PubMed

Identification of a novel phosphorylation site on TBC1D4 regulated by AMP-activated protein kinase in skeletal muscle.

Treebak JT, Taylor EB, Witczak CA, An D, Toyoda T, Koh HJ, Xie J, Feener EP, Wojtaszewski JF, Hirshman MF, Goodyear LJ.

Am J Physiol Cell Physiol. 2009 Nov 18. [Epub ahead of print]PMID: 19923418 [PubMed - as supplied by publisher]Related articles

Effects of exercise training on subcutaneous and visceral adipose tissue in normal- and high-fat diet-fed rats.

Gollisch KS, Brandauer J, Jessen N, Toyoda T, Nayer A, Hirshman MF, Goodyear LJ.

Am J Physiol Endocrinol Metab. 2009 Aug;297(2):E495-504. Epub 2009 Jun 2.PMID: 19491293 [PubMed - indexed for MEDLINE]Related articles

Stretch-stimulated glucose uptake in skeletal muscle is mediated by reactive oxygen species and p38 MAP-kinase.

Chambers MA, Moylan JS, Smith JD, Goodyear LJ, Reid MB.

J Physiol. 2009 Jul 1;587(Pt 13):3363-73. Epub 2009 Apr 29.PMID: 19403598 [PubMed - indexed for MEDLINE]Related articles

Estradiol stimulates Akt, AMP-activated protein kinase (AMPK) and TBC1D1/4, but not glucose uptake in rat soleus.

Rogers NH, Witczak CA, Hirshman MF, Goodyear LJ, Greenberg AS.

Biochem Biophys Res Commun. 2009 May 15;382(4):646-50. Epub 2009 Mar 3.PMID: 19265681 [PubMed - indexed for MEDLINE]Related articles

The exercise pill--too good to be true?

Goodyear LJ.

N Engl J Med. 2008 Oct 23;359(17):1842-4. No abstract available. PMID: 18946072 [PubMed - indexed for MEDLINE]Related articles

AMP-activated protein kinase in skeletal muscle: from structure and localization to its role as a master regulator of cellular metabolism.

Witczak CA, Sharoff CG, Goodyear LJ.

Cell Mol Life Sci. 2008 Nov;65(23):3737-55. Review.PMID: 18810325 [PubMed - indexed for MEDLINE]Related articles

Ablation of AMP-activated protein kinase alpha2 activity exacerbates insulin resistance induced by high-fat feeding of mice.

Fujii N, Ho RC, Manabe Y, Jessen N, Toyoda T, Holland WL, Summers SA, Hirshman MF, Goodyear LJ.

Diabetes. 2008 Nov;57(11):2958-66. Epub 2008 Aug 26.PMID: 18728234 [PubMed - indexed for MEDLINE]Related articlesFree article

Endogenous peroxisome proliferator-activated receptor-gamma augments fatty acid uptake in oxidative muscle.

Norris AW, Hirshman MF, Yao J, Jessen N, Musi N, Chen L, Sivitz WI, Goodyear LJ, Kahn CR.

Endocrinology. 2008 Nov;149(11):5374-83. Epub 2008 Jul 24.PMID: 18653710 [PubMed - indexed for MEDLINE]Related articlesFree article

Highly efficient, functional engraftment of skeletal muscle stem cells in dystrophic muscles.

Cerletti M, Jurga S, Witczak CA, Hirshman MF, Shadrach JL, Goodyear LJ, Wagers AJ.

Cell. 2008 Jul 11;134(1):37-47.PMID: 18614009 [PubMed - indexed for MEDLINE]Related articles

LKB1 and AMPK and the regulation of skeletal muscle metabolism.

Koh HJ, Brandauer J, Goodyear LJ.

Curr Opin Clin Nutr Metab Care. 2008 May;11(3):227-32. Review.PMID: 18403917 [PubMed - indexed for MEDLINE]Related articles

Signaling mechanisms in skeletal muscle: acute responses and chronic adaptations to exercise.

Röckl KS, Witczak CA, Goodyear LJ.

