PubMed

A thorough QTc study to assess the effect of sitagliptin, a DPP4 inhibitor, on ventricular repolarization in healthy subjects.

Bloomfield DM, Krishna R, Hreniuk D, Hickey L, Ghosh K, Bergman AJ, Miller J, Gutierrez MJ, Stoltz R, Gottesdiener KM, Herman GA, Wagner JA.

J Clin Pharmacol. 2009 Aug;49(8):937-46.PMID: 19602719 [PubMed - indexed for MEDLINE]Related articles

Effect of rifampin, a potent inducer of drug-metabolizing enzymes, on the pharmacokinetics of raltegravir.

Wenning LA, Hanley WD, Brainard DM, Petry AS, Ghosh K, Jin B, Mangin E, Marbury TC, Berg JK, Chodakewitz JA, Stone JA, Gottesdiener KM, Wagner JA, Iwamoto M.

Antimicrob Agents Chemother. 2009 Jul;53(7):2852-6. Epub 2009 May 11.PMID: 19433563 [PubMed - indexed for MEDLINE]Related articles

Effect of tipranavir-ritonavir on pharmacokinetics of raltegravir.

Hanley WD, Wenning LA, Moreau A, Kost JT, Mangin E, Shamp T, Stone JA, Gottesdiener KM, Wagner JA, Iwamoto M.

Antimicrob Agents Chemother. 2009 Jul;53(7):2752-5. Epub 2009 Apr 27.PMID: 19398643 [PubMed - indexed for MEDLINE]Related articles

Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): a double-blind, randomised, placebo-controlled, test-of-concept trial.

Buchbinder SP, Mehrotra DV, Duerr A, Fitzgerald DW, Mogg R, Li D, Gilbert PB, Lama JR, Marmor M, Del Rio C, McElrath MJ, Casimiro DR, Gottesdiener KM, Chodakewitz JA, Corey L, Robertson MN; Step Study Protocol Team.

Lancet. 2008 Nov 29;372(9653):1881-93. Epub 2008 Nov 13.PMID: 19012954 [PubMed - indexed for MEDLINE]Related articlesFree article

Minimal effects of ritonavir and efavirenz on the pharmacokinetics of raltegravir.

Iwamoto M, Wenning LA, Petry AS, Laethem M, De Smet M, Kost JT, Breidinger SA, Mangin EC, Azrolan N, Greenberg HE, Haazen W, Stone JA, Gottesdiener KM, Wagner JA.

Antimicrob Agents Chemother. 2008 Dec;52(12):4338-43. Epub 2008 Oct 6.PMID: 18838589 [PubMed - indexed for MEDLINE]Related articlesFree article

Concomitant use of the oral pentavalent human-bovine reassortant rotavirus vaccine and oral poliovirus vaccine.

Ciarlet M, Sani-Grosso R, Yuan G, Liu GF, Heaton PM, Gottesdiener KM, Arredondo JL, Schödel F.

Pediatr Infect Dis J. 2008 Oct;27(10):874-80.PMID: 18756184 [PubMed - indexed for MEDLINE]Related articles

Lack of a significant drug interaction between raltegravir and tenofovir.

Wenning LA, Friedman EJ, Kost JT, Breidinger SA, Stek JE, Lasseter KC, Gottesdiener KM, Chen J, Teppler H, Wagner JA, Stone JA, Iwamoto M.

Antimicrob Agents Chemother. 2008 Sep;52(9):3253-8. Epub 2008 Jul 14.PMID: 18625763 [PubMed - indexed for MEDLINE]Related articlesFree article

Multiple-dose pharmacodynamics and pharmacokinetics of anacetrapib, a potent cholesteryl ester transfer protein (CETP) inhibitor, in healthy subjects.

Krishna R, Bergman AJ, Jin B, Fallon M, Cote J, Van Hoydonck P, Laethem T, Gendrano IN 3rd, Van Dyck K, Hilliard D, Laterza O, Snyder K, Chavez-Eng C, Lutz R, Chen J, Bloomfield DM, De Smet M, Van Bortel LM, Gutierrez M, Al-Huniti N, Dykstra K, Gottesdiener KM, Wagner JA.

