PubMed

FoxO1 links insulin resistance to proinflammatory cytokine IL-1beta production in macrophages.

Su D, Coudriet GM, Hyun Kim D, Lu Y, Perdomo G, Qu S, Slusher S, Tse HM, Piganelli J, Giannoukakis N, Zhang J, Henry Dong H.

Diabetes. 2009 Nov;58(11):2624-33. Epub 2009 Aug 3.PMID: 19651810 [PubMed - in process]Related articles

Dendritic cell mediated therapy for immunoregulation of type 1 diabetes mellitus.

Phillips BE, Giannoukakis N, Trucco M.

Pediatr Endocrinol Rev. 2008 Jun;5(4):873-9. Review.PMID: 18552749 [PubMed - indexed for MEDLINE]Related articles

Toward a cure for type 1 diabetes mellitus: diabetes-suppressive dendritic cells and beyond.

Giannoukakis N, Phillips B, Trucco M.

Pediatr Diabetes. 2008 Jun;9(3 Pt 2):4-13.PMID: 18540865 [PubMed - indexed for MEDLINE]Related articles

Renal diseases as targets of gene therapy.

Phillips B, Giannoukakis N, Trucco M.

Contrib Nephrol. 2008;159:1-12.PMID: 18391581 [PubMed - indexed for MEDLINE]Related articles

Ranirestat as a therapeutic aldose reductase inhibitor for diabetic complications.

Giannoukakis N.

Expert Opin Investig Drugs. 2008 Apr;17(4):575-81. Review.PMID: 18363521 [PubMed - indexed for MEDLINE]Related articles

Type 1 diabetes: MHC tailored for diabetes cell therapy.

Trucco M, Giannoukakis N.

Gene Ther. 2005 Apr;12(7):553-4. No abstract available. PMID: 18360949 [PubMed - indexed for MEDLINE]Related articles

A microsphere-based vaccine prevents and reverses new-onset autoimmune diabetes.

Phillips B, Nylander K, Harnaha J, Machen J, Lakomy R, Styche A, Gillis K, Brown L, Lafreniere D, Gallo M, Knox J, Hogeland K, Trucco M, Giannoukakis N.

Diabetes. 2008 Jun;57(6):1544-55. Epub 2008 Mar 3.PMID: 18316361 [PubMed - indexed for MEDLINE]Related articlesFree article

Induction of immune tolerance to facilitate beta cell regeneration in type 1 diabetes.

Pasquali L, Giannoukakis N, Trucco M.

Adv Drug Deliv Rev. 2008 Jan 14;60(2):106-13. Epub 2007 Oct 9. Review.PMID: 18053613 [PubMed - indexed for MEDLINE]Related articles

BIM-51077, a dipeptidyl peptidase-IV-resistant glucagon-like peptide-1 analog.

Giannoukakis N.

Curr Opin Investig Drugs. 2007 Oct;8(10):842-8. Review.PMID: 17907061 [PubMed - indexed for MEDLINE]Related articles

Immunoregulatory dendritic cells to prevent and reverse new-onset Type 1 diabetes mellitus.

Trucco M, Giannoukakis N.

Expert Opin Biol Ther. 2007 Jul;7(7):951-63. Review.PMID: 17665986 [PubMed - indexed for MEDLINE]Related articles

Gene therapy for type 1 diabetes: is it ready for the clinic?

D'Anneo A, Rood P, Bottino R, Balamurugan AN, He J, Giannoukakis N.

Immunol Res. 2006;36(1-3):83-9. Review.PMID: 17337769 [PubMed - indexed for MEDLINE]Related articles

Drug evaluation: ranirestat--an aldose reductase inhibitor for the potential treatment of diabetic complications.

Giannoukakis N.

Curr Opin Investig Drugs. 2006 Oct;7(10):916-23. Review.PMID: 17086937 [PubMed - indexed for MEDLINE]Related articles

Prospective and challenges of islet transplantation for the therapy of autoimmune diabetes.

