PubMed

AATF mediates an antiapoptotic effect of the unfolded protein response through transcriptional regulation of AKT1.

Ishigaki S, Fonseca SG, Oslowski CM, Jurczyk A, Shearstone JR, Zhu LJ, Permutt MA, Greiner DL, Bortell R, Urano F.

Cell Death Differ. 2009 Nov 13. [Epub ahead of print]PMID: 19911006 [PubMed - as supplied by publisher]Related articles

Dengue virus infection and virus-specific HLA-A2 restricted immune responses in humanized NOD-scid IL2rgammanull mice.

Jaiswal S, Pearson T, Friberg H, Shultz LD, Greiner DL, Rothman AL, Mathew A.

PLoS One. 2009 Oct 5;4(10):e7251.PMID: 19802382 [PubMed - in process]Related articlesFree article

INFECTION WITH VIRUSES FROM SEVERAL FAMILIES TRIGGERS AUTOIMMUNE DIABETES IN LEW.1WR1 RATS: Prevention of Diabetes by Maternal Immunization.

Tirabassi RS, Guberski DL, Blankenhorn EP, Leif JH, Woda BA, Liu Z, Winans D, Greiner DL, Mordes JP.

Diabetes. 2009 Sep 30. [Epub ahead of print]PMID: 19794063 [PubMed - as supplied by publisher]Related articles

VIRUS-INDUCED AUTOIMMUNE DIABETES IN THE LEW.1WR1 RAT REQUIRES Iddm14 AND A GENETIC LOCUS PROXIMAL TO THE MAJOR HISTOCOMPATIBILITY COMPLEX.

Blankenhorn EP, Cort L, Greiner DL, Guberski DL, Mordes JP.

Diabetes. 2009 Aug 31. [Epub ahead of print]PMID: 19720792 [PubMed - as supplied by publisher]Related articles

Human peripheral blood leucocyte non-obese diabetic-severe combined immunodeficiency interleukin-2 receptor gamma chain gene mouse model of xenogeneic graft-versus-host-like disease and the role of host major histocompatibility complex.

King MA, Covassin L, Brehm MA, Racki W, Pearson T, Leif J, Laning J, Fodor W, Foreman O, Burzenski L, Chase TH, Gott B, Rossini AA, Bortell R, Shultz LD, Greiner DL.

Clin Exp Immunol. 2009 Jul;157(1):104-18.PMID: 19659776 [PubMed - indexed for MEDLINE]Related articles

CHOP mediates endoplasmic reticulum stress-induced apoptosis in Gimap5-deficient T cells.

Pino SC, O'Sullivan-Murphy B, Lidstone EA, Yang C, Lipson KL, Jurczyk A, diIorio P, Brehm MA, Mordes JP, Greiner DL, Rossini AA, Bortell R.

PLoS One. 2009;4(5):e5468. Epub 2009 May 8.PMID: 19424493 [PubMed - indexed for MEDLINE]Related articlesFree article

Failure of alpha-galactosylceramide to prevent diabetes in virus-inducible models of type 1 diabetes in the rat.

Chopra P, Diiorio P, Pino SC, Wilson SB, Phillips NE, Mordes JP, Rossini AA, Greiner DL, Shultz LD, Bortell R.

In Vivo. 2009 Mar-Apr;23(2):195-201.PMID: 19414403 [PubMed - indexed for MEDLINE]Related articlesFree article

TLR agonists prevent the establishment of allogeneic hematopoietic chimerism in mice treated with costimulation blockade.

Miller DM, Thornley TB, Pearson T, Kruger AJ, Yamazaki M, Shultz LD, Welsh RM, Brehm MA, Rossini AA, Greiner DL.

J Immunol. 2009 May 1;182(9):5547-59.PMID: 19380803 [PubMed - indexed for MEDLINE]Related articles

Depletion of the programmed death-1 receptor completely reverses established clonal anergy in CD4(+) T lymphocytes via an interleukin-2-dependent mechanism.

Bishop KD, Harris JE, Mordes JP, Greiner DL, Rossini AA, Czech MP, Phillips NE.

