PubMed

The effect of high-dose sodium salicylate on chronically elevated plasma non-esterified fatty acid-induced insulin resistance and {beta}-cell dysfunction.

Xiao C, Giacca A, Lewis GF.

Am J Physiol Endocrinol Metab. 2009 Sep 15. [Epub ahead of print]PMID: 19755670 [PubMed - as supplied by publisher]Related articles

A monolithic polymeric microdevice for pH-responsive drug delivery.

Chen J, Chu M, Koulajian K, Wu XY, Giacca A, Sun Y.

Biomed Microdevices. 2009 Dec;11(6):1251-7.PMID: 19672717 [PubMed - in process]Related articles

Insulin increases reendothelialization and inhibits cell migration and neointimal growth after arterial injury.

Breen DM, Chan KK, Dhaliwall JK, Ward MR, Al Koudsi N, Lam L, De Souza M, Ghanim H, Dandona P, Stewart DJ, Bendeck MP, Giacca A.

Arterioscler Thromb Vasc Biol. 2009 Jul;29(7):1060-6. Epub 2009 Apr 9.PMID: 19359661 [PubMed - indexed for MEDLINE]Related articles

Insulin resistance and secretion in vivo: effects of different antipsychotics in an animal model.

Chintoh AF, Mann SW, Lam L, Giacca A, Fletcher P, Nobrega J, Remington G.

Schizophr Res. 2009 Mar;108(1-3):127-33. Epub 2009 Jan 20.PMID: 19157785 [PubMed - indexed for MEDLINE]Related articles

Acute dipeptidyl peptidase-4 inhibition rapidly enhances insulin-mediated suppression of endogenous glucose production in mice.

Duez H, Smith AC, Xiao C, Giacca A, Szeto L, Drucker DJ, Lewis GF.

Endocrinology. 2009 Jan;150(1):56-62. Epub 2008 Sep 18.PMID: 18801896 [PubMed - indexed for MEDLINE]Related articles

Insulin resistance and decreased glucose-stimulated insulin secretion after acute olanzapine administration.

Chintoh AF, Mann SW, Lam L, Lam C, Cohn TA, Fletcher PJ, Nobrega JN, Giacca A, Remington G.

J Clin Psychopharmacol. 2008 Oct;28(5):494-9.PMID: 18794643 [PubMed - indexed for MEDLINE]Related articles

UCP2 is highly expressed in pancreatic alpha-cells and influences secretion and survival.

Diao J, Allister EM, Koshkin V, Lee SC, Bhattacharjee A, Tang C, Giacca A, Chan CB, Wheeler MB.

Proc Natl Acad Sci U S A. 2008 Aug 19;105(33):12057-62. Epub 2008 Aug 13.PMID: 18701716 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin resistance following continuous, chronic olanzapine treatment: an animal model.

Chintoh AF, Mann SW, Lam TK, Giacca A, Remington G.

Schizophr Res. 2008 Sep;104(1-3):23-30.PMID: 18675538 [PubMed - indexed for MEDLINE]Related articles

Stimulation of muscle cell glucose uptake by resveratrol through sirtuins and AMPK.

Breen DM, Sanli T, Giacca A, Tsiani E.

Biochem Biophys Res Commun. 2008 Sep 12;374(1):117-22. Epub 2008 Jul 2.PMID: 18601907 [PubMed - indexed for MEDLINE]Related articles

High multivitamin intake by Wistar rats during pregnancy results in increased food intake and components of the metabolic syndrome in male offspring.

Szeto IM, Aziz A, Das PJ, Taha AY, Okubo N, Reza-Lopez S, Giacca A, Anderson GH.

Am J Physiol Regul Integr Comp Physiol. 2008 Aug;295(2):R575-82. Epub 2008 Jun 4.PMID: 18525008 [PubMed - indexed for MEDLINE]Related articles

Oral taurine but not N-acetylcysteine ameliorates NEFA-induced impairment in insulin sensitivity and beta cell function in obese and overweight, non-diabetic men.