Balamurugan AN, Bottino R, Giannoukakis N, Smetanka C.

Pancreas. 2006 Apr;32(3):231-43. Review.PMID: 16628077 [PubMed - indexed for MEDLINE]Related articles

Interleukin-7 is a survival factor for CD4+ CD25+ T-cells and is expressed by diabetes-suppressive dendritic cells.

Harnaha J, Machen J, Wright M, Lakomy R, Styche A, Trucco M, Makaroun S, Giannoukakis N.

Diabetes. 2006 Jan;55(1):158-70.PMID: 16380489 [PubMed - indexed for MEDLINE]Related articlesFree article

Gene therapy for type 1 diabetes.

Giannoukakis N, Trucco M.

Am J Ther. 2005 Nov-Dec;12(6):512-28. Review.PMID: 16280645 [PubMed - indexed for MEDLINE]Related articles

DiaPep277 (DeveloGen).

Giannoukakis N.

Curr Opin Investig Drugs. 2005 Oct;6(10):1043-50. Review.PMID: 16259226 [PubMed - indexed for MEDLINE]Related articles

Gene therapy for type 1 diabetes: a proposal to move to the next level.

Giannoukakis N, Trucco M.

Curr Opin Mol Ther. 2005 Oct;7(5):467-75. Review.PMID: 16248282 [PubMed - indexed for MEDLINE]Related articles

Footer: a quantitative comparative genomics method for efficient recognition of cis-regulatory elements.

Corcoran DL, Feingold E, Dominick J, Wright M, Harnaha J, Trucco M, Giannoukakis N, Benos PV.

Genome Res. 2005 Jun;15(6):840-7.PMID: 15930494 [PubMed - indexed for MEDLINE]Related articlesFree article

Pyridoxamine (BioStratum).

Giannoukakis N.

Curr Opin Investig Drugs. 2005 Apr;6(4):410-8. Review.PMID: 15898348 [PubMed - indexed for MEDLINE]Related articles

Antisense oligonucleotides down-regulating costimulation confer diabetes-preventive properties to nonobese diabetic mouse dendritic cells.

Machen J, Harnaha J, Lakomy R, Styche A, Trucco M, Giannoukakis N.

J Immunol. 2004 Oct 1;173(7):4331-41.PMID: 15383562 [PubMed - indexed for MEDLINE]Related articlesFree article

Prolongation of islet allograft survival following ex vivo transduction with adenovirus encoding a soluble type 1 TNF receptor-Ig fusion decoy.

Machen J, Bertera S, Chang Y, Bottino R, Balamurugan AN, Robbins PD, Trucco M, Giannoukakis N.

Gene Ther. 2004 Oct;11(20):1506-14.PMID: 15229635 [PubMed - indexed for MEDLINE]Related articles

Islet/pancreas transplantation: challenges for pediatrics.

Bottino R, Balamurugan AN, Giannoukakis N, Trucco M.

Pediatr Diabetes. 2002 Dec;3(4):210-23.PMID: 15016150 [PubMed]Related articles

CJC-1131. ConjuChem.

Giannoukakis N.

Curr Opin Investig Drugs. 2003 Oct;4(10):1245-9. Review.PMID: 14649218 [PubMed - indexed for MEDLINE]Related articles

Fidarestat. Sanwa Kagaku/NC Curex/Sankyo.

Giannoukakis N.

Curr Opin Investig Drugs. 2003 Oct;4(10):1233-9. Review.PMID: 14649216 [PubMed - indexed for MEDLINE]Related articles

Current status and prospects for gene and cell therapeutics for type 1 diabetes mellitus.

Giannoukakis N, Trucco M.

Rev Endocr Metab Disord. 2003 Dec;4(4):369-80. Review. No abstract available. PMID: 14618022 [PubMed - indexed for MEDLINE]Related articles

Prevention of diabetes in NOD mice by administration of dendritic cells deficient in nuclear transcription factor-kappaB activity.

