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Hyperglycaemic clamp test for diabetes risk assessment in IA-2-antibody-positive relatives of type 1 diabetic patients.

Vandemeulebroucke E, Keymeulen B, Decochez K, Weets I, De Block C, Féry F, Van de Velde U, Vermeulen I, De Pauw P, Mathieu C, Pipeleers DG, Gorus FK; The Belgian Diabetes Registry.

Diabetologia. 2009 Nov 7. [Epub ahead of print]PMID: 19898832 [PubMed - as supplied by publisher]Related articles

Insulin treatment in IA-2A-positive relatives of type 1 diabetic patients.

Vandemeulebroucke E, Gorus FK, Decochez K, Weets I, Keymeulen B, De Block C, Tits J, Pipeleers DG, Mathieu C; Belgian Diabetes Registry.

Diabetes Metab. 2009 Sep;35(4):319-27. Epub 2009 Jul 31.PMID: 19647467 [PubMed - in process]Related articles

Differences in baseline lymphocyte counts and autoreactivity are associated with differences in outcome of islet cell transplantation in type 1 diabetic patients.

Hilbrands R, Huurman VA, Gillard P, Velthuis JH, De Waele M, Mathieu C, Kaufman L, Pipeleers-Marichal M, Ling Z, Movahedi B, Jacobs-Tulleneers-Thevissen D, Monbaliu D, Ysebaert D, Gorus FK, Roep BO, Pipeleers DG, Keymeulen B.

Diabetes. 2009 Oct;58(10):2267-76. Epub 2009 Jul 14.PMID: 19602536 [PubMed - indexed for MEDLINE]Related articles

IFIH1 gene polymorphisms in type 1 diabetes: genetic association analysis and genotype-phenotype correlation in the Belgian population.

Aminkeng F, Van Autreve JE, Weets I, Quartier E, Van Schravendijk C, Gorus FK, Van der Auwera BJ; Belgian Diabetes Registry.

Hum Immunol. 2009 Sep;70(9):706-10. Epub 2009 Jun 16.PMID: 19539001 [PubMed - in process]Related articles

Total error profiling of a proinsulin time-resolved fluorescence immunoassay.

De Pauw PE, Mackin RB, Goubert P, Van Schravendijk C, Gorus FK.

J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Aug 1;877(23):2403-6. Epub 2008 Nov 19.PMID: 19041285 [PubMed - indexed for MEDLINE]Related articles

Simultaneous measurement of plasma concentrations of proinsulin and C-peptide and their ratio with a trefoil-type time-resolved fluorescence immunoassay.

De Pauw PE, Vermeulen I, Ubani OC, Truyen I, Vekens EM, van Genderen FT, De Grijse JW, Pipeleers DG, Van Schravendijk C, Gorus FK.

Clin Chem. 2008 Dec;54(12):1990-8. Epub 2008 Oct 9.PMID: 18845769 [PubMed - indexed for MEDLINE]Related articles

Cellular islet autoimmunity associates with clinical outcome of islet cell transplantation.

Huurman VA, Hilbrands R, Pinkse GG, Gillard P, Duinkerken G, van de Linde P, van der Meer-Prins PM, Versteeg-van der Voort Maarschalk MF, Verbeeck K, Alizadeh BZ, Mathieu C, Gorus FK, Roelen DL, Claas FH, Keymeulen B, Pipeleers DG, Roep BO.

PLoS One. 2008 Jun 18;3(6):e2435.PMID: 18560516 [PubMed - indexed for MEDLINE]Related articlesFree article

[Epidemiology, prediction and prevention of type 1 diabetes: not one fiction in Belgium]

Gorus FK.

Verh K Acad Geneeskd Belg. 2008;70(1):5-24. Review. Dutch. PMID: 18512356 [PubMed - indexed for MEDLINE]Related articles

Adiponectin levels do not predict clinical onset of type 1 diabetes in antibody-positive relatives.

Truyen I, De Grijse J, Van Schravendijk C, De Smet D, Decochez K, Vandemeulebroucke E, Giri M, Keymeulen B, Mathieu C, Van Gaal L, De Pauw P, Weets I, Pipeleers DG, Gorus FK; Belgian Diabetes Registry.

Diabetologia. 2007 Oct;50(10):2143-6. Epub 2007 Aug 9.PMID: 17687539 [PubMed - indexed for MEDLINE]Related articles

TNFa microsatellite polymorphism modulates the risk of type 1 diabetes in the Belgian population, independent of HLA-DQ.

Aminkeng F, Van Autreve JE, Koeleman BP, Quartier E, Van Schravendijk C, Gorus FK, Van der Auwera BJ; Belgian Diabetes Registry.

