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Genetic Variants of the ENPP1/PC-1 Gene Are Associated with Hypertriglyceridemia in Male Subjects.

Tanyolaç S, Bremer AA, Hodoglugil U, Movsesyan I, Pullinger CR, Heiner SW, Malloy MJ, Kane JP, Goldfine ID.

Metab Syndr Relat Disord. 2009 Aug 5. [Epub ahead of print]PMID: 19656007 [PubMed - as supplied by publisher]Related articles

Influence of gender on the relationship between insulin sensitivity, adiposity, and plasma lipids in lean nondiabetic subjects.

Masharani U, Goldfine ID, Youngren JF.

Metabolism. 2009 Nov;58(11):1602-8. Epub 2009 Jul 15.PMID: 19604524 [PubMed - indexed for MEDLINE]Related articles

Design, synthesis, and structure-activity relationships of novel insulin receptor tyrosine kinase activators.

Lum RT, Cheng M, Cristobal CP, Goldfine ID, Evans JL, Keck JG, Macsata RW, Manchem VP, Matsumoto Y, Park SJ, Rao SS, Robinson L, Shi S, Spevak WR, Schow SR.

J Med Chem. 2008 Oct 9;51(19):6173-87. Epub 2008 Sep 13.PMID: 18788731 [PubMed - indexed for MEDLINE]Related articles

Gender differences in the relationship of ENPP1/PC-1 variants to obesity in a Turkish population.

Tanyolaç S, Mahley RW, Hodoglugil U, Goldfine ID.

Obesity (Silver Spring). 2008 Nov;16(11):2468-71. Epub 2008 Aug 21.PMID: 18719658 [PubMed - indexed for MEDLINE]Related articles

Inhibitory effects of nordihydroguaiaretic acid (NDGA) on the IGF-1 receptor and androgen dependent growth of LAPC-4 prostate cancer cells.

Ryan CJ, Zavodovskaya M, Youngren JF, Campbell M, Diamond M, Jones J, Shiry L, Allan G, Maddux BA, Goldfine ID.

Prostate. 2008 Aug 1;68(11):1232-40.PMID: 18491370 [PubMed - indexed for MEDLINE]Related articles

A pilot dose-escalation study of the effects of nordihydroguareacetic acid on hormone and prostate specific antigen levels in patients with relapsed prostate cancer.

Ryan CJ, Harzstark AH, Rosenberg J, Lin A, Claros C, Goldfine ID, Kerner JF, Small EJ, Youngren JF.

BJU Int. 2008 Feb;101(4):436-9. Erratum in: BJU Int. 2008 Jun;101(11):1483. Youngren, Jack F [added]. PMID: 18234062 [PubMed - indexed for MEDLINE]Related articles

Novel approach to treat insulin resistance, type 2 diabetes, and the metabolic syndrome: simultaneous activation of PPARalpha, PPARgamma, and PPARdelta.

Evans JL, Lin JJ, Goldfine ID.

Curr Diabetes Rev. 2005 Aug;1(3):299-307. Review.PMID: 18220606 [PubMed - indexed for MEDLINE]Related articles

The role of membrane glycoprotein plasma cell antigen 1/ectonucleotide pyrophosphatase phosphodiesterase 1 in the pathogenesis of insulin resistance and related abnormalities.

Goldfine ID, Maddux BA, Youngren JF, Reaven G, Accili D, Trischitta V, Vigneri R, Frittitta L.

Endocr Rev. 2008 Feb;29(1):62-75. Epub 2008 Jan 16. Review. Erratum in: Endocr Rev. 2009 Feb;30(1):117. PMID: 18199690 [PubMed - indexed for MEDLINE]Related articlesFree article

Technical evaluation of in vivo abdominal fat and IMCL quantification using MRI and MRSI at 3 T.

Li X, Youngren JF, Hyun B, Sakkas GK, Mulligan K, Majumdar S, Masharani UB, Schambelan M, Goldfine ID.