Cell Immunol. 2009;256(1-2):86-91. Epub 2009 Feb 23.PMID: 19230866 [PubMed - indexed for MEDLINE]Related articles

Analysis of the rat Iddm14 diabetes susceptibility locus in multiple rat strains: identification of a susceptibility haplotype in the Tcrb-V locus.

Mordes JP, Cort L, Norowski E, Leif J, Fuller JM, Lernmark A, Greiner DL, Blankenhorn EP.

Mamm Genome. 2009 Mar;20(3):162-9. Epub 2009 Feb 10.PMID: 19205800 [PubMed - indexed for MEDLINE]Related articles

Role of innate immunity in transplantation tolerance.

Miller DM, Rossini AA, Greiner DL.

Crit Rev Immunol. 2008;28(5):403-39. Review.PMID: 19166387 [PubMed - indexed for MEDLINE]Related articles

TLR agonists abrogate co-stimulation blockade-induced mixed chimerism and transplantation tolerance.

Miller DM, Thornley T, Pearson T, Yamazaki M, Brehm MA, Rossini AA, Greiner DL.

Ann N Y Acad Sci. 2008 Dec;1150:149-51.PMID: 19120285 [PubMed - indexed for MEDLINE]Related articles

Closing the circle between the bedside and the bench: Toll-like receptors in models of virally induced diabetes.

Bortell R, Pino SC, Greiner DL, Zipris D, Rossini AA.

Ann N Y Acad Sci. 2008 Dec;1150:112-22. Review.PMID: 19120279 [PubMed - indexed for MEDLINE]Related articles

Humanized mice for the study of type 1 diabetes and beta cell function.

King M, Pearson T, Rossini AA, Shultz LD, Greiner DL.

Ann N Y Acad Sci. 2008 Dec;1150:46-53. Review.PMID: 19120266 [PubMed - indexed for MEDLINE]Related articles

Idd loci synergize to prolong islet allograft survival induced by costimulation blockade in NOD mice.

Mangada J, Pearson T, Brehm MA, Wicker LS, Peterson LB, Shultz LD, Serreze DV, Rossini AA, Greiner DL.

Diabetes. 2009 Jan;58(1):165-73. Epub 2008 Nov 4.PMID: 18984741 [PubMed - indexed for MEDLINE]Related articlesFree article

Viral infection: a potent barrier to transplantation tolerance.

Miller DM, Thornley TB, Greiner DL, Rossini AA.

Clin Dev Immunol. 2008;2008:742810. Review.PMID: 18815618 [PubMed - indexed for MEDLINE]Related articlesFree article

Non-obese diabetic-recombination activating gene-1 (NOD-Rag1 null) interleukin (IL)-2 receptor common gamma chain (IL2r gamma null) null mice: a radioresistant model for human lymphohaematopoietic engraftment.

Pearson T, Shultz LD, Miller D, King M, Laning J, Fodor W, Cuthbert A, Burzenski L, Gott B, Lyons B, Foreman O, Rossini AA, Greiner DL.

Clin Exp Immunol. 2008 Nov;154(2):270-84. Epub 2008 Sep 8.PMID: 18785974 [PubMed - indexed for MEDLINE]Related articlesFree article

Human BLyS facilitates engraftment of human PBL derived B cells in immunodeficient mice.

Schmidt MR, Appel MC, Giassi LJ, Greiner DL, Shultz LD, Woodland RT.

PLoS One. 2008 Sep 11;3(9):e3192.PMID: 18784835 [PubMed - indexed for MEDLINE]Related articlesFree article

T cell-specific siRNA delivery suppresses HIV-1 infection in humanized mice.

Kumar P, Ban HS, Kim SS, Wu H, Pearson T, Greiner DL, Laouar A, Yao J, Haridas V, Habiro K, Yang YG, Jeong JH, Lee KY, Kim YH, Kim SW, Peipp M, Fey GH, Manjunath N, Shultz LD, Lee SK, Shankar P.

Cell. 2008 Aug 22;134(4):577-86. Epub 2008 Aug 7.PMID: 18691745 [PubMed - indexed for MEDLINE]Related articles

Expanded CD34+ human umbilical cord blood cells generate multiple lymphohematopoietic lineages in NOD-scid IL2rgamma(null) mice.

