PubMed

Serum anti-toxin B antibody correlates with protection from recurrent Clostridium difficile infection (CDI).

Leav BA, Blair B, Leney M, Knauber M, Reilly C, Lowy I, Gerding DN, Kelly CP, Katchar K, Baxter R, Ambrosino D, Molrine D.

Vaccine. 2009 Nov 23. [Epub ahead of print]PMID: 19941990 [PubMed - as supplied by publisher]

Impact of an intervention to control Clostridium difficile infection on hospital and community onset disease; an interrupted time series analysis.

Price J, Cheek E, Lippett S, Cubbon M, Gerding DN, Sambol SP, Citron DM, Llewelyn M.

Clin Microbiol Infect. 2009 Oct 14. [Epub ahead of print]PMID: 19832710 [PubMed - as supplied by publisher]Related articles

Comparative genome and phenotypic analysis of Clostridium difficile 027 strains provides insight into the evolution of a hypervirulent bacterium.

Stabler RA, He M, Dawson L, Martin M, Valiente E, Corton C, Lawley TD, Sebaihia M, Quail MA, Rose G, Gerding DN, Gibert M, Popoff MR, Parkhill J, Dougan G, Wren BW.

Genome Biol. 2009;10(9):R102. Epub 2009 Sep 25.PMID: 19781061 [PubMed - in process]Related articlesFree article

Molecular epidemiology of Clostridium difficile over the course of 10 years in a tertiary care hospital.

Belmares J, Johnson S, Parada JP, Olson MM, Clabots CR, Bettin KM, Peterson LR, Gerding DN.

Clin Infect Dis. 2009 Oct 15;49(8):1141-7.PMID: 19780659 [PubMed - indexed for MEDLINE]Related articles

Typing and susceptibility of bacterial isolates from the fidaxomicin (OPT-80) phase II study for C. difficile infection.

Citron DM, Babakhani F, Goldstein EJ, Nagaro K, Sambol S, Sears P, Shue YK, Gerding DN.

Anaerobe. 2009 Sep 12. [Epub ahead of print]PMID: 19755166 [PubMed - as supplied by publisher]Related articles

Distribution of Clostridium difficile strains from a North American, European and Australian trial of treatment for C. difficile infections: 2005-2007.

Cheknis AK, Sambol SP, Davidson DM, Nagaro KJ, Mancini MC, Aida Hidalgo-Arroyo G, Brazier JS, Johnson S, Gerding DN.

Anaerobe. 2009 Sep 6. [Epub ahead of print]PMID: 19737618 [PubMed - as supplied by publisher]Related articles

Elevated levels of intestinal inflammation in Clostridium difficile infection associated with fluoroquinolone-resistant C. difficile.

Pawlowski SW, Archbald-Pannone L, Carman RJ, Alcantara-Warren C, Lyerly D, Genheimer CW, Gerding DN, Guerrant RL.

J Hosp Infect. 2009 Oct;73(2):185-7. Epub 2009 Aug 26. No abstract available. PMID: 19709778 [PubMed - in process]Related articles

Rifaximin Redux: Treatment of recurrent Clostridium difficile infections with Rifaximin immediately post-vancomycin treatment.

Johnson S, Schriever C, Patel U, Patel T, Hecht DW, Gerding DN.

Anaerobe. 2009 Aug 18. [Epub ahead of print]PMID: 19698797 [PubMed - as supplied by publisher]Related articles

New approach to the management of Clostridium difficile infection: colonisation with non-toxigenic C. difficile during daily ampicillin or ceftriaxone administration.

Merrigan MM, Sambol SP, Johnson S, Gerding DN.

Int J Antimicrob Agents. 2009 Mar;33 Suppl 1:S46-50.PMID: 19303570 [PubMed - indexed for MEDLINE]Related articles

Clostridium difficile 30 years on: what has, or has not, changed and why?

Gerding DN.

Int J Antimicrob Agents. 2009 Mar;33 Suppl 1:S2-8. Review.PMID: 19303564 [PubMed - indexed for MEDLINE]Related articles

Clostridium difficile infection: new developments in epidemiology and pathogenesis.

Rupnik M, Wilcox MH, Gerding DN.

