PubMed

Insulin crystallization depends on zinc transporter ZnT8 expression, but is not required for normal glucose homeostasis in mice.

Lemaire K, Ravier MA, Schraenen A, Creemers JW, Van de Plas R, Granvik M, Van Lommel L, Waelkens E, Chimienti F, Rutter GA, Gilon P, in't Veld PA, Schuit FC.

Proc Natl Acad Sci U S A. 2009 Sep 1;106(35):14872-7. Epub 2009 Aug 18.PMID: 19706465 [PubMed - indexed for MEDLINE]Related articles

NALCN: a regulated leak channel.

Gilon P, Rorsman P.

EMBO Rep. 2009 Sep;10(9):963-4. Epub 2009 Aug 7. No abstract available. PMID: 19662077 [PubMed - indexed for MEDLINE]Related articles

Glucose and pharmacological modulators of ATP-sensitive K+ channels control [Ca2+]c by different mechanisms in isolated mouse alpha-cells.

Quoix N, Cheng-Xue R, Mattart L, Zeinoun Z, Guiot Y, Beauvois MC, Henquin JC, Gilon P.

Diabetes. 2009 Feb;58(2):412-21. Epub 2008 Nov 13.PMID: 19008345 [PubMed - indexed for MEDLINE]Related articlesFree article

The GluCre-ROSA26EYFP mouse: a new model for easy identification of living pancreatic alpha-cells.

Quoix N, Cheng-Xue R, Guiot Y, Herrera PL, Henquin JC, Gilon P.

FEBS Lett. 2007 Sep 4;581(22):4235-40. Epub 2007 Aug 7.PMID: 17706201 [PubMed - indexed for MEDLINE]Related articles

Glucose acutely decreases pH of secretory granules in mouse pancreatic islets. Mechanisms and influence on insulin secretion.

Stiernet P, Guiot Y, Gilon P, Henquin JC.

J Biol Chem. 2006 Aug 4;281(31):22142-51. Epub 2006 Jun 7.PMID: 16760469 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose-induced mixed [Ca2+]c oscillations in mouse beta-cells are controlled by the membrane potential and the SERCA3 Ca2+-ATPase of the endoplasmic reticulum.

Beauvois MC, Merezak C, Jonas JC, Ravier MA, Henquin JC, Gilon P.

Am J Physiol Cell Physiol. 2006 Jun;290(6):C1503-11. Epub 2005 Dec 28.PMID: 16381799 [PubMed - indexed for MEDLINE]Related articlesFree article

Atypical Ca2+-induced Ca2+ release from a sarco-endoplasmic reticulum Ca2+-ATPase 3-dependent Ca2+ pool in mouse pancreatic beta-cells.

Beauvois MC, Arredouani A, Jonas JC, Rolland JF, Schuit F, Henquin JC, Gilon P.

J Physiol. 2004 Aug 15;559(Pt 1):141-56. Epub 2004 Jun 24.PMID: 15218077 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased glucose sensitivity of both triggering and amplifying pathways of insulin secretion in rat islets cultured for 1 wk in high glucose.

Khaldi MZ, Guiot Y, Gilon P, Henquin JC, Jonas JC.

Am J Physiol Endocrinol Metab. 2004 Aug;287(2):E207-17. Epub 2004 Apr 20.PMID: 15100093 [PubMed - indexed for MEDLINE]Related articlesFree article

Hierarchy of the beta-cell signals controlling insulin secretion.

Henquin JC, Ravier MA, Nenquin M, Jonas JC, Gilon P.

Eur J Clin Invest. 2003 Sep;33(9):742-50. Review. No abstract available. PMID: 12925032 [PubMed - indexed for MEDLINE]Related articles

SERCA3 ablation does not impair insulin secretion but suggests distinct roles of different sarcoendoplasmic reticulum Ca(2+) pumps for Ca(2+) homeostasis in pancreatic beta-cells.

Arredouani A, Guiot Y, Jonas JC, Liu LH, Nenquin M, Pertusa JA, Rahier J, Rolland JF, Shull GE, Stevens M, Wuytack F, Henquin JC, Gilon P.

Diabetes. 2002 Nov;51(11):3245-53.PMID: 12401716 [PubMed - indexed for MEDLINE]Related articlesFree article

G protein-independent activation of an inward Na(+) current by muscarinic receptors in mouse pancreatic beta-cells.

Rolland JF, Henquin JC, Gilon P.