Xiao C, Giacca A, Lewis GF.

Diabetologia. 2008 Jan;51(1):139-46. Epub 2007 Nov 17.PMID: 18026714 [PubMed - indexed for MEDLINE]Related articles

Salicylate prevents hepatic insulin resistance caused by short-term elevation of free fatty acids in vivo.

Park E, Wong V, Guan X, Oprescu AI, Giacca A.

J Endocrinol. 2007 Nov;195(2):323-31.PMID: 17951543 [PubMed - indexed for MEDLINE]Related articlesFree article

Free fatty acid-induced reduction in glucose-stimulated insulin secretion: evidence for a role of oxidative stress in vitro and in vivo.

Oprescu AI, Bikopoulos G, Naassan A, Allister EM, Tang C, Park E, Uchino H, Lewis GF, Fantus IG, Rozakis-Adcock M, Wheeler MB, Giacca A.

Diabetes. 2007 Dec;56(12):2927-37. Epub 2007 Aug 23.PMID: 17717282 [PubMed - indexed for MEDLINE]Related articlesFree article

Evidence for a role of superoxide generation in glucose-induced beta-cell dysfunction in vivo.

Tang C, Han P, Oprescu AI, Lee SC, Gyulkhandanyan AV, Chan GN, Wheeler MB, Giacca A.

Diabetes. 2007 Nov;56(11):2722-31. Epub 2007 Aug 6.PMID: 17682092 [PubMed - indexed for MEDLINE]Related articlesFree article

Direct and indirect effects of insulin on hepatic glucose production in diabetic depancreatized dogs during euglycemia.

Gupta N, Park E, Sandhu H, Goh T, Tchipashvili V, Giacca A.

J Endocrinol. 2006 Sep;190(3):695-702.PMID: 17003270 [PubMed - indexed for MEDLINE]Related articlesFree article

Lipid-induced beta-cell dysfunction in vivo in models of progressive beta-cell failure.

Goh TT, Mason TM, Gupta N, So A, Lam TK, Lam L, Lewis GF, Mari A, Giacca A.

Am J Physiol Endocrinol Metab. 2007 Feb;292(2):E549-60. Epub 2006 Sep 26.PMID: 17003242 [PubMed - indexed for MEDLINE]Related articlesFree article

Oleate-induced decrease in hepatocyte insulin binding is mediated by PKC-delta.

Chen S, Lam TK, Park E, Burdett E, Wang PY, Wiesenthal SR, Lam L, Tchipashvili V, Fantus IG, Giacca A.

Biochem Biophys Res Commun. 2006 Aug 4;346(3):931-7. Epub 2006 Jun 9.PMID: 16781675 [PubMed - indexed for MEDLINE]Related articles

Differential effects of monounsaturated, polyunsaturated and saturated fat ingestion on glucose-stimulated insulin secretion, sensitivity and clearance in overweight and obese, non-diabetic humans.

Xiao C, Giacca A, Carpentier A, Lewis GF.

Diabetologia. 2006 Jun;49(6):1371-9. Epub 2006 Apr 5.PMID: 16596361 [PubMed - indexed for MEDLINE]Related articles

Hyperinsulinemia, but not other factors associated with insulin resistance, acutely enhances colorectal epithelial proliferation in vivo.

Tran TT, Naigamwalla D, Oprescu AI, Lam L, McKeown-Eyssen G, Bruce WR, Giacca A.

Endocrinology. 2006 Apr;147(4):1830-7. Epub 2006 Jan 12.PMID: 16410309 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of portal free fatty acid elevation on insulin clearance and hepatic glucose flux.

Yoshii H, Lam TK, Gupta N, Goh T, Haber CA, Uchino H, Kim TT, Chong VZ, Shah K, Fantus IG, Mari A, Kawamori R, Giacca A.

Am J Physiol Endocrinol Metab. 2006 Jun;290(6):E1089-97. Epub 2006 Jan 3.PMID: 16390863 [PubMed - indexed for MEDLINE]Related articlesFree article

Anti-atherogenic effect of insulin in vivo.