Hum Immunol. 2007 Aug;68(8):690-7. Epub 2007 Jun 11.PMID: 17678725 [PubMed - indexed for MEDLINE]Related articles

The age at diagnosis of type 1 diabetes continues to decrease in Belgian boys but not in girls: a 15-year survey.

Weets I, Rooman R, Coeckelberghs M, De Block C, Van Gaal L, Kaufman JM, Keymeulen B, Mathieu C, Weber E, Pipeleers DG, Gorus FK; Belgian Diabetes Registry.

Diabetes Metab Res Rev. 2007 Nov;23(8):637-43.PMID: 17631647 [PubMed - indexed for MEDLINE]Related articles

Identification of prediabetes in first-degree relatives at intermediate risk of type I diabetes.

Truyen I, De Grijse J, Weets I, Kaufman L, Pipeleers L, Nanos N, Decochez K, Hilbrands R, Kaufman JM, Keymeulen B, Mathieu C, Van Gaal L, Pipeleers DG, Gorus FK; Belgian Diabetes Registry.

Clin Exp Immunol. 2007 Aug;149(2):243-50. Epub 2007 May 22.PMID: 17521324 [PubMed - indexed for MEDLINE]Related articlesFree article

Species and epitope specificity of two 65 kDa glutamate decarboxylase time-resolved fluorometric immunoassays.

Rui M, Hampe CS, Wang C, Ling Z, Gorus FK, Lernmark A, Pipeleers DG, De Pauw PE.

J Immunol Methods. 2007 Jan 30;319(1-2):133-43. Epub 2006 Dec 14.PMID: 17210161 [PubMed - indexed for MEDLINE]Related articles

MICA is associated with type 1 diabetes in the Belgian population, independent of HLA-DQ.

Van Autreve JE, Koeleman BP, Quartier E, Aminkeng F, Weets I, Gorus FK, Van der Auwera BJ; Belgian Diabetes Registry.

Hum Immunol. 2006 Jan-Feb;67(1-2):94-101. Epub 2006 Mar 31.PMID: 16698430 [PubMed - indexed for MEDLINE]Related articles

Indoxyl sulphate and the purple urine bag syndrome: a case report.

Achtergael W, Michielsen D, Gorus FK, Gerlo E.

Acta Clin Belg. 2006 Jan-Feb;61(1):38-41.PMID: 16673616 [PubMed - indexed for MEDLINE]Related articles

Sex- and season-dependent differences in C-peptide levels at diagnosis of immune-mediated type 1 diabetes.

Weets I, Truyen I, Verschraegen I, Van der Auwera B, De Schepper J, Dorchy H, Lebrethon MC, Van Gaal L, Van Rooy P, Pipeleers DG, Gorus FK; Belgian Diabetes Registry.

Diabetologia. 2006 Jun;49(6):1158-62. Epub 2006 Mar 29.PMID: 16570164 [PubMed - indexed for MEDLINE]Related articles

Proinsulin levels and the proinsulin:c-peptide ratio complement autoantibody measurement for predicting type 1 diabetes.

Truyen I, De Pauw P, Jørgensen PN, Van Schravendijk C, Ubani O, Decochez K, Vandemeulebroucke E, Weets I, Mao R, Pipeleers DG, Gorus FK; Belgian Diabetes Registry.

Diabetologia. 2005 Nov;48(11):2322-9. Epub 2005 Oct 7.PMID: 16211374 [PubMed - indexed for MEDLINE]Related articles

Evaluation of the Stratus CS fluorometer for the determination of plasma myoglobin.

Couck P, Claeys R, Vanderstraeten E, Gorus FK.

Acta Clin Belg. 2005 Mar-Apr;60(2):75-8.PMID: 16082992 [PubMed - indexed for MEDLINE]Related articles

Combined positivity for HLA DQ2/DQ8 and IA-2 antibodies defines population at high risk of developing type 1 diabetes.

Decochez K, Truyen I, van der Auwera B, Weets I, Vandemeulebroucke E, de Leeuw IH, Keymeulen B, Mathieu C, Rottiers R, Pipeleers DG, Gorus FK; Belgian Diabetes Registry.

Diabetologia. 2005 Apr;48(4):687-94. Epub 2005 Mar 9.PMID: 15756536 [PubMed - indexed for MEDLINE]Related articles

The rare HLA-DQA1*03-DQB1*02 haplotype confers susceptibility to type 1 diabetes in whites and is preferentially associated with early clinical disease onset in male subjects.

van Autreve JE, Weets I, Gulbis B, Vertongen F, Gorus FK, van der Auwera BJ; Belgian Diabetes Registry.

