PubMed

The PPAR-gamma agonist, darglitazone, restores acute inflammatory responses to cerebral hypoxia-ischemia in the diabetic ob/ob mouse.

Kumari R, Willing LB, Patel SD, Krady JK, Zavadoski WJ, Gibbs EM, Vannucci SJ, Simpson IA.

J Cereb Blood Flow Metab. 2009 Oct 28. [Epub ahead of print]PMID: 19861974 [PubMed - as supplied by publisher]Related articles

Loss of myotubularin function results in T-tubule disorganization in zebrafish and human myotubular myopathy.

Dowling JJ, Vreede AP, Low SE, Gibbs EM, Kuwada JY, Bonnemann CG, Feldman EL.

PLoS Genet. 2009 Feb;5(2):e1000372. Epub 2009 Feb 6.PMID: 19197364 [PubMed - indexed for MEDLINE]Related articlesFree article

Membrane traffic and muscle: lessons from human disease.

Dowling JJ, Gibbs EM, Feldman EL.

Traffic. 2008 Jul;9(7):1035-43. Epub 2008 Feb 4. Review.PMID: 18266915 [PubMed - indexed for MEDLINE]Related articles

Acute effects of atypical antipsychotics on whole-body insulin resistance in rats: implications for adverse metabolic effects.

Houseknecht KL, Robertson AS, Zavadoski W, Gibbs EM, Johnson DE, Rollema H.

Neuropsychopharmacology. 2007 Feb;32(2):289-97. Epub 2006 Oct 11.PMID: 17035934 [PubMed - indexed for MEDLINE]Related articlesFree article

Establishment of correlation between in vitro enzyme binding potency and in vivo pharmacological activity: application to liver glycogen phosphorylase a inhibitors.

Yu LJ, Chen Y, Treadway JL, McPherson RK, McCoid SC, Gibbs EM, Hoover DJ.

J Pharmacol Exp Ther. 2006 Jun;317(3):1230-7. Epub 2006 Mar 14.PMID: 16537796 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibitory effects of antipsychotics on carbachol-enhanced insulin secretion from perifused rat islets: role of muscarinic antagonism in antipsychotic-induced diabetes and hyperglycemia.

Johnson DE, Yamazaki H, Ward KM, Schmidt AW, Lebel WS, Treadway JL, Gibbs EM, Zawalich WS, Rollema H.

Diabetes. 2005 May;54(5):1552-8.PMID: 15855345 [PubMed - indexed for MEDLINE]Related articlesFree article

Endogenous effectors of human liver glycogen phosphorylase modulate effects of indole-site inhibitors.

Ercan-Fang N, Taylor MR, Treadway JL, Levy CB, Genereux PE, Gibbs EM, Rath VL, Kwon Y, Gannon MC, Nuttall FQ.

Am J Physiol Endocrinol Metab. 2005 Sep;289(3):E366-72. Epub 2005 Mar 29.PMID: 15797986 [PubMed - indexed for MEDLINE]Related articlesFree article

Dual-action hypoglycemic and hypocholesterolemic agents that inhibit glycogen phosphorylase and lanosterol demethylase.

Harwood HJ Jr, Petras SF, Hoover DJ, Mankowski DC, Soliman VF, Sugarman ED, Hulin B, Kwon Y, Gibbs EM, Mayne JT, Treadway JL.

J Lipid Res. 2005 Mar;46(3):547-63. Epub 2004 Dec 16.PMID: 15604516 [PubMed - indexed for MEDLINE]Related articlesFree article

5-Chloroindoloyl glycine amide inhibitors of glycogen phosphorylase: synthesis, in vitro, in vivo, and X-ray crystallographic characterization.

Wright SW, Rath VL, Genereux PE, Hageman DL, Levy CB, McClure LD, McCoid SC, McPherson RK, Schelhorn TM, Wilder DE, Zavadoski WJ, Gibbs EM, Treadway JL.

