PubMed

Recurring mutations found by sequencing an acute myeloid leukemia genome.

Mardis ER, Ding L, Dooling DJ, Larson DE, McLellan MD, Chen K, Koboldt DC, Fulton RS, Delehaunty KD, McGrath SD, Fulton LA, Locke DP, Magrini VJ, Abbott RM, Vickery TL, Reed JS, Robinson JS, Wylie T, Smith SM, Carmichael L, Eldred JM, Harris CC, Walker J, Peck JB, Du F, Dukes AF, Sanderson GE, Brummett AM, Clark E, McMichael JF, Meyer RJ, Schindler JK, Pohl CS, Wallis JW, Shi X, Lin L, Schmidt H, Tang Y, Haipek C, Wiechert ME, Ivy JV, Kalicki J, Elliott G, Ries RE, Payton JE, Westervelt P, Tomasson MH, Watson MA, Baty J, Heath S, Shannon WD, Nagarajan R, Link DC, Walter MJ, Graubert TA, DiPersio JF, Wilson RK, Ley TJ.

N Engl J Med. 2009 Sep 10;361(11):1058-66. Epub 2009 Aug 5.PMID: 19657110 [PubMed - indexed for MEDLINE]Related articles

Acquired copy number alterations in adult acute myeloid leukemia genomes.

Walter MJ, Payton JE, Ries RE, Shannon WD, Deshmukh H, Zhao Y, Baty J, Heath S, Westervelt P, Watson MA, Tomasson MH, Nagarajan R, O'Gara BP, Bloomfield CD, Mrózek K, Selzer RR, Richmond TA, Kitzman J, Geoghegan J, Eis PS, Maupin R, Fulton RS, McLellan M, Wilson RK, Mardis ER, Link DC, Graubert TA, DiPersio JF, Ley TJ.

Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):12950-5. Epub 2009 Jul 27.PMID: 19651600 [PubMed - indexed for MEDLINE]Related articlesFree article

Therapy related acute myeloid leukemia in breast cancer survivors, a population-based study.

Martin MG, Welch JS, Luo J, Ellis MJ, Graubert TA, Walter MJ.

Breast Cancer Res Treat. 2009 Dec;118(3):593-8. Epub 2009 Mar 26.PMID: 19322652 [PubMed - in process]Related articles

Genome-wide association study to identify novel loci associated with therapy-related myeloid leukemia susceptibility.

Knight JA, Skol AD, Shinde A, Hastings D, Walgren RA, Shao J, Tennant TR, Banerjee M, Allan JM, Le Beau MM, Larson RA, Graubert TA, Cox NJ, Onel K.

Blood. 2009 May 28;113(22):5575-82. Epub 2009 Mar 18.PMID: 19299336 [PubMed - indexed for MEDLINE]Related articles

The impact of copy number variation on local gene expression in mouse hematopoietic stem and progenitor cells.

Cahan P, Li Y, Izumi M, Graubert TA.

Nat Genet. 2009 Apr;41(4):430-7. Epub 2009 Mar 8.PMID: 19270704 [PubMed - indexed for MEDLINE]Related articlesFree article

Integrated genomic analysis implicates haploinsufficiency of multiple chromosome 5q31.2 genes in de novo myelodysplastic syndromes pathogenesis.

Graubert TA, Payton MA, Shao J, Walgren RA, Monahan RS, Frater JL, Walshauser MA, Martin MG, Kasai Y, Walter MJ.

PLoS One. 2009;4(2):e4583. Epub 2009 Feb 25.PMID: 19240791 [PubMed - indexed for MEDLINE]Related articlesFree article

DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome.

Ley TJ, Mardis ER, Ding L, Fulton B, McLellan MD, Chen K, Dooling D, Dunford-Shore BH, McGrath S, Hickenbotham M, Cook L, Abbott R, Larson DE, Koboldt DC, Pohl C, Smith S, Hawkins A, Abbott S, Locke D, Hillier LW, Miner T, Fulton L, Magrini V, Wylie T, Glasscock J, Conyers J, Sander N, Shi X, Osborne JR, Minx P, Gordon D, Chinwalla A, Zhao Y, Ries RE, Payton JE, Westervelt P, Tomasson MH, Watson M, Baty J, Ivanovich J, Heath S, Shannon WD, Nagarajan R, Walter MJ, Link DC, Graubert TA, DiPersio JF, Wilson RK.

Nature. 2008 Nov 6;456(7218):66-72.PMID: 18987736 [PubMed - indexed for MEDLINE]Related articlesFree article

Quantitative trait loci associated with susceptibility to therapy-related acute murine promyelocytic leukemia in hCG-PML/RARA transgenic mice.

Funk RK, Maxwell TJ, Izumi M, Edwin D, Kreisel F, Ley TJ, Cheverud JM, Graubert TA.