Nat Rev Microbiol. 2009 Jul;7(7):526-36. Review.PMID: 19528959 [PubMed - indexed for MEDLINE]Related articles

Clostridium difficile infection caused by the epidemic BI/NAP1/027 strain.

O'Connor JR, Johnson S, Gerding DN.

Gastroenterology. 2009 May;136(6):1913-24. Epub 2009 May 7. Review. Erratum in: Gastroenterology. 2009 Aug;137(2):743. PMID: 19457419 [PubMed - indexed for MEDLINE]Related articles

Toxin B is essential for virulence of Clostridium difficile.

Lyras D, O'Connor JR, Howarth PM, Sambol SP, Carter GP, Phumoonna T, Poon R, Adams V, Vedantam G, Johnson S, Gerding DN, Rood JI.

Nature. 2009 Apr 30;458(7242):1176-9. Epub 2009 Mar 1.PMID: 19252482 [PubMed - indexed for MEDLINE]Related articlesFree article

Antimotility agents for the treatment of Clostridium difficile infection: is the juice worth the squeeze?

Gerding DN.

Clin Infect Dis. 2009 Mar 1;48(5):606-8. Review. No abstract available. PMID: 19191647 [PubMed - indexed for MEDLINE]Related articles

Measuring the severity of Clostridium difficile infection: implications for management and drug development.

Belmares J, Gerding DN, Tillotson G, Johnson S.

Expert Rev Anti Infect Ther. 2008 Dec;6(6):897-908.PMID: 19053902 [PubMed - indexed for MEDLINE]Related articles

A mouse model of Clostridium difficile-associated disease.

Chen X, Katchar K, Goldsmith JD, Nanthakumar N, Cheknis A, Gerding DN, Kelly CP.

Gastroenterology. 2008 Dec;135(6):1984-92. Epub 2008 Sep 10.PMID: 18848941 [PubMed - indexed for MEDLINE]Related articles

Strategies to prevent clostridium difficile infections in acute care hospitals.

Dubberke ER, Gerding DN, Classen D, Arias KM, Podgorny K, Anderson DJ, Burstin H, Calfee DP, Coffin SE, Fraser V, Griffin FA, Gross P, Kaye KS, Klompas M, Lo E, Marschall J, Mermel LA, Nicolle L, Pegues DA, Perl TM, Saint S, Salgado CD, Weinstein RA, Wise R, Yokoe DS.

Infect Control Hosp Epidemiol. 2008 Oct;29 Suppl 1:S81-92. No abstract available. PMID: 18840091 [PubMed - indexed for MEDLINE]Related articles

Strategies to prevent transmission of methicillin-resistant Staphylococcus aureus in acute care hospitals.

Calfee DP, Salgado CD, Classen D, Arias KM, Podgorny K, Anderson DJ, Burstin H, Coffin SE, Dubberke ER, Fraser V, Gerding DN, Griffin FA, Gross P, Kaye KS, Klompas M, Lo E, Marschall J, Mermel LA, Nicolle L, Pegues DA, Perl TM, Saint S, Weinstein RA, Wise R, Yokoe DS.

Infect Control Hosp Epidemiol. 2008 Oct;29 Suppl 1:S62-80. No abstract available. PMID: 18840090 [PubMed - indexed for MEDLINE]Related articles

Strategies to prevent surgical site infections in acute care hospitals.

Anderson DJ, Kaye KS, Classen D, Arias KM, Podgorny K, Burstin H, Calfee DP, Coffin SE, Dubberke ER, Fraser V, Gerding DN, Griffin FA, Gross P, Klompas M, Lo E, Marschall J, Mermel LA, Nicolle L, Pegues DA, Perl TM, Saint S, Salgado CD, Weinstein RA, Wise R, Yokoe DS.

Infect Control Hosp Epidemiol. 2008 Oct;29 Suppl 1:S51-61. No abstract available. PMID: 18840089 [PubMed - indexed for MEDLINE]Related articles

Strategies to prevent catheter-associated urinary tract infections in acute care hospitals.

Lo E, Nicolle L, Classen D, Arias KM, Podgorny K, Anderson DJ, Burstin H, Calfee DP, Coffin SE, Dubberke ER, Fraser V, Gerding DN, Griffin FA, Gross P, Kaye KS, Klompas M, Marschall J, Mermel LA, Pegues DA, Perl TM, Saint S, Salgado CD, Weinstein RA, Wise R, Yokoe DS.