Bioorg Med Chem Lett. 2005 Jan 17;15(2):459-65.PMID: 15603973 [PubMed - indexed for MEDLINE]Related articles

Structure-activity analysis of the purine binding site of human liver glycogen phosphorylase.

Ekstrom JL, Pauly TA, Carty MD, Soeller WC, Culp J, Danley DE, Hoover DJ, Treadway JL, Gibbs EM, Fletterick RJ, Day YS, Myszka DG, Rath VL.

Chem Biol. 2002 Aug;9(8):915-24.PMID: 12204691 [PubMed - indexed for MEDLINE]Related articles

Identification of a novel glucose transporter-like protein-GLUT-12.

Rogers S, Macheda ML, Docherty SE, Carty MD, Henderson MA, Soeller WC, Gibbs EM, James DE, Best JD.

Am J Physiol Endocrinol Metab. 2002 Mar;282(3):E733-8.PMID: 11832379 [PubMed - indexed for MEDLINE]Related articlesFree article

GLUT4 overexpression in db/db mice dose-dependently ameliorates diabetes but is not a lifelong cure.

Brozinick JT Jr, McCoid SC, Reynolds TH, Nardone NA, Hargrove DM, Stevenson RW, Cushman SW, Gibbs EM.

Diabetes. 2001 Mar;50(3):593-600.PMID: 11246879 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose metabolism in perfused mouse hearts overexpressing human GLUT-4 glucose transporter.

Belke DD, Larsen TS, Gibbs EM, Severson DL.

Am J Physiol Endocrinol Metab. 2001 Mar;280(3):E420-7.PMID: 11171596 [PubMed - indexed for MEDLINE]Related articlesFree article

Altered metabolism causes cardiac dysfunction in perfused hearts from diabetic (db/db) mice.

Belke DD, Larsen TS, Gibbs EM, Severson DL.

Am J Physiol Endocrinol Metab. 2000 Nov;279(5):E1104-13.PMID: 11052966 [PubMed - indexed for MEDLINE]Related articlesFree article

Human liver glycogen phosphorylase inhibitors bind at a new allosteric site.

Rath VL, Ammirati M, Danley DE, Ekstrom JL, Gibbs EM, Hynes TR, Mathiowetz AM, McPherson RK, Olson TV, Treadway JL, Hoover DJ.

Chem Biol. 2000 Sep;7(9):677-82.PMID: 10980448 [PubMed - indexed for MEDLINE]Related articles

Effects of overexpression of human GLUT4 gene on maternal diabetes and fetal growth in spontaneous gestational diabetic C57BLKS/J Lepr(db/+) mice.

Ishizuka T, Klepcyk P, Liu S, Panko L, Liu S, Gibbs EM, Friedman JE.

Diabetes. 1999 May;48(5):1061-9.PMID: 10331411 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin-sensitive regulation of glucose transport and GLUT4 translocation in skeletal muscle of GLUT1 transgenic mice.

Etgen GJ Jr, Zavadoski WJ, Holman GD, Gibbs EM.

Biochem J. 1999 Jan 1;337 ( Pt 1):51-7.PMID: 9854024 [PubMed - indexed for MEDLINE]Related articlesFree article

Indole-2-carboxamide inhibitors of human liver glycogen phosphorylase.

Hoover DJ, Lefkowitz-Snow S, Burgess-Henry JL, Martin WH, Armento SJ, Stock IA, McPherson RK, Genereux PE, Gibbs EM, Treadway JL.

J Med Chem. 1998 Jul 30;41(16):2934-8. No abstract available. PMID: 9685232 [PubMed - indexed for MEDLINE]Related articles

Possibility of distinct insulin-signaling pathways beyond phosphatidylinositol 3-kinase-mediating glucose transport and lipogenesis.

Stevenson RW, Kreutter DK, Andrews KM, Genereux PE, Gibbs EM.

