PubMed

Derivation of insulin-producing cells from human embryonic stem cells.

Van Hoof D, D'Amour KA, German MS.

Stem Cell Res. 2009 Sep-Nov;3(2-3):73-87. Epub 2009 Aug 26.PMID: 19766074 [PubMed - in process]Related articles

Chronology of islet differentiation revealed by temporal cell labeling.

Miyatsuka T, Li Z, German MS.

Diabetes. 2009 Aug;58(8):1863-8. Epub 2009 May 28.PMID: 19478145 [PubMed - indexed for MEDLINE]Related articlesFree article

Homeodomain transcription factor NKX2.2 functions in immature cells to control enteroendocrine differentiation and is expressed in gastrointestinal neuroendocrine tumors.

Wang YC, Gallego-Arteche E, Iezza G, Yuan X, Matli MR, Choo SP, Zuraek MB, Gogia R, Lynn FC, German MS, Bergsland EK, Donner DB, Warren RS, Nakakura EK.

Endocr Relat Cancer. 2009 Mar;16(1):267-79. Epub 2008 Nov 5.PMID: 18987169 [PubMed - indexed for MEDLINE]Related articles

New beta-cells from old acini.

German MS.

Nat Biotechnol. 2008 Oct;26(10):1092-3. No abstract available. PMID: 18846076 [PubMed - indexed for MEDLINE]Related articles

The role of Lmx1a in the differentiation of human embryonic stem cells into midbrain dopamine neurons in culture and after transplantation into a Parkinson's disease model.

Cai J, Donaldson A, Yang M, German MS, Enikolopov G, Iacovitti L.

Stem Cells. 2009 Jan;27(1):220-9.PMID: 18832589 [PubMed - indexed for MEDLINE]Related articles

Mouse let-7 miRNA populations exhibit RNA editing that is constrained in the 5'-seed/ cleavage/anchor regions and stabilize predicted mmu-let-7a:mRNA duplexes.

Reid JG, Nagaraja AK, Lynn FC, Drabek RB, Muzny DM, Shaw CA, Weiss MK, Naghavi AO, Khan M, Zhu H, Tennakoon J, Gunaratne GH, Corry DB, Miller J, McManus MT, German MS, Gibbs RA, Matzuk MM, Gunaratne PH.

Genome Res. 2008 Oct;18(10):1571-81. Epub 2008 Jul 9.PMID: 18614752 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of the bHLH factor Math6 as a novel component of the embryonic pancreas transcriptional network.

Lynn FC, Sanchez L, Gomis R, German MS, Gasa R.

PLoS One. 2008 Jun 18;3(6):e2430.PMID: 18560595 [PubMed - indexed for MEDLINE]Related articlesFree article

Signals from the neural crest regulate beta-cell mass in the pancreas.

Nekrep N, Wang J, Miyatsuka T, German MS.

Development. 2008 Jun;135(12):2151-60.PMID: 18506029 [PubMed - indexed for MEDLINE]Related articlesFree article

Gender and neurogenin3 influence the pathogenesis of ketosis-prone diabetes.

Louet JF, Smith SB, Gautier JF, Molokhia M, Virally ML, Kevorkian JP, Guillausseau PJ, Vexiau P, Charpentier G, German MS, Vaisse C, Urbanek M, Mauvais-Jarvis F.

Diabetes Obes Metab. 2008 Sep;10(10):912-20. Epub 2007 Dec 17.PMID: 18093211 [PubMed - indexed for MEDLINE]Related articles

Induction of pancreatic islet cell differentiation by the neurogenin-neuroD cascade.

Gasa R, Mrejen C, Lynn FC, Skewes-Cox P, Sanchez L, Yang KY, Lin CH, Gomis R, German MS.

Differentiation. 2008 Apr;76(4):381-91. Epub 2007 Oct 9.PMID: 17924961 [PubMed - indexed for MEDLINE]Related articles

MicroRNA expression is required for pancreatic islet cell genesis in the mouse.

Lynn FC, Skewes-Cox P, Kosaka Y, McManus MT, Harfe BD, German MS.

Diabetes. 2007 Dec;56(12):2938-45. Epub 2007 Sep 5.PMID: 17804764 [PubMed - indexed for MEDLINE]Related articlesFree article

Sox9 coordinates a transcriptional network in pancreatic progenitor cells.

Lynn FC, Smith SB, Wilson ME, Yang KY, Nekrep N, German MS.

Proc Natl Acad Sci U S A. 2007 Jun 19;104(25):10500-5. Epub 2007 Jun 11.PMID: 17563382 [PubMed - indexed for MEDLINE]Related articlesFree article

Activin A-induced expression of PAX4 in AR42J-B13 cells involves the increase in transactivation of E47/E12.