Clin Pharmacol Ther. 2008 Dec;84(6):679-83. Epub 2008 Jun 25. No abstract available. PMID: 18580870 [PubMed - indexed for MEDLINE]Related articles

Atazanavir modestly increases plasma levels of raltegravir in healthy subjects.

Iwamoto M, Wenning LA, Mistry GC, Petry AS, Liou SY, Ghosh K, Breidinger S, Azrolan N, Gutierrez MJ, Bridson WE, Stone JA, Gottesdiener KM, Wagner JA.

Clin Infect Dis. 2008 Jul 1;47(1):137-40.PMID: 18513146 [PubMed - indexed for MEDLINE]Related articles

Sitagliptin, an dipeptidyl peptidase-4 inhibitor, does not alter the pharmacokinetics of the sulphonylurea, glyburide, in healthy subjects.

Mistry GC, Bergman AJ, Zheng W, Hreniuk D, Zinny MA, Gottesdiener KM, Wagner JA, Herman GA, Ruddy M.

Br J Clin Pharmacol. 2008 Jul;66(1):36-42. Epub 2008 May 22.PMID: 18503607 [PubMed - indexed for MEDLINE]Related articlesFree article

Raltegravir thorough QT/QTc study: a single supratherapeutic dose of raltegravir does not prolong the QTcF interval.

Iwamoto M, Kost JT, Mistry GC, Wenning LA, Breidinger SA, Marbury TC, Stone JA, Gottesdiener KM, Bloomfield DM, Wagner JA.

J Clin Pharmacol. 2008 Jun;48(6):726-33. Epub 2008 Apr 25.PMID: 18441333 [PubMed - indexed for MEDLINE]Related articles

Effect of sitagliptin, a dipeptidyl peptidase-4 inhibitor, on blood pressure in nondiabetic patients with mild to moderate hypertension.

Mistry GC, Maes AL, Lasseter KC, Davies MJ, Gottesdiener KM, Wagner JA, Herman GA.

J Clin Pharmacol. 2008 May;48(5):592-8. Epub 2008 Mar 19.PMID: 18353996 [PubMed - indexed for MEDLINE]Related articles

Lack of a pharmacokinetic effect of raltegravir on midazolam: in vitro/in vivo correlation.

Iwamoto M, Kassahun K, Troyer MD, Hanley WD, Lu P, Rhoton A, Petry AS, Ghosh K, Mangin E, DeNoia EP, Wenning LA, Stone JA, Gottesdiener KM, Wagner JA.

J Clin Pharmacol. 2008 Feb;48(2):209-14. Epub 2007 Dec 12.PMID: 18077730 [PubMed - indexed for MEDLINE]Related articles

Effect of the cholesteryl ester transfer protein inhibitor, anacetrapib, on lipoproteins in patients with dyslipidaemia and on 24-h ambulatory blood pressure in healthy individuals: two double-blind, randomised placebo-controlled phase I studies.

Krishna R, Anderson MS, Bergman AJ, Jin B, Fallon M, Cote J, Rosko K, Chavez-Eng C, Lutz R, Bloomfield DM, Gutierrez M, Doherty J, Bieberdorf F, Chodakewitz J, Gottesdiener KM, Wagner JA.

Lancet. 2007 Dec 8;370(9603):1907-14.PMID: 18068514 [PubMed - indexed for MEDLINE]Related articles

Effects of etoricoxib and comparator nonsteroidal anti-inflammatory drugs on urinary sodium excretion, blood pressure, and other renal function indicators in elderly subjects consuming a controlled sodium diet.

Schwartz JI, Thach C, Lasseter KC, Miller J, Hreniuk D, Hilliard DA, Snyder KM, Gertz BJ, Gottesdiener KM.

J Clin Pharmacol. 2007 Dec;47(12):1521-31. Epub 2007 Oct 9.PMID: 17925592 [PubMed - indexed for MEDLINE]Related articles

Safety, tolerability, and pharmacokinetics of raltegravir after single and multiple doses in healthy subjects.

