PubMed

Slit2-Robo4 signalling promotes vascular stability by blocking Arf6 activity.

Jones CA, Nishiya N, London NR, Zhu W, Sorensen LK, Chan AC, Lim CJ, Chen H, Zhang Q, Schultz PG, Hayallah AM, Thomas KR, Famulok M, Zhang K, Ginsberg MH, Li DY.

Nat Cell Biol. 2009 Nov;11(11):1325-31. Epub 2009 Oct 18.PMID: 19855388 [PubMed - indexed for MEDLINE]Related articles

{beta} integrin tyrosine phosphorylation is a conserved mechanism for regulating talin-induced integrin activation.

Anthis NJ, Haling JR, Oxley CL, Memo M, Wegener KL, Lim CJ, Ginsberg MH, Campbell ID.

J Biol Chem. 2009 Oct 20. [Epub ahead of print]PMID: 19843520 [PubMed - as supplied by publisher]Related articlesFree article

Dependence of proliferative vascular smooth muscle cells on CD98hc (4F2hc, SLC3A2).

Fogelstrand P, Féral CC, Zargham R, Ginsberg MH.

J Exp Med. 2009 Oct 26;206(11):2397-406. Epub 2009 Oct 19.PMID: 19841087 [PubMed - indexed for MEDLINE]Related articles

The structure of an integrin/talin complex reveals the basis of inside-out signal transduction.

Anthis NJ, Wegener KL, Ye F, Kim C, Goult BT, Lowe ED, Vakonakis I, Bate N, Critchley DR, Ginsberg MH, Campbell ID.

EMBO J. 2009 Nov 18;28(22):3623-32. Epub 2009 Oct 1.PMID: 19798053 [PubMed - in process]Related articles

Talin phosphorylation by Cdk5 regulates Smurf1-mediated talin head ubiquitylation and cell migration.

Huang C, Rajfur Z, Yousefi N, Chen Z, Jacobson K, Ginsberg MH.

Nat Cell Biol. 2009 May;11(5):624-30. Epub 2009 Apr 12.PMID: 19363486 [PubMed - indexed for MEDLINE]Related articlesFree article

An easy to assemble microfluidic perfusion device with a magnetic clamp.

Tkachenko E, Gutierrez E, Ginsberg MH, Groisman A.

Lab Chip. 2009 Apr 21;9(8):1085-95. Epub 2009 Feb 6.PMID: 19350090 [PubMed - indexed for MEDLINE]Related articlesFree article

The structure of the integrin alphaIIbbeta3 transmembrane complex explains integrin transmembrane signalling.

Lau TL, Kim C, Ginsberg MH, Ulmer TS.

EMBO J. 2009 May 6;28(9):1351-61. Epub 2009 Mar 12.PMID: 19279667 [PubMed - indexed for MEDLINE]Related articles

CD98hc facilitates B cell proliferation and adaptive humoral immunity.

Cantor J, Browne CD, Ruppert R, Féral CC, Fässler R, Rickert RC, Ginsberg MH.

Nat Immunol. 2009 Apr;10(4):412-9. Epub 2009 Mar 8.PMID: 19270713 [PubMed - indexed for MEDLINE]Related articlesFree article

Interactions of platelet integrin alphaIIb and beta3 transmembrane domains in mammalian cell membranes and their role in integrin activation.

Kim C, Lau TL, Ulmer TS, Ginsberg MH.

Blood. 2009 May 7;113(19):4747-53. Epub 2009 Feb 13.PMID: 19218549 [PubMed - indexed for MEDLINE]Related articles

Structural determinants of integrin binding to the talin rod.

Gingras AR, Ziegler WH, Bobkov AA, Joyce MG, Fasci D, Himmel M, Rothemund S, Ritter A, Grossmann JG, Patel B, Bate N, Goult BT, Emsley J, Barsukov IL, Roberts GC, Liddington RC, Ginsberg MH, Critchley DR.