Kim T, Chan KK, Dhaliwall JK, Huynh N, Suen R, Uchino H, Naigamwalla D, Bendeck MP, Giacca A.

J Vasc Res. 2005 Nov-Dec;42(6):455-62. Epub 2005 Sep 6.PMID: 16155361 [PubMed - indexed for MEDLINE]Related articles

A pilot randomised controlled trial to reduce colorectal cancer risk markers associated with B-vitamin deficiency, insulin resistance and colonic inflammation.

Bruce WR, Cirocco M, Giacca A, Kim YI, Marcon N, Minkin S.

Br J Cancer. 2005 Sep 19;93(6):639-46.PMID: 16136044 [PubMed - indexed for MEDLINE]Related articlesFree article

FK-614, a selective peroxisome proliferator-activated receptor gamma agonist, improves peripheral glucose utilization while decreasing hepatic insulin extraction in alloxan-induced diabetic dogs.

Uchino H, Kim T, Lam TK, Yoshii H, Klement P, Williams W, Kawamori R, Giacca A.

Metabolism. 2005 Sep;54(9):1250-8.PMID: 16125538 [PubMed - indexed for MEDLINE]Related articles

Hyperglycemia after protein ingestion concurrent with injection of a GLP-1 receptor agonist in rats: a possible role for dietary peptides.

Aziz A, Anderson GH, Giacca A, Cho F.

Am J Physiol Regul Integr Comp Physiol. 2005 Sep;289(3):R688-94. Epub 2005 May 5.PMID: 15879053 [PubMed - indexed for MEDLINE]Related articles

Muscle-specific Pten deletion protects against insulin resistance and diabetes.

Wijesekara N, Konrad D, Eweida M, Jefferies C, Liadis N, Giacca A, Crackower M, Suzuki A, Mak TW, Kahn CR, Klip A, Woo M.

Mol Cell Biol. 2005 Feb;25(3):1135-45.PMID: 15657439 [PubMed - indexed for MEDLINE]Related articlesFree article

The hyperglycemia-induced inflammatory response in adipocytes: the role of reactive oxygen species.

Lin Y, Berg AH, Iyengar P, Lam TK, Giacca A, Combs TP, Rajala MW, Du X, Rollman B, Li W, Hawkins M, Barzilai N, Rhodes CJ, Fantus IG, Brownlee M, Scherer PE.

J Biol Chem. 2005 Feb 11;280(6):4617-26. Epub 2004 Nov 9.PMID: 15536073 [PubMed - indexed for MEDLINE]Related articlesFree article

Prolonged increase of plasma non-esterified fatty acids fully abolishes the stimulatory effect of 24 hours of moderate hyperglycaemia on insulin sensitivity and pancreatic beta-cell function in obese men.

Leung N, Sakaue T, Carpentier A, Uffelman K, Giacca A, Lewis GF.

Diabetologia. 2004 Feb;47(2):204-13. Epub 2004 Jan 8.PMID: 14712348 [PubMed - indexed for MEDLINE]Related articles

Gene and protein kinase expression profiling of reactive oxygen species-associated lipotoxicity in the pancreatic beta-cell line MIN6.

Wang X, Li H, De Leo D, Guo W, Koshkin V, Fantus IG, Giacca A, Chan CB, Der S, Wheeler MB.

Diabetes. 2004 Jan;53(1):129-40.PMID: 14693707 [PubMed - indexed for MEDLINE]Related articlesFree article

N-acetylcysteine and taurine prevent hyperglycemia-induced insulin resistance in vivo: possible role of oxidative stress.

Haber CA, Lam TK, Yu Z, Gupta N, Goh T, Bogdanovic E, Giacca A, Fantus IG.

Am J Physiol Endocrinol Metab. 2003 Oct;285(4):E744-53. Epub 2003 Jun 10.PMID: 12799318 [PubMed - indexed for MEDLINE]Related articlesFree article

Free fatty acid-mediated impairment of glucose-stimulated insulin secretion in nondiabetic Oji-Cree individuals from the Sandy Lake community of Ontario, Canada: a population at very high risk for developing type 2 diabetes.