Magn Reson Imaging. 2008 Feb;26(2):188-97. Epub 2007 Aug 2.PMID: 17683890 [PubMed - indexed for MEDLINE]Related articlesFree article

Nordihydroguaiaretic acid (NDGA), an inhibitor of the HER2 and IGF-1 receptor tyrosine kinases, blocks the growth of HER2-overexpressing human breast cancer cells.

Zavodovskaya M, Campbell MJ, Maddux BA, Shiry L, Allan G, Hodges L, Kushner P, Kerner JA, Youngren JF, Goldfine ID.

J Cell Biochem. 2008 Feb 1;103(2):624-35.PMID: 17562544 [PubMed - indexed for MEDLINE]Related articles

Chromium picolinate and biotin combination improves glucose metabolism in treated, uncontrolled overweight to obese patients with type 2 diabetes.

Albarracin CA, Fuqua BC, Evans JL, Goldfine ID.

Diabetes Metab Res Rev. 2008 Jan-Feb;24(1):41-51.PMID: 17506119 [PubMed - indexed for MEDLINE]Related articles

Nordihydroguaiaretic acid inhibits insulin-like growth factor signaling, growth, and survival in human neuroblastoma cells.

Meyer GE, Chesler L, Liu D, Gable K, Maddux BA, Goldenberg DD, Youngren JF, Goldfine ID, Weiss WA, Matthay KK, Rosenthal SM.

J Cell Biochem. 2007 Dec 15;102(6):1529-41.PMID: 17486636 [PubMed - indexed for MEDLINE]Related articles

Expression of insulin-like growth factor-1 receptor in local and metastatic prostate cancer.

Ryan CJ, Haqq CM, Simko J, Nonaka DF, Chan JM, Weinberg V, Small EJ, Goldfine ID.

Urol Oncol. 2007 Mar-Apr;25(2):134-40.PMID: 17349528 [PubMed - indexed for MEDLINE]Related articles

Parallel synthesis of diarylureas and their evaluation as inhibitors of insulin-like growth factor receptor.

Anderson MO, Yu H, Penaranda C, Maddux BA, Goldfine ID, Youngren JF, Guy RK.

J Comb Chem. 2006 Sep-Oct;8(5):784-90.PMID: 16961415 [PubMed - indexed for MEDLINE]Related articles

IGF-binding protein-1 levels are related to insulin-mediated glucose disposal and are a potential serum marker of insulin resistance.

Maddux BA, Chan A, De Filippis EA, Mandarino LJ, Goldfine ID.

Diabetes Care. 2006 Jul;29(7):1535-7. Erratum in: Diabetes Care. 2006 Nov;29(11):2571. De Filippis, Elena A [added]. PMID: 16801575 [PubMed - indexed for MEDLINE]Related articlesFree article

Diarylureas are small-molecule inhibitors of insulin-like growth factor I receptor signaling and breast cancer cell growth.

Gable KL, Maddux BA, Penaranda C, Zavodovskaya M, Campbell MJ, Lobo M, Robinson L, Schow S, Kerner JA, Goldfine ID, Youngren JF.

Mol Cancer Ther. 2006 Apr;5(4):1079-86.PMID: 16648580 [PubMed - indexed for MEDLINE]Related articlesFree article

Overexpression of the insulin receptor inhibitor PC-1/ENPP1 induces insulin resistance and hyperglycemia.

Maddux BA, Chang YN, Accili D, McGuinness OP, Youngren JF, Goldfine ID.

Am J Physiol Endocrinol Metab. 2006 Apr;290(4):E746-9. Epub 2005 Nov 8.PMID: 16278247 [PubMed - indexed for MEDLINE]Related articlesFree article

Nordihydroguaiaretic acid (NDGA) inhibits the IGF-1 and c-erbB2/HER2/neu receptors and suppresses growth in breast cancer cells.

Youngren JF, Gable K, Penaranda C, Maddux BA, Zavodovskaya M, Lobo M, Campbell M, Kerner J, Goldfine ID.

