PubMed

Impaired wound healing in mouse models of diabetes is mediated by TNF-alpha dysregulation and associated with enhanced activation of forkhead box O1 (FOXO1).

Siqueira MF, Li J, Chehab L, Desta T, Chino T, Krothpali N, Behl Y, Alikhani M, Yang J, Braasch C, Graves DT.

Diabetologia. 2009 Nov 10. [Epub ahead of print]PMID: 19902175 [PubMed - as supplied by publisher]Related articles

High levels of tumor necrosis factor-alpha contribute to accelerated loss of cartilage in diabetic fracture healing.

Alblowi J, Kayal RA, Siqueria M, McKenzie E, Krothapalli N, McLean J, Conn J, Nikolajczyk B, Einhorn TA, Gerstenfeld L, Graves DT.

Am J Pathol. 2009 Oct;175(4):1574-85. Epub 2009 Sep 10.PMID: 19745063 [PubMed - in process]Related articles

BMP2 is essential for post natal osteogenesis but not for recruitment of osteogenic stem cells.

Bais MV, Wigner N, Young M, Toholka R, Graves DT, Morgan EF, Gerstenfeld LC, Einhorn TA.

Bone. 2009 Aug;45(2):254-66. Epub 2009 May 3.PMID: 19398045 [PubMed - indexed for MEDLINE]Related articles

FOXO1 plays an important role in enhanced microvascular cell apoptosis and microvascular cell loss in type 1 and type 2 diabetic rats.

Behl Y, Krothapalli P, Desta T, Roy S, Graves DT.

Diabetes. 2009 Apr;58(4):917-25. Epub 2009 Jan 23.PMID: 19168598 [PubMed - indexed for MEDLINE]Related articlesFree article

Activation of the acquired immune response reduces coupled bone formation in response to a periodontal pathogen.

Behl Y, Siqueira M, Ortiz J, Li J, Desta T, Faibish D, Graves DT.

J Immunol. 2008 Dec 15;181(12):8711-8.PMID: 19050291 [PubMed - indexed for MEDLINE]Related articles

Comparison of effects of the bisphosphonate alendronate versus the RANKL inhibitor denosumab on murine fracture healing.

Gerstenfeld LC, Sacks DJ, Pelis M, Mason ZD, Graves DT, Barrero M, Ominsky MS, Kostenuik PJ, Morgan EF, Einhorn TA.

J Bone Miner Res. 2009 Feb;24(2):196-208.PMID: 19016594 [PubMed - indexed for MEDLINE]Related articles

Diabetes causes the accelerated loss of cartilage during fracture repair which is reversed by insulin treatment.

Kayal RA, Alblowi J, McKenzie E, Krothapalli N, Silkman L, Gerstenfeld L, Einhorn TA, Graves DT.

Bone. 2009 Feb;44(2):357-63. Epub 2008 Oct 29.PMID: 19010456 [PubMed - indexed for MEDLINE]Related articles

The transcription factor ST18 regulates proapoptotic and proinflammatory gene expression in fibroblasts.

Yang J, Siqueira MF, Behl Y, Alikhani M, Graves DT.

FASEB J. 2008 Nov;22(11):3956-67. Epub 2008 Aug 1.PMID: 18676404 [PubMed - indexed for MEDLINE]Related articlesFree article

P. gingivalis and E. coli lipopolysaccharides exhibit different systemic but similar local induction of inflammatory markers.

Liu R, Desta T, Raptis M, Darveau RP, Graves DT.

J Periodontol. 2008 Jul;79(7):1241-7.PMID: 18597607 [PubMed - indexed for MEDLINE]Related articlesFree article

Diabetes-enhanced tumor necrosis factor-alpha production promotes apoptosis and the loss of retinal microvascular cells in type 1 and type 2 models of diabetic retinopathy.

Behl Y, Krothapalli P, Desta T, DiPiazza A, Roy S, Graves DT.

Am J Pathol. 2008 May;172(5):1411-8. Epub 2008 Apr 10.PMID: 18403591 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of experimental periodontitis by a topical boron-based antimicrobial.

Luan Q, Desta T, Chehab L, Sanders VJ, Plattner J, Graves DT.

J Dent Res. 2008 Feb;87(2):148-52.PMID: 18218841 [PubMed - indexed for MEDLINE]Related articles

Molecular mechanisms controlling bone formation during fracture healing and distraction osteogenesis.

Ai-Aql ZS, Alagl AS, Graves DT, Gerstenfeld LC, Einhorn TA.

