PubMed

Increase in plasma endotoxin concentrations and the expression of Toll-like receptors and suppressor of cytokine signaling-3 in mononuclear cells after a high-fat, high-carbohydrate meal: implications for insulin resistance.

Ghanim H, Abuaysheh S, Sia CL, Korzeniewski K, Chaudhuri A, Fernandez-Real JM, Dandona P.

Diabetes Care. 2009 Dec;32(12):2281-7. Epub 2009 Sep 15.PMID: 19755625 [PubMed - in process]Related articlesFree article

Acute myocardial infarction, hyperglycemia, and insulin.

Dandona P, Chaudhuri A, Ghanim H.

J Am Coll Cardiol. 2009 Apr 21;53(16):1437-9. No abstract available. PMID: 19371827 [PubMed - indexed for MEDLINE]Related articles

Insulin increases reendothelialization and inhibits cell migration and neointimal growth after arterial injury.

Breen DM, Chan KK, Dhaliwall JK, Ward MR, Al Koudsi N, Lam L, De Souza M, Ghanim H, Dandona P, Stewart DJ, Bendeck MP, Giacca A.

Arterioscler Thromb Vasc Biol. 2009 Jul;29(7):1060-6. Epub 2009 Apr 9.PMID: 19359661 [PubMed - indexed for MEDLINE]Related articles

Insulin as an anti-inflammatory and antiatherogenic modulator.

Dandona P, Chaudhuri A, Ghanim H, Mohanty P.

J Am Coll Cardiol. 2009 Feb 3;53(5 Suppl):S14-20. Review.PMID: 19179212 [PubMed - indexed for MEDLINE]Related articles

Insulin therapy and lipid overload in type 2 diabetes.

Dandona P, Chaudhuri A, Ghanim H.

JAMA. 2008 Aug 20;300(7):788-9; author reply 790. No abstract available. PMID: 18714056 [PubMed - indexed for MEDLINE]Related articles

Maternal obesity and fetal programming: effects of a high-carbohydrate nutritional modification in the immediate postnatal life of female rats.

Srinivasan M, Dodds C, Ghanim H, Gao T, Ross PJ, Browne RW, Dandona P, Patel MS.

Am J Physiol Endocrinol Metab. 2008 Oct;295(4):E895-903. Epub 2008 Aug 5.PMID: 18682533 [PubMed - indexed for MEDLINE]Related articlesFree article

Acute modulation of toll-like receptors by insulin.

Ghanim H, Mohanty P, Deopurkar R, Sia CL, Korzeniewski K, Abuaysheh S, Chaudhuri A, Dandona P.

Diabetes Care. 2008 Sep;31(9):1827-31. Epub 2008 Jun 12.PMID: 18556339 [PubMed - indexed for MEDLINE]Related articlesFree article

A high-carbohydrate diet in the immediate postnatal life of rats induces adaptations predisposing to adult-onset obesity.

Srinivasan M, Mitrani P, Sadhanandan G, Dodds C, Shbeir-ElDika S, Thamotharan S, Ghanim H, Dandona P, Devaskar SU, Patel MS.

J Endocrinol. 2008 Jun;197(3):565-74.PMID: 18492820 [PubMed - indexed for MEDLINE]Related articlesFree article

Do thiazolidinediones exert their insulin-sensitizing effect through the suppression of free Fatty acids?

Dandona P, Dhindsa S, Ghanim H, Aljada A.

Metab Syndr Relat Disord. 2004 Fall;2(4):287-9. No abstract available. PMID: 18370697 [PubMed - in process]Related articles

Use of insulin to improve glycemic control in diabetes mellitus.

Dandona P, Chaudhuri A, Ghanim H, Mohanty P.

Cardiovasc Drugs Ther. 2008 Jun;22(3):241-51. Epub 2008 Mar 18. Review.PMID: 18347965 [PubMed - indexed for MEDLINE]Related articles

Thiazolidinediones-improving endothelial function and potential long-term benefits on cardiovascular disease in subjects with type 2 diabetes.