Iwamoto M, Wenning LA, Petry AS, Laethem M, De Smet M, Kost JT, Merschman SA, Strohmaier KM, Ramael S, Lasseter KC, Stone JA, Gottesdiener KM, Wagner JA.

Clin Pharmacol Ther. 2008 Feb;83(2):293-9. Epub 2007 Aug 22.PMID: 17713476 [PubMed - indexed for MEDLINE]Related articles

NPY5R antagonism does not augment the weight loss efficacy of orlistat or sibutramine.

Erondu N, Addy C, Lu K, Mallick M, Musser B, Gantz I, Proietto J, Astrup A, Toubro S, Rissannen AM, Tonstad S, Haynes WG, Gottesdiener KM, Kaufman KD, Amatruda JM, Heymsfield SB.

Obesity (Silver Spring). 2007 Aug;15(8):2027-42.PMID: 17712121 [PubMed - indexed for MEDLINE]Related articles

The effect of etoricoxib on the pharmacodynamics and pharmacokinetics of warfarin.

Schwartz JI, Agrawal NG, Hartford AH, Cote J, Hunt TL, Verbesselt R, Eckols DR, Gottesdiener KM.

J Clin Pharmacol. 2007 May;47(5):620-7.PMID: 17442687 [PubMed - indexed for MEDLINE]Related articles

Multiple-dose administration of sitagliptin, a dipeptidyl peptidase-4 inhibitor, does not alter the single-dose pharmacokinetics of rosiglitazone in healthy subjects.

Mistry GC, Bergman AJ, Luo WL, Cilissen C, Haazen W, Davies MJ, Gottesdiener KM, Wagner JA, Herman GA.

J Clin Pharmacol. 2007 Feb;47(2):159-64.PMID: 17244766 [PubMed - indexed for MEDLINE]Related articles

The effect of MK-0524, a prostaglandin D(2) receptor antagonist, on prostaglandin D (2)-induced nasal airway obstruction in healthy volunteers.

Van Hecken A, Depré M, De Lepeleire I, Thach C, Oeyen M, Van Effen J, Laethem T, Mazina K, Crumley T, Wenning L, Gottesdiener KM, Deutsch P, Clement P, Lai E, de Hoon JN.

Eur J Clin Pharmacol. 2007 Feb;63(2):135-41. Epub 2007 Jan 3.PMID: 17200838 [PubMed - indexed for MEDLINE]Related articles

A study to determine the effects of food and multiple dosing on the pharmacokinetics of vorinostat given orally to patients with advanced cancer.

Rubin EH, Agrawal NG, Friedman EJ, Scott P, Mazina KE, Sun L, Du L, Ricker JL, Frankel SR, Gottesdiener KM, Wagner JA, Iwamoto M.

Clin Cancer Res. 2006 Dec 1;12(23):7039-45.PMID: 17145826 [PubMed - indexed for MEDLINE]Related articlesFree article

Neuropeptide Y5 receptor antagonism does not induce clinically meaningful weight loss in overweight and obese adults.

Erondu N, Gantz I, Musser B, Suryawanshi S, Mallick M, Addy C, Cote J, Bray G, Fujioka K, Bays H, Hollander P, Sanabria-Bohórquez SM, Eng W, Långström B, Hargreaves RJ, Burns HD, Kanatani A, Fukami T, MacNeil DJ, Gottesdiener KM, Amatruda JM, Kaufman KD, Heymsfield SB.

Cell Metab. 2006 Oct;4(4):275-82.PMID: 17011500 [PubMed - indexed for MEDLINE]Related articles

Effect of single oral doses of sitagliptin, a dipeptidyl peptidase-4 inhibitor, on incretin and plasma glucose levels after an oral glucose tolerance test in patients with type 2 diabetes.

Herman GA, Bergman A, Stevens C, Kotey P, Yi B, Zhao P, Dietrich B, Golor G, Schrodter A, Keymeulen B, Lasseter KC, Kipnes MS, Snyder K, Hilliard D, Tanen M, Cilissen C, De Smet M, de Lepeleire I, Van Dyck K, Wang AQ, Zeng W, Davies MJ, Tanaka W, Holst JJ, Deacon CF, Gottesdiener KM, Wagner JA.