Diabetes. 1998 Feb;47(2):179-85.PMID: 9519710 [PubMed - indexed for MEDLINE]Related articles

Nitric oxide stimulates skeletal muscle glucose transport through a calcium/contraction- and phosphatidylinositol-3-kinase-independent pathway.

Etgen GJ Jr, Fryburg DA, Gibbs EM.

Diabetes. 1997 Nov;46(11):1915-9.PMID: 9356048 [PubMed - indexed for MEDLINE]Related articles

Glucose utilization and glucose transporter proteins GLUT-1 and GLUT-3 in brains of diabetic (db/db) mice.

Vannucci SJ, Gibbs EM, Simpson IA.

Am J Physiol. 1997 Feb;272(2 Pt 1):E267-74.PMID: 9124334 [PubMed - indexed for MEDLINE]Related articles

Regulation of cell surface GLUT4 in skeletal muscle of transgenic mice.

Brozinick JT Jr, McCoid SC, Reynolds TH, Wilson CM, Stevenson RW, Cushman SW, Gibbs EM.

Biochem J. 1997 Jan 1;321 ( Pt 1):75-81.PMID: 9003403 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose transport-enhancing and hypoglycemic activity of 2-methyl-2-phenoxy-3-phenylpropanoic acids.

Sarges R, Hank RF, Blake JF, Bordner J, Bussolotti DL, Hargrove DM, Treadway JL, Gibbs EM.

J Med Chem. 1996 Nov 22;39(24):4783-803.PMID: 8941393 [PubMed - indexed for MEDLINE]Related articles

Predicting injection site muscle damage. III: Evaluation of intramuscular formulations in the L6 cell model.

Evans LA, Genereux PE, Gibbs EM, Sutton SC.

Pharm Res. 1996 Oct;13(10):1585-7. No abstract available. PMID: 8899856 [PubMed - indexed for MEDLINE]Related articles

Hypoglycemic activity of a series of alpha-alkylthio and alpha-alkoxy carboxylic acids related to ciglitazone.

Hulin B, Newton LS, Lewis DM, Genereux PE, Gibbs EM, Clark DA.

J Med Chem. 1996 Sep 27;39(20):3897-907.PMID: 8831756 [PubMed - indexed for MEDLINE]Related articles

Glucose transport and GLUT4 protein distribution in skeletal muscle of GLUT4 transgenic mice.

Brozinick JT Jr, Yaspelkis BB 3rd, Wilson CM, Grant KE, Gibbs EM, Cushman SW, Ivy JL.

Biochem J. 1996 Jan 1;313 ( Pt 1):133-40.PMID: 8546674 [PubMed - indexed for MEDLINE]Related articlesFree article

The antihyperglycemic agent englitazone prevents the defect in glucose transport in rats fed a high-fat diet.

Stevenson RW, McPherson RK, Persson LM, Genereux PE, Swick AG, Spitzer J, Herbst JJ, Andrews KM, Kreutter DK, Gibbs EM.

Diabetes. 1996 Jan;45(1):60-6.PMID: 8522061 [PubMed - indexed for MEDLINE]Related articles

Effect of the activation of phosphatidylinositol 3-kinase by a thiophosphotyrosine peptide on glucose transport in 3T3-L1 adipocytes.

Herbst JJ, Andrews GC, Contillo LG, Singleton DH, Genereux PE, Gibbs EM, Lienhard GE.

J Biol Chem. 1995 Oct 27;270(43):26000-5.PMID: 7592791 [PubMed - indexed for MEDLINE]Related articlesFree article

Glycemic improvement in diabetic db/db mice by overexpression of the human insulin-regulatable glucose transporter (GLUT4).

Gibbs EM, Stock JL, McCoid SC, Stukenbrok HA, Pessin JE, Stevenson RW, Milici AJ, McNeish JD.

J Clin Invest. 1995 Apr;95(4):1512-8.PMID: 7706456 [PubMed - indexed for MEDLINE]Related articlesFree article

Enhanced peripheral glucose utilization in transgenic mice expressing the human GLUT4 gene.