IUBMB Life. 2008 Mar;60(3):145-53. Review.PMID: 18380005 [PubMed - indexed for MEDLINE]Related articles

Oxidative stress stimulates skeletal muscle glucose uptake through a phosphatidylinositol 3-kinase-dependent pathway.

Higaki Y, Mikami T, Fujii N, Hirshman MF, Koyama K, Seino T, Tanaka K, Goodyear LJ.

Am J Physiol Endocrinol Metab. 2008 May;294(5):E889-97. Epub 2008 Feb 26.PMID: 18303121 [PubMed - indexed for MEDLINE]Related articlesFree article

Discovery of TBC1D1 as an insulin-, AICAR-, and contraction-stimulated signaling nexus in mouse skeletal muscle.

Taylor EB, An D, Kramer HF, Yu H, Fujii NL, Roeckl KS, Bowles N, Hirshman MF, Xie J, Feener EP, Goodyear LJ.

J Biol Chem. 2008 Apr 11;283(15):9787-96. Epub 2008 Feb 13.PMID: 18276596 [PubMed - indexed for MEDLINE]Related articlesFree article

Targeting skeletal muscle AMP-activated protein kinase to treat type 2 diabetes.

Taylor EB, Goodyear LJ.

Curr Diab Rep. 2007 Dec;7(6):399-401. No abstract available. PMID: 18254999 [PubMed - indexed for MEDLINE]Related articles

Insulin promotes glycogen synthesis in the absence of GSK3 phosphorylation in skeletal muscle.

Bouskila M, Hirshman MF, Jensen J, Goodyear LJ, Sakamoto K.

Am J Physiol Endocrinol Metab. 2008 Jan;294(1):E28-35. Epub 2007 Nov 14.PMID: 18003720 [PubMed - indexed for MEDLINE]Related articlesFree article

Large GLUT4 vesicles are stationary while locally and reversibly depleted during transient insulin stimulation of skeletal muscle of living mice: imaging analysis of GLUT4-enhanced green fluorescent protein vesicle dynamics.

Lauritzen HP, Galbo H, Brandauer J, Goodyear LJ, Ploug T.

Diabetes. 2008 Feb;57(2):315-24. Epub 2007 Oct 31.PMID: 17977960 [PubMed - indexed for MEDLINE]Related articlesFree article

Calmodulin-binding domain of AS160 regulates contraction- but not insulin-stimulated glucose uptake in skeletal muscle.

Kramer HF, Taylor EB, Witczak CA, Fujii N, Hirshman MF, Goodyear LJ.

Diabetes. 2007 Dec;56(12):2854-62. Epub 2007 Aug 23.PMID: 17717281 [PubMed - indexed for MEDLINE]Related articlesFree article

Dissociation of AMP-activated protein kinase and p38 mitogen-activated protein kinase signaling in skeletal muscle.

Ho RC, Fujii N, Witters LA, Hirshman MF, Goodyear LJ.

Biochem Biophys Res Commun. 2007 Oct 19;362(2):354-9. Epub 2007 Aug 7.PMID: 17709097 [PubMed - indexed for MEDLINE]Related articlesFree article

Skeletal muscle adaptation to exercise training: AMP-activated protein kinase mediates muscle fiber type shift.

Röckl KS, Hirshman MF, Brandauer J, Fujii N, Witters LA, Goodyear LJ.

Diabetes. 2007 Aug;56(8):2062-9. Epub 2007 May 18.PMID: 17513699 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of AMP-activated protein kinase in exercise capacity, whole body glucose homeostasis, and glucose transport in skeletal muscle -insight from analysis of a transgenic mouse model-.

Fujii N, Seifert MM, Kane EM, Peter LE, Ho RC, Winstead S, Hirshman MF, Goodyear LJ.

Diabetes Res Clin Pract. 2007 Sep;77 Suppl 1:S92-8. Epub 2007 Apr 23.PMID: 17452058 [PubMed - indexed for MEDLINE]Related articles

Aberrant activation of AMP-activated protein kinase remodels metabolic network in favor of cardiac glycogen storage.