Dandona P, Ghanim H, Chaudhuri A, Mohanty P.

J Diabetes Complications. 2008 Jan-Feb;22(1):62-75. Review.PMID: 18191079 [PubMed - indexed for MEDLINE]Related articles

Effect of modified glucose-insulin-potassium on free fatty acids, matrix metalloproteinase, and myoglobin in ST-elevation myocardial infarction.

Chaudhuri A, Janicke D, Wilson M, Ghanim H, Wilding GE, Aljada A, Dandona P.

Am J Cardiol. 2007 Dec 1;100(11):1614-8.PMID: 18036357 [PubMed - indexed for MEDLINE]Related articles

Prolonged reactive oxygen species generation and nuclear factor-kappaB activation after a high-fat, high-carbohydrate meal in the obese.

Patel C, Ghanim H, Ravishankar S, Sia CL, Viswanathan P, Mohanty P, Dandona P.

J Clin Endocrinol Metab. 2007 Nov;92(11):4476-9. Epub 2007 Sep 4.PMID: 17785362 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of hyperglycemia and insulin in acute coronary syndromes.

Dandona P, Chaudhuri A, Ghanim H, Mohanty P.

Am J Cardiol. 2007 Jun 4;99(11A):12H-18H. Review.PMID: 17665748 [PubMed - indexed for MEDLINE]Related articles

Anti-inflammatory effects of insulin.

Dandona P, Chaudhuri A, Mohanty P, Ghanim H.

Curr Opin Clin Nutr Metab Care. 2007 Jul;10(4):511-7. Review. Erratum in: Curr Opin Clin Nutr Metab Care. 2007 Sep;10(5):660. PMID: 17563472 [PubMed - indexed for MEDLINE]Related articles

Anti-inflammatory effects of insulin and the pro-inflammatory effects of glucose.

Dandona P, Chaudhuri A, Ghanim H, Mohanty P.

Semin Thorac Cardiovasc Surg. 2006 Winter;18(4):293-301. Review.PMID: 17395025 [PubMed - indexed for MEDLINE]Related articles

Orange juice or fructose intake does not induce oxidative and inflammatory response.

Ghanim H, Mohanty P, Pathak R, Chaudhuri A, Sia CL, Dandona P.

Diabetes Care. 2007 Jun;30(6):1406-11. Epub 2007 Mar 23.PMID: 17384340 [PubMed - indexed for MEDLINE]Related articlesFree article

Antioxidant activity of carvedilol in cardiovascular disease.

Dandona P, Ghanim H, Brooks DP.

J Hypertens. 2007 Apr;25(4):731-41. Review.PMID: 17351362 [PubMed - indexed for MEDLINE]Related articles

Proinflammatory effects of glucose and anti-inflammatory effect of insulin: relevance to cardiovascular disease.

Dandona P, Chaudhuri A, Ghanim H, Mohanty P.

Am J Cardiol. 2007 Feb 19;99(4A):15B-26B. Epub 2006 Dec 27. Review.PMID: 17307055 [PubMed - indexed for MEDLINE]Related articles

Anti-inflammatory effects of insulin and pro-inflammatory effects of glucose: relevance to the management of acute myocardial infarction and other acute coronary syndromes.

Dandona P, Chaudhuri A, Ghanim H, Mohanty P.

Rev Cardiovasc Med. 2006;7 Suppl 2:S25-34. Review.PMID: 17224874 [PubMed - indexed for MEDLINE]Related articles

Role of inflammatory mediators in the suppression of insulin receptor phosphorylation in circulating mononuclear cells of obese subjects.

Ghanim H, Aljada A, Daoud N, Deopurkar R, Chaudhuri A, Dandona P.