Treadway JL, Hargrove DM, Nardone NA, McPherson RK, Russo JF, Milici AJ, Stukenbrok HA, Gibbs EM, Stevenson RW, Pessin JE.

J Biol Chem. 1994 Nov 25;269(47):29956-61.PMID: 7961994 [PubMed - indexed for MEDLINE]Related articlesFree article

Evidence for a role of phosphatidylinositol 3-kinase in the regulation of glucose transport in Xenopus oocytes.

Gould GW, Jess TJ, Andrews GC, Herbst JJ, Plevin RJ, Gibbs EM.

J Biol Chem. 1994 Oct 28;269(43):26622-5.PMID: 7929393 [PubMed - indexed for MEDLINE]Related articlesFree article

Potent activation of phosphatidylinositol 3'-kinase by simple phosphotyrosine peptides derived from insulin receptor substrate 1 containing two YMXM motifs for binding SH2 domains.

Herbst JJ, Andrews G, Contillo L, Lamphere L, Gardner J, Lienhard GE, Gibbs EM.

Biochemistry. 1994 Aug 16;33(32):9376-81.PMID: 7520748 [PubMed - indexed for MEDLINE]Related articles

Growth factor-induced stimulation of hexose transport in 3T3-L1 adipocytes: evidence that insulin-induced translocation of GLUT4 is independent of activation of MAP kinase.

Gould GW, Merrall NW, Martin S, Jess TJ, Campbell IW, Calderhead DM, Gibbs EM, Holman GD, Plevin RJ.

Cell Signal. 1994 Mar;6(3):313-20.PMID: 7917789 [PubMed - indexed for MEDLINE]Related articles

Transgenic mice expressing the human GLUT4/muscle-fat facilitative glucose transporter protein exhibit efficient glycemic control.

Liu ML, Gibbs EM, McCoid SC, Milici AJ, Stukenbrok HA, McPherson RK, Treadway JL, Pessin JE.

Proc Natl Acad Sci U S A. 1993 Dec 1;90(23):11346-50.PMID: 8248251 [PubMed - indexed for MEDLINE]Related articlesFree article

Germline manipulation of glucose homeostasis via alteration of glucose transporter levels in skeletal muscle.

Marshall BA, Ren JM, Johnson DW, Gibbs EM, Lillquist JS, Soeller WC, Holloszy JO, Mueckler M.

J Biol Chem. 1993 Sep 5;268(25):18442-5.PMID: 8360145 [PubMed - indexed for MEDLINE]Related articlesFree article

Hydroxyurea derivatives as hypoglycemic agents.

Goldstein SW, McDermott RE, Gibbs EM, Stevenson RW.

J Med Chem. 1993 Jul 23;36(15):2238-40. No abstract available. PMID: 8340926 [PubMed - indexed for MEDLINE]Related articles

Analysis of the glucose transporter content of islet cell lines: implications for glucose-stimulated insulin release.

Brant AM, McCoid S, Thomas HM, Baldwin SA, Davies A, Parker JC, Gibbs EM, Gould GW.

Cell Signal. 1992 Nov;4(6):641-50.PMID: 1489658 [PubMed - indexed for MEDLINE]Related articles

Distribution of GLUT3 glucose transporter protein in human tissues.

Shepherd PR, Gould GW, Colville CA, McCoid SC, Gibbs EM, Kahn BB.

Biochem Biophys Res Commun. 1992 Oct 15;188(1):149-54.PMID: 1417839 [PubMed - indexed for MEDLINE]Related articles

Human small intestine facilitative fructose/glucose transporter (GLUT5) is also present in insulin-responsive tissues and brain. Investigation of biochemical characteristics and translocation.

Shepherd PR, Gibbs EM, Wesslau C, Gould GW, Kahn BB.