Blood. 2008 Aug 15;112(4):1434-42. Epub 2008 Jun 13.PMID: 18552208 [PubMed - indexed for MEDLINE]Related articlesFree article

wuHMM: a robust algorithm to detect DNA copy number variation using long oligonucleotide microarray data.

Cahan P, Godfrey LE, Eis PS, Richmond TA, Selzer RR, Brent M, McLeod HL, Ley TJ, Graubert TA.

Nucleic Acids Res. 2008 Apr;36(7):e41. Epub 2008 Mar 11.PMID: 18334530 [PubMed - indexed for MEDLINE]Related articlesFree article

Somatic mutations and germline sequence variants in the expressed tyrosine kinase genes of patients with de novo acute myeloid leukemia.

Tomasson MH, Xiang Z, Walgren R, Zhao Y, Kasai Y, Miner T, Ries RE, Lubman O, Fremont DH, McLellan MD, Payton JE, Westervelt P, DiPersio JF, Link DC, Walter MJ, Graubert TA, Watson M, Baty J, Heath S, Shannon WD, Nagarajan R, Bloomfield CD, Mardis ER, Wilson RK, Ley TJ.

Blood. 2008 May 1;111(9):4797-808. Epub 2008 Feb 12.PMID: 18270328 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of somatic JAK1 mutations in patients with acute myeloid leukemia.

Xiang Z, Zhao Y, Mitaksov V, Fremont DH, Kasai Y, Molitoris A, Ries RE, Miner TL, McLellan MD, DiPersio JF, Link DC, Payton JE, Graubert TA, Watson M, Shannon W, Heath SE, Nagarajan R, Mardis ER, Wilson RK, Ley TJ, Tomasson MH.

Blood. 2008 May 1;111(9):4809-12. Epub 2007 Dec 26.PMID: 18160671 [PubMed - indexed for MEDLINE]Related articlesFree article

Distinct patterns of mutations occurring in de novo AML versus AML arising in the setting of severe congenital neutropenia.

Link DC, Kunter G, Kasai Y, Zhao Y, Miner T, McLellan MD, Ries RE, Kapur D, Nagarajan R, Dale DC, Bolyard AA, Boxer LA, Welte K, Zeidler C, Donadieu J, Bellanné-Chantelot C, Vardiman JW, Caligiuri MA, Bloomfield CD, DiPersio JF, Tomasson MH, Graubert TA, Westervelt P, Watson M, Shannon W, Baty J, Mardis ER, Wilson RK, Ley TJ.

Blood. 2007 Sep 1;110(5):1648-55. Epub 2007 May 9.PMID: 17494858 [PubMed - indexed for MEDLINE]Related articlesFree article

A high-resolution map of segmental DNA copy number variation in the mouse genome.

Graubert TA, Cahan P, Edwin D, Selzer RR, Richmond TA, Eis PS, Shannon WD, Li X, McLeod HL, Cheverud JM, Ley TJ.

PLoS Genet. 2007 Jan 5;3(1):e3. Epub 2006 Nov 22.PMID: 17206864 [PubMed - indexed for MEDLINE]Related articlesFree article

Does autologous transplantation directly increase the risk of secondary leukemia in lymphoma patients?

Hake CR, Graubert TA, Fenske TS.

Bone Marrow Transplant. 2007 Jan;39(2):59-70. Epub 2006 Dec 4. Review.PMID: 17143301 [PubMed - indexed for MEDLINE]Related articles

Pharmacogenetics of alkylator-associated acute myeloid leukemia.

Knoche E, McLeod HL, Graubert TA.

Pharmacogenomics. 2006 Jul;7(5):719-29. Review.PMID: 16886897 [PubMed - indexed for MEDLINE]Related articles

Identification of candidate alkylator-induced cancer susceptibility genes by whole genome scanning in mice.

Fenske TS, McMahon C, Edwin D, Jarvis JC, Cheverud JM, Minn M, Mathews V, Bogue MA, Province MA, McLeod HL, Graubert TA.

Cancer Res. 2006 May 15;66(10):5029-38.PMID: 16707424 [PubMed - indexed for MEDLINE]Related articlesFree article

Roles of Sca-1 in hematopoietic stem/progenitor cell function.

Bradfute SB, Graubert TA, Goodell MA.

Exp Hematol. 2005 Jul;33(7):836-43.PMID: 15963860 [PubMed - indexed for MEDLINE]Related articles

Dominant negative effects of the AML1/ETO fusion oncoprotein.

Fenske TS, Pengue G, Graubert TA.

Cell Cycle. 2005 Jan;4(1):33-6. Epub 2005 Jan 19.PMID: 15611635 [PubMed - indexed for MEDLINE]Related articlesFree article

Stem cell expression of the AML1/ETO fusion protein induces a myeloproliferative disorder in mice.