Diabetologia. 2007 Feb;50(2):278-85. Epub 2006 Dec 16.PMID: 17180352 [PubMed - indexed for MEDLINE]Related articles

Angiotensin II and inflammation: the effect of angiotensin-converting enzyme inhibition and angiotensin II receptor blockade.

Dandona P, Dhindsa S, Ghanim H, Chaudhuri A.

J Hum Hypertens. 2007 Jan;21(1):20-7. Epub 2006 Nov 9. Review.PMID: 17096009 [PubMed - indexed for MEDLINE]Related articles

Low testosterone and high C-reactive protein concentrations predict low hematocrit in type 2 diabetes.

Bhatia V, Chaudhuri A, Tomar R, Dhindsa S, Ghanim H, Dandona P.

Diabetes Care. 2006 Oct;29(10):2289-94.PMID: 17003308 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose ingestion induces an increase in intranuclear nuclear factor kappaB, a fall in cellular inhibitor kappaB, and an increase in tumor necrosis factor alpha messenger RNA by mononuclear cells in healthy human subjects.

Aljada A, Friedman J, Ghanim H, Mohanty P, Hofmeyer D, Chaudhuri A, Dandona P.

Metabolism. 2006 Sep;55(9):1177-85.PMID: 16919536 [PubMed - indexed for MEDLINE]Related articles

Low-dose rosiglitazone exerts an antiinflammatory effect with an increase in adiponectin independently of free fatty acid fall and insulin sensitization in obese type 2 diabetics.

Ghanim H, Dhindsa S, Aljada A, Chaudhuri A, Viswanathan P, Dandona P.

J Clin Endocrinol Metab. 2006 Sep;91(9):3553-8. Epub 2006 Jun 27.PMID: 16804037 [PubMed - indexed for MEDLINE]Related articlesFree article

Free fatty acid-induced insulin resistance in the obese is not prevented by rosiglitazone treatment.

Dhindsa S, Tripathy D, Sanalkumar N, Ravishankar S, Ghanim H, Aljada A, Dandona P.

J Clin Endocrinol Metab. 2005 Sep;90(9):5058-63. Epub 2005 Jun 28.PMID: 15985490 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased plasma concentration of macrophage migration inhibitory factor (MIF) and MIF mRNA in mononuclear cells in the obese and the suppressive action of metformin.

Dandona P, Aljada A, Ghanim H, Mohanty P, Tripathy C, Hofmeyer D, Chaudhuri A.

J Clin Endocrinol Metab. 2004 Oct;89(10):5043-7.PMID: 15472203 [PubMed - indexed for MEDLINE]Related articlesFree article

Circulating mononuclear cells in the obese are in a proinflammatory state.

Ghanim H, Aljada A, Hofmeyer D, Syed T, Mohanty P, Dandona P.

Circulation. 2004 Sep 21;110(12):1564-71. Epub 2004 Sep 13.PMID: 15364812 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose intake induces an increase in activator protein 1 and early growth response 1 binding activities, in the expression of tissue factor and matrix metalloproteinase in mononuclear cells, and in plasma tissue factor and matrix metalloproteinase concentrations.

Aljada A, Ghanim H, Mohanty P, Syed T, Bandyopadhyay A, Dandona P.

Am J Clin Nutr. 2004 Jul;80(1):51-7.PMID: 15213027 [PubMed - indexed for MEDLINE]Related articlesFree article

Evidence for a potent antiinflammatory effect of rosiglitazone.

Mohanty P, Aljada A, Ghanim H, Hofmeyer D, Tripathy D, Syed T, Al-Haddad W, Dhindsa S, Dandona P.

J Clin Endocrinol Metab. 2004 Jun;89(6):2728-35.PMID: 15181049 [PubMed - indexed for MEDLINE]Related articlesFree article

Increase in intranuclear nuclear factor kappaB and decrease in inhibitor kappaB in mononuclear cells after a mixed meal: evidence for a proinflammatory effect.