J Biol Chem. 2002 Oct 11;277(41):38373-80. Epub 2002 Aug 2.PMID: 12161432 [PubMed - indexed for MEDLINE]Related articlesFree article

Contribution of the endoplasmic reticulum to the glucose-induced [Ca(2+)](c) response in mouse pancreatic islets.

Arredouani A, Henquin JC, Gilon P.

Am J Physiol Endocrinol Metab. 2002 May;282(5):E982-91.PMID: 11934662 [PubMed - indexed for MEDLINE]Related articlesFree article

Control mechanisms of the oscillations of insulin secretion in vitro and in vivo.

Gilon P, Ravier MA, Jonas JC, Henquin JC.

Diabetes. 2002 Feb;51 Suppl 1:S144-51. Review.PMID: 11815474 [PubMed - indexed for MEDLINE]Related articlesFree article

Feedback control of the ATP-sensitive K(+) current by cytosolic Ca(2+) contributes to oscillations of the membrane potential in pancreatic beta-cells.

Rolland JF, Henquin JC, Gilon P.

Diabetes. 2002 Feb;51(2):376-84.PMID: 11812744 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanisms and physiological significance of the cholinergic control of pancreatic beta-cell function.

Gilon P, Henquin JC.

Endocr Rev. 2001 Oct;22(5):565-604. Review.PMID: 11588141 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of protein synthesis sequentially impairs distinct steps of stimulus-secretion coupling in pancreatic beta cells.

Garcia-Barrado MJ, Ravier MA, Rolland JF, Gilon P, Nenquin M, Henquin JC.

Endocrinology. 2001 Jan;142(1):299-307.PMID: 11145593 [PubMed - indexed for MEDLINE]Related articlesFree article

Oscillations of insulin secretion can be triggered by imposed oscillations of cytoplasmic Ca2+ or metabolism in normal mouse islets.

Ravier MA, Gilon P, Henquin JC.

Diabetes. 1999 Dec;48(12):2374-82.PMID: 10580426 [PubMed - indexed for MEDLINE]Related articlesFree article

Influence of cell number on the characteristics and synchrony of Ca2+ oscillations in clusters of mouse pancreatic islet cells.

Jonkers FC, Jonas JC, Gilon P, Henquin JC.

J Physiol. 1999 Nov 1;520 Pt 3:839-49.PMID: 10545148 [PubMed - indexed for MEDLINE]Related articlesFree article

Multiple sites of purinergic control of insulin secretion in mouse pancreatic beta-cells.

Poulsen CR, Bokvist K, Olsen HL, Høy M, Capito K, Gilon P, Gromada J.

Diabetes. 1999 Nov;48(11):2171-81.PMID: 10535451 [PubMed - indexed for MEDLINE]Related articlesFree article

Altered cAMP and Ca2+ signaling in mouse pancreatic islets with glucagon-like peptide-1 receptor null phenotype.

Flamez D, Gilon P, Moens K, Van Breusegem A, Delmeire D, Scrocchi LA, Henquin JC, Drucker DJ, Schuit F.

Diabetes. 1999 Oct;48(10):1979-86.PMID: 10512362 [PubMed - indexed for MEDLINE]Related articlesFree article

Alterations of insulin secretion from mouse islets treated with sulphonylureas: perturbations of Ca2+ regulation prevail over changes in insulin content.

Anello M, Gilon P, Henquin JC.

Br J Pharmacol. 1999 Aug;127(8):1883-91.PMID: 10482920 [PubMed - indexed for MEDLINE]Related articlesFree article

Uptake and release of Ca2+ by the endoplasmic reticulum contribute to the oscillations of the cytosolic Ca2+ concentration triggered by Ca2+ influx in the electrically excitable pancreatic B-cell.

Gilon P, Arredouani A, Gailly P, Gromada J, Henquin JC.

J Biol Chem. 1999 Jul 16;274(29):20197-205.PMID: 10400636 [PubMed - indexed for MEDLINE]Related articlesFree article

Temporal and quantitative correlations between insulin secretion and stably elevated or oscillatory cytoplasmic Ca2+ in mouse pancreatic beta-cells.

Jonas JC, Gilon P, Henquin JC.

Diabetes. 1998 Aug;47(8):1266-73.PMID: 9703327 [PubMed - indexed for MEDLINE]Related articlesFree article

Interplay between cytoplasmic Ca2+ and the ATP/ADP ratio: a feedback control mechanism in mouse pancreatic islets.

Detimary P, Gilon P, Henquin JC.