Luptak I, Shen M, He H, Hirshman MF, Musi N, Goodyear LJ, Yan J, Wakimoto H, Morita H, Arad M, Seidman CE, Seidman JG, Ingwall JS, Balschi JA, Tian R.

J Clin Invest. 2007 May;117(5):1432-9. Epub 2007 Apr 12.PMID: 17431505 [PubMed - indexed for MEDLINE]Related articlesFree article

Exercise, MAPK, and NF-kappaB signaling in skeletal muscle.

Kramer HF, Goodyear LJ.

J Appl Physiol. 2007 Jul;103(1):388-95. Epub 2007 Feb 15. Review.PMID: 17303713 [PubMed - indexed for MEDLINE]Related articlesFree article

Ca2+/calmodulin-dependent protein kinase kinase-alpha regulates skeletal muscle glucose uptake independent of AMP-activated protein kinase and Akt activation.

Witczak CA, Fujii N, Hirshman MF, Goodyear LJ.

Diabetes. 2007 May;56(5):1403-9. Epub 2007 Feb 7.PMID: 17287469 [PubMed - indexed for MEDLINE]Related articlesFree article

Adrenaline is a critical mediator of acute exercise-induced AMP-activated protein kinase activation in adipocytes.

Koh HJ, Hirshman MF, He H, Li Y, Manabe Y, Balschi JA, Goodyear LJ.

Biochem J. 2007 May 1;403(3):473-81.PMID: 17253964 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic model for the chronic activation of skeletal muscle AMP-activated protein kinase leads to glycogen accumulation.

Barré L, Richardson C, Hirshman MF, Brozinick J, Fiering S, Kemp BE, Goodyear LJ, Witters LA.

Am J Physiol Endocrinol Metab. 2007 Mar;292(3):E802-11. Epub 2006 Nov 14.PMID: 17106064 [PubMed - indexed for MEDLINE]Related articlesFree article

JNK1 deficiency does not enhance muscle glucose metabolism in lean mice.

Witczak CA, Hirshman MF, Jessen N, Fujii N, Seifert MM, Brandauer J, Hotamisligil GS, Goodyear LJ.

Biochem Biophys Res Commun. 2006 Dec 1;350(4):1063-8. Epub 2006 Oct 6.PMID: 17045576 [PubMed - indexed for MEDLINE]Related articlesFree article

Skeletal muscle-selective knockout of LKB1 increases insulin sensitivity, improves glucose homeostasis, and decreases TRB3.

Koh HJ, Arnolds DE, Fujii N, Tran TT, Rogers MJ, Jessen N, Li Y, Liew CW, Ho RC, Hirshman MF, Kulkarni RN, Kahn CR, Goodyear LJ.

Mol Cell Biol. 2006 Nov;26(22):8217-27. Epub 2006 Sep 11.PMID: 16966378 [PubMed - indexed for MEDLINE]Related articlesFree article

AS160 regulates insulin- and contraction-stimulated glucose uptake in mouse skeletal muscle.

Kramer HF, Witczak CA, Taylor EB, Fujii N, Hirshman MF, Goodyear LJ.

J Biol Chem. 2006 Oct 20;281(42):31478-85. Epub 2006 Aug 25.PMID: 16935857 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin-stimulated insulin receptor substrate-2-associated phosphatidylinositol 3-kinase activity is enhanced in human skeletal muscle after exercise.

Howlett KF, Sakamoto K, Yu H, Goodyear LJ, Hargreaves M.

Metabolism. 2006 Aug;55(8):1046-52.PMID: 16839840 [PubMed - indexed for MEDLINE]Related articles

AMP-activated protein kinase and the regulation of glucose transport.

Fujii N, Jessen N, Goodyear LJ.

Am J Physiol Endocrinol Metab. 2006 Nov;291(5):E867-77. Epub 2006 Jul 5. Review.PMID: 16822958 [PubMed - indexed for MEDLINE]Related articlesFree article

Distinct signals regulate AS160 phosphorylation in response to insulin, AICAR, and contraction in mouse skeletal muscle.