Carpentier A, Zinman B, Leung N, Giacca A, Hanley AJ, Harris SB, Hegele RA, Lewis GF.

Diabetes. 2003 Jun;52(6):1485-95.PMID: 12765961 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanisms of the free fatty acid-induced increase in hepatic glucose production.

Lam TK, Carpentier A, Lewis GF, van de Werve G, Fantus IG, Giacca A.

Am J Physiol Endocrinol Metab. 2003 May;284(5):E863-73. Review.PMID: 12676648 [PubMed - indexed for MEDLINE]Related articlesFree article

Vasopeptidase inhibitor omapatrilat induces profound insulin sensitization and increases myocardial glucose uptake in Zucker fatty rats: Studies comparing a vasopeptidase inhibitor, angiotensin-converting enzyme inhibitor, and angiotensin II type I receptor blocker.

Wang CH, Leung N, Lapointe N, Szeto L, Uffelman KD, Giacca A, Rouleau JL, Lewis GF.

Circulation. 2003 Apr 15;107(14):1923-9. Epub 2003 Mar 31.PMID: 12668518 [PubMed - indexed for MEDLINE]Related articlesFree article

Direct measure of insulin sensitivity with the hyperinsulinemic-euglycemic clamp and surrogate measures of insulin sensitivity with the oral glucose tolerance test: correlations with aberrant crypt foci promotion in rats.

Tran TT, Gupta N, Goh T, Naigamwalla D, Chia MC, Koohestani N, Mehrotra S, McKeown-Eyssen G, Giacca A, Bruce WR.

Cancer Epidemiol Biomarkers Prev. 2003 Jan;12(1):47-56.PMID: 12540503 [PubMed - indexed for MEDLINE]Related articlesFree article

Free fatty acids increase basal hepatic glucose production and induce hepatic insulin resistance at different sites.

Lam TK, van de Werve G, Giacca A.

Am J Physiol Endocrinol Metab. 2003 Feb;284(2):E281-90.PMID: 12531742 [PubMed - indexed for MEDLINE]Related articlesFree article

Possible mechanisms relating diet to colorectal cancer risk.

Bruce WR, Giacca A, Medline A.

IARC Sci Publ. 2002;156:277-81. Review. No abstract available. PMID: 12484187 [PubMed - indexed for MEDLINE]Related articles

Insulin inhibits glucose production by a direct effect in diabetic depancreatized dogs during euglycemia.

Gupta N, Sandhu H, Goh T, Shah K, Wiesenthal SR, Yoshii H, Chong V, Lam TK, Haber CA, Williams W, Tchipashvili V, Giacca A.

Am J Physiol Endocrinol Metab. 2002 Nov;283(5):E1002-7.PMID: 12376328 [PubMed - indexed for MEDLINE]Related articlesFree article

Free fatty acid-induced hepatic insulin resistance: a potential role for protein kinase C-delta.

Lam TK, Yoshii H, Haber CA, Bogdanovic E, Lam L, Fantus IG, Giacca A.

Am J Physiol Endocrinol Metab. 2002 Oct;283(4):E682-91.PMID: 12217885 [PubMed - indexed for MEDLINE]Related articlesFree article

The composition of dietary fat directly influences glucose-stimulated insulin secretion in rats.

Dobbins RL, Szczepaniak LS, Myhill J, Tamura Y, Uchino H, Giacca A, McGarry JD.

Diabetes. 2002 Jun;51(6):1825-33.PMID: 12031970 [PubMed - indexed for MEDLINE]Related articlesFree article

Disordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 diabetes.

Lewis GF, Carpentier A, Adeli K, Giacca A.

Endocr Rev. 2002 Apr;23(2):201-29.PMID: 11943743 [PubMed - indexed for MEDLINE]Related articlesFree article

The effect of chronic insulin delivery via the intraperitoneal versus the subcutaneous route on hepatic triglyceride secretion rate in streptozotocin diabetic rats.