Giassi LJ, Pearson T, Shultz LD, Laning J, Biber K, Kraus M, Woda BA, Schmidt MR, Woodland RT, Rossini AA, Greiner DL.

Exp Biol Med (Maywood). 2008 Aug;233(8):997-1012.PMID: 18653783 [PubMed - indexed for MEDLINE]Related articlesFree article

A new immunodeficient hyperglycaemic mouse model based on the Ins2Akita mutation for analyses of human islet and beta stem and progenitor cell function.

Pearson T, Shultz LD, Lief J, Burzenski L, Gott B, Chase T, Foreman O, Rossini AA, Bottino R, Trucco M, Greiner DL.

Diabetologia. 2008 Aug;51(8):1449-56. Epub 2008 Jun 19.PMID: 18563383 [PubMed - indexed for MEDLINE]Related articlesFree article

Creation of "humanized" mice to study human immunity.

Pearson T, Greiner DL, Shultz LD.

Curr Protoc Immunol. 2008 May;Chapter 15:Unit 15.21.PMID: 18491294 [PubMed - indexed for MEDLINE]Related articles

Humanized SCID mouse models for biomedical research.

Pearson T, Greiner DL, Shultz LD.

Curr Top Microbiol Immunol. 2008;324:25-51. Review.PMID: 18481451 [PubMed - indexed for MEDLINE]Related articles

Protein kinase C signaling during T cell activation induces the endoplasmic reticulum stress response.

Pino SC, O'Sullivan-Murphy B, Lidstone EA, Thornley TB, Jurczyk A, Urano F, Greiner DL, Mordes JP, Rossini AA, Bortell R.

Cell Stress Chaperones. 2008 Dec;13(4):421-34. Epub 2008 Apr 17.PMID: 18418732 [PubMed - indexed for MEDLINE]Related articlesFree article

A new Hu-PBL model for the study of human islet alloreactivity based on NOD-scid mice bearing a targeted mutation in the IL-2 receptor gamma chain gene.

King M, Pearson T, Shultz LD, Leif J, Bottino R, Trucco M, Atkinson MA, Wasserfall C, Herold KC, Woodland RT, Schmidt MR, Woda BA, Thompson MJ, Rossini AA, Greiner DL.

Clin Immunol. 2008 Mar;126(3):303-14. Epub 2007 Dec 21.PMID: 18096436 [PubMed - indexed for MEDLINE]Related articles

Type 1 IFN mediates cross-talk between innate and adaptive immunity that abrogates transplantation tolerance.

Thornley TB, Phillips NE, Beaudette-Zlatanova BC, Markees TG, Bahl K, Brehm MA, Shultz LD, Kurt-Jones EA, Mordes JP, Welsh RM, Rossini AA, Greiner DL.

J Immunol. 2007 Nov 15;179(10):6620-9.PMID: 17982052 [PubMed - indexed for MEDLINE]Related articlesFree article

A novel alloantigen-specific CD8+PD1+ regulatory T cell induced by ICOS-B7h blockade in vivo.

Izawa A, Yamaura K, Albin MJ, Jurewicz M, Tanaka K, Clarkson MR, Ueno T, Habicht A, Freeman GJ, Yagita H, Abdi R, Pearson T, Greiner DL, Sayegh MH, Najafian N.

J Immunol. 2007 Jul 15;179(2):786-96.PMID: 17617568 [PubMed - indexed for MEDLINE]Related articlesFree article

Different mechanisms control peripheral and central tolerance in hematopoietic chimeric mice.

Yamazaki M, Pearson T, Brehm MA, Miller DM, Mangada JA, Markees TG, Shultz LD, Mordes JP, Rossini AA, Greiner DL.

Am J Transplant. 2007 Jul;7(7):1710-21.PMID: 17564635 [PubMed - indexed for MEDLINE]Related articles

Refinement of the Iddm4 diabetes susceptibility locus reveals TCRVbeta4 as a candidate gene.

Blankenhorn EP, Descipio C, Rodemich L, Cort L, Leif JH, Greiner DL, Mordes JP.

Ann N Y Acad Sci. 2007 Apr;1103:128-31. Epub 2007 Mar 21.PMID: 17376830 [PubMed - indexed for MEDLINE]Related articles

Diabetes research in jeopardy: the extinction of clinical diabetes researchers.