Ma L, Qian S, Liang X, Wang L, Woodward JE, Giannoukakis N, Robbins PD, Bertera S, Trucco M, Fung JJ, Lu L.

Diabetes. 2003 Aug;52(8):1976-85.PMID: 12882913 [PubMed - indexed for MEDLINE]Related articlesFree article

Gene therapy technology applied to disorders of glucose metabolism: promise, achievements, and prospects.

Giannoukakis N, Trucco M.

Biotechniques. 2003 Jul;35(1):122-45. Review.PMID: 12866413 [PubMed - indexed for MEDLINE]Related articles

Exenatide. Amylin/Eli Lilly.

Giannoukakis N.

Curr Opin Investig Drugs. 2003 Apr;4(4):459-65. Review.PMID: 12808888 [PubMed - indexed for MEDLINE]Related articles

NBI-6024 (Neurocrine Biosciences).

Giannoukakis N.

IDrugs. 2002 Dec;5(12):1162-7.PMID: 12800057 [PubMed]Related articles

Gene- and cell-based therapeutics for type I diabetes mellitus.

Bottino R, Lemarchand P, Trucco M, Giannoukakis N.

Gene Ther. 2003 May;10(10):875-89. Review.PMID: 12732873 [PubMed - indexed for MEDLINE]Related articles

Gene therapy strategies to prevent autoimmune disorders.

Trucco M, Robbins PD, Thomson AW, Giannoukakis N.

Curr Gene Ther. 2002 Sep;2(3):341-54. Review.PMID: 12189720 [PubMed - indexed for MEDLINE]Related articles

Immunosuppressive effects of glucosamine.

Ma L, Rudert WA, Harnaha J, Wright M, Machen J, Lakomy R, Qian S, Lu L, Robbins PD, Trucco M, Giannoukakis N.

J Biol Chem. 2002 Oct 18;277(42):39343-9. Epub 2002 Aug 9.PMID: 12176986 [PubMed - indexed for MEDLINE]Related articlesFree article

Therapeutic strategies for Type 1 and Type 2 diabetes mellitus.

Giannoukakis N, Pietropaolo M, Trucco M.

Diabetes Nutr Metab. 2002 Jun;15(3):173-203. Review.PMID: 12173733 [PubMed - indexed for MEDLINE]Related articles

Gene and cell therapies for diabetes mellitus: strategies and clinical potential.

Giannoukakis N, Robbins PD.

BioDrugs. 2002;16(3):149-73. Review.PMID: 12102644 [PubMed - indexed for MEDLINE]Related articles

Genes and engineered cells as drugs for type I and type II diabetes mellitus therapy and prevention.

Giannoukakis N, Pietropaolo M, Trucco M.

Curr Opin Investig Drugs. 2002 May;3(5):735-51. Review.PMID: 12090547 [PubMed - indexed for MEDLINE]Related articles

Cellular environment and freedom of gene expression.

Pietropaolo M, Giannoukakis N, Trucco M.

Nat Immunol. 2002 Apr;3(4):335; author reply 336. No abstract available. PMID: 11919570 [PubMed - indexed for MEDLINE]Related articles

Prevention of beta cell dysfunction and apoptosis activation in human islets by adenoviral gene transfer of the insulin-like growth factor I.

Giannoukakis N, Mi Z, Rudert WA, Gambotto A, Trucco M, Robbins P.

Gene Ther. 2000 Dec;7(23):2015-22.PMID: 11175313 [PubMed - indexed for MEDLINE]Related articlesFree article

Protection of human islets from the effects of interleukin-1beta by adenoviral gene transfer of an Ikappa B repressor.

Giannoukakis N, Rudert WA, Trucco M, Robbins PD.