J Biol Chem. 2009 Mar 27;284(13):8866-76. Epub 2009 Jan 27.PMID: 19176533 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of cardiovascular development and integrity by the heart of glass-cerebral cavernous malformation protein pathway.

Kleaveland B, Zheng X, Liu JJ, Blum Y, Tung JJ, Zou Z, Sweeney SM, Chen M, Guo L, Lu MM, Zhou D, Kitajewski J, Affolter M, Ginsberg MH, Kahn ML.

Nat Med. 2009 Feb;15(2):169-76. Epub 2009 Jan 18. Erratum in: Nat Med. 2009 May;15(5):584. Sweeney, Shawn M [added]. PMID: 19151727 [PubMed - indexed for MEDLINE]Related articlesFree article

RIAM activates integrins by linking talin to ras GTPase membrane-targeting sequences.

Lee HS, Lim CJ, Puzon-McLaughlin W, Shattil SJ, Ginsberg MH.

J Biol Chem. 2009 Feb 20;284(8):5119-27. Epub 2008 Dec 19.PMID: 19098287 [PubMed - indexed for MEDLINE]Related articles

Antithrombotic effects of targeting alphaIIbbeta3 signaling in platelets.

Ablooglu AJ, Kang J, Petrich BG, Ginsberg MH, Shattil SJ.

Blood. 2009 Apr 9;113(15):3585-92. Epub 2008 Nov 12.PMID: 19005179 [PubMed - indexed for MEDLINE]Related articles

Microfluidic devices for studies of shear-dependent platelet adhesion.

Gutierrez E, Petrich BG, Shattil SJ, Ginsberg MH, Groisman A, Kasirer-Friede A.

Lab Chip. 2008 Sep;8(9):1486-95. Epub 2008 Jul 23.PMID: 18818803 [PubMed - indexed for MEDLINE]Related articlesFree article

UV-C irradiation disrupts platelet surface disulfide bonds and activates the platelet integrin alphaIIbbeta3.

Verhaar R, Dekkers DW, De Cuyper IM, Ginsberg MH, de Korte D, Verhoeven AJ.

Blood. 2008 Dec 15;112(13):4935-9. Epub 2008 Sep 16. Erratum in: Blood. 2009 Aug 6;114(6):1281. PMID: 18796633 [PubMed - indexed for MEDLINE]Related articles

Integrin-mediated protein kinase A activation at the leading edge of migrating cells.

Lim CJ, Kain KH, Tkachenko E, Goldfinger LE, Gutierrez E, Allen MD, Groisman A, Zhang J, Ginsberg MH.

Mol Biol Cell. 2008 Nov;19(11):4930-41. Epub 2008 Sep 10.PMID: 18784251 [PubMed - indexed for MEDLINE]Related articlesFree article

Cell-to-cell contact and extracellular matrix.

Ginsberg MH, Schwarzbauer JE.

Curr Opin Cell Biol. 2008 Oct;20(5):492-4. Epub 2008 Aug 3. No abstract available. PMID: 18656543 [PubMed - indexed for MEDLINE]Related articles

Integrin-associated proteins as potential therapeutic targets.

Cantor JM, Ginsberg MH, Rose DM.

Immunol Rev. 2008 Jun;223:236-51. Review.PMID: 18613840 [PubMed - indexed for MEDLINE]Related articles

Localized alpha4 integrin phosphorylation directs shear stress-induced endothelial cell alignment.

Goldfinger LE, Tzima E, Stockton R, Kiosses WB, Kinbara K, Tkachenko E, Gutierrez E, Groisman A, Nguyen P, Chien S, Ginsberg MH.

Circ Res. 2008 Jul 18;103(2):177-85. Epub 2008 Jun 26.PMID: 18583710 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanisms and consequences of agonist-induced talin recruitment to platelet integrin alphaIIbbeta3.

Watanabe N, Bodin L, Pandey M, Krause M, Coughlin S, Boussiotis VA, Ginsberg MH, Shattil SJ.

