review.PMID: 12023875 [PubMed - indexed for MEDLINE]Related articles

Structural basis for the interference between nicorandil and sulfonylurea action.

Reimann F, Ashcroft FM, Gribble FM.

Diabetes. 2001 Oct;50(10):2253-9.PMID: 11574406 [PubMed - indexed for MEDLINE]Related articlesFree article

Randomized dose ranging study of the reduction of fasting and postprandial glucose in type 2 diabetes by nateglinide (A-4166).

Gribble FM, Manley SE, Levy JC.

Diabetes Care. 2001 Jul;24(7):1221-5.PMID: 11423506 [PubMed - indexed for MEDLINE]Related articlesFree article

New windows on the mechanism of action of K(ATP) channel openers.

Ashcroft FM, Gribble FM.

Trends Pharmacol Sci. 2000 Nov;21(11):439-45. Review.PMID: 11121575 [PubMed - indexed for MEDLINE]Related articles

Differential response of K(ATP) channels containing SUR2A or SUR2B subunits to nucleotides and pinacidil.

Reimann F, Gribble FM, Ashcroft FM.

Mol Pharmacol. 2000 Dec;58(6):1318-25.PMID: 11093769 [PubMed - indexed for MEDLINE]Related articlesFree article

Sulfonylurea sensitivity of adenosine triphosphate-sensitive potassium channels from beta cells and extrapancreatic tissues.

Gribble FM, Ashcroft FM.

Metabolism. 2000 Oct;49(10 Suppl 2):3-6. Review.PMID: 11078468 [PubMed - indexed for MEDLINE]Related articles

The antimalarial agent mefloquine inhibits ATP-sensitive K-channels.

Gribble FM, Davis TM, Higham CE, Clark A, Ashcroft FM.

Br J Pharmacol. 2000 Oct;131(4):756-60.PMID: 11030725 [PubMed - indexed for MEDLINE]Related articlesFree article

Tissue-specific effects of sulfonylureas: lessons from studies of cloned K(ATP) channels.

Ashcroft FM, Gribble FM.

J Diabetes Complications. 2000 Jul-Aug;14(4):192-6. Review.PMID: 11004427 [PubMed - indexed for MEDLINE]Related articles

A novel method for measurement of submembrane ATP concentration.

Gribble FM, Loussouarn G, Tucker SJ, Zhao C, Nichols CG, Ashcroft FM.

J Biol Chem. 2000 Sep 29;275(39):30046-9.PMID: 10866996 [PubMed - indexed for MEDLINE]Related articlesFree article

Nucleotide modulation of pinacidil stimulation of the cloned K(ATP) channel Kir6.2/SUR2A.

Gribble FM, Reimann F, Ashfield R, Ashcroft FM.

Mol Pharmacol. 2000 Jun;57(6):1256-61.PMID: 10825398 [PubMed - indexed for MEDLINE]Related articlesFree article

In vitro mechanism of action on insulin release of S-22068, a new putative antidiabetic compound.

Le Brigand L, Virsolvy A, Manechez D, Godfroid JJ, Guardiola-Lemaître B, Gribble FM, Ashcroft FM, Bataille D.

Br J Pharmacol. 1999 Nov;128(5):1021-6.PMID: 10556939 [PubMed - indexed for MEDLINE]Related articlesFree article

ATP-sensitive K+ channels and insulin secretion: their role in health and disease.

Ashcroft FM, Gribble FM.

Diabetologia. 1999 Aug;42(8):903-19. Review. No abstract available. PMID: 10491749 [PubMed - indexed for MEDLINE]Related articles

Differential sensitivity of beta-cell and extrapancreatic K(ATP) channels to gliclazide.

Gribble FM, Ashcroft FM.

Diabetologia. 1999 Jul;42(7):845-8.PMID: 10440127 [PubMed - indexed for MEDLINE]Related articles

Identification of the high-affinity tolbutamide site on the SUR1 subunit of the K(ATP) channel.

Ashfield R, Gribble FM, Ashcroft SJ, Ashcroft FM.

Diabetes. 1999 Jun;48(6):1341-7.PMID: 10342826 [PubMed - indexed for MEDLINE]Related articlesFree article

Involvement of the N-terminus of Kir6.2 in the inhibition of the KATP channel by ATP.

Proks P, Gribble FM, Adhikari R, Tucker SJ, Ashcroft FM.

J Physiol. 1999 Jan 1;514 ( Pt 1):19-25.PMID: 9831713 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanism of cloned ATP-sensitive potassium channel activation by oleoyl-CoA.

Gribble FM, Proks P, Corkey BE, Ashcroft FM.

J Biol Chem. 1998 Oct 9;273(41):26383-7.PMID: 9756869 [PubMed - indexed for MEDLINE]Related articlesFree article

Tissue specificity of sulfonylureas: studies on cloned cardiac and beta-cell K(ATP) channels.

Gribble FM, Tucker SJ, Seino S, Ashcroft FM.

Diabetes. 1998 Sep;47(9):1412-8.PMID: 9726229 [PubMed - indexed for MEDLINE]Related articlesFree article

Correlating structure and function in ATP-sensitive K+ channels.

Ashcroft FM, Gribble FM.

Trends Neurosci. 1998 Jul;21(7):288-94. Review.PMID: 9683320 [PubMed - indexed for MEDLINE]Related articles

Human alpha-endosulfine, a possible regulator of sulfonylurea-sensitive KATP channel: molecular cloning, expression and biological properties.

Heron L, Virsolvy A, Peyrollier K, Gribble FM, Le Cam A, Ashcroft FM, Bataille D.

Proc Natl Acad Sci U S A. 1998 Jul 7;95(14):8387-91.PMID: 9653196 [PubMed - indexed for MEDLINE]Related articlesFree article

Molecular determinants of KATP channel inhibition by ATP.

Tucker SJ, Gribble FM, Proks P, Trapp S, Ryder TJ, Haug T, Reimann F, Ashcroft FM.

EMBO J. 1998 Jun 15;17(12):3290-6.PMID: 9628866 [PubMed - indexed for MEDLINE]Related articlesFree article