PubMed

Efficacy and safety of bimatoprost as replacement for latanoprost in patients with glaucoma or ocular hypertension: a uniocular switch study.

Casson RJ, Liu L, Graham SL, Morgan WH, Grigg JR, Galanopoulos A, Crawford A, House PH.

J Glaucoma. 2009 Oct-Nov;18(8):582-8.PMID: 19826386 [PubMed - in process]Related articles

A conformational constraint improves a beta-secretase inhibitor but for an unexpected reason.

Hills ID, Holloway MK, de León P, Nomland A, Zhu H, Rajapakse H, Allison TJ, Munshi SK, Colussi D, Pietrak BL, Toolan D, Haugabook SJ, Graham SL, Stachel SJ.

Bioorg Med Chem Lett. 2009 Sep 1;19(17):4993-5. Epub 2009 Jul 17.PMID: 19640712 [PubMed - in process]Related articles

The identification of potent, orally bioavailable tricyclic CGRP receptor antagonists.

Bell IM, Bednar RA, Corcoran HA, Fay JF, Gallicchio SN, Johnston VK, Hershey JC, Miller-Stein CM, Moore EL, Mosser SD, Roller SA, Salvatore CA, Theberge CR, Wong BK, Blair Zartman C, Kane SA, Williams TM, Graham SL, Vacca JP.

Bioorg Med Chem Lett. 2009 Aug 15;19(16):4740-2. Epub 2009 Jun 17.PMID: 19577468 [PubMed - indexed for MEDLINE]Related articles

Effect of P-glycoprotein-mediated efflux on cerebrospinal fluid concentrations in rhesus monkeys.

Tang C, Kuo Y, Pudvah NT, Ellis JD, Michener MS, Egbertson M, Graham SL, Cook JJ, Hochman JH, Prueksaritanont T.

Biochem Pharmacol. 2009 Sep 15;78(6):642-7. Epub 2009 May 27.PMID: 19481060 [PubMed - indexed for MEDLINE]Related articles

Discovery of aminoheterocycles as a novel beta-secretase inhibitor class: pH dependence on binding activity part 1.

Stachel SJ, Coburn CA, Rush D, Jones KL, Zhu H, Rajapakse H, Graham SL, Simon A, Katharine Holloway M, Allison TJ, Munshi SK, Espeseth AS, Zuck P, Colussi D, Wolfe A, Pietrak BL, Lai MT, Vacca JP.

Bioorg Med Chem Lett. 2009 Jun 1;19(11):2977-80. Epub 2009 Apr 18.PMID: 19409780 [PubMed - indexed for MEDLINE]Related articles

Prevalence of nocturnal oxygen desaturation and self-reported sleep-disordered breathing in glaucoma.

Roberts TV, Hodge C, Graham SL, Burlutsky G, Mitchell P.

J Glaucoma. 2009 Feb;18(2):114-8.PMID: 19225346 [PubMed - indexed for MEDLINE]Related articles

Plasma homocysteine, MTHFR gene mutation, and open-angle glaucoma.

Clement CI, Goldberg I, Healey PR, Graham SL.

J Glaucoma. 2009 Jan;18(1):73-8.PMID: 19142139 [PubMed - indexed for MEDLINE]Related articles

Evolution of tertiary carbinamine BACE-1 inhibitors: Abeta reduction in rhesus CSF upon oral dosing.

Nantermet PG, Rajapakse HA, Stanton MG, Stauffer SR, Barrow JC, Gregro AR, Moore KP, Steinbeiser MA, Swestock J, Selnick HG, Graham SL, McGaughey GB, Colussi D, Lai MT, Sankaranarayanan S, Simon AJ, Munshi S, Cook JJ, Holahan MA, Michener MS, Vacca JP.

ChemMedChem. 2009 Jan;4(1):37-40. No abstract available. PMID: 19085994 [PubMed - indexed for MEDLINE]Related articles

Identification of a small molecule beta-secretase inhibitor that binds without catalytic aspartate engagement.

Steele TG, Hills ID, Nomland AA, de León P, Allison T, McGaughey G, Colussi D, Tugusheva K, Haugabook SJ, Espeseth AS, Zuck P, Graham SL, Stachel SJ.