Breast Cancer Res Treat. 2005 Nov;94(1):37-46.PMID: 16142439 [PubMed - indexed for MEDLINE]Related articles

Variants of ENPP1 are associated with childhood and adult obesity and increase the risk of glucose intolerance and type 2 diabetes.

Meyre D, Bouatia-Naji N, Tounian A, Samson C, Lecoeur C, Vatin V, Ghoussaini M, Wachter C, Hercberg S, Charpentier G, Patsch W, Pattou F, Charles MA, Tounian P, Clément K, Jouret B, Weill J, Maddux BA, Goldfine ID, Walley A, Boutin P, Dina C, Froguel P.

Nat Genet. 2005 Aug;37(8):863-7. Epub 2005 Jul 17.PMID: 16025115 [PubMed - indexed for MEDLINE]Related articlesFree article

The molecular basis for oxidative stress-induced insulin resistance.

Evans JL, Maddux BA, Goldfine ID.

Antioxid Redox Signal. 2005 Jul-Aug;7(7-8):1040-52. Review.PMID: 15998259 [PubMed - indexed for MEDLINE]Related articles

Analysis of insulin-stimulated insulin receptor activation and glucose transport in cultured skeletal muscle cells from obese subjects.

Pender C, Goldfine ID, Kulp JL, Tanner CJ, Maddux BA, MacDonald KG, Houmard JA, Youngren JF.

Metabolism. 2005 May;54(5):598-603.PMID: 15877289 [PubMed - indexed for MEDLINE]Related articles

Insulin and hybrid insulin/IGF receptors are major regulators of breast cancer cells.

Frasca F, Pandini G, Vigneri R, Goldfine ID.

Breast Dis. 2003;17:73-89.PMID: 15687679 [PubMed]Related articles

Increased hepatic levels of the insulin receptor inhibitor, PC-1/NPP1, induce insulin resistance and glucose intolerance.

Dong H, Maddux BA, Altomonte J, Meseck M, Accili D, Terkeltaub R, Johnson K, Youngren JF, Goldfine ID.

Diabetes. 2005 Feb;54(2):367-72.PMID: 15677494 [PubMed - indexed for MEDLINE]Related articlesFree article

Effective treatments for insulin resistance: trim the fat and douse the fire.

Evans JL, Youngren JF, Goldfine ID.

Trends Endocrinol Metab. 2004 Nov;15(9):425-31. Review.PMID: 15519889 [PubMed - indexed for MEDLINE]Related articles

In vitro and in vivo prevention of HIV protease inhibitor-induced insulin resistance by a novel small molecule insulin receptor activator.

Cheng M, Chen S, Schow SR, Manchem VP, Spevak WR, Cristobal CP, Shi S, Macsata RW, Lum RT, Goldfine ID, Keck JG.

J Cell Biochem. 2004 Aug 15;92(6):1234-45.PMID: 15258906 [PubMed - indexed for MEDLINE]Related articles

Muscle insulin receptor concentrations in obese patients post bariatric surgery: relationship to hyperinsulinemia.

Pender C, Goldfine ID, Tanner CJ, Pories WJ, MacDonald KG, Havel PJ, Houmard JA, Youngren JF.

Int J Obes Relat Metab Disord. 2004 Mar;28(3):363-9.PMID: 14724657 [PubMed - indexed for MEDLINE]Related articles

Inadvertent sulfonylurea overdosage and hypoglycemia in an elderly woman: failure of serum hypoglycemia screening.

Earle KE, Rushakoff RJ, Goldfine ID.

Diabetes Technol Ther. 2003;5(3):449-51.PMID: 12828829 [PubMed - indexed for MEDLINE]Related articles

Are oxidative stress-activated signaling pathways mediators of insulin resistance and beta-cell dysfunction?

Evans JL, Goldfine ID, Maddux BA, Grodsky GM.

Diabetes. 2003 Jan;52(1):1-8. Review.PMID: 12502486 [PubMed - indexed for MEDLINE]Related articlesFree article

Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes.

Evans JL, Goldfine ID, Maddux BA, Grodsky GM.