J Dent Res. 2008 Feb;87(2):107-18. Review.PMID: 18218835 [PubMed - indexed for MEDLINE]Related articles

The use of rodent models to investigate host-bacteria interactions related to periodontal diseases.

Graves DT, Fine D, Teng YT, Van Dyke TE, Hajishengallis G.

J Clin Periodontol. 2008 Feb;35(2):89-105. Review.PMID: 18199146 [PubMed - indexed for MEDLINE]Related articlesFree article

Diabetic complications and dysregulated innate immunity.

Graves DT, Kayal RA.

Front Biosci. 2008 Jan 1;13:1227-39. Review.PMID: 17981625 [PubMed - indexed for MEDLINE]Related articles

Diabetes-enhanced inflammation and apoptosis: impact on periodontal pathosis.

Graves DT, Liu R, Oates TW.

Periodontol 2000. 2007;45:128-37. Review. No abstract available. PMID: 17850453 [PubMed - indexed for MEDLINE]Related articles

Apoptosis in gingival overgrowth tissues.

Kantarci A, Augustin P, Firatli E, Sheff MC, Hasturk H, Graves DT, Trackman PC.

J Dent Res. 2007 Sep;86(9):888-92.PMID: 17720861 [PubMed - indexed for MEDLINE]Related articles

Fibroblast apoptosis induced by Porphyromonas gingivalis is stimulated by a gingipain and caspase-independent pathway that involves apoptosis-inducing factor.

Desta T, Graves DT.

Cell Microbiol. 2007 Nov;9(11):2667-75. Epub 2007 Jun 24.PMID: 17587332 [PubMed - indexed for MEDLINE]Related articles

Diminished bone formation during diabetic fracture healing is related to the premature resorption of cartilage associated with increased osteoclast activity.

Kayal RA, Tsatsas D, Bauer MA, Allen B, Al-Sebaei MO, Kakar S, Leone CW, Morgan EF, Gerstenfeld LC, Einhorn TA, Graves DT.

J Bone Miner Res. 2007 Apr;22(4):560-8.PMID: 17243865 [PubMed - indexed for MEDLINE]Related articles

Advanced glycation end products stimulate osteoblast apoptosis via the MAP kinase and cytosolic apoptotic pathways.

Alikhani M, Alikhani Z, Boyd C, MacLellan CM, Raptis M, Liu R, Pischon N, Trackman PC, Gerstenfeld L, Graves DT.

Bone. 2007 Feb;40(2):345-53. Epub 2006 Oct 24.PMID: 17064973 [PubMed - indexed for MEDLINE]Related articlesFree article

Advanced glycation end products induce apoptosis in fibroblasts through activation of ROS, MAP kinases, and the FOXO1 transcription factor.

Alikhani M, Maclellan CM, Raptis M, Vora S, Trackman PC, Graves DT.

Am J Physiol Cell Physiol. 2007 Feb;292(2):C850-6. Epub 2006 Sep 27.PMID: 17005604 [PubMed - indexed for MEDLINE]Related articlesFree article

Three-dimensional reconstruction of fracture callus morphogenesis.

Gerstenfeld LC, Alkhiary YM, Krall EA, Nicholls FH, Stapleton SN, Fitch JL, Bauer M, Kayal R, Graves DT, Jepsen KJ, Einhorn TA.

J Histochem Cytochem. 2006 Nov;54(11):1215-28. Epub 2006 Jul 24.PMID: 16864894 [PubMed - indexed for MEDLINE]Related articlesFree article

Diabetes enhances periodontal bone loss through enhanced resorption and diminished bone formation.

Liu R, Bal HS, Desta T, Krothapalli N, Alyassi M, Luan Q, Graves DT.

J Dent Res. 2006 Jun;85(6):510-4.PMID: 16723646 [PubMed - indexed for MEDLINE]Related articlesFree article

Immunization enhances inflammation and tissue destruction in response to Porphyromonas gingivalis.

Leone CW, Bokhadhoor H, Kuo D, Desta T, Yang J, Siqueira MF, Amar S, Graves DT.

Infect Immun. 2006 Apr;74(4):2286-92.PMID: 16552059 [PubMed - indexed for MEDLINE]Related articlesFree article

Tumor necrosis factor-alpha mediates diabetes-enhanced apoptosis of matrix-producing cells and impairs diabetic healing.

Liu R, Bal HS, Desta T, Behl Y, Graves DT.

Am J Pathol. 2006 Mar;168(3):757-64.PMID: 16507891 [PubMed - indexed for MEDLINE]Related articlesFree article

Diabetes enhances mRNA levels of proapoptotic genes and caspase activity, which contribute to impaired healing.