Mason TM, Chan B, El-Bahrani B, Goh T, Gupta N, Gamble J, Qing Shi Z, Prentki M, Steiner G, Giacca A.

Atherosclerosis. 2002 Apr;161(2):345-52.PMID: 11888517 [PubMed - indexed for MEDLINE]Related articles

Effect of increased plasma non-esterified fatty acids (NEFAs) on arginine-stimulated insulin secretion in obese humans.

Carpentier A, Giacca A, Lewis GF.

Diabetologia. 2001 Nov;44(11):1989-97.PMID: 11719829 [PubMed - indexed for MEDLINE]Related articles

The effect of systemic versus portal insulin delivery in pancreas transplantation on insulin action and VLDL metabolism.

Carpentier A, Patterson BW, Uffelman KD, Giacca A, Vranic M, Cattral MS, Lewis GF.

Diabetes. 2001 Jun;50(6):1402-13.PMID: 11375342 [PubMed - indexed for MEDLINE]Related articlesFree article

Possible mechanisms relating diet and risk of colon cancer.

Bruce WR, Giacca A, Medline A.

Cancer Epidemiol Biomarkers Prev. 2000 Dec;9(12):1271-9. Review.PMID: 11142411 [PubMed - indexed for MEDLINE]Related articlesFree article

Low-dose IGF-I has no selective advantage over insulin in regulating glucose metabolism in hyperglycemic depancreatized dogs.

Fisher SJ, Shi ZQ, Lickley HL, Efendic S, Vranic M, Giacca A.

J Endocrinol. 2001 Jan;168(1):49-58.PMID: 11139769 [PubMed - indexed for MEDLINE]Related articlesFree article

Chronic intraperitoneal insulin delivery, as compared with subcutaneous delivery, improves hepatic glucose metabolism in streptozotocin diabetic rats.

Mason TM, Gupta N, Goh T, El-Bahrani B, Zannis J, van de Werve G, Giacca A.

Metabolism. 2000 Nov;49(11):1411-6.PMID: 11092503 [PubMed - indexed for MEDLINE]Related articles

Mechanisms linking diet and colorectal cancer: the possible role of insulin resistance.

Bruce WR, Wolever TM, Giacca A.

Nutr Cancer. 2000;37(1):19-26. Review.PMID: 10965515 [PubMed - indexed for MEDLINE]Related articles

Increased responses of glucagon and glucose production to hypoglycemia with intraperitoneal versus subcutaneous insulin treatment.

Wan CK, Giacca A, Matsuhisa M, El-Bahrani B, Lam L, Rodgers C, Shi ZQ.

Metabolism. 2000 Aug;49(8):984-9.PMID: 10954014 [PubMed - indexed for MEDLINE]Related articles

Effect of JTT-501 on net hepatic glucose balance and peripheral glucose uptake in alloxan-induced diabetic dogs.

Niwa M, Rashid S, Shum K, Mathoo JM, Chan O, Tchipashvili V, Kawamori R, Vranic M, Giacca A.

Metabolism. 2000 Jul;49(7):862-7.PMID: 10909996 [PubMed - indexed for MEDLINE]Related articles

Prolonged elevation of plasma free fatty acids impairs pancreatic beta-cell function in obese nondiabetic humans but not in individuals with type 2 diabetes.

Carpentier A, Mittelman SD, Bergman RN, Giacca A, Lewis GF.

Diabetes. 2000 Mar;49(3):399-408.PMID: 10868961 [PubMed - indexed for MEDLINE]Related articlesFree article

Acute enhancement of insulin secretion by FFA in humans is lost with prolonged FFA elevation.

Carpentier A, Mittelman SD, Lamarche B, Bergman RN, Giacca A, Lewis GF.

Am J Physiol. 1999 Jun;276(6 Pt 1):E1055-66.PMID: 10362618 [PubMed - indexed for MEDLINE]Related articlesFree article