Biochem J. 1998 Jul 15;333 ( Pt 2):269-74.PMID: 9657965 [PubMed - indexed for MEDLINE]Related articlesFree article

Functional significance of Ca2+ oscillations in pancreatic beta cells.

Henquin JC, Jonas JC, Gilon P.

Diabetes Metab. 1998 Feb;24(1):30-6. Review.PMID: 9534006 [PubMed - indexed for MEDLINE]Related articlesFree article

Tolbutamide and diazoxide influence insulin secretion by changing the concentration but not the action of cytoplasmic Ca2+ in beta-cells.

Mariot P, Gilon P, Nenquin M, Henquin JC.

Diabetes. 1998 Mar;47(3):365-73.PMID: 9519741 [PubMed - indexed for MEDLINE]Related articlesFree article

Okadaic acid-induced decrease in the magnitude and efficacy of the Ca2+ signal in pancreatic beta cells and inhibition of insulin secretion.

Sato Y, Mariot P, Detimary P, Gilon P, Henquin JC.

Br J Pharmacol. 1998 Jan;123(1):97-105.PMID: 9484859 [PubMed - indexed for MEDLINE]Related articlesFree article

Emptying of intracellular Ca2+ stores stimulates Ca2+ entry in mouse pancreatic beta-cells by both direct and indirect mechanisms.

Miura Y, Henquin JC, Gilon P.

J Physiol. 1997 Sep 1;503 ( Pt 2):387-98.PMID: 9306280 [PubMed - indexed for MEDLINE]Related articlesFree article

G protein-dependent inhibition of L-type Ca2+ currents by acetylcholine in mouse pancreatic B-cells.

Gilon P, Yakel J, Gromada J, Zhu Y, Henquin JC, Rorsman P.

J Physiol. 1997 Feb 15;499 ( Pt 1):65-76.PMID: 9061640 [PubMed - indexed for MEDLINE]Related articlesFree article

Direct glucocorticoid inhibition of insulin secretion. An in vitro study of dexamethasone effects in mouse islets.

Lambillotte C, Gilon P, Henquin JC.

J Clin Invest. 1997 Feb 1;99(3):414-23.PMID: 9022074 [PubMed - indexed for MEDLINE]Related articlesFree article

No evidence for a role of reverse Na(+)-Ca2+ exchange in insulin release from mouse pancreatic islets.

Garcia-Barrado MJ, Gilon P, Sato Y, Nenquin M, Henquin JC.

Am J Physiol. 1996 Sep;271(3 Pt 1):E426-33.PMID: 8843734 [PubMed - indexed for MEDLINE]Related articles

Muscarinic stimulation increases Na+ entry in pancreatic B-cells by a mechanism other than the emptying of intracellular Ca2+ pools.

Miura Y, Gilon P, Henquin JC.

Biochem Biophys Res Commun. 1996 Jul 5;224(1):67-73.PMID: 8694835 [PubMed - indexed for MEDLINE]Related articles

Sulphonylureas do not increase insulin secretion by a mechanism other than a rise in cytoplasmic Ca2+ in pancreatic B-cells.

Garcia-Barrado MJ, Jonas JC, Gilon P, Henquin JC.

Eur J Pharmacol. 1996 Mar 18;298(3):279-86.PMID: 8846827 [PubMed - indexed for MEDLINE]Related articles

Ketoisocaproic acid and leucine increase cytoplasmic pH in mouse pancreatic B cells: role of cytoplasmic Ca2+ and pH-regulating exchangers.

Shepherd RM, Gilon P, Henquin JC.

Endocrinology. 1996 Feb;137(2):677-85.PMID: 8593817 [PubMed - indexed for MEDLINE]Related articles

Distinct effects of glucose on the synchronous oscillations of insulin release and cytoplasmic Ca2+ concentration measured simultaneously in single mouse islets.

Gilon P, Henquin JC.

Endocrinology. 1995 Dec;136(12):5725-30.PMID: 7588329 [PubMed - indexed for MEDLINE]Related articles

Role of cyclic GMP in the control of capacitative Ca2+ entry in rat pancreatic acinar cells.

Gilon P, Obie JF, Bian X, Bird GS, Putney JW Jr.

Biochem J. 1995 Oct 15;311 ( Pt 2):649-56.PMID: 7487909 [PubMed - indexed for MEDLINE]Related articlesFree article

Muscarinic stimulation exerts both stimulatory and inhibitory effects on the concentration of cytoplasmic Ca2+ in the electrically excitable pancreatic B-cell.