J Cell Biol. 2008 Jun 30;181(7):1211-22. Epub 2008 Jun 23.PMID: 18573917 [PubMed - indexed for MEDLINE]Related articlesFree article

Differences in regulation of Drosophila and vertebrate integrin affinity by talin.

Helsten TL, Bunch TA, Kato H, Yamanouchi J, Choi SH, Jannuzi AL, Féral CC, Ginsberg MH, Brower DL, Shattil SJ.

Mol Biol Cell. 2008 Aug;19(8):3589-98. Epub 2008 May 28.PMID: 18508915 [PubMed - indexed for MEDLINE]Related articlesFree article

Blockade of alpha4 integrin signaling ameliorates the metabolic consequences of high-fat diet-induced obesity.

Féral CC, Neels JG, Kummer C, Slepak M, Olefsky JM, Ginsberg MH.

Diabetes. 2008 Jul;57(7):1842-51. Epub 2008 Apr 21.PMID: 18426864 [PubMed - indexed for MEDLINE]Related articlesFree article

Integrin activation.

Banno A, Ginsberg MH.

Biochem Soc Trans. 2008 Apr;36(Pt 2):229-34. Review.PMID: 18363565 [PubMed - indexed for MEDLINE]Related articlesFree article

Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability.

Jones CA, London NR, Chen H, Park KW, Sauvaget D, Stockton RA, Wythe JD, Suh W, Larrieu-Lahargue F, Mukouyama YS, Lindblom P, Seth P, Frias A, Nishiya N, Ginsberg MH, Gerhardt H, Zhang K, Li DY.

Nat Med. 2008 Apr;14(4):448-53. Epub 2008 Mar 16. Erratum in: Nat Med. 2008 May;14(5):585. PMID: 18345009 [PubMed - indexed for MEDLINE]Related articles

A small molecule inhibitor of alpha4 integrin-dependent cell migration.

Lee J, Hong J, Nam TG, Peters EC, Orth AP, Geierstanger BH, Goldfinger LE, Ginsberg MH, Cho CY, Schultz PG.

Bioorg Med Chem. 2009 Feb 1;17(3):977-80. Epub 2008 Feb 26.PMID: 18329275 [PubMed - indexed for MEDLINE]Related articles

Structure of the integrin beta3 transmembrane segment in phospholipid bicelles and detergent micelles.

Lau TL, Partridge AW, Ginsberg MH, Ulmer TS.

Biochemistry. 2008 Apr 1;47(13):4008-16. Epub 2008 Mar 6.PMID: 18321071 [PubMed - indexed for MEDLINE]Related articles

Talin is required for integrin-mediated platelet function in hemostasis and thrombosis.

Petrich BG, Marchese P, Ruggeri ZM, Spiess S, Weichert RA, Ye F, Tiedt R, Skoda RC, Monkley SJ, Critchley DR, Ginsberg MH.

J Exp Med. 2007 Dec 24;204(13):3103-11. Epub 2007 Dec 17.PMID: 18086863 [PubMed - indexed for MEDLINE]Related articlesFree article

KRIT-1/CCM1 is a Rap1 effector that regulates endothelial cell cell junctions.

Glading A, Han J, Stockton RA, Ginsberg MH.

J Cell Biol. 2007 Oct 22;179(2):247-54.PMID: 17954608 [PubMed - indexed for MEDLINE]Related articlesFree article

CD98hc (SLC3A2) participates in fibronectin matrix assembly by mediating integrin signaling.

Féral CC, Zijlstra A, Tkachenko E, Prager G, Gardel ML, Slepak M, Ginsberg MH.

J Cell Biol. 2007 Aug 13;178(4):701-11. Epub 2007 Aug 6.PMID: 17682053 [PubMed - indexed for MEDLINE]Related articlesFree article

The antithrombotic potential of selective blockade of talin-dependent integrin alpha IIb beta 3 (platelet GPIIb-IIIa) activation.

Petrich BG, Fogelstrand P, Partridge AW, Yousefi N, Ablooglu AJ, Shattil SJ, Ginsberg MH.