Kramer HF, Witczak CA, Fujii N, Jessen N, Taylor EB, Arnolds DE, Sakamoto K, Hirshman MF, Goodyear LJ.

Diabetes. 2006 Jul;55(7):2067-76.PMID: 16804077 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of Akt2 in contraction-stimulated cell signaling and glucose uptake in skeletal muscle.

Sakamoto K, Arnolds DE, Fujii N, Kramer HF, Hirshman MF, Goodyear LJ.

Am J Physiol Endocrinol Metab. 2006 Nov;291(5):E1031-7. Epub 2006 Jun 27.PMID: 16803855 [PubMed - indexed for MEDLINE]Related articlesFree article

Loss of class IA PI3K signaling in muscle leads to impaired muscle growth, insulin response, and hyperlipidemia.

Luo J, Sobkiw CL, Hirshman MF, Logsdon MN, Li TQ, Goodyear LJ, Cantley LC.

Cell Metab. 2006 May;3(5):355-66.PMID: 16679293 [PubMed - indexed for MEDLINE]Related articles

Muscle-specific overexpression of wild type and R225Q mutant AMP-activated protein kinase gamma3-subunit differentially regulates glycogen accumulation.

Yu H, Hirshman MF, Fujii N, Pomerleau JM, Peter LE, Goodyear LJ.

Am J Physiol Endocrinol Metab. 2006 Sep;291(3):E557-65. Epub 2006 Apr 25.PMID: 16638825 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin resistance and improvements in signal transduction.

Musi N, Goodyear LJ.

Endocrine. 2006 Feb;29(1):73-80. Review.PMID: 16622294 [PubMed - indexed for MEDLINE]Related articles

Regulation of dishevelled and beta-catenin in rat skeletal muscle: an alternative exercise-induced GSK-3beta signaling pathway.

Aschenbach WG, Ho RC, Sakamoto K, Fujii N, Li Y, Kim YB, Hirshman MF, Goodyear LJ.

Am J Physiol Endocrinol Metab. 2006 Jul;291(1):E152-8. Epub 2006 Feb 14.PMID: 16478782 [PubMed - indexed for MEDLINE]Related articlesFree article

Exercise training decreases the concentration of malonyl-CoA and increases the expression and activity of malonyl-CoA decarboxylase in human muscle.

Kuhl JE, Ruderman NB, Musi N, Goodyear LJ, Patti ME, Crunkhorn S, Dronamraju D, Thorell A, Nygren J, Ljungkvist O, Degerblad M, Stahle A, Brismar TB, Andersen KL, Saha AK, Efendic S, Bavenholm PN.

Am J Physiol Endocrinol Metab. 2006 Jun;290(6):E1296-303. Epub 2006 Jan 24.PMID: 16434556 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased alpha2 subunit-associated AMPK activity and PRKAG2 cardiomyopathy.

Ahmad F, Arad M, Musi N, He H, Wolf C, Branco D, Perez-Atayde AR, Stapleton D, Bali D, Xing Y, Tian R, Goodyear LJ, Berul CI, Ingwall JS, Seidman CE, Seidman JG.

Circulation. 2005 Nov 15;112(20):3140-8. Epub 2005 Nov 7.PMID: 16275868 [PubMed - indexed for MEDLINE]Related articlesFree article

Muscle-specific deletion of the Glut4 glucose transporter alters multiple regulatory steps in glycogen metabolism.

Kim YB, Peroni OD, Aschenbach WG, Minokoshi Y, Kotani K, Zisman A, Kahn CR, Goodyear LJ, Kahn BB.

Mol Cell Biol. 2005 Nov;25(21):9713-23.PMID: 16227617 [PubMed - indexed for MEDLINE]Related articlesFree article

AMP-activated protein kinase alpha2 activity is not essential for contraction- and hyperosmolarity-induced glucose transport in skeletal muscle.