Bioorg Med Chem Lett. 2009 Jan 1;19(1):17-20. Epub 2008 Nov 13.PMID: 19036583 [PubMed - indexed for MEDLINE]Related articles

The discovery of highly potent CGRP receptor antagonists.

Stump CA, Bell IM, Bednar RA, Bruno JG, Fay JF, Gallicchio SN, Johnston VK, Moore EL, Mosser SD, Quigley AG, Salvatore CA, Theberge CR, Blair Zartman C, Zhang XF, Kane SA, Graham SL, Vacca JP, Williams TM.

Bioorg Med Chem Lett. 2009 Jan 1;19(1):214-7. Epub 2008 Oct 31.PMID: 19010673 [PubMed - indexed for MEDLINE]Related articles

Potent benzimidazolone-based CGRP receptor antagonists.

Theberge CR, Bednar RA, Bell IM, Corcoran HA, Fay JF, Hershey JC, Johnston VK, Kane SA, Mosser S, Salvatore CA, Williams TM, Zartman CB, Zhang XF, Graham SL, Vacca JP.

Bioorg Med Chem Lett. 2008 Dec 1;18(23):6122-5. Epub 2008 Oct 7.PMID: 18947992 [PubMed - indexed for MEDLINE]Related articles

First demonstration of cerebrospinal fluid and plasma A beta lowering with oral administration of a beta-site amyloid precursor protein-cleaving enzyme 1 inhibitor in nonhuman primates.

Sankaranarayanan S, Holahan MA, Colussi D, Crouthamel MC, Devanarayan V, Ellis J, Espeseth A, Gates AT, Graham SL, Gregro AR, Hazuda D, Hochman JH, Holloway K, Jin L, Kahana J, Lai MT, Lineberger J, McGaughey G, Moore KP, Nantermet P, Pietrak B, Price EA, Rajapakse H, Stauffer S, Steinbeiser MA, Seabrook G, Selnick HG, Shi XP, Stanton MG, Swestock J, Tugusheva K, Tyler KX, Vacca JP, Wong J, Wu G, Xu M, Cook JJ, Simon AJ.

J Pharmacol Exp Ther. 2009 Jan;328(1):131-40. Epub 2008 Oct 14.PMID: 18854490 [PubMed - indexed for MEDLINE]Related articles

Discovery and X-ray crystallographic analysis of a spiropiperidine iminohydantoin inhibitor of beta-secretase.

Barrow JC, Stauffer SR, Rittle KE, Ngo PL, Yang Z, Selnick HG, Graham SL, Munshi S, McGaughey GB, Holloway MK, Simon AJ, Price EA, Sankaranarayanan S, Colussi D, Tugusheva K, Lai MT, Espeseth AS, Xu M, Huang Q, Wolfe A, Pietrak B, Zuck P, Levorse DA, Hazuda D, Vacca JP.

J Med Chem. 2008 Oct 23;51(20):6259-62. Epub 2008 Sep 24.PMID: 18811140 [PubMed - indexed for MEDLINE]Related articles

Synthesis of the (3R,6S)-3-amino-6-(2,3-difluorophenyl)azepan-2-one of telcagepant (MK-0974), a calcitonin gene-related peptide receptor antagonist for the treatment of migraine headache.

Burgey CS, Paone DV, Shaw AW, Deng JZ, Nguyen DN, Potteiger CM, Graham SL, Vacca JP, Williams TM.

Org Lett. 2008 Aug 7;10(15):3235-8. Epub 2008 Jul 1.PMID: 18590336 [PubMed - indexed for MEDLINE]Related articles

Pharmacological characterization of MK-0974 [N-[(3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl]-4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide], a potent and orally active calcitonin gene-related peptide receptor antagonist for the treatment of migraine.

Salvatore CA, Hershey JC, Corcoran HA, Fay JF, Johnston VK, Moore EL, Mosser SD, Burgey CS, Paone DV, Shaw AW, Graham SL, Vacca JP, Williams TM, Koblan KS, Kane SA.