Endocr Rev. 2002 Oct;23(5):599-622. Review.PMID: 12372842 [PubMed - indexed for MEDLINE]Related articlesFree article

Decreased insulin receptor (IR) autophosphorylation in fibroblasts from patients with PCOS: effects of serine kinase inhibitors and IR activators.

Li M, Youngren JF, Dunaif A, Goldfine ID, Maddux BA, Zhang BB, Evans JL.

J Clin Endocrinol Metab. 2002 Sep;87(9):4088-93.PMID: 12213853 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of insulin receptor function by a small molecule insulin receptor activator.

Pender C, Goldfine ID, Manchem VP, Evans JL, Spevak WR, Shi S, Rao S, Bajjalieh S, Maddux BA, Youngren JF.

J Biol Chem. 2002 Nov 15;277(46):43565-71. Epub 2002 Sep 3.PMID: 12213804 [PubMed - indexed for MEDLINE]Related articlesFree article

Pharmacokinetics, tolerability, and fructosamine-lowering effect of a novel, controlled-release formulation of alpha-lipoic acid.

Evans JL, Heymann CJ, Goldfine ID, Gavin LA.

Endocr Pract. 2002 Jan-Feb;8(1):29-35.PMID: 11951812 [PubMed - indexed for MEDLINE]Related articles

Elevated plasma cell membrane glycoprotein levels and diminished insulin receptor autophosphorylation in obese, insulin-resistant rhesus monkeys.

Pender C, Ortmeyer HK, Hansen BC, Goldfine ID, Youngren JF.

Metabolism. 2002 Apr;51(4):465-70.PMID: 11912555 [PubMed - indexed for MEDLINE]Related articles

Small molecule insulin receptor activators potentiate insulin action in insulin-resistant cells.

Li M, Youngren JF, Manchem VP, Kozlowski M, Zhang BB, Maddux BA, Goldfine ID.

Diabetes. 2001 Oct;50(10):2323-8.PMID: 11574415 [PubMed - indexed for MEDLINE]Related articlesFree article

Alpha-lipoic acid: a multifunctional antioxidant that improves insulin sensitivity in patients with type 2 diabetes.

Evans JL, Goldfine ID.

Diabetes Technol Ther. 2000 Autumn;2(3):401-13. Review.PMID: 11467343 [PubMed - indexed for MEDLINE]Related articles

A novel small molecule that directly sensitizes the insulin receptor in vitro and in vivo.

Manchem VP, Goldfine ID, Kohanski RA, Cristobal CP, Lum RT, Schow SR, Shi S, Spevak WR, Laborde E, Toavs DK, Villar HO, Wick MM, Kozlowski MR.

Diabetes. 2001 Apr;50(4):824-30.PMID: 11289048 [PubMed - indexed for MEDLINE]Related articlesFree article

Protection against oxidative stress-induced insulin resistance in rat L6 muscle cells by mircomolar concentrations of alpha-lipoic acid.

Maddux BA, See W, Lawrence JC Jr, Goldfine AL, Goldfine ID, Evans JL.

Diabetes. 2001 Feb;50(2):404-10.PMID: 11272154 [PubMed - indexed for MEDLINE]Related articlesFree article

Enhanced muscle insulin receptor autophosphorylation with short-term aerobic exercise training.

Youngren JF, Keen S, Kulp JL, Tanner CJ, Houmard JA, Goldfine ID.

Am J Physiol Endocrinol Metab. 2001 Mar;280(3):E528-33.PMID: 11171609 [PubMed - indexed for MEDLINE]Related articlesFree article

Transcriptional regulation of human insulin receptor gene by the high-mobility group protein HMGI(Y).

Brunetti A, Manfioletti G, Chiefari E, Goldfine ID, Foti D.

FASEB J. 2001 Feb;15(2):492-500. Erratum in: FASEB J 2001 Apr;15(6):1115. PMID: 11156965 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of PC-1 in the etiology of insulin resistance.