Gilon P, Nenquin M, Henquin JC.

Biochem J. 1995 Oct 1;311 ( Pt 1):259-67.PMID: 7575463 [PubMed - indexed for MEDLINE]Related articlesFree article

The Ca(2+)-mobilizing actions of a Jurkat cell extract on mammalian cells and Xenopus laevis oocytes.

Gilon P, Bird GJ, Bian X, Yakel JL, Putney JW Jr.

J Biol Chem. 1995 Apr 7;270(14):8050-5.PMID: 7713906 [PubMed - indexed for MEDLINE]Related articlesFree article

Multiple effects and stimulation of insulin secretion by the tyrosine kinase inhibitor genistein in normal mouse islets.

Jonas JC, Plant TD, Gilon P, Detimary P, Nenquin M, Henquin JC.

Br J Pharmacol. 1995 Feb;114(4):872-80.PMID: 7773549 [PubMed - indexed for MEDLINE]Related articlesFree article

Activation of 5-HT3 receptors expressed in Xenopus oocytes does not increase cytoplasmic Ca2+ levels.

Gilon P, Yakel JL.

Receptors Channels. 1995;3(2):83-8.PMID: 8581403 [PubMed - indexed for MEDLINE]Related articles

Culture duration and conditions affect the oscillations of cytoplasmic calcium concentration induced by glucose in mouse pancreatic islets.

Gilon P, Jonas JC, Henquin JC.

Diabetologia. 1994 Oct;37(10):1007-14.PMID: 7851679 [PubMed - indexed for MEDLINE]Related articles

The role of protein kinase-C in signal transduction through vasopressin and acetylcholine receptors in pancreatic B-cells from normal mouse.

Gao ZY, Gilon P, Henquin JC.

Endocrinology. 1994 Jul;135(1):191-9.PMID: 8013353 [PubMed - indexed for MEDLINE]Related articles

Mechanisms of the stimulation of insulin release by saturated fatty acids. A study of palmitate effects in mouse beta-cells.

Warnotte C, Gilon P, Nenquin M, Henquin JC.

Diabetes. 1994 May;43(5):703-11.PMID: 8168648 [PubMed - indexed for MEDLINE]Related articles

Multisite control of insulin release by glucose.

Henquin JC, Gembal M, Detimary P, Gao ZY, Warnotte C, Gilon P.

Diabete Metab. 1994 Mar-Apr;20(2):132-7. Review.PMID: 7805950 [PubMed - indexed for MEDLINE]Related articles

Two sites of glucose control of insulin release with distinct dependence on the energy state in pancreatic B-cells.

Detimary P, Gilon P, Nenquin M, Henquin JC.

Biochem J. 1994 Feb 1;297 ( Pt 3):455-61.PMID: 8110181 [PubMed - indexed for MEDLINE]Related articlesFree article

[Biophysical aspects of control of insulin secretion]

Henquin JC, Detimary P, Gembal M, Jonas JC, Shepherd RM, Warnotte C, Gilon P.

Journ Annu Diabetol Hotel Dieu. 1994:21-32. Review. French. No abstract available. PMID: 8051822 [PubMed - indexed for MEDLINE]Related articles

Oscillations of secretion driven by oscillations of cytoplasmic Ca2+ as evidences in single pancreatic islets.

Gilon P, Shepherd RM, Henquin JC.

J Biol Chem. 1993 Oct 25;268(30):22265-8.PMID: 8226733 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanisms by which glucose can control insulin release independently from its action on adenosine triphosphate-sensitive K+ channels in mouse B cells.

Gembal M, Detimary P, Gilon P, Gao ZY, Henquin JC.

J Clin Invest. 1993 Mar;91(3):871-80.PMID: 8383702 [PubMed - indexed for MEDLINE]Related articlesFree article

Activation of muscarinic receptors increases the concentration of free Na+ in mouse pancreatic B-cells.

Gilon P, Henquin JC.

FEBS Lett. 1993 Jan 11;315(3):353-6.PMID: 8380774 [PubMed - indexed for MEDLINE]Related articles

Influence of membrane potential changes on cytoplasmic Ca2+ concentration in an electrically excitable cell, the insulin-secreting pancreatic B-cell.

Gilon P, Henquin JC.

J Biol Chem. 1992 Oct 15;267(29):20713-20.PMID: 1400388 [PubMed - indexed for MEDLINE]Related articlesFree article