Kanno R, Ogihara T, Igarashi Y, Tanaka Y, Smith SB, Kojima I, German MS, Kawamori R, Watada H.

Biochim Biophys Acta. 2006 Jan-Feb;1759(1-2):44-50. Epub 2006 Feb 13.PMID: 16546275 [PubMed - indexed for MEDLINE]Related articles

Ngn3 expression during postnatal in vitro beta cell neogenesis induced by the JAK/STAT pathway.

Baeyens L, Bonné S, German MS, Ravassard P, Heimberg H, Bouwens L.

Cell Death Differ. 2006 Nov;13(11):1892-9. Epub 2006 Mar 3.PMID: 16514419 [PubMed - indexed for MEDLINE]Related articlesFree article

The HMG box transcription factor Sox4 contributes to the development of the endocrine pancreas.

Wilson ME, Yang KY, Kalousova A, Lau J, Kosaka Y, Lynn FC, Wang J, Mrejen C, Episkopou V, Clevers HC, German MS.

Diabetes. 2005 Dec;54(12):3402-9.PMID: 16306355 [PubMed - indexed for MEDLINE]Related articlesFree article

Hedgehog signaling regulates expansion of pancreatic epithelial cells.

Kawahira H, Scheel DW, Smith SB, German MS, Hebrok M.

Dev Biol. 2005 Apr 1;280(1):111-21.PMID: 15766752 [PubMed - indexed for MEDLINE]Related articles

PAX4 gene variations predispose to ketosis-prone diabetes.

Mauvais-Jarvis F, Smith SB, Le May C, Leal SM, Gautier JF, Molokhia M, Riveline JP, Rajan AS, Kevorkian JP, Zhang S, Vexiau P, German MS, Vaisse C.

Hum Mol Genet. 2004 Dec 15;13(24):3151-9. Epub 2004 Oct 27.PMID: 15509590 [PubMed - indexed for MEDLINE]Related articlesFree article

MAP kinases and their roles in pancreatic beta-cells.

Khoo S, Gibson TB, Arnette D, Lawrence M, January B, McGlynn K, Vanderbilt CA, Griffen SC, German MS, Cobb MH.

Cell Biochem Biophys. 2004;40(3 Suppl):191-200. Review.PMID: 15289654 [PubMed - indexed for MEDLINE]Related articles

Neurogenin3 activates the islet differentiation program while repressing its own expression.

Smith SB, Watada H, German MS.

Mol Endocrinol. 2004 Jan;18(1):142-9. Epub 2003 Oct 23.PMID: 14576336 [PubMed - indexed for MEDLINE]Related articlesFree article

Hnf6 and Tcf2 (MODY5) are linked in a gene network operating in a precursor cell domain of the embryonic pancreas.

Maestro MA, Boj SF, Luco RF, Pierreux CE, Cabedo J, Servitja JM, German MS, Rousseau GG, Lemaigre FP, Ferrer J.

Hum Mol Genet. 2003 Dec 15;12(24):3307-14. Epub 2003 Oct 21.PMID: 14570708 [PubMed - indexed for MEDLINE]Related articlesFree article

Hes6 promotes cortical neurogenesis and inhibits Hes1 transcription repression activity by multiple mechanisms.

Gratton MO, Torban E, Jasmin SB, Theriault FM, German MS, Stifani S.

Mol Cell Biol. 2003 Oct;23(19):6922-35.PMID: 12972610 [PubMed - indexed for MEDLINE]Related articlesFree article

Activated Notch1 prevents differentiation of pancreatic acinar cells and attenuate endocrine development.

Hald J, Hjorth JP, German MS, Madsen OD, Serup P, Jensen J.

Dev Biol. 2003 Aug 15;260(2):426-37.PMID: 12921743 [PubMed - indexed for MEDLINE]Related articles

Pdx1 expression in Irs2-deficient mouse beta-cells is regulated in a strain-dependent manner.

Suzuki R, Tobe K, Terauchi Y, Komeda K, Kubota N, Eto K, Yamauchi T, Azuma K, Kaneto H, Taguchi T, Koga T, German MS, Watada H, Kawamori R, Wright CV, Kajimoto Y, Kimura S, Nagai R, Kadowaki T.

J Biol Chem. 2003 Oct 31;278(44):43691-8. Epub 2003 Jul 16.PMID: 12869553 [PubMed - indexed for MEDLINE]Related articlesFree article

Neurogenin3 and hepatic nuclear factor 1 cooperate in activating pancreatic expression of Pax4.

Smith SB, Gasa R, Watada H, Wang J, Griffen SC, German MS.

J Biol Chem. 2003 Oct 3;278(40):38254-9. Epub 2003 Jul 1.PMID: 12837760 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of insulin gene transcription by ERK1 and ERK2 in pancreatic beta cells.