J Clin Endocrinol Metab. 2006 Nov;91(11):4612-9. Epub 2006 Aug 15.PMID: 16912128 [PubMed - indexed for MEDLINE]Related articlesFree article

A dual PPAR alpha/gamma agonist increases adiponectin and improves plasma lipid profiles in healthy subjects.

Decochez K, Rippley RK, Miller JL, De Smet M, Yan KX, Matthijs Z, Riffel KA, Song H, Zhu H, Maynor HO, Tanaka W, Johnson-Levonas AO, Davies MJ, Gottesdiener KM, Keymeulen B, Wagner JA.

Drugs R D. 2006;7(2):99-110.PMID: 16542056 [PubMed - indexed for MEDLINE]Related articles

Pharmacokinetics and pharmacodynamics of sitagliptin, an inhibitor of dipeptidyl peptidase IV, in healthy subjects: results from two randomized, double-blind, placebo-controlled studies with single oral doses.

Herman GA, Stevens C, Van Dyck K, Bergman A, Yi B, De Smet M, Snyder K, Hilliard D, Tanen M, Tanaka W, Wang AQ, Zeng W, Musson D, Winchell G, Davies MJ, Ramael S, Gottesdiener KM, Wagner JA.

Clin Pharmacol Ther. 2005 Dec;78(6):675-88.PMID: 16338283 [PubMed - indexed for MEDLINE]Related articles

The effect of ketoconazole on the pharmacokinetics of a selective alpha 1A-adrenoceptor antagonist.

Winchell GA, Mistry GC, Kari PP, Marbury T, Miller JL, Simpson RC, Rodrigues AD, Gottesdiener KM, Wagner JA.

J Clin Pharmacol. 2005 Jun;45(6):699-703. No abstract available. PMID: 15901753 [PubMed - indexed for MEDLINE]Related articles

Individual and combined effects of peroxisome proliferator-activated receptor and {gamma} agonists, fenofibrate and rosiglitazone, on biomarkers of lipid and glucose metabolism in healthy nondiabetic volunteers.

Wagner JA, Larson PJ, Weiss S, Miller JL, Doebber TW, Wu MS, Moller DE, Gottesdiener KM.

J Clin Pharmacol. 2005 May;45(5):504-13.PMID: 15831773 [PubMed - indexed for MEDLINE]Related articles

Lack of effect of aprepitant on the pharmacokinetics of docetaxel in cancer patients.

Nygren P, Hande K, Petty KJ, Fedgchin M, van Dyck K, Majumdar A, Panebianco D, de Smet M, Ahmed T, Murphy MG, Gottesdiener KM, Cocquyt V, van Belle S.

Cancer Chemother Pharmacol. 2005 Jun;55(6):609-16. Epub 2005 Feb 19.PMID: 15723220 [PubMed - indexed for MEDLINE]Related articles

The effects of modifying in vivo cytochrome P450 3A (CYP3A) activity on etoricoxib pharmacokinetics and of etoricoxib administration on CYP3A activity.

Agrawal NG, Matthews CZ, Mazenko RS, Woolf EJ, Porras AG, Chen X, Miller JL, Michiels N, Wehling M, Schultz A, Gottlieb AB, Kraft WK, Greenberg HE, Waldman SA, Curtis SP, Gottesdiener KM.

J Clin Pharmacol. 2004 Oct;44(10):1125-31.PMID: 15342613 [PubMed - indexed for MEDLINE]Related articles

Pharmacokinetics of etoricoxib in patients with renal impairment.

Agrawal NG, Matthews CZ, Mazenko RS, Kline WF, Woolf EJ, Porras AG, Geer LA, Wong PH, Cho M, Cote J, Marbury TC, Moncrief JW, Alcorn H Jr, Swan S, Sack MR, Robson RA, Petty KJ, Schwartz JI, Gottesdiener KM.

J Clin Pharmacol. 2004 Jan;44(1):48-58.PMID: 14681341 [PubMed - indexed for MEDLINE]Related articles

Pharmacokinetics of etoricoxib in patients with hepatic impairment.