Fujii N, Hirshman MF, Kane EM, Ho RC, Peter LE, Seifert MM, Goodyear LJ.

J Biol Chem. 2005 Nov 25;280(47):39033-41. Epub 2005 Sep 26.PMID: 16186119 [PubMed - indexed for MEDLINE]Related articlesFree article

Contraction signaling to glucose transport in skeletal muscle.

Jessen N, Goodyear LJ.

J Appl Physiol. 2005 Jul;99(1):330-7. Review.PMID: 16036906 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of IkappaB kinase and NF-kappaB in contracting adult rat skeletal muscle.

Ho RC, Hirshman MF, Li Y, Cai D, Farmer JR, Aschenbach WG, Witczak CA, Shoelson SE, Goodyear LJ.

Am J Physiol Cell Physiol. 2005 Oct;289(4):C794-801. Epub 2005 May 11.PMID: 15888549 [PubMed - indexed for MEDLINE]Related articlesFree article

Functional role of AMP-activated protein kinase in the heart during exercise.

Musi N, Hirshman MF, Arad M, Xing Y, Fujii N, Pomerleau J, Ahmad F, Berul CI, Seidman JG, Tian R, Goodyear LJ.

FEBS Lett. 2005 Apr 11;579(10):2045-50.PMID: 15811316 [PubMed - indexed for MEDLINE]Related articles

Long-term AICAR administration and exercise prevents diabetes in ZDF rats.

Pold R, Jensen LS, Jessen N, Buhl ES, Schmitz O, Flyvbjerg A, Fujii N, Goodyear LJ, Gotfredsen CF, Brand CL, Lund S.

Diabetes. 2005 Apr;54(4):928-34.PMID: 15793229 [PubMed - indexed for MEDLINE]Related articlesFree article

Beta-cell secretory dysfunction in the pathogenesis of low birth weight-associated diabetes: a murine model.

Jimenez-Chillaron JC, Hernandez-Valencia M, Reamer C, Fisher S, Joszi A, Hirshman M, Oge A, Walrond S, Przybyla R, Boozer C, Goodyear LJ, Patti ME.

Diabetes. 2005 Mar;54(3):702-11.PMID: 15734846 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of glucose transport by the AMP-activated protein kinase.

Fujii N, Aschenbach WG, Musi N, Hirshman MF, Goodyear LJ.

Proc Nutr Soc. 2004 May;63(2):205-10. Review.PMID: 15294031 [PubMed - indexed for MEDLINE]Related articles

Exercise regulates Akt and glycogen synthase kinase-3 activities in human skeletal muscle.

Sakamoto K, Arnolds DE, Ekberg I, Thorell A, Goodyear LJ.

Biochem Biophys Res Commun. 2004 Jun 25;319(2):419-25.PMID: 15178423 [PubMed - indexed for MEDLINE]Related articles

cDNA cloning and functional characterization of a novel splice variant of c-Cbl-associated protein from mouse skeletal muscle.

Alcazar O, Ho RC, Fujii N, Goodyear LJ.

Biochem Biophys Res Commun. 2004 Apr 23;317(1):285-93.PMID: 15047181 [PubMed - indexed for MEDLINE]Related articles

Overexpression or ablation of JNK in skeletal muscle has no effect on glycogen synthase activity.

Fujii N, Boppart MD, Dufresne SD, Crowley PF, Jozsi AC, Sakamoto K, Yu H, Aschenbach WG, Kim S, Miyazaki H, Rui L, White MF, Hirshman MF, Goodyear LJ.

Am J Physiol Cell Physiol. 2004 Jul;287(1):C200-8. Epub 2004 Mar 10.PMID: 15013949 [PubMed - indexed for MEDLINE]Related articlesFree article

5' adenosine monophosphate-activated protein kinase, metabolism and exercise.

Aschenbach WG, Sakamoto K, Goodyear LJ.

Sports Med. 2004;34(2):91-103. Review.PMID: 14965188 [PubMed - indexed for MEDLINE]Related articles