Hum Immunol. 2004 Jul;65(7):729-36.PMID: 15301863 [PubMed - indexed for MEDLINE]Related articles

Seasonality in clinical onset of type 1 diabetes in belgian patients above the age of 10 is restricted to HLA-DQ2/DQ8-negative males, which explains the male to female excess in incidence.

Weets I, Kaufman L, Van der Auwera B, Crenier L, Rooman RP, De Block C, Casteels K, Weber E, Coeckelberghs M, Laron Z, Pipeleers DG, Gorus FK; Belgian Diabetes Registry.

Diabetologia. 2004 Apr;47(4):614-21.PMID: 15298337 [PubMed - indexed for MEDLINE]Related articles

Epidemiology of type 1 and type 2 diabetes. The added value of diabetes registries for conducting clinical studies: the Belgian paradigm.

Gorus FK, Weets I, Couck P, Pipeleers DG; Belgian Diabetes Registry.

Acta Clin Belg. 2004 Jan-Feb;59(1):1-13. Review.PMID: 15065690 [PubMed - indexed for MEDLINE]Related articles

[Preventative biology of type 1 diabetes: implications for clinical preventative studies]

Gorus FK, Weets I, Decochez K, van der Auwera BJ.

Verh K Acad Geneeskd Belg. 2003;65(4):203-29; discussion 229-31. Review. Dutch. PMID: 14534938 [PubMed - indexed for MEDLINE]Related articles

IA-2 autoantibodies predict impending type I diabetes in siblings of patients.

Decochez K, De Leeuw IH, Keymeulen B, Mathieu C, Rottiers R, Weets I, Vandemeulebroucke E, Truyen I, Kaufman L, Schuit FC, Pipeleers DG, Gorus FK; Belgian Diabetes Registry.

Diabetologia. 2002 Dec;45(12):1658-66. Epub 2002 Nov 12.PMID: 12488955 [PubMed - indexed for MEDLINE]Related articles

Non-transmitted maternal HLA DQ2 or DQ8 alleles and risk of Type I diabetes in offspring: the importance of foetal or post partum exposure to diabetogenic molecules.

Pani MA, Van Autreve J, Van der Auwera BJ, Gorus FK, Badenhoop K.

Diabetologia. 2002 Sep;45(9):1340-3. Epub 2002 Jul 6.PMID: 12242468 [PubMed - indexed for MEDLINE]Related articles

Relation between disease phenotype and HLA-DQ genotype in diabetic patients diagnosed in early adulthood.

Weets I, Siraux V, Daubresse JC, De Leeuw IH, Féry F, Keymeulen B, Krzentowski G, Letiexhe M, Mathieu C, Nobels F, Rottiers R, Scheen A, Van Gaal L, Schuit FC, Van der Auwera B, Rui M, De Pauw P, Kaufman L, Gorus FK; Belgian Diabetes Registry.

J Clin Endocrinol Metab. 2002 Jun;87(6):2597-605.PMID: 12050221 [PubMed - indexed for MEDLINE]Related articlesFree article

The incidence of type 1 diabetes in the age group 0-39 years has not increased in Antwerp (Belgium) between 1989 and 2000: evidence for earlier disease manifestation.

Weets I, De Leeuw IH, Du Caju MV, Rooman R, Keymeulen B, Mathieu C, Rottiers R, Daubresse JC, Rocour-Brumioul D, Pipeleers DG, Gorus FK; Belgian Diabetes Registry.

Diabetes Care. 2002 May;25(5):840-6.PMID: 11978678 [PubMed - indexed for MEDLINE]Related articlesFree article

To: T.J. Wilkin (2001) The accelerator hypothesis: weight gain as the missing link between Type I and Type II diabetes. Diabetologia 44: 914-921.

Gorus FK, Weets I, Pipeleers DG.

Diabetologia. 2002 Feb;45(2):288-9; author reply 289. No abstract available. PMID: 11942314 [PubMed - indexed for MEDLINE]Related articles

Plasma procalcitonin and C-reactive protein in acute septic shock: clinical and biological correlates.

Claeys R, Vinken S, Spapen H, ver Elst K, Decochez K, Huyghens L, Gorus FK.

Crit Care Med. 2002 Apr;30(4):757-62.PMID: 11940741 [PubMed - indexed for MEDLINE]Related articles

Relative and absolute HLA-DQA1-DQB1 linked risk for developing type I diabetes before 40 years of age in the Belgian population: implications for future prevention studies.