Rossini AA, Greiner DL.

Ann N Y Acad Sci. 2007 Apr;1103:33-44. Epub 2007 Mar 21.PMID: 17376823 [PubMed - indexed for MEDLINE]Related articles

Development of new-generation HU-PBMC-NOD/SCID mice to study human islet alloreactivity.

King M, Pearson T, Shultz LD, Leif J, Bottino R, Trucco M, Atkinson M, Wasserfall C, Herold K, Mordes JP, Rossini AA, Greiner DL.

Ann N Y Acad Sci. 2007 Apr;1103:90-3. Epub 2007 Mar 21.PMID: 17376822 [PubMed - indexed for MEDLINE]Related articles

Humanized NOD/LtSz-scid IL2 receptor common gamma chain knockout mice in diabetes research.

Shultz LD, Pearson T, King M, Giassi L, Carney L, Gott B, Lyons B, Rossini AA, Greiner DL.

Ann N Y Acad Sci. 2007 Apr;1103:77-89. Epub 2007 Mar 1.PMID: 17332083 [PubMed - indexed for MEDLINE]Related articles

Humanized mice in translational biomedical research.

Shultz LD, Ishikawa F, Greiner DL.

Nat Rev Immunol. 2007 Feb;7(2):118-30. Review.PMID: 17259968 [PubMed - indexed for MEDLINE]Related articles

TLR9-signaling pathways are involved in Kilham rat virus-induced autoimmune diabetes in the biobreeding diabetes-resistant rat.

Zipris D, Lien E, Nair A, Xie JX, Greiner DL, Mordes JP, Rossini AA.

J Immunol. 2007 Jan 15;178(2):693-701.PMID: 17202329 [PubMed - indexed for MEDLINE]Related articlesFree article

A regulatory CD4+ T cell subset in the BB rat model of autoimmune diabetes expresses neither CD25 nor Foxp3.

Hillebrands JL, Whalen B, Visser JT, Koning J, Bishop KD, Leif J, Rozing J, Mordes JP, Greiner DL, Rossini AA.

J Immunol. 2006 Dec 1;177(11):7820-32.PMID: 17114453 [PubMed - indexed for MEDLINE]Related articlesFree article

Partial versus full allogeneic hemopoietic chimerization is a preferential means to inhibit type 1 diabetes as the latter induces generalized immunosuppression.

Serreze DV, Osborne MA, Chen YG, Chapman HD, Pearson T, Brehm MA, Greiner DL.

J Immunol. 2006 Nov 15;177(10):6675-84.PMID: 17082580 [PubMed - indexed for MEDLINE]Related articlesFree article

Costimulatory blockade induces hyporesponsiveness in T cells that recognize alloantigen via indirect antigen presentation.

Phillips NE, Greiner DL, Mordes JP, Rossini AA.

Transplantation. 2006 Oct 27;82(8):1085-92.PMID: 17060858 [PubMed - indexed for MEDLINE]Related articles

Rapid quantification of naive alloreactive T cells by TNF-alpha production and correlation with allograft rejection in mice.

Brehm MA, Mangada J, Markees TG, Pearson T, Daniels KA, Thornley TB, Welsh RM, Rossini AA, Greiner DL.

Blood. 2007 Jan 15;109(2):819-26. Epub 2006 Sep 14.PMID: 16973964 [PubMed - indexed for MEDLINE]Related articlesFree article

ART2, a T cell surface mono-ADP-ribosyltransferase, generates extracellular poly(ADP-ribose).

Morrison AR, Moss J, Stevens LA, Evans JE, Farrell C, Merithew E, Lambright DG, Greiner DL, Mordes JP, Rossini AA, Bortell R.

J Biol Chem. 2006 Nov 3;281(44):33363-72. Epub 2006 Aug 24.PMID: 16931513 [PubMed - indexed for MEDLINE]Related articlesFree article

Anti-mouse CD154 antibody treatment facilitates generation of mixed xenogeneic rat hematopoietic chimerism, prevents wasting disease and prolongs xenograft survival in mice.

Masaki H, Appel MC, Leahy L, Leif J, Paquin L, Shultz LD, Mordes JP, Greiner DL, Rossini AA.