Goldfine ID, Maddux BA, Youngren JF, Trischitta V, Frittitta L.

Ann N Y Acad Sci. 1999 Nov 18;892:204-22. Review.PMID: 10842664 [PubMed - indexed for MEDLINE]Related articles

Membrane glycoprotein PC-1 inhibition of insulin receptor function occurs via direct interaction with the receptor alpha-subunit.

Maddux BA, Goldfine ID.

Diabetes. 2000 Jan;49(1):13-9.PMID: 10615944 [PubMed - indexed for MEDLINE]Related articlesFree article

A polymorphism (K121Q) of the human glycoprotein PC-1 gene coding region is strongly associated with insulin resistance.

Pizzuti A, Frittitta L, Argiolas A, Baratta R, Goldfine ID, Bozzali M, Ercolino T, Scarlato G, Iacoviello L, Vigneri R, Tassi V, Trischitta V.

Diabetes. 1999 Sep;48(9):1881-4.PMID: 10480624 [PubMed - indexed for MEDLINE]Related articlesFree article

Unraveling the riddle of insulin resistance.

Goldfine ID.

J Lab Clin Med. 1999 Aug;134(2):100-2. No abstract available. PMID: 10444021 [PubMed - indexed for MEDLINE]Related articles

Insulin and insulin-like growth factor-I (IGF-I) receptor overexpression in breast cancers leads to insulin/IGF-I hybrid receptor overexpression: evidence for a second mechanism of IGF-I signaling.

Pandini G, Vigneri R, Costantino A, Frasca F, Ippolito A, Fujita-Yamaguchi Y, Siddle K, Goldfine ID, Belfiore A.

Clin Cancer Res. 1999 Jul;5(7):1935-44.PMID: 10430101 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin receptor autophosphorylation in cultured myoblasts correlates to glucose disposal in Pima Indians.

Youngren JF, Goldfine ID, Pratley RE.

Am J Physiol. 1999 May;276(5 Pt 1):E990-4.PMID: 10329994 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin receptor activation by IGF-II in breast cancers: evidence for a new autocrine/paracrine mechanism.

Sciacca L, Costantino A, Pandini G, Mineo R, Frasca F, Scalia P, Sbraccia P, Goldfine ID, Vigneri R, Belfiore A.

Oncogene. 1999 Apr 15;18(15):2471-9.PMID: 10229198 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin receptor isoform A, a newly recognized, high-affinity insulin-like growth factor II receptor in fetal and cancer cells.

Frasca F, Pandini G, Scalia P, Sciacca L, Mineo R, Costantino A, Goldfine ID, Belfiore A, Vigneri R.

Mol Cell Biol. 1999 May;19(5):3278-88.PMID: 10207053 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin-stimulated cell growth in insulin receptor substrate-1-deficient ZR-75-1 cells is mediated by a phosphatidylinositol-3-kinase-independent pathway.

Gliozzo B, Sung CK, Scalia P, Papa V, Frasca F, Sciacca L, Giorgino F, Milazzo G, Goldfine ID, Vigneri R, Pezzino V.

J Cell Biochem. 1998 Aug 1;70(2):268-80.PMID: 9671232 [PubMed - indexed for MEDLINE]Related articles

Elevated PC-1 content in cultured skin fibroblasts correlates with decreased in vivo and in vitro insulin action in nondiabetic subjects: evidence that PC-1 may be an intrinsic factor in impaired insulin receptor signaling.

Frittitta L, Spampinato D, Solini A, Nosadini R, Goldfine ID, Vigneri R, Trischitta V.

Diabetes. 1998 Jul;47(7):1095-100.PMID: 9648833 [PubMed - indexed for MEDLINE]Related articlesFree article

Membrane glycoprotein PC-1 and insulin resistance.

Goldfine ID, Maddux BA, Youngren JF, Frittitta L, Trischitta V, Dohm GL.

Mol Cell Biochem. 1998 May;182(1-2):177-84. Review.PMID: 9609127 [PubMed - indexed for MEDLINE]Related articles