J Pharmacol Exp Ther. 2008 Feb;324(2):416-21. Epub 2007 Nov 26.PMID: 18039958 [PubMed - indexed for MEDLINE]Related articlesFree article

Calcitonin gene-related peptide (CGRP) receptor antagonists: investigations of a pyridinone template.

Nguyen DN, Paone DV, Shaw AW, Burgey CS, Mosser SD, Johnston V, Salvatore CA, Leonard YM, Miller-Stein CM, Kane SA, Koblan KS, Vacca JP, Graham SL, Williams TM.

Bioorg Med Chem Lett. 2008 Jan 15;18(2):755-8. Epub 2007 Nov 17.PMID: 18039571 [PubMed - indexed for MEDLINE]Related articles

Potent, orally bioavailable calcitonin gene-related peptide receptor antagonists for the treatment of migraine: discovery of N-[(3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1- (2,2,2-trifluoroethyl)azepan-3-yl]-4- (2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin- 1-yl)piperidine-1-carboxamide (MK-0974).

Paone DV, Shaw AW, Nguyen DN, Burgey CS, Deng JZ, Kane SA, Koblan KS, Salvatore CA, Mosser SD, Johnston VK, Wong BK, Miller-Stein CM, Hershey JC, Graham SL, Vacca JP, Williams TM.

J Med Chem. 2007 Nov 15;50(23):5564-7. Epub 2007 Oct 11.PMID: 17929795 [PubMed - indexed for MEDLINE]Related articles

Strategies toward improving the brain penetration of macrocyclic tertiary carbinamine BACE-1 inhibitors.

Moore KP, Zhu H, Rajapakse HA, McGaughey GB, Colussi D, Price EA, Sankaranarayanan S, Simon AJ, Pudvah NT, Hochman JH, Allison T, Munshi SK, Graham SL, Vacca JP, Nantermet PG.

Bioorg Med Chem Lett. 2007 Nov 1;17(21):5831-5. Epub 2007 Aug 23.PMID: 17827011 [PubMed - indexed for MEDLINE]Related articles

Multifocal blue-on-yellow visual evoked potentials in early glaucoma.

Klistorner A, Graham SL, Martins A, Grigg JR, Arvind H, Kumar RS, James AC, Billson FA.

Ophthalmology. 2007 Sep;114(9):1613-21.PMID: 17822971 [PubMed - indexed for MEDLINE]Related articles

Caprolactams as potent CGRP receptor antagonists for the treatment of migraine.

Shaw AW, Paone DV, Nguyen DN, Stump CA, Burgey CS, Mosser SD, Salvatore CA, Rutledge RZ, Kane SA, Koblan KS, Graham SL, Vacca JP, Williams TM.

Bioorg Med Chem Lett. 2007 Sep 1;17(17):4795-8. Epub 2007 Jun 26.PMID: 17616394 [PubMed - indexed for MEDLINE]Related articles

Discovery of isonicotinamide derived beta-secretase inhibitors: in vivo reduction of beta-amyloid.

Stanton MG, Stauffer SR, Gregro AR, Steinbeiser M, Nantermet P, Sankaranarayanan S, Price EA, Wu G, Crouthamel MC, Ellis J, Lai MT, Espeseth AS, Shi XP, Jin L, Colussi D, Pietrak B, Huang Q, Xu M, Simon AJ, Graham SL, Vacca JP, Selnick H.

J Med Chem. 2007 Jul 26;50(15):3431-3. Epub 2007 Jun 21.PMID: 17583334 [PubMed - indexed for MEDLINE]Related articles

Design, synthesis, and SAR of macrocyclic tertiary carbinamine BACE-1 inhibitors.

Lindsley SR, Moore KP, Rajapakse HA, Selnick HG, Young MB, Zhu H, Munshi S, Kuo L, McGaughey GB, Colussi D, Crouthamel MC, Lai MT, Pietrak B, Price EA, Sankaranarayanan S, Simon AJ, Seabrook GR, Hazuda DJ, Pudvah NT, Hochman JH, Graham SL, Vacca JP, Nantermet PG.