J Biol Chem. 2000 Nov 24;275(47):36509-13.PMID: 10967112 [PubMed - indexed for MEDLINE]Related articlesFree article

Prolongation of cardiac allograft survival using dendritic cells treated with NF-kB decoy oligodeoxyribonucleotides.

Giannoukakis N, Bonham CA, Qian S, Chen Z, Peng L, Harnaha J, Li W, Thomson AW, Fung JJ, Robbins PD, Lu L.

Mol Ther. 2000 May;1(5 Pt 1):430-7. Erratum in: Mol Ther 2000 Sep;2(3):298. Zhou, Z [corrected to Chen, Z]. PMID: 10933964 [PubMed - indexed for MEDLINE]Related articlesFree article

Immunology of type 1 diabetes. Intervention and prevention strategies.

Bertera S, Alexander A, Giannoukakis N, Robbins PD, Trucco M.

Endocrinol Metab Clin North Am. 1999 Dec;28(4):841-64, x. Review.PMID: 10609123 [PubMed - indexed for MEDLINE]Related articles

Targeting autoimmune diabetes with gene therapy.

Giannoukakis N, Rudert WA, Robbins PD, Trucco M.

Diabetes. 1999 Nov;48(11):2107-21. Review.PMID: 10535443 [PubMed - indexed for MEDLINE]Related articlesFree article

Infection of intact human islets by a lentiviral vector.

Giannoukakis N, Mi Z, Gambotto A, Eramo A, Ricordi C, Trucco M, Robbins P.

Gene Ther. 1999 Sep;6(9):1545-51.PMID: 10490763 [PubMed - indexed for MEDLINE]Related articlesFree article

Gene therapy in transplantation.

Giannoukakis N, Thomson A, Robbins P.

Gene Ther. 1999 Sep;6(9):1499-511. Review.PMID: 10490759 [PubMed - indexed for MEDLINE]Related articlesFree article

Adenoviral gene transfer of the interleukin-1 receptor antagonist protein to human islets prevents IL-1beta-induced beta-cell impairment and activation of islet cell apoptosis in vitro.

Giannoukakis N, Rudert WA, Ghivizzani SC, Gambotto A, Ricordi C, Trucco M, Robbins PD.

Diabetes. 1999 Sep;48(9):1730-6.PMID: 10480601 [PubMed - indexed for MEDLINE]Related articlesFree article

The INS 5' variable number of tandem repeats is associated with IGF2 expression in humans.

Paquette J, Giannoukakis N, Polychronakos C, Vafiadis P, Deal C.

J Biol Chem. 1998 Jun 5;273(23):14158-64.PMID: 9603916 [PubMed - indexed for MEDLINE]Related articlesFree article

Polymorphic functional imprinting of the human IGF2 gene among individuals, in blood cells, is associated with H19 expression.

Giannoukakis N, Deal C, Paquette J, Kukuvitis A, Polychronakos C.

Biochem Biophys Res Commun. 1996 Mar 27;220(3):1014-9.PMID: 8607783 [PubMed - indexed for MEDLINE]Related articles

Parental imprinting effect at the INS-IGF2 diabetes susceptibility locus.

Polychronakos C, Kukuvitis A, Giannoukakis N, Colle E.

Diabetologia. 1995 Jun;38(6):715-9.PMID: 7672495 [PubMed - indexed for MEDLINE]Related articles

Imprinting of IGF2, insulin-dependent diabetes, immune function, and apoptosis: a hypothesis.

Polychronakos C, Giannoukakis N, Deal CL.

Dev Genet. 1995;17(3):253-62.PMID: 8565331 [PubMed - indexed for MEDLINE]Related articles

Parental genomic imprinting of the human IGF2 gene.

Giannoukakis N, Deal C, Paquette J, Goodyer CG, Polychronakos C.

Nat Genet. 1993 May;4(1):98-101.PMID: 8099843 [PubMed - indexed for MEDLINE]Related articles