Van der Auwera BJ, Schuit FC, Weets I, Ivens A, Van Autreve JE, Gorus FK; Belgian Diabetes Registry.

Hum Immunol. 2002 Jan;63(1):40-50.PMID: 11916169 [PubMed - indexed for MEDLINE]Related articles

Beta-cell, thyroid, gastric, adrenal and coeliac autoimmunity and HLA-DQ types in type 1 diabetes.

De Block CE, De Leeuw IH, Vertommen JJ, Rooman RP, Du Caju MV, Van Campenhout CM, Weyler JJ, Winnock F, Van Autreve J, Gorus FK; Belgian Diabetes Registry.

Clin Exp Immunol. 2001 Nov;126(2):236-41.PMID: 11703366 [PubMed - indexed for MEDLINE]Related articlesFree article

Prospects for predicting and stopping the development of type 1 of diabetes.

Gorus FK, Pipeleers DG; Belgian Diabetes Registry.

Best Pract Res Clin Endocrinol Metab. 2001 Sep;15(3):371-89. Review.PMID: 11554777 [PubMed - indexed for MEDLINE]Related articles

The presence of thyrogastric antibodies in first degree relatives of type 1 diabetic patients is associated with age and proband antibody status.

De Block CE, De Leeuw IH, Decochez K, Winnock F, Van Autreve J, Van Campenhout CM, Martin M, Gorus FK; Belgian Diabetes Registry.

J Clin Endocrinol Metab. 2001 Sep;86(9):4358-63.PMID: 11549675 [PubMed - indexed for MEDLINE]Related articlesFree article

Autoantibodies to a 38-kDa glycosylated islet cell membrane-associated antigen in (pre)type 1 diabetes: association with IA-2 and islet cell autoantibodies.

Winnock F, Christie MR, Batstra MR, Aanstoot HJ, Weets I, Decochez K, Jopart P, Nicolaij D, Gorus FK; Belgian Diabetes Registry.

Diabetes Care. 2001 Jul;24(7):1181-6.PMID: 11423499 [PubMed - indexed for MEDLINE]Related articlesFree article

Capillary zone electrophoresis of proteins in body fluids: comparison of capillary and agarose gel electrophoresis.

Claeys R, Groven C, Gorus FK.

Clin Chem. 2001 May;47(5):967-70. No abstract available. PMID: 11325915 [PubMed - indexed for MEDLINE]Related articlesFree article

Male-to-female excess in diabetes diagnosed in early adulthood is not specific for the immune-mediated form nor is it HLA-DQ restricted: possible relation to increased body mass index.

Weets I, Van Autreve J, Van der Auwera BJ, Schuit FC, Du Caju MV, Decochez K, De Leeuw IH, Keymeulen B, Mathieu C, Rottiers R, Dorchy H, Quartier E, Gorus FK; Belgian Diabetes Registry.

Diabetologia. 2001 Jan;44(1):40-7.PMID: 11206410 [PubMed - indexed for MEDLINE]Related articles

High frequency of persisting or increasing islet-specific autoantibody levels after diagnosis of type 1 diabetes presenting before 40 years of age. The Belgian Diabetes Registry.

Decochez K, Tits J, Coolens JL, Van Gaal L, Krzentowski G, Winnock F, Anckaert E, Weets I, Pipeleers DG, Gorus FK.

Diabetes Care. 2000 Jun;23(6):838-44.PMID: 10841006 [PubMed - indexed for MEDLINE]Related articlesFree article

Cardiac troponins I and T are biological markers of left ventricular dysfunction in septic shock.

ver Elst KM, Spapen HD, Nguyen DN, Garbar C, Huyghens LP, Gorus FK.

Clin Chem. 2000 May;46(5):650-7.PMID: 10794747 [PubMed - indexed for MEDLINE]Related articlesFree article

Analytic and clinical evaluation of the Abbott AxSYM cardiac troponin I assay.

ver Elst KM, Chapelle JP, Boland P, Demolder JS, Gorus FK.

Am J Clin Pathol. 1999 Dec;112(6):745-52.PMID: 10587695 [PubMed - indexed for MEDLINE]Related articles

Dancing eye syndrome and hyperphosphatasemia.

Hasaerts DE, Gorus FK, De Meirleir LJ.

Pediatr Neurol. 1998 May;18(5):432-4.PMID: 9650686 [PubMed - indexed for MEDLINE]Related articles

Implantation of standardized beta-cell grafts in a liver segment of IDDM patients: graft and recipients characteristics in two cases of insulin-independence under maintenance immunosuppression for prior kidney graft.