J Clin Invest. 2007 Aug;117(8):2250-9.PMID: 17627302 [PubMed - indexed for MEDLINE]Related articlesFree article

Integrin modulation and signaling in leukocyte adhesion and migration.

Rose DM, Alon R, Ginsberg MH.

Immunol Rev. 2007 Aug;218:126-34. Review.PMID: 17624949 [PubMed - indexed for MEDLINE]Related articles

Neurite outgrowth on a fibronectin isoform expressed during peripheral nerve regeneration is mediated by the interaction of paxillin with alpha4beta1 integrins.

Vogelezang M, Forster UB, Han J, Ginsberg MH, ffrench-Constant C.

BMC Neurosci. 2007 Jun 29;8:44.PMID: 17603879 [PubMed - indexed for MEDLINE]Related articlesFree article

CD98hc (SLC3A2) interaction with the integrin beta subunit cytoplasmic domain mediates adhesive signaling.

Prager GW, Féral CC, Kim C, Han J, Ginsberg MH.

J Biol Chem. 2007 Aug 17;282(33):24477-84. Epub 2007 Jun 27.PMID: 17597067 [PubMed - indexed for MEDLINE]Related articlesFree article

Small-molecule synergist of the Wnt/beta-catenin signaling pathway.

Zhang Q, Major MB, Takanashi S, Camp ND, Nishiya N, Peters EC, Ginsberg MH, Jian X, Randazzo PA, Schultz PG, Moon RT, Ding S.

Proc Natl Acad Sci U S A. 2007 May 1;104(18):7444-8. Epub 2007 Apr 25. Erratum in: Proc Natl Acad Sci U S A. 2007 Jul 24;104(30):12581. Jian, Xiaoying [added]; Randazzo, Paul A [added]. PMID: 17460038 [PubMed - indexed for MEDLINE]Related articlesFree article

An experimentally derived database of candidate Ras-interacting proteins.

Goldfinger LE, Ptak C, Jeffery ED, Shabanowitz J, Han J, Haling JR, Sherman NE, Fox JW, Hunt DF, Ginsberg MH.

J Proteome Res. 2007 May;6(5):1806-11. Epub 2007 Apr 17.PMID: 17439166 [PubMed - indexed for MEDLINE]Related articles

Alpha4 integrins are type I cAMP-dependent protein kinase-anchoring proteins.

Lim CJ, Han J, Yousefi N, Ma Y, Amieux PS, McKnight GS, Taylor SS, Ginsberg MH.

Nat Cell Biol. 2007 Apr;9(4):415-21. Epub 2007 Mar 18.PMID: 17369818 [PubMed - indexed for MEDLINE]Related articles

Syk, c-Src, the alphavbeta3 integrin, and ITAM immunoreceptors, in concert, regulate osteoclastic bone resorption.

Zou W, Kitaura H, Reeve J, Long F, Tybulewicz VL, Shattil SJ, Ginsberg MH, Ross FP, Teitelbaum SL.

J Cell Biol. 2007 Mar 12;176(6):877-88.PMID: 17353363 [PubMed - indexed for MEDLINE]Related articlesFree article

PEA-15 inhibits tumor cell invasion by binding to extracellular signal-regulated kinase 1/2.

Glading A, Koziol JA, Krueger J, Ginsberg MH.

Cancer Res. 2007 Feb 15;67(4):1536-44.PMID: 17308092 [PubMed - indexed for MEDLINE]Related articlesFree article

Structural basis of integrin activation by talin.

Wegener KL, Partridge AW, Han J, Pickford AR, Liddington RC, Ginsberg MH, Campbell ID.

Cell. 2007 Jan 12;128(1):171-82.PMID: 17218263 [PubMed - indexed for MEDLINE]Related articles

Reconstructing and deconstructing agonist-induced activation of integrin alphaIIbbeta3.

Han J, Lim CJ, Watanabe N, Soriani A, Ratnikov B, Calderwood DA, Puzon-McLaughlin W, Lafuente EM, Boussiotis VA, Shattil SJ, Ginsberg MH.