Agrawal NG, Rose MJ, Matthews CZ, Woolf EJ, Porras AG, Geer LA, Larson PJ, Cote J, Dilzer SC, Lasseter KC, Alam I, Petty KJ, Gottesdiener KM.

J Clin Pharmacol. 2003 Oct;43(10):1136-48.PMID: 14517196 [PubMed - indexed for MEDLINE]Related articles

Lack of effect of aprepitant on digoxin pharmacokinetics in healthy subjects.

Feuring M, Lee Y, Orlowski LH, Michiels N, De Smet M, Majumdar AK, Petty KJ, Goldberg MR, Murphy MG, Gottesdiener KM, Hesney M, Brackett LE, Wehling M.

J Clin Pharmacol. 2003 Aug;43(8):912-7.PMID: 12953348 [PubMed - indexed for MEDLINE]Related articles

Effects of aprepitant on cytochrome P450 3A4 activity using midazolam as a probe.

Majumdar AK, McCrea JB, Panebianco DL, Hesney M, Dru J, Constanzer M, Goldberg MR, Murphy G, Gottesdiener KM, Lines CR, Petty KJ, Blum RA.

Clin Pharmacol Ther. 2003 Aug;74(2):150-6.PMID: 12891225 [PubMed - indexed for MEDLINE]Related articles

Effects of aprepitant on the pharmacokinetics of ondansetron and granisetron in healthy subjects.

Blum RA, Majumdar A, McCrea J, Busillo J, Orlowski LH, Panebianco D, Hesney M, Petty KJ, Goldberg MR, Murphy MG, Gottesdiener KM, Hustad CM, Lates C, Kraft WK, Van Buren S, Waldman SA, Greenberg HE.

Clin Ther. 2003 May;25(5):1407-19. Review.PMID: 12867217 [PubMed - indexed for MEDLINE]Related articles

Effects of the neurokinin1 receptor antagonist aprepitant on the pharmacokinetics of dexamethasone and methylprednisolone.

McCrea JB, Majumdar AK, Goldberg MR, Iwamoto M, Gargano C, Panebianco DL, Hesney M, Lines CR, Petty KJ, Deutsch PJ, Murphy MG, Gottesdiener KM, Goldwater DR, Blum RA.

Clin Pharmacol Ther. 2003 Jul;74(1):17-24.PMID: 12844131 [PubMed - indexed for MEDLINE]Related articles

Single- and multiple-dose pharmacokinetics of etoricoxib, a selective inhibitor of cyclooxygenase-2, in man.

Agrawal NG, Porras AG, Matthews CZ, Rose MJ, Woolf EJ, Musser BJ, Dynder AL, Mazina KE, Lasseter KC, Hunt TL, Schwartz JI, McCrea JB, Gottesdiener KM.

J Clin Pharmacol. 2003 Mar;43(3):268-76.PMID: 12638395 [PubMed - indexed for MEDLINE]Related articles

Absorption, metabolism, and excretion of etoricoxib, a potent and selective cyclooxygenase-2 inhibitor, in healthy male volunteers.

Rodrigues AD, Halpin RA, Geer LA, Cui D, Woolf EJ, Matthews CZ, Gottesdiener KM, Larson PJ, Lasseter KC, Agrawal NG.

Drug Metab Dispos. 2003 Feb;31(2):224-32.PMID: 12527704 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of a 28-d treatment with L-796568, a novel beta(3)-adrenergic receptor agonist, on energy expenditure and body composition in obese men.

Larsen TM, Toubro S, van Baak MA, Gottesdiener KM, Larson P, Saris WH, Astrup A.

Am J Clin Nutr. 2002 Oct;76(4):780-8.PMID: 12324291 [PubMed - indexed for MEDLINE]Related articlesFree article

Comparison of rofecoxib, celecoxib, and naproxen on renal function in elderly subjects receiving a normal-salt diet.

Schwartz JI, Vandormael K, Malice MP, Kalyani RN, Lasseter KC, Holmes GB, Gertz BJ, Gottesdiener KM, Laurenzi M, Redfern KJ, Brune K.