Infect Control Hosp Epidemiol. 2008 Oct;29 Suppl 1:S41-50. No abstract available. PMID: 18840088 [PubMed - indexed for MEDLINE]Related articles

Strategies to prevent ventilator-associated pneumonia in acute care hospitals.

Coffin SE, Klompas M, Classen D, Arias KM, Podgorny K, Anderson DJ, Burstin H, Calfee DP, Dubberke ER, Fraser V, Gerding DN, Griffin FA, Gross P, Kaye KS, Lo E, Marschall J, Mermel LA, Nicolle L, Pegues DA, Perl TM, Saint S, Salgado CD, Weinstein RA, Wise R, Yokoe DS.

Infect Control Hosp Epidemiol. 2008 Oct;29 Suppl 1:S31-40. No abstract available. PMID: 18840087 [PubMed - indexed for MEDLINE]Related articles

Strategies to prevent central line-associated bloodstream infections in acute care hospitals.

Marschall J, Mermel LA, Classen D, Arias KM, Podgorny K, Anderson DJ, Burstin H, Calfee DP, Coffin SE, Dubberke ER, Fraser V, Gerding DN, Griffin FA, Gross P, Kaye KS, Klompas M, Lo E, Nicolle L, Pegues DA, Perl TM, Saint S, Salgado CD, Weinstein RA, Wise R, Yokoe DS.

Infect Control Hosp Epidemiol. 2008 Oct;29 Suppl 1:S22-30. No abstract available. Erratum in: Infect Control Hosp Epidemiol. 2009 Aug;30(8):815. PMID: 18840085 [PubMed - indexed for MEDLINE]Related articles

A compendium of strategies to prevent healthcare-associated infections in acute care hospitals.

Yokoe DS, Mermel LA, Anderson DJ, Arias KM, Burstin H, Calfee DP, Coffin SE, Dubberke ER, Fraser V, Gerding DN, Griffin FA, Gross P, Kaye KS, Klompas M, Lo E, Marschall J, Nicolle L, Pegues DA, Perl TM, Podgorny K, Saint S, Salgado CD, Weinstein RA, Wise R, Classen D.

Infect Control Hosp Epidemiol. 2008 Oct;29 Suppl 1:S12-21.PMID: 18840084 [PubMed - indexed for MEDLINE]Related articles

Toxinotype V Clostridium difficile in humans and food animals.

Jhung MA, Thompson AD, Killgore GE, Zukowski WE, Songer G, Warny M, Johnson S, Gerding DN, McDonald LC, Limbago BM.

Emerg Infect Dis. 2008 Jul;14(7):1039-45.PMID: 18598622 [PubMed - indexed for MEDLINE]Related articlesFree article

Rifampin and rifaximin resistance in clinical isolates of Clostridium difficile.

O'Connor JR, Galang MA, Sambol SP, Hecht DW, Vedantam G, Gerding DN, Johnson S.

Antimicrob Agents Chemother. 2008 Aug;52(8):2813-7. Epub 2008 Jun 16.PMID: 18559647 [PubMed - indexed for MEDLINE]Related articlesFree article

Measures to control and prevent Clostridium difficile infection.

Gerding DN, Muto CA, Owens RC Jr.

Clin Infect Dis. 2008 Jan 15;46 Suppl 1:S43-9.PMID: 18177221 [PubMed - indexed for MEDLINE]Related articles

Treatment of Clostridium difficile infection.

Gerding DN, Muto CA, Owens RC Jr.

Clin Infect Dis. 2008 Jan 15;46 Suppl 1:S32-42. Review.PMID: 18177219 [PubMed - indexed for MEDLINE]Related articles

Clinical recognition and diagnosis of Clostridium difficile infection.

Bartlett JG, Gerding DN.

Clin Infect Dis. 2008 Jan 15;46 Suppl 1:S12-8. Review.PMID: 18177217 [PubMed - indexed for MEDLINE]Related articles

Clostridium difficile-associated disease treatment response depends on definition of cure.

Lawrence SJ, Dubberke ER, Johnson S, Gerding DN.

Clin Infect Dis. 2007 Dec 15;45(12):1648; author reply 1649-51. No abstract available. PMID: 18190331 [PubMed - indexed for MEDLINE]Related articles

Infection of hamsters with historical and epidemic BI types of Clostridium difficile.