Khoo S, Griffen SC, Xia Y, Baer RJ, German MS, Cobb MH.

J Biol Chem. 2003 Aug 29;278(35):32969-77. Epub 2003 Jun 16.PMID: 12810726 [PubMed - indexed for MEDLINE]Related articlesFree article

p38 MAPK is involved in activin A- and hepatocyte growth factor-mediated expression of pro-endocrine gene neurogenin 3 in AR42J-B13 cells.

Ogihara T, Watada H, Kanno R, Ikeda F, Nomiyama T, Tanaka Y, Nakao A, German MS, Kojima I, Kawamori R.

J Biol Chem. 2003 Jun 13;278(24):21693-700. Epub 2003 Apr 1.PMID: 12670941 [PubMed - indexed for MEDLINE]Related articlesFree article

Distinct gene expression programs function in progenitor and mature islet cells.

Watada H, Scheel DW, Leung J, German MS.

J Biol Chem. 2003 May 9;278(19):17130-40. Epub 2003 Feb 25.PMID: 12604598 [PubMed - indexed for MEDLINE]Related articlesFree article

Gene expression cascades in pancreatic development.

Wilson ME, Scheel D, German MS.

Mech Dev. 2003 Jan;120(1):65-80. Review.PMID: 12490297 [PubMed - indexed for MEDLINE]Related articles

Cloning, expression and genomic structure of human LMX1A, and variant screening in Pima Indians.

Thameem F, Wolford JK, Wang J, German MS, Bogardus C, Prochazka M.

Gene. 2002 May 15;290(1-2):217-25.PMID: 12062816 [PubMed - indexed for MEDLINE]Related articles

Expression pattern of IAPP and prohormone convertase 1/3 reveals a distinctive set of endocrine cells in the embryonic pancreas.

Wilson ME, Kalamaras JA, German MS.

Mech Dev. 2002 Jul;115(1-2):171-6.PMID: 12049785 [PubMed - indexed for MEDLINE]Related articles

Regulation of the pancreatic pro-endocrine gene neurogenin3.

Lee JC, Smith SB, Watada H, Lin J, Scheel D, Wang J, Mirmira RG, German MS.

Diabetes. 2001 May;50(5):928-36. Erratum in: Diabetes 2001 Jun;50(6):1512. PMID: 11334435 [PubMed - indexed for MEDLINE]Related articlesFree article

Cyclic adenosine 3',5'-monophosphate increases pancreatic glucokinase activity and gene expression.

Fernandez-Mejia C, Vega-Allende J, Rojas-Ochoa A, Rodriguez-Dorantes M, Romero-Navarro G, Matschinsky FM, Wang J, German MS.

Endocrinology. 2001 Apr;142(4):1448-52.PMID: 11250924 [PubMed - indexed for MEDLINE]Related articlesFree article

Mutations in the coding region of the neurogenin 3 gene (NEUROG3) are not a common cause of maturity-onset diabetes of the young in Japanese subjects.

del Bosque-Plata L, Lin J, Horikawa Y, Schwarz PE, Cox NJ, Iwasaki N, Ogata M, Iwamoto Y, German MS, Bell GI.

Diabetes. 2001 Mar;50(3):694-6.PMID: 11246894 [PubMed - indexed for MEDLINE]Related articlesFree article

A genetic defect in beta-cell gene expression segregates independently from the fa locus in the ZDF rat.

Griffen SC, Wang J, German MS.

Diabetes. 2001 Jan;50(1):63-8.PMID: 11147796 [PubMed - indexed for MEDLINE]Related articlesFree article

beta-cell transcription factors and diabetes: no evidence for diabetes-associated mutations in the gene encoding the basic helix-loop-helix transcription factor neurogenic differentiation 4 (NEUROD4) in Japanese patients with MODY.

Horikawa Y, Horikawa Y, Cox NJ, Iwasaki N, Ogata M, Iwamoto Y, Schwitzgebel V, German MS, Bell GI.

Diabetes. 2000 Nov;49(11):1955-7.PMID: 11078465 [PubMed - indexed for MEDLINE]Related articlesFree article

Autoregulation and maturity onset diabetes of the young transcription factors control the human PAX4 promoter.

Smith SB, Watada H, Scheel DW, Mrejen C, German MS.

J Biol Chem. 2000 Nov 24;275(47):36910-9.PMID: 10967107 [PubMed - indexed for MEDLINE]Related articlesFree article

Intramolecular control of transcriptional activity by the NK2-specific domain in NK-2 homeodomain proteins.

Watada H, Mirmira RG, Kalamaras J, German MS.