Clin Pharmacol Ther. 2002 Jul;72(1):50-61.PMID: 12152004 [PubMed - indexed for MEDLINE]Related articles

Acute effect of L-796568, a novel beta 3-adrenergic receptor agonist, on energy expenditure in obese men.

van Baak MA, Hul GB, Toubro S, Astrup A, Gottesdiener KM, DeSmet M, Saris WH.

Clin Pharmacol Ther. 2002 Apr;71(4):272-9.PMID: 11956510 [PubMed - indexed for MEDLINE]Related articles

Induction of adipocyte complement-related protein of 30 kilodaltons by PPARgamma agonists: a potential mechanism of insulin sensitization.

Combs TP, Wagner JA, Berger J, Doebber T, Wang WJ, Zhang BB, Tanen M, Berg AH, O'Rahilly S, Savage DB, Chatterjee K, Weiss S, Larson PJ, Gottesdiener KM, Gertz BJ, Charron MJ, Scherer PE, Moller DE.

Endocrinology. 2002 Mar;143(3):998-1007.PMID: 11861525 [PubMed - indexed for MEDLINE]Related articlesFree article

Dose proportionality of oral etoricoxib, a highly selective cyclooxygenase-2 inhibitor, in healthy volunteers.

Agrawal NG, Porras AG, Matthews CZ, Woolf EJ, Miller JL, Mukhopadhyay S, Neu DC, Gottesdiener KM.

J Clin Pharmacol. 2001 Oct;41(10):1106-10.PMID: 11583479 [PubMed - indexed for MEDLINE]Related articles

A Trypanosoma brucei bloodstream form mutant deficient in ornithine decarboxylase can protect against wild-type infection in mice.

Mutomba MC, Li F, Gottesdiener KM, Wang CC.

Exp Parasitol. 1999 Feb;91(2):176-84.PMID: 9990346 [PubMed - indexed for MEDLINE]Related articles

Trypanosoma brucei brucei: characterization of an ODC null bloodstream form mutant and the action of alpha-difluoromethylornithine.

Li F, Hua SB, Wang CC, Gottesdiener KM.

Exp Parasitol. 1998 Mar;88(3):255-7.PMID: 9562432 [PubMed - indexed for MEDLINE]Related articles

Binding of trans-acting factors to the double-stranded variant surface glycoprotein (VSG) expression site promoter of Trypanosoma brucei.

Pham VP, Rothman PB, Gottesdiener KM.

Mol Biochem Parasitol. 1997 Oct;89(1):11-23.PMID: 9297697 [PubMed - indexed for MEDLINE]Related articles

Procyclic Trypanosoma brucei cell lines deficient in ornithine decarboxylase activity.

Li F, Hua SB, Wang CC, Gottesdiener KM.

Mol Biochem Parasitol. 1996 Jun;78(1-2):227-36.PMID: 8813692 [PubMed - indexed for MEDLINE]Related articles

Analysis of a hybrid PARP/VSG ES promoter in procyclic trypanosomes.

Qi CC, Urményi T, Gottesdiener KM.

Mol Biochem Parasitol. 1996 May;77(2):147-59.PMID: 8813661 [PubMed - indexed for MEDLINE]Related articles

Cloning by functional complementation in Trypanosoma brucei.

Sommer JM, Hua S, Li F, Gottesdiener KM, Wang CC.

Mol Biochem Parasitol. 1996 Feb-Mar;76(1-2):83-9.PMID: 8919997 [PubMed - indexed for MEDLINE]Related articles

An efficient method for stable transfection of bloodstream-form Trypanosoma brucei.

Li F, Gottesdiener KM.

Nucleic Acids Res. 1996 Feb 1;24(3):534-5. No abstract available. PMID: 8602369 [PubMed - indexed for MEDLINE]Related articlesFree article

A detailed mutational analysis of the VSG gene expression site promoter.

Pham VP, Qi CC, Gottesdiener KM.

Mol Biochem Parasitol. 1996 Jan;75(2):241-54.PMID: 8992322 [PubMed - indexed for MEDLINE]Related articles