Aljada A, Mohanty P, Ghanim H, Abdo T, Tripathy D, Chaudhuri A, Dandona P.

Am J Clin Nutr. 2004 Apr;79(4):682-90.PMID: 15051615 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential effects of glucose and alcohol on reactive oxygen species generation and intranuclear nuclear factor-kappaB in mononuclear cells.

Dhindsa S, Tripathy D, Mohanty P, Ghanim H, Syed T, Aljada A, Dandona P.

Metabolism. 2004 Mar;53(3):330-4.PMID: 15015145 [PubMed - indexed for MEDLINE]Related articles

Anti-inflammatory and profibrinolytic effect of insulin in acute ST-segment-elevation myocardial infarction.

Chaudhuri A, Janicke D, Wilson MF, Tripathy D, Garg R, Bandyopadhyay A, Calieri J, Hoffmeyer D, Syed T, Ghanim H, Aljada A, Dandona P.

Circulation. 2004 Feb 24;109(7):849-54. Epub 2004 Feb 2.PMID: 14757687 [PubMed - indexed for MEDLINE]Related articlesFree article

Elevation of free fatty acids induces inflammation and impairs vascular reactivity in healthy subjects.

Tripathy D, Mohanty P, Dhindsa S, Syed T, Ghanim H, Aljada A, Dandona P.

Diabetes. 2003 Dec;52(12):2882-7.PMID: 14633847 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin suppresses plasma concentration of vascular endothelial growth factor and matrix metalloproteinase-9.

Dandona P, Aljada A, Mohanty P, Ghanim H, Bandyopadhyay A, Chaudhuri A.

Diabetes Care. 2003 Dec;26(12):3310-4.PMID: 14633819 [PubMed - indexed for MEDLINE]Related articlesFree article

Angiotensin II receptor blocker valsartan suppresses reactive oxygen species generation in leukocytes, nuclear factor-kappa B, in mononuclear cells of normal subjects: evidence of an antiinflammatory action.

Dandona P, Kumar V, Aljada A, Ghanim H, Syed T, Hofmayer D, Mohanty P, Tripathy D, Garg R.

J Clin Endocrinol Metab. 2003 Sep;88(9):4496-501.PMID: 12970329 [PubMed - indexed for MEDLINE]Related articlesFree article

Translocation of p47phox and activation of NADPH oxidase in mononuclear cells.

Aljada A, Ghanim H, Dandona P.

Methods Mol Biol. 2002;196:99-103. No abstract available. PMID: 12152222 [PubMed - indexed for MEDLINE]Related articles

Activation of nuclear factor-kappa B (NF-kappa B) in mononuclear cells (MNC).

Aljada A, Ghanim H, Dandona P.

Methods Mol Biol. 2002;196:105-10. No abstract available. PMID: 12152187 [PubMed - indexed for MEDLINE]Related articles

Both lipid and protein intakes stimulate increased generation of reactive oxygen species by polymorphonuclear leukocytes and mononuclear cells.

Mohanty P, Ghanim H, Hamouda W, Aljada A, Garg R, Dandona P.

Am J Clin Nutr. 2002 Apr;75(4):767-72.PMID: 11916766 [PubMed - indexed for MEDLINE]Related articlesFree article

Tumor necrosis factor-alpha inhibits insulin-induced increase in endothelial nitric oxide synthase and reduces insulin receptor content and phosphorylation in human aortic endothelial cells.

Aljada A, Ghanim H, Assian E, Dandona P.

Metabolism. 2002 Apr;51(4):487-91.PMID: 11912559 [PubMed - indexed for MEDLINE]Related articles

Insulin inhibits the pro-inflammatory transcription factor early growth response gene-1 (Egr)-1 expression in mononuclear cells (MNC) and reduces plasma tissue factor (TF) and plasminogen activator inhibitor-1 (PAI-1) concentrations.

