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    Results: 1 to 50 of 86

    1.

    MicroRNA-125a is over-expressed in insulin target tissues in a spontaneous rat model of Type 2 Diabetes.

    Herrera BM, Lockstone HE, Taylor JM, Wills QF, Kaisaki PJ, Barrett A, Camps C, Fernandez C, Ragoussis J, Gauguier D, McCarthy MI, Lindgren CM.

    BMC Med Genomics. 2009 Aug 18;2:54.PMID: 19689793 [PubMed - in process]Related articlesFree article

    2.

    Functional annotations of diabetes nephropathy susceptibility loci through analysis of genome-wide renal gene expression in rat models of diabetes mellitus.

    Hu Y, Kaisaki PJ, Argoud K, Wilder SP, Wallace KJ, Woon PY, Blancher C, Tarnow L, Groop PH, Hadjadj S, Marre M, Parving HH, Farrall M, Cox RD, Lathrop M, Vionnet N, Bihoreau MT, Gauguier D.

    BMC Med Genomics. 2009 Jul 9;2:41.PMID: 19586551 [PubMed - in process]Related articlesFree article

    3.

    Comparative analysis of methods for gene transcription profiling data derived from different microarray technologies in rat and mouse models of diabetes.

    Wilder SP, Kaisaki PJ, Argoud K, Salhan A, Ragoussis J, Bihoreau MT, Gauguier D.

    BMC Genomics. 2009 Feb 5;10:63.PMID: 19196459 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    A resource for the simultaneous high-resolution mapping of multiple quantitative trait loci in rats: the NIH heterogeneous stock.

    Johannesson M, Lopez-Aumatell R, Stridh P, Diez M, Tuncel J, Blázquez G, Martinez-Membrives E, Cañete T, Vicens-Costa E, Graham D, Copley RR, Hernandez-Pliego P, Beyeen AD, Ockinger J, Fernández-Santamaría C, Gulko PS, Brenner M, Tobeña A, Guitart-Masip M, Giménez-Llort L, Dominiczak A, Holmdahl R, Gauguier D, Olsson T, Mott R, Valdar W, Redei EE, Fernández-Teruel A, Flint J.

    Genome Res. 2009 Jan;19(1):150-8. Epub 2008 Oct 29.PMID: 18971309 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    Pathophysiological, genetic and gene expression features of a novel rodent model of the cardio-metabolic syndrome.

    Wallis RH, Collins SC, Kaisaki PJ, Argoud K, Wilder SP, Wallace KJ, Ria M, Ktorza A, Rorsman P, Bihoreau MT, Gauguier D.

    PLoS One. 2008 Aug 13;3(8):e2962.PMID: 18698428 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    G/T substitution in intron 1 of the UNC13B gene is associated with increased risk of nephropathy in patients with type 1 diabetes.

    Trégouet DA, Groop PH, McGinn S, Forsblom C, Hadjadj S, Marre M, Parving HH, Tarnow L, Telgmann R, Godefroy T, Nicaud V, Rousseau R, Parkkonen M, Hoverfält A, Gut I, Heath S, Matsuda F, Cox R, Kazeem G, Farrall M, Gauguier D, Brand-Herrmann SM, Cambien F, Lathrop M, Vionnet N; EURAGEDIC Consortium.

    Diabetes. 2008 Oct;57(10):2843-50. Epub 2008 Jul 15.PMID: 18633107 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    [Novel tools for chromosomal mapping and identification of genes underlying complex traits in the rat]

    Gauguier D, Bihoreau MT.

    Med Sci (Paris). 2008 May;24(5):545-7. French. No abstract available. PMID: 18466735 [PubMed - indexed for MEDLINE]Related articles

    8.

    SNP and haplotype mapping for genetic analysis in the rat.

    STAR Consortium, Saar K, Beck A, Bihoreau MT, Birney E, Brocklebank D, Chen Y, Cuppen E, Demonchy S, Dopazo J, Flicek P, Foglio M, Fujiyama A, Gut IG, Gauguier D, Guigo R, Guryev V, Heinig M, Hummel O, Jahn N, Klages S, Kren V, Kube M, Kuhl H, Kuramoto T, Kuroki Y, Lechner D, Lee YA, Lopez-Bigas N, Lathrop GM, Mashimo T, Medina I, Mott R, Patone G, Perrier-Cornet JA, Platzer M, Pravenec M, Reinhardt R, Sakaki Y, Schilhabel M, Schulz H, Serikawa T, Shikhagaie M, Tatsumoto S, Taudien S, Toyoda A, Voigt B, Zelenika D, Zimdahl H, Hubner N.

    Nat Genet. 2008 May;40(5):560-6.PMID: 18443594 [PubMed - indexed for MEDLINE]Related articles

    9.

    Progress and prospects in rat genetics: a community view.

    Aitman TJ, Critser JK, Cuppen E, Dominiczak A, Fernandez-Suarez XM, Flint J, Gauguier D, Geurts AM, Gould M, Harris PC, Holmdahl R, Hubner N, Izsvák Z, Jacob HJ, Kuramoto T, Kwitek AE, Marrone A, Mashimo T, Moreno C, Mullins J, Mullins L, Olsson T, Pravenec M, Riley L, Saar K, Serikawa T, Shull JD, Szpirer C, Twigger SN, Voigt B, Worley K.

    Nat Genet. 2008 May;40(5):516-22. Review.PMID: 18443588 [PubMed - indexed for MEDLINE]Related articles

    10.

    Genomic organization and mutation screening of the human ortholog of Pkdr