Proc Natl Acad Sci U S A. 2000 Aug 15;97(17):9443-8.PMID: 10944215 [PubMed - indexed for MEDLINE]Related articlesFree article

Transcriptional and translational regulation of beta-cell differentiation factor Nkx6.1.

Watada H, Mirmira RG, Leung J, German MS.

J Biol Chem. 2000 Nov 3;275(44):34224-30.PMID: 10938085 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression of neurogenin3 reveals an islet cell precursor population in the pancreas.

Schwitzgebel VM, Scheel DW, Conners JR, Kalamaras J, Lee JE, Anderson DJ, Sussel L, Johnson JD, German MS.

Development. 2000 Aug;127(16):3533-42.PMID: 10903178 [PubMed - indexed for MEDLINE]Related articlesFree article

Beta-cell differentiation factor Nkx6.1 contains distinct DNA binding interference and transcriptional repression domains.

Mirmira RG, Watada H, German MS.

J Biol Chem. 2000 May 12;275(19):14743-51.PMID: 10799563 [PubMed - indexed for MEDLINE]Related articlesFree article

LMX1B transactivation and expression in nail-patella syndrome.

Dreyer SD, Morello R, German MS, Zabel B, Winterpacht A, Lunstrum GP, Horton WA, Oberg KC, Lee B.

Hum Mol Genet. 2000 Apr 12;9(7):1067-74.PMID: 10767331 [PubMed - indexed for MEDLINE]Related articlesFree article

The homeodomain of PDX-1 mediates multiple protein-protein interactions in the formation of a transcriptional activation complex on the insulin promoter.

Ohneda K, Mirmira RG, Wang J, Johnson JD, German MS.

Mol Cell Biol. 2000 Feb;20(3):900-11.PMID: 10629047 [PubMed - indexed for MEDLINE]Related articlesFree article

Paired-homeodomain transcription factor PAX4 acts as a transcriptional repressor in early pancreatic development.

Smith SB, Ee HC, Conners JR, German MS.

Mol Cell Biol. 1999 Dec;19(12):8272-80.PMID: 10567552 [PubMed - indexed for MEDLINE]Related articlesFree article

Biotin regulation of pancreatic glucokinase and insulin in primary cultured rat islets and in biotin-deficient rats.

Romero-Navarro G, Cabrera-Valladares G, German MS, Matschinsky FM, Velazquez A, Wang J, Fernandez-Mejia C.

Endocrinology. 1999 Oct;140(10):4595-600.PMID: 10499515 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of retinoic acid on glucokinase activity and gene expression and on insulin secretion in primary cultures of pancreatic islets.

Cabrera-Valladares G, German MS, Matschinsky FM, Wang J, Fernandez-Mejia C.

Endocrinology. 1999 Jul;140(7):3091-6.PMID: 10385401 [PubMed - indexed for MEDLINE]Related articlesFree article

A novel glucose-responsive element in the human insulin gene functions uniquely in primary cultured islets.

Sander M, Griffen SC, Huang J, German MS.

Proc Natl Acad Sci U S A. 1998 Sep 29;95(20):11572-7.PMID: 9751707 [PubMed - indexed for MEDLINE]Related articlesFree article

Beta-cell transcription factors and diabetes: mutations in the coding region of the BETA2/NeuroD1 (NEUROD1) and Nkx2.2 (NKX2B) genes are not associated with maturity-onset diabetes of the young in Japanese.

Furuta H, Horikawa Y, Iwasaki N, Hara M, Sussel L, Le Beau MM, Davis EM, Ogata M, Iwamoto Y, German MS, Bell GI.

Diabetes. 1998 Aug;47(8):1356-8. No abstract available. PMID: 9703340 [PubMed - indexed for MEDLINE]Related articlesFree article

Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells.

Sussel L, Kalamaras J, Hartigan-O'Connor DJ, Meneses JJ, Pedersen RA, Rubenstein JL, German MS.

Development. 1998 Jun;125(12):2213-21.PMID: 9584121 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of a human LMX1 (LMX1.1)-related gene, LMX1.2: tissue-specific expression and linkage mapping on chromosome 9.

Iannotti CA, Inoue H, Bernal E, Aoki M, Liu L, Donis-Keller H, German MS, Permutt MA.

Genomics. 1997 Dec 15;46(3):520-4.PMID: 9441763 [PubMed - indexed for MEDLINE]Related articles

The endocrine secretion of human insulin and growth hormone by exocrine glands of the gastrointestinal tract.

Goldfine ID, German MS, Tseng HC, Wang J, Bolaffi JL, Chen JW, Olson DC, Rothman SS.

Nat Biotechnol. 1997 Dec;15(13):1378-82.PMID: 9415890 [PubMed - indexed for MEDLINE]Related articles