Fenske TS, Pengue G, Mathews V, Hanson PT, Hamm SE, Riaz N, Graubert TA.

Proc Natl Acad Sci U S A. 2004 Oct 19;101(42):15184-9. Epub 2004 Oct 11.PMID: 15477599 [PubMed - indexed for MEDLINE]Related articlesFree article

Recruitment of bone marrow-derived endothelial cells to sites of pancreatic beta-cell injury.

Mathews V, Hanson PT, Ford E, Fujita J, Polonsky KS, Graubert TA.

Diabetes. 2004 Jan;53(1):91-8.PMID: 14693702 [PubMed - indexed for MEDLINE]Related articlesFree article

A pilot study of high-throughput, sequence-based mutational profiling of primary human acute myeloid leukemia cell genomes.

Ley TJ, Minx PJ, Walter MJ, Ries RE, Sun H, McLellan M, DiPersio JF, Link DC, Tomasson MH, Graubert TA, McLeod H, Khoury H, Watson M, Shannon W, Trinkaus K, Heath S, Vardiman JW, Caligiuri MA, Bloomfield CD, Milbrandt JD, Mardis ER, Wilson RK.

Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14275-80. Epub 2003 Nov 12.PMID: 14614138 [PubMed - indexed for MEDLINE]Related articlesFree article

A mouse-based strategy for cyclophosphamide pharmacogenomic discovery.

Watters JW, Kloss EF, Link DC, Graubert TA, McLeod HL.

J Appl Physiol. 2003 Oct;95(4):1352-60.PMID: 12970373 [PubMed - indexed for MEDLINE]Related articlesFree article

Enhanced green fluorescent protein targeted to the Sca-1 (Ly-6A) locus in transgenic mice results in efficient marking of hematopoietic stem cells in vivo.

Hanson P, Mathews V, Marrus SH, Graubert TA.

Exp Hematol. 2003 Feb;31(2):159-67.PMID: 12591281 [PubMed - indexed for MEDLINE]Related articles

Sca-1(pos) cells in the mouse mammary gland represent an enriched progenitor cell population.

Welm BE, Tepera SB, Venezia T, Graubert TA, Rosen JM, Goodell MA.

Dev Biol. 2002 May 1;245(1):42-56.PMID: 11969254 [PubMed - indexed for MEDLINE]Related articles

Characterization of Ly-6M, a novel member of the Ly-6 family of hematopoietic proteins.

Patterson JM, Johnson MH, Zimonjic DB, Graubert TA.

Blood. 2000 May 15;95(10):3125-32.PMID: 10807778 [PubMed - indexed for MEDLINE]Related articlesFree article

Granzyme A initiates an alternative pathway for granule-mediated apoptosis.

Shresta S, Graubert TA, Thomas DA, Raptis SZ, Ley TJ.

Immunity. 1999 May;10(5):595-605.PMID: 10367905 [PubMed - indexed for MEDLINE]Related articles

How do cytotoxic lymphocytes kill their targets?

Shresta S, Pham CT, Thomas DA, Graubert TA, Ley TJ.

Curr Opin Immunol. 1998 Oct;10(5):581-7. Review.PMID: 9794837 [PubMed - indexed for MEDLINE]Related articles

Stochastic, stage-specific mechanisms account for the variegation of a human globin transgene.

Graubert TA, Hug BA, Wesselschmidt R, Hsieh CL, Ryan TM, Townes TM, Ley TJ.

Nucleic Acids Res. 1998 Jun 15;26(12):2849-58.PMID: 9611227 [PubMed - indexed for MEDLINE]Related articlesFree article

Perforin/granzyme-dependent and independent mechanisms are both important for the development of graft-versus-host disease after murine bone marrow transplantation.

Graubert TA, DiPersio JF, Russell JH, Ley TJ.

J Clin Invest. 1997 Aug 15;100(4):904-11.PMID: 9259590 [PubMed - indexed for MEDLINE]Related articlesFree article

How do lymphocytes kill tumor cells?

Graubert TA, Ley TJ.

Clin Cancer Res. 1996 May;2(5):785-9. Review. No abstract available. PMID: 9816231 [PubMed - indexed for MEDLINE]Related articlesFree article

The role of granzyme B in murine models of acute graft-versus-host disease and graft rejection.

Graubert TA, Russell JH, Ley TJ.

Blood. 1996 Feb 15;87(4):1232-7.PMID: 8608209 [PubMed - indexed for MEDLINE]Related articlesFree article

Recombinant retroviral systems for the analysis of drug resistant HIV.

Strair RK, Medina DJ, Nelson CJ, Graubert TA, Mellors JW.

Nucleic Acids Res. 1993 Oct 11;21(20):4836-42.PMID: 8233833 [PubMed - indexed for MEDLINE]Related articlesFree article