Al-Mashat HA, Kandru S, Liu R, Behl Y, Desta T, Graves DT.

Diabetes. 2006 Feb;55(2):487-95.PMID: 16443785 [PubMed - indexed for MEDLINE]Related articlesFree article

Diabetes-enhanced inflammation and apoptosis--impact on periodontal pathology.

Graves DT, Liu R, Alikhani M, Al-Mashat H, Trackman PC.

J Dent Res. 2006 Jan;85(1):15-21. Review.PMID: 16373675 [PubMed - indexed for MEDLINE]Related articles

Porphyromonas gingivalis fimbriae are pro-inflammatory but do not play a prominent role in the innate immune response to P. gingivalis.

Graves DT, Naguib G, Lu H, Desta T, Amar S.

J Endotoxin Res. 2005;11(1):13-8.PMID: 15826373 [PubMed - indexed for MEDLINE]Related articles

Inflammation is more persistent in type 1 diabetic mice.

Graves DT, Naguib G, Lu H, Leone C, Hsue H, Krall E.

J Dent Res. 2005 Apr;84(4):324-8.PMID: 15790737 [PubMed - indexed for MEDLINE]Related articles

Tumor necrosis factor alpha (TNF-alpha) coordinately regulates the expression of specific matrix metalloproteinases (MMPS) and angiogenic factors during fracture healing.

Lehmann W, Edgar CM, Wang K, Cho TJ, Barnes GL, Kakar S, Graves DT, Rueger JM, Gerstenfeld LC, Einhorn TA.

Bone. 2005 Feb;36(2):300-10.PMID: 15780956 [PubMed - indexed for MEDLINE]Related articles

Cytokine profiling of macrophages exposed to Porphyromonas gingivalis, its lipopolysaccharide, or its FimA protein.

Zhou Q, Desta T, Fenton M, Graves DT, Amar S.

Infect Immun. 2005 Feb;73(2):935-43. Erratum in: Infect Immun. 2006 Mar;74(3):1995. PMID: 15664935 [PubMed - indexed for MEDLINE]Related articlesFree article

Evidence that diabetes mellitus aggravates periodontal diseases and modifies the response to an oral pathogen in animal models.

Graves DT, Al-Mashat H, Liu R.

Compend Contin Educ Dent. 2004 Jul;25(7 Suppl 1):38-45.PMID: 15645885 [PubMed - indexed for MEDLINE]Related articles

FOXO1 functions as a master switch that regulates gene expression necessary for tumor necrosis factor-induced fibroblast apoptosis.

Alikhani M, Alikhani Z, Graves DT.

J Biol Chem. 2005 Apr 1;280(13):12096-102. Epub 2005 Jan 4.PMID: 15632117 [PubMed - indexed for MEDLINE]Related articlesFree article

Advanced glycation end products enhance expression of pro-apoptotic genes and stimulate fibroblast apoptosis through cytoplasmic and mitochondrial pathways.

Alikhani Z, Alikhani M, Boyd CM, Nagao K, Trackman PC, Graves DT.

J Biol Chem. 2005 Apr 1;280(13):12087-95. Epub 2004 Dec 6.PMID: 15590648 [PubMed - indexed for MEDLINE]Related articlesFree article

TNF-alpha in vivo stimulates apoptosis in fibroblasts through caspase-8 activation and modulates the expression of pro-apoptotic genes.

Alikhani M, Alikhani Z, Raptis M, Graves DT.

J Cell Physiol. 2004 Dec;201(3):341-8.PMID: 15389560 [PubMed - indexed for MEDLINE]Related articles

Interleukin-1 receptor signaling mediates atherosclerosis associated with bacterial exposure and/or a high-fat diet in a murine apolipoprotein E heterozygote model: pharmacotherapeutic implications.

Chi H, Messas E, Levine RA, Graves DT, Amar S.

Circulation. 2004 Sep 21;110(12):1678-85. Epub 2004 Sep 7.PMID: 15353494 [PubMed - indexed for MEDLINE]Related articlesFree article

Apoptotic effects of LPS on fibroblasts are indirectly mediated through TNFR1.

Alikhani M, Alikhani Z, Graves DT.

J Dent Res. 2004 Sep;83(9):671-6.PMID: 15329370 [PubMed - indexed for MEDLINE]Related articles

Short- and long-term effects of IL-1 and TNF antagonists on periodontal wound healing.

Zhang X, Kohli M, Zhou Q, Graves DT, Amar S.