Diabetes. 1992 Oct;41(10):1360-5.PMID: 1397712 [PubMed - indexed for MEDLINE]Related articles

Immunological identification of five members of the human facilitative glucose transporter family.

Brant AM, Gibbs EM, Gould GW, Thomas HM.

Biochem Soc Trans. 1992 Aug;20(3):236S. No abstract available. PMID: 1426534 [PubMed - indexed for MEDLINE]Related articles

Examination of the glycosidation state of five members of the human facilitative glucose transporter family.

Brant AM, Gibbs EM, Gould GW.

Biochem Soc Trans. 1992 Aug;20(3):235S. No abstract available. PMID: 1426533 [PubMed - indexed for MEDLINE]Related articles

Expression of the brain-type glucose transporter is restricted to brain and neuronal cells in mice.

Gould GW, Brant AM, Kahn BB, Shepherd PR, McCoid SC, Gibbs EM.

Diabetologia. 1992 Apr;35(4):304-9.PMID: 1516757 [PubMed - indexed for MEDLINE]Related articles

Phorbol ester only partially mimics the effects of insulin on glucose transport and glucose-transporter distribution in 3T3-L1 adipocytes.

Gibbs EM, Calderhead DM, Holman GD, Gould GW.

Biochem J. 1991 Apr 1;275 ( Pt 1):145-50.PMID: 2018470 [PubMed - indexed for MEDLINE]Related articlesFree article

Substituted dihydrobenzopyran and dihydrobenzofuran thiazolidine-2,4-diones as hypoglycemic agents.

Clark DA, Goldstein SW, Volkmann RA, Eggler JF, Holland GF, Hulin B, Stevenson RW, Kreutter DK, Gibbs EM, Krupp MN, et al.

J Med Chem. 1991 Jan;34(1):319-25.PMID: 1992133 [PubMed - indexed for MEDLINE]Related articles

Insulinlike activity of new antidiabetic agent CP 68722 in 3T3-L1 adipocytes.

Kreutter DK, Andrews KM, Gibbs EM, Hutson NJ, Stevenson RW.

Diabetes. 1990 Nov;39(11):1414-9.PMID: 2227113 [PubMed - indexed for MEDLINE]Related articles

Effect of phenylarsine oxide on fluid phase endocytosis: further evidence for activation of the glucose transporter.

Frost SC, Lane MD, Gibbs EM.

J Cell Physiol. 1989 Dec;141(3):467-74.PMID: 2687296 [PubMed - indexed for MEDLINE]Related articles

Insulin-stimulated translocation of the HepG2/erythrocyte-type glucose transporter expressed in 3T3-L1 adipocytes.

Gould GW, Derechin V, James DE, Tordjman K, Ahern S, Gibbs EM, Lienhard GE, Mueckler M.

J Biol Chem. 1989 Feb 5;264(4):2180-4.PMID: 2536700 [PubMed - indexed for MEDLINE]Related articlesFree article

Phenylarsine oxide stimulates hexose transport in 3T3-L1 adipocytes by a mechanism other than an increase in surface transporters.

Gould GW, Lienhard GE, Tanner LI, Gibbs EM.

Arch Biochem Biophys. 1989 Jan;268(1):264-75.PMID: 2643384 [PubMed - indexed for MEDLINE]Related articles

Characterization of vesicles containing insulin-responsive intracellular glucose transporters isolated from 3T3-L1 adipocytes by an improved procedure.

Brown SJ, Gould GW, Davies A, Baldwin SA, Lienhard GE, Gibbs EM.

Biochim Biophys Acta. 1988 Oct 7;971(3):339-50.PMID: 3048418 [PubMed - indexed for MEDLINE]Related articles

Insulin-induced translocation of glucose transporters to the plasma membrane precedes full stimulation of hexose transport.

Gibbs EM, Lienhard GE, Gould GW.

Biochemistry. 1988 Sep 6;27(18):6681-5.PMID: 3058203 [PubMed - indexed for MEDLINE]Related articles