Xenotransplantation. 2006 May;13(3):224-32.PMID: 16756565 [PubMed - indexed for MEDLINE]Related articles

Costimulation and autoimmune diabetes in BB rats.

Beaudette-Zlatanova BC, Whalen B, Zipris D, Yagita H, Rozing J, Groen H, Benjamin CD, Hunig T, Drexhage HA, Ansari MJ, Leif J, Mordes JP, Greiner DL, Sayegh MH, Rossini AA.

Am J Transplant. 2006 May;6(5 Pt 1):894-902.PMID: 16611325 [PubMed - indexed for MEDLINE]Related articles

TLR agonists abrogate costimulation blockade-induced prolongation of skin allografts.

Thornley TB, Brehm MA, Markees TG, Shultz LD, Mordes JP, Welsh RM, Rossini AA, Greiner DL.

J Immunol. 2006 Feb 1;176(3):1561-70.PMID: 16424185 [PubMed - indexed for MEDLINE]Related articlesFree article

LEW.1WR1 rats develop autoimmune diabetes spontaneously and in response to environmental perturbation.

Mordes JP, Guberski DL, Leif JH, Woda BA, Flanagan JF, Greiner DL, Kislauskis EH, Tirabassi RS.

Diabetes. 2005 Sep;54(9):2727-33.PMID: 16123363 [PubMed - indexed for MEDLINE]Related articlesFree article

Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells.

Shultz LD, Lyons BL, Burzenski LM, Gott B, Chen X, Chaleff S, Kotb M, Gillies SD, King M, Mangada J, Greiner DL, Handgretinger R.

J Immunol. 2005 May 15;174(10):6477-89.PMID: 15879151 [PubMed - indexed for MEDLINE]Related articlesFree article

Disruption of the Jnk2 (Mapk9) gene reduces destructive insulitis and diabetes in a mouse model of type I diabetes.

Jaeschke A, Rincón M, Doran B, Reilly J, Neuberg D, Greiner DL, Shultz LD, Rossini AA, Flavell RA, Davis RJ.

Proc Natl Acad Sci U S A. 2005 May 10;102(19):6931-5. Epub 2005 May 2.PMID: 15867147 [PubMed - indexed for MEDLINE]Related articlesFree article

The rat diabetes susceptibility locus Iddm4 and at least one additional gene are required for autoimmune diabetes induced by viral infection.

Blankenhorn EP, Rodemich L, Martin-Fernandez C, Leif J, Greiner DL, Mordes JP.

Diabetes. 2005 Apr;54(4):1233-7.PMID: 15793267 [PubMed - indexed for MEDLINE]Related articlesFree article

Autoimmune diabetes and resistance to xenograft transplantation tolerance in NOD mice.

Gordon EJ, Wicker LS, Peterson LB, Serreze DV, Markees TG, Shultz LD, Rossini AA, Greiner DL, Mordes JP.

Diabetes. 2005 Jan;54(1):107-15.PMID: 15616017 [PubMed - indexed for MEDLINE]Related articlesFree article

TLR activation synergizes with Kilham rat virus infection to induce diabetes in BBDR rats.

Zipris D, Lien E, Xie JX, Greiner DL, Mordes JP, Rossini AA.

J Immunol. 2005 Jan 1;174(1):131-42.PMID: 15611235 [PubMed - indexed for MEDLINE]Related articlesFree article

Evaluation of donor-specific transfusion sources: unique failure of bone marrow cells to induce prolonged skin allograft survival with anti-CD154 monoclonal antibody.

Markees TG, Pearson T, Cuthbert A, Pearson AL, Shultz LD, Leif J, Phillips NE, Mordes JP, Greiner DL, Rossini AA.

Transplantation. 2004 Dec 15;78(11):1601-8.PMID: 15591948 [PubMed - indexed for MEDLINE]Related articles

Early growth response gene-2, a zinc-finger transcription factor, is required for full induction of clonal anergy in CD4+ T cells.

Harris JE, Bishop KD, Phillips NE, Mordes JP, Greiner DL, Rossini AA, Czech MP.

J Immunol. 2004 Dec 15;173(12):7331-8.PMID: 15585857 [PubMed - indexed for MEDLINE]Related articlesFree article