Razaq N, Sambol S, Nagaro K, Zukowski W, Cheknis A, Johnson S, Gerding DN.

J Infect Dis. 2007 Dec 15;196(12):1813-9.PMID: 18190262 [PubMed - indexed for MEDLINE]Related articles

Comparison of seven techniques for typing international epidemic strains of Clostridium difficile: restriction endonuclease analysis, pulsed-field gel electrophoresis, PCR-ribotyping, multilocus sequence typing, multilocus variable-number tandem-repeat analysis, amplified fragment length polymorphism, and surface layer protein A gene sequence typing.

Killgore G, Thompson A, Johnson S, Brazier J, Kuijper E, Pepin J, Frost EH, Savelkoul P, Nicholson B, van den Berg RJ, Kato H, Sambol SP, Zukowski W, Woods C, Limbago B, Gerding DN, McDonald LC.

J Clin Microbiol. 2008 Feb;46(2):431-7. Epub 2007 Nov 26.PMID: 18039796 [PubMed - indexed for MEDLINE]Related articlesFree article

Outcome of metronidazole therapy for Clostridium difficile disease and correlation with a scoring system.

Belmares J, Gerding DN, Parada JP, Miskevics S, Weaver F, Johnson S.

J Infect. 2007 Dec;55(6):495-501. Epub 2007 Nov 5. Review.PMID: 17983659 [PubMed - indexed for MEDLINE]Related articles

Onset of symptoms and time to diagnosis of Clostridium difficile-associated disease following discharge from an acute care hospital.

Chang HT, Krezolek D, Johnson S, Parada JP, Evans CT, Gerding DN.

Infect Control Hosp Epidemiol. 2007 Aug;28(8):926-31. Epub 2007 Jun 14.PMID: 17620239 [PubMed - indexed for MEDLINE]Related articles

In vitro activities of 15 antimicrobial agents against 110 toxigenic clostridium difficile clinical isolates collected from 1983 to 2004.

Hecht DW, Galang MA, Sambol SP, Osmolski JR, Johnson S, Gerding DN.

Antimicrob Agents Chemother. 2007 Aug;51(8):2716-9. Epub 2007 May 21.PMID: 17517836 [PubMed - indexed for MEDLINE]Related articlesFree article

Interruption of recurrent Clostridium difficile-associated diarrhea episodes by serial therapy with vancomycin and rifaximin.

Johnson S, Schriever C, Galang M, Kelly CP, Gerding DN.

Clin Infect Dis. 2007 Mar 15;44(6):846-8. Epub 2007 Feb 2.PMID: 17304459 [PubMed - indexed for MEDLINE]Related articles

New definitions will help, but cultures are critical for resolving unanswered questions about Clostridium difficile.

Gerding DN.

Infect Control Hosp Epidemiol. 2007 Feb;28(2):113-5. Epub 2007 Jan 31. No abstract available. PMID: 17265390 [PubMed - indexed for MEDLINE]Related articles

Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America guidelines for developing an institutional program to enhance antimicrobial stewardship.

Dellit TH, Owens RC, McGowan JE Jr, Gerding DN, Weinstein RA, Burke JP, Huskins WC, Paterson DL, Fishman NO, Carpenter CF, Brennan PJ, Billeter M, Hooton TM; Infectious Diseases Society of America; Society for Healthcare Epidemiology of America.

Clin Infect Dis. 2007 Jan 15;44(2):159-77. Epub 2006 Dec 13. No abstract available. PMID: 17173212 [PubMed - indexed for MEDLINE]Related articles

Comparative phylogenomics of Clostridium difficile reveals clade specificity and microevolution of hypervirulent strains.

Stabler RA, Gerding DN, Songer JG, Drudy D, Brazier JS, Trinh HT, Witney AA, Hinds J, Wren BW.

J Bacteriol. 2006 Oct;188(20):7297-305.PMID: 17015669 [PubMed - indexed for MEDLINE]Related articlesFree article

Susceptibility of hamsters to human pathogenic Clostridium difficile strain B1 following clindamycin, ampicillin or ceftriaxone administration.

Merrigan M, Sambol S, Johnson S, Gerding DN.