Aljada A, Ghanim H, Mohanty P, Kapur N, Dandona P.

J Clin Endocrinol Metab. 2002 Mar;87(3):1419-22.PMID: 11889219 [PubMed - indexed for MEDLINE]Related articlesFree article

Hydrocortisone suppresses intranuclear activator-protein-1 (AP-1) binding activity in mononuclear cells and plasma matrix metalloproteinase 2 and 9 (MMP-2 and MMP-9).

Aljada A, Ghanim H, Mohanty P, Hofmeyer D, Tripathy D, Dandona P.

J Clin Endocrinol Metab. 2001 Dec;86(12):5988-91.PMID: 11739475 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin inhibits intranuclear nuclear factor kappaB and stimulates IkappaB in mononuclear cells in obese subjects: evidence for an anti-inflammatory effect?

Dandona P, Aljada A, Mohanty P, Ghanim H, Hamouda W, Assian E, Ahmad S.

J Clin Endocrinol Metab. 2001 Jul;86(7):3257-65.PMID: 11443198 [PubMed - indexed for MEDLINE]Related articlesFree article

Nuclear factor-kappaB suppressive and inhibitor-kappaB stimulatory effects of troglitazone in obese patients with type 2 diabetes: evidence of an antiinflammatory action?

Aljada A, Garg R, Ghanim H, Mohanty P, Hamouda W, Assian E, Dandona P.

J Clin Endocrinol Metab. 2001 Jul;86(7):3250-6.PMID: 11443197 [PubMed - indexed for MEDLINE]Related articlesFree article

Troglitazone reduces the expression of PPARgamma while stimulating that of PPARalpha in mononuclear cells in obese subjects.

Aljada A, Ghanim H, Friedman J, Garg R, Mohanty P, Dandona P.

J Clin Endocrinol Metab. 2001 Jul;86(7):3130-3.PMID: 11443177 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibitory effect of a two day fast on reactive oxygen species (ROS) generation by leucocytes and plasma ortho-tyrosine and meta-tyrosine concentrations.

Dandona P, Mohanty P, Hamouda W, Ghanim H, Aljada A, Garg R, Kumar V.

J Clin Endocrinol Metab. 2001 Jun;86(6):2899-902.PMID: 11397907 [PubMed - indexed for MEDLINE]Related articlesFree article

Acute suppressive effect of hydrocortisone on p47 subunit of nicotinamide adenine dinucleotide phosphate oxidase.

Dandona P, Aljada A, Ghanim H, Mohanty P, Hamouda W, Al-Haddad W.

Metabolism. 2001 May;50(5):548-52.PMID: 11319715 [PubMed - indexed for MEDLINE]Related articles

Suppression of nuclear factor-kappaB and stimulation of inhibitor kappaB by troglitazone: evidence for an anti-inflammatory effect and a potential antiatherosclerotic effect in the obese.

Ghanim H, Garg R, Aljada A, Mohanty P, Kumbkarni Y, Assian E, Hamouda W, Dandona P.

J Clin Endocrinol Metab. 2001 Mar;86(3):1306-12.PMID: 11238525 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin inhibits NFkappaB and MCP-1 expression in human aortic endothelial cells.

Aljada A, Ghanim H, Saadeh R, Dandona P.

J Clin Endocrinol Metab. 2001 Jan;86(1):450-3.PMID: 11232040 [PubMed - indexed for MEDLINE]Related articlesFree article

The suppressive effect of dietary restriction and weight loss in the obese on the generation of reactive oxygen species by leukocytes, lipid peroxidation, and protein carbonylation.

Dandona P, Mohanty P, Ghanim H, Aljada A, Browne R, Hamouda W, Prabhala A, Afzal A, Garg R.

J Clin Endocrinol Metab. 2001 Jan;86(1):355-62.PMID: 11232024 [PubMed - indexed for MEDLINE]Related articlesFree article