J Immunol. 2004 Sep 1;173(5):3514-23.PMID: 15322216 [PubMed - indexed for MEDLINE]Related articlesFree article

Influence of diabetes on the exacerbation of an inflammatory response in cardiovascular tissue.

Lu H, Raptis M, Black E, Stan M, Amar S, Graves DT.

Endocrinology. 2004 Nov;145(11):4934-9. Epub 2004 Jul 29.PMID: 15284196 [PubMed - indexed for MEDLINE]Related articlesFree article

Diabetes prolongs the inflammatory response to a bacterial stimulus through cytokine dysregulation.

Naguib G, Al-Mashat H, Desta T, Graves DT.

J Invest Dermatol. 2004 Jul;123(1):87-92.PMID: 15191547 [PubMed - indexed for MEDLINE]Related articlesFree article

Diabetes alters the response to bacteria by enhancing fibroblast apoptosis.

Liu R, Desta T, He H, Graves DT.

Endocrinology. 2004 Jun;145(6):2997-3003. Epub 2004 Mar 19.PMID: 15033911 [PubMed - indexed for MEDLINE]Related articlesFree article

Lipopolysaccharides indirectly stimulate apoptosis and global induction of apoptotic genes in fibroblasts.

Alikhani M, Alikhani Z, He H, Liu R, Popek BI, Graves DT.

J Biol Chem. 2003 Dec 26;278(52):52901-8. Epub 2003 Oct 9.PMID: 14551216 [PubMed - indexed for MEDLINE]Related articlesFree article

Diabetes causes decreased osteoclastogenesis, reduced bone formation, and enhanced apoptosis of osteoblastic cells in bacteria stimulated bone loss.

He H, Liu R, Desta T, Leone C, Gerstenfeld LC, Graves DT.

Endocrinology. 2004 Jan;145(1):447-52. Epub 2003 Oct 2.PMID: 14525917 [PubMed - indexed for MEDLINE]Related articlesFree article

Impaired fracture healing in the absence of TNF-alpha signaling: the role of TNF-alpha in endochondral cartilage resorption.

Gerstenfeld LC, Cho TJ, Kon T, Aizawa T, Tsay A, Fitch J, Barnes GL, Graves DT, Einhorn TA.

J Bone Miner Res. 2003 Sep;18(9):1584-92.PMID: 12968667 [PubMed - indexed for MEDLINE]Related articles

A role for advanced glycation end products in diminished bone healing in type 1 diabetes.

Santana RB, Xu L, Chase HB, Amar S, Graves DT, Trackman PC.

Diabetes. 2003 Jun;52(6):1502-10.PMID: 12765963 [PubMed - indexed for MEDLINE]Related articlesFree article

The contribution of interleukin-1 and tumor necrosis factor to periodontal tissue destruction.

Graves DT, Cochran D.

J Periodontol. 2003 Mar;74(3):391-401. Review.PMID: 12710761 [PubMed - indexed for MEDLINE]Related articles

Quantification and localization of platelet-derived growth factor in gingiva of periodontitis patients.

Pinheiro ML, Feres-Filho EJ, Graves DT, Takiya CM, Elsas MI, Elsas PP, Luz RA.

J Periodontol. 2003 Mar;74(3):323-8.PMID: 12710751 [PubMed - indexed for MEDLINE]Related articles

Healing is delayed in oral compared to dermal excisional wounds.

Nooh N, Graves DT.

J Periodontol. 2003 Feb;74(2):242-6.PMID: 12666713 [PubMed - indexed for MEDLINE]Related articles

Fracture healing as a post-natal developmental process: molecular, spatial, and temporal aspects of its regulation.

Gerstenfeld LC, Cullinane DM, Barnes GL, Graves DT, Einhorn TA.

J Cell Biochem. 2003 Apr 1;88(5):873-84. Review.PMID: 12616527 [PubMed - indexed for MEDLINE]Related articles

Diabetes interferes with the bone formation by affecting the expression of transcription factors that regulate osteoblast differentiation.

Lu H, Kraut D, Gerstenfeld LC, Graves DT.

Endocrinology. 2003 Jan;144(1):346-52.PMID: 12488363 [PubMed - indexed for MEDLINE]Related articlesFree article

Inflammation and tissue loss caused by periodontal pathogens is reduced by interleukin-1 antagonists.

Delima AJ, Karatzas S, Amar S, Graves DT.

J Infect Dis. 2002 Aug 15;186(4):511-6. Epub 2002 Jul 24.PMID: 12195378 [PubMed - indexed for MEDLINE]Related articles