Anaerobe. 2003 Apr;9(2):91-5.PMID: 16887694 [PubMed]Related articles

Multilocus variable-number tandem-repeat analysis for investigation of Clostridium difficile transmission in Hospitals.

Marsh JW, O'Leary MM, Shutt KA, Pasculle AW, Johnson S, Gerding DN, Muto CA, Harrison LH.

J Clin Microbiol. 2006 Jul;44(7):2558-66.PMID: 16825380 [PubMed - indexed for MEDLINE]Related articlesFree article

Genotypic and phenotypic analysis of Clostridium difficile correlated with previous antibiotic exposure.

Samore MH, Venkataraman L, DeGirolami PC, Merrigan MM, Johnson S, Gerding DN, Carmeli Y, Harbarth S.

Microb Drug Resist. 2006 Spring;12(1):23-8.PMID: 16584304 [PubMed - indexed for MEDLINE]Related articles

Binary toxin-producing, large clostridial toxin-negative Clostridium difficile strains are enterotoxic but do not cause disease in hamsters.

Geric B, Carman RJ, Rupnik M, Genheimer CW, Sambol SP, Lyerly DM, Gerding DN, Johnson S.

J Infect Dis. 2006 Apr 15;193(8):1143-50. Epub 2006 Mar 6.PMID: 16544255 [PubMed - indexed for MEDLINE]Related articles

An epidemic, toxin gene-variant strain of Clostridium difficile.

McDonald LC, Killgore GE, Thompson A, Owens RC Jr, Kazakova SV, Sambol SP, Johnson S, Gerding DN.

N Engl J Med. 2005 Dec 8;353(23):2433-41. Epub 2005 Dec 1.PMID: 16322603 [PubMed - indexed for MEDLINE]Related articlesFree article

Metronidazole for Clostridium difficile-associated disease: is it okay for Mom?

Gerding DN.

Clin Infect Dis. 2005 Jun 1;40(11):1598-600. Epub 2005 Apr 25. No abstract available. PMID: 15889356 [PubMed - indexed for MEDLINE]Related articles

Revised nomenclature of Clostridium difficile toxins and associated genes.

Rupnik M, Dupuy B, Fairweather NF, Gerding DN, Johnson S, Just I, Lyerly DM, Popoff MR, Rood JI, Sonenshein AL, Thelestam M, Wren BW, Wilkins TD, von Eichel-Streiber C.

J Med Microbiol. 2005 Feb;54(Pt 2):113-7.PMID: 15673503 [PubMed - indexed for MEDLINE]Related articlesFree article

A hospital outbreak of Clostridium difficile disease associated with isolates carrying binary toxin genes.

McEllistrem MC, Carman RJ, Gerding DN, Genheimer CW, Zheng L.

Clin Infect Dis. 2005 Jan 15;40(2):265-72. Epub 2004 Dec 15.PMID: 15655746 [PubMed - indexed for MEDLINE]Related articles

Staphylococcus aureus and Clostridium difficile cause distinct pseudomembranous intestinal diseases.

Froberg MK, Palavecino E, Dykoski R, Gerding DN, Peterson LR, Johnson S.

Clin Infect Dis. 2004 Sep 1;39(5):747-50. Epub 2004 Aug 13.PMID: 15356793 [PubMed - indexed for MEDLINE]Related articles

Distribution of Clostridium difficile variant toxinotypes and strains with binary toxin genes among clinical isolates in an American hospital.

Geric B, Rupnik M, Gerding DN, Grabnar M, Johnson S.

J Med Microbiol. 2004 Sep;53(Pt 9):887-94.PMID: 15314196 [PubMed - indexed for MEDLINE]Related articlesFree article

Clindamycin, cephalosporins, fluoroquinolones, and Clostridium difficile-associated diarrhea: this is an antimicrobial resistance problem.

Gerding DN.

Clin Infect Dis. 2004 Mar 1;38(5):646-8. Epub 2004 Feb 11. No abstract available. PMID: 14986247 [PubMed - indexed for MEDLINE]Related articles

Prevention of fatal Clostridium difficile-associated disease during continuous administration of clindamycin in hamsters.

Merrigan MM, Sambol SP, Johnson S, Gerding DN.

J Infect Dis. 2003 Dec 15;188(12):1922-7. Epub 2003 Dec 9.PMID: 14673773 [PubMed - indexed for MEDLINE]Related articles