Keymeulen B, Ling Z, Gorus FK, Delvaux G, Bouwens L, Grupping A, Hendrieckx C, Pipeleers-Marichal M, Van Schravendijk C, Salmela K, Pipeleers DG.

Diabetologia. 1998 Apr;41(4):452-9.PMID: 9562350 [PubMed - indexed for MEDLINE]Related articles

Diabetes registries and early biological markers of insulin-dependent diabetes mellitus. Belgian Diabetes Registry.

Gorus FK.

Diabetes Metab Rev. 1997 Dec;13(4):247-74. Review. No abstract available. PMID: 9509278 [PubMed - indexed for MEDLINE]Related articles

Increased prevalence of abnormal immunoglobulin M, G, and A concentrations at clinical onset of insulin-dependent diabetes mellitus: a registry-based study. The Belgian Diabetes Registry.

Gorus FK, Vandewalle CL, Winnock F, Lebleu F, Keymeulen B, Van der Auwera B, Falorni A, Dorchy H, Féry F, Pipeleers DG.

Pancreas. 1998 Jan;16(1):50-9.PMID: 9436863 [PubMed - indexed for MEDLINE]Related articles

CTLA-4 gene polymorphism confers susceptibility to insulin-dependent diabetes mellitus (IDDM) independently from age and from other genetic or immune disease markers. The Belgian Diabetes Registry.

Van der Auwera BJ, Vandewalle CL, Schuit FC, Winnock F, De Leeuw IH, Van Imschoot S, Lamberigts G, Gorus FK.

Clin Exp Immunol. 1997 Oct;110(1):98-103.PMID: 9353155 [PubMed - indexed for MEDLINE]Related articlesFree article

Epidemiology, clinical aspects, and biology of IDDM patients under age 40 years. Comparison of data from Antwerp with complete ascertainment with data from Belgium with 40% ascertainment. The Belgian Diabetes Registry.

Vandewalle CL, Coeckelberghs MI, De Leeuw IH, Du Caju MV, Schuit FC, Pipeleers DG, Gorus FK.

Diabetes Care. 1997 Oct;20(10):1556-61.PMID: 9314635 [PubMed - indexed for MEDLINE]Related articles

Associations of GAD65- and IA-2- autoantibodies with genetic risk markers in new-onset IDDM patients and their siblings. The Belgian Diabetes Registry.

Vandewalle CL, Falorni A, Lernmark A, Goubert P, Dorchy H, Coucke W, Semakula C, Van der Auwera B, Kaufman L, Schuit FC, Pipeleers DG, Gorus FK.

Diabetes Care. 1997 Oct;20(10):1547-52.PMID: 9314633 [PubMed - indexed for MEDLINE]Related articles

21-hydroxylase autoantibodies in adult patients with endocrine autoimmune diseases are highly specific for Addison's disease. Belgian Diabetes Registry.

Falorni A, Laureti S, Nikoshkov A, Picchio ML, Hallengren B, Vandewalle CL, Gorus FK, Tortoioli C, Luthman H, Brunetti P, Santeusanio F.

Clin Exp Immunol. 1997 Feb;107(2):341-6.PMID: 9030873 [PubMed - indexed for MEDLINE]Related articlesFree article

IA-2-autoantibodies complement GAD65-autoantibodies in new-onset IDDM patients and help predict impending diabetes in their siblings. The Belgian Diabetes Registry.

Gorus FK, Goubert P, Semakula C, Vandewalle CL, De Schepper J, Scheen A, Christie MR, Pipeleers DG.

Diabetologia. 1997 Jan;40(1):95-9.PMID: 9028724 [PubMed - indexed for MEDLINE]Related articles

The CTLA-4 gene region of chromosome 2q33 is linked to, and associated with, type 1 diabetes. Belgian Diabetes Registry.

Nisticò L, Buzzetti R, Pritchard LE, Van der Auwera B, Giovannini C, Bosi E, Larrad MT, Rios MS, Chow CC, Cockram CS, Jacobs K, Mijovic C, Bain SC, Barnett AH, Vandewalle CL, Schuit F, Gorus FK, Tosi R, Pozzilli P, Todd JA.

Hum Mol Genet. 1996 Jul;5(7):1075-80.PMID: 8817351 [PubMed - indexed for MEDLINE]Related articlesFree article

Evaluation of an immunoturbidimetric assay for haemoglobin A1c on a Cobas Mira S analyser.

Weets I, Gorus FK, Gerlo E.

Eur J Clin Chem Clin Biochem. 1996 May;34(5):449-53.PMID: 8790983 [PubMed - indexed for MEDLINE]Related articles