Bioorg Med Chem Lett. 2007 Jul 15;17(14):4057-61. Epub 2007 Apr 27.PMID: 17482814 [PubMed - indexed for MEDLINE]Related articles

Design and synthesis of 2,3,5-substituted imidazolidin-4-one inhibitors of BACE-1.

Barrow JC, Rittle KE, Ngo PL, Selnick HG, Graham SL, Pitzenberger SM, McGaughey GB, Colussi D, Lai MT, Huang Q, Tugusheva K, Espeseth AS, Simon AJ, Munshi SK, Vacca JP.

ChemMedChem. 2007 Jul;2(7):995-9. No abstract available. PMID: 17458843 [PubMed - indexed for MEDLINE]Related articles

Most people and organizations agree that the health insurance system should be reformed to ensure medical coverage for all Americans.

Graham SL.

Bull Am Coll Surg. 2002 May;87(5):46. No abstract available. PMID: 17390449 [PubMed - indexed for MEDLINE]Related articles

Discovery and SAR of isonicotinamide BACE-1 inhibitors that bind beta-secretase in a N-terminal 10s-loop down conformation.

Stauffer SR, Stanton MG, Gregro AR, Steinbeiser MA, Shaffer JR, Nantermet PG, Barrow JC, Rittle KE, Collusi D, Espeseth AS, Lai MT, Pietrak BL, Holloway MK, McGaughey GB, Munshi SK, Hochman JH, Simon AJ, Selnick HG, Graham SL, Vacca JP.

Bioorg Med Chem Lett. 2007 Mar 15;17(6):1788-92. Epub 2006 Dec 21.PMID: 17257835 [PubMed - indexed for MEDLINE]Related articles

Beta-secretase (BACE-1) inhibitors: accounting for 10s loop flexibility using rigid active sites.

McGaughey GB, Colussi D, Graham SL, Lai MT, Munshi SK, Nantermet PG, Pietrak B, Rajapakse HA, Selnick HG, Stauffer SR, Holloway MK.

Bioorg Med Chem Lett. 2007 Feb 15;17(4):1117-21. Epub 2006 Nov 6.PMID: 17112725 [PubMed - indexed for MEDLINE]Related articles

Macrocyclic inhibitors of beta-secretase: functional activity in an animal model.

Stachel SJ, Coburn CA, Sankaranarayanan S, Price EA, Wu G, Crouthamel M, Pietrak BL, Huang Q, Lineberger J, Espeseth AS, Jin L, Ellis J, Holloway MK, Munshi S, Allison T, Hazuda D, Simon AJ, Graham SL, Vacca JP.

J Med Chem. 2006 Oct 19;49(21):6147-50. Erratum in: J Med Chem. 2006 Nov 30;49(24):7252. Wu, Guoxin [added]; Crouthamel, Michelle [added]. PMID: 17034118 [PubMed - indexed for MEDLINE]Related articles

Identification of novel, orally bioavailable spirohydantoin CGRP receptor antagonists.

Bell IM, Bednar RA, Fay JF, Gallicchio SN, Hochman JH, McMasters DR, Miller-Stein C, Moore EL, Mosser SD, Pudvah NT, Quigley AG, Salvatore CA, Stump CA, Theberge CR, Wong BK, Zartman CB, Zhang XF, Kane SA, Graham SL, Vacca JP, Williams TM.

Bioorg Med Chem Lett. 2006 Dec 15;16(24):6165-9. Epub 2006 Oct 5.PMID: 17027263 [PubMed - indexed for MEDLINE]Related articles

The effects of glaucoma on the latency of the multifocal visual evoked potential.

Graham SL.

Br J Ophthalmol. 2006 Sep;90(9):1077-8. No abstract available. PMID: 16929054 [PubMed - indexed for MEDLINE]Related articlesFree article

Benzodiazepine calcitonin gene-related peptide (CGRP) receptor antagonists: optimization of the 4-substituted piperidine.

Burgey CS, Stump CA, Nguyen DN, Deng JZ, Quigley AG, Norton BR, Bell IM, Mosser SD, Salvatore CA, Rutledge RZ, Kane SA, Koblan KS, Vacca JP, Graham SL, Williams TM.