Curr Biol. 2006 Sep 19;16(18):1796-806.PMID: 16979556 [PubMed - indexed for MEDLINE]Related articles

RLIP76 (RalBP1) is an R-Ras effector that mediates adhesion-dependent Rac activation and cell migration.

Goldfinger LE, Ptak C, Jeffery ED, Shabanowitz J, Hunt DF, Ginsberg MH.

J Cell Biol. 2006 Sep 11;174(6):877-88.PMID: 16966426 [PubMed - indexed for MEDLINE]Related articlesFree article

Matrix-specific suppression of integrin activation in shear stress signaling.

Orr AW, Ginsberg MH, Shattil SJ, Deckmyn H, Schwartz MA.

Mol Biol Cell. 2006 Nov;17(11):4686-97. Epub 2006 Aug 23.PMID: 16928957 [PubMed - indexed for MEDLINE]Related articlesFree article

Phospholipase C epsilon suppresses integrin activation.

Lad Y, McHugh B, Hodkinson PS, Mackinnon AC, Haslett C, Ginsberg MH, Sethi T.

J Biol Chem. 2006 Oct 6;281(40):29501-12. Epub 2006 Aug 8.PMID: 16895916 [PubMed - indexed for MEDLINE]Related articlesFree article

New approaches to blockade of alpha4-integrins, proven therapeutic targets in chronic inflammation.

Kummer C, Ginsberg MH.

Biochem Pharmacol. 2006 Nov 30;72(11):1460-8. Epub 2006 Jul 25. Review.PMID: 16870156 [PubMed - indexed for MEDLINE]Related articles

Blocking the alpha 4 integrin-paxillin interaction selectively impairs mononuclear leukocyte recruitment to an inflammatory site.

Féral CC, Rose DM, Han J, Fox N, Silverman GJ, Kaushansky K, Ginsberg MH.

J Clin Invest. 2006 Mar;116(3):715-23. Epub 2006 Feb 9.PMID: 16470243 [PubMed - indexed for MEDLINE]Related articlesFree article

Alpha4beta1-dependent adhesion strengthening under mechanical strain is regulated by paxillin association with the alpha4-cytoplasmic domain.

Alon R, Feigelson SW, Manevich E, Rose DM, Schmitz J, Overby DR, Winter E, Grabovsky V, Shinder V, Matthews BD, Sokolovsky-Eisenberg M, Ingber DE, Benoit M, Ginsberg MH.

J Cell Biol. 2005 Dec 19;171(6):1073-84.PMID: 16365170 [PubMed - indexed for MEDLINE]Related articlesFree article

Talin phosphorylation sites mapped by mass spectrometry.

Ratnikov B, Ptak C, Han J, Shabanowitz J, Hunt DF, Ginsberg MH.

J Cell Sci. 2005 Nov 1;118(Pt 21):4921-3. No abstract available. PMID: 16254238 [PubMed - indexed for MEDLINE]Related articlesFree article

Integrin alpha4beta1 promotes focal adhesion kinase-independent cell motility via alpha4 cytoplasmic domain-specific activation of c-Src.

Hsia DA, Lim ST, Bernard-Trifilo JA, Mitra SK, Tanaka S, den Hertog J, Streblow DN, Ilic D, Ginsberg MH, Schlaepfer DD.

Mol Cell Biol. 2005 Nov;25(21):9700-12.PMID: 16227616 [PubMed - indexed for MEDLINE]Related articlesFree article

Antitumor effect of E1A in ovarian cancer by cytoplasmic sequestration of activated ERK by PEA15.

Bartholomeusz C, Itamochi H, Nitta M, Saya H, Ginsberg MH, Ueno NT.

Oncogene. 2006 Jan 5;25(1):79-90.PMID: 16170361 [PubMed - indexed for MEDLINE]Related articles

Integrin activation by talin.

Ratnikov BI, Partridge AW, Ginsberg MH.

J Thromb Haemost. 2005 Aug;3(8):1783-90. Review.PMID: 16102045 [PubMed - indexed for MEDLINE]Related articles