Bioorg Med Chem Lett. 2006 Oct 1;16(19):5052-6. Epub 2006 Aug 2.PMID: 16889959 [PubMed - indexed for MEDLINE]Related articles

Multifocal visual evoked responses to dichoptic stimulation using virtual reality goggles: Multifocal VER to dichoptic stimulation.

Arvind H, Klistorner A, Graham SL, Grigg JR.

Doc Ophthalmol. 2006 May;112(3):189-99. Epub 2006 Jun 22.PMID: 16794775 [PubMed - indexed for MEDLINE]Related articles

BACE-1 inhibition by a series of psi[CH2NH] reduced amide isosteres.

Coburn CA, Stachel SJ, Jones KG, Steele TG, Rush DM, DiMuzio J, Pietrak BL, Lai MT, Huang Q, Lineberger J, Jin L, Munshi S, Katharine Holloway M, Espeseth A, Simon A, Hazuda D, Graham SL, Vacca JP.

Bioorg Med Chem Lett. 2006 Jul 15;16(14):3635-8. Epub 2006 May 11.PMID: 16690314 [PubMed - indexed for MEDLINE]Related articles

Comparison of objective diagnostic tests in glaucoma: Heidelberg retinal tomography and multifocal visual evoked potentials.

Balachandran C, Graham SL, Klistorner A, Goldberg I.

J Glaucoma. 2006 Apr;15(2):110-6.PMID: 16633223 [PubMed - indexed for MEDLINE]Related articles

Non-peptide calcitonin gene-related peptide receptor antagonists from a benzodiazepinone lead.

Williams TM, Stump CA, Nguyen DN, Quigley AG, Bell IM, Gallicchio SN, Zartman CB, Wan BL, Penna KD, Kunapuli P, Kane SA, Koblan KS, Mosser SD, Rutledge RZ, Salvatore C, Fay JF, Vacca JP, Graham SL.

Bioorg Med Chem Lett. 2006 May 15;16(10):2595-8. Epub 2006 Mar 9.PMID: 16527483 [PubMed - indexed for MEDLINE]Related articles

Intertest variability of mfVEP amplitude: reducing its effect on the interpretation of sequential tests.

Klistorner A, Graham SL.

Doc Ophthalmol. 2005 Nov;111(3):159-67. Epub 2006 Mar 6.PMID: 16523233 [PubMed - indexed for MEDLINE]Related articles

Multifocal visual evoked potential analysis of inflammatory or demyelinating optic neuritis.

Fraser CL, Klistorner A, Graham SL, Garrick R, Billson FA, Grigg JR.

Ophthalmology. 2006 Feb;113(2):323.e1-323.e2. Epub 2006 Jan 10.PMID: 16406544 [PubMed - indexed for MEDLINE]Related articles

Effect of eccentricity on pattern-pulse multifocal VEP.

Klistorner AI, Graham SL.

Doc Ophthalmol. 2005 Mar-May;110(2-3):209-18.PMID: 16328929 [PubMed - indexed for MEDLINE]Related articles

Conformationally biased P3 amide replacements of beta-secretase inhibitors.

Stachel SJ, Coburn CA, Steele TG, Crouthamel MC, Pietrak BL, Lai MT, Holloway MK, Munshi SK, Graham SL, Vacca JP.

Bioorg Med Chem Lett. 2006 Feb;16(3):641-4. Epub 2005 Nov 2.PMID: 16263281 [PubMed - indexed for MEDLINE]Related articles

Protease inhibitors as potential disease-modifying therapeutics for Alzheimer's disease.

Beher D, Graham SL.

Expert Opin Investig Drugs. 2005 Nov;14(11):1385-409. Review.PMID: 16255678 [PubMed - indexed for MEDLINE]Related articles

Biochemical and structural characterization of a novel class of inhibitors of the type 1 insulin-like growth factor and insulin receptor kinases.

Bell IM, Stirdivant SM, Ahern J, Culberson JC, Darke PL, Dinsmore CJ, Drakas RA, Gallicchio SN, Graham SL, Heimbrook DC, Hall DL, Hua J, Kett NR, Kim AS, Kornienko M, Kuo LC, Munshi SK, Quigley AG, Reid JC, Trotter BW, Waxman LH, Williams TM, Zartman CB.

Biochemistry. 2005 Jul 12;44(27):9430-40.PMID: 15996097 [PubMed - indexed for MEDLINE]Related articles

Biochemical and cell-based assays for characterization of BACE-1 inhibitors.

Pietrak BL, Crouthamel MC, Tugusheva K, Lineberger JE, Xu M, DiMuzio JM, Steele T, Espeseth AS, Stachel SJ, Coburn CA, Graham SL, Vacca JP, Shi XP, Simon AJ, Hazuda DJ, Lai MT.

Anal Biochem. 2005 Jul 1;342(1):144-51.PMID: 15958191 [PubMed - indexed for MEDLINE]Related articles

Clinical application of objective perimetry using multifocal visual evoked potentials in glaucoma practice.

Graham SL, Klistorner AI, Goldberg I.

Arch Ophthalmol. 2005 Jun;123(6):729-39.PMID: 15955974 [PubMed - indexed for MEDLINE]Related articles

Objective perimetry using the multifocal visual evoked potential in central visual pathway lesions.

Klistorner AI, Graham SL, Grigg J, Balachandran C.

Br J Ophthalmol. 2005 Jun;89(6):739-44.PMID: 15923511 [PubMed - indexed for MEDLINE]Related articlesFree article

Spatial distribution of antibodies to Salmonella enterica serovar Typhimurium O antigens in bulk milk from Texas dairy herds.

Graham SL, Barling KS, Waghela S, Scott HM, Thompson JA.

Prev Vet Med. 2005 Jun 10;69(1-2):53-61.PMID: 15899296 [PubMed - indexed for MEDLINE]Related articles

Macrocyclic piperazinones as potent dual inhibitors of farnesyltransferase and geranylgeranyltransferase-I.

Dinsmore CJ, Zartman CB, Bergman JM, Abrams MT, Buser CA, Culberson JC, Davide JP, Ellis-Hutchings M, Fernandes C, Graham SL, Hartman GD, Huber HE, Lobell RB, Mosser SD, Robinson RG, Williams TM.

Bioorg Med Chem Lett. 2004 Feb 9;14(3):639-43.PMID: 14741259 [PubMed - indexed for MEDLINE]Related articles

Detection of early visual field loss in glaucoma using frequency-doubling perimetry and short-wavelength automated perimetry.

Landers JA, Goldberg I, Graham SL.

Arch Ophthalmol. 2003 Dec;121(12):1705-10.PMID: 14662589 [PubMed - indexed for MEDLINE]Related articles

Effect of pupil size on multifocal pattern visual evoked potentials.

Martins A, Balachandran C, Klistorner AI, Graham SL, Billson FA.

Clin Experiment Ophthalmol. 2003 Aug;31(4):354-6.PMID: 12880463 [PubMed - indexed for MEDLINE]Related articles

Dual protein farnesyltransferase-geranylgeranyltransferase-I inhibitors as potential cancer chemotherapeutic agents.

deSolms SJ, Ciccarone TM, MacTough SC, Shaw AW, Buser CA, Ellis-Hutchings M, Fernandes C, Hamilton KA, Huber HE, Kohl NE, Lobell RB, Robinson RG, Tsou NN, Walsh ES, Graham SL, Beese LS, Taylor JS.

J Med Chem. 2003 Jul 3;46(14):2973-84.PMID: 12825937 [PubMed - indexed for MEDLINE]Related articles

Effect of stimulus check size on multifocal visual evoked potentials.

Balachandran C, Klistorner AI, Graham SL.

Doc Ophthalmol. 2003 Mar;106(2):183-8.PMID: 12678283 [PubMed - indexed for MEDLINE]Related articles

Evaluation of an inactivated Neospora caninum vaccine in beef feedlot steers.

Barling KS, Lunt DK, Graham SL, Choromanski LJ.

J Am Vet Med Assoc. 2003 Mar 1;222(5):624-7.PMID: 12619843 [PubMed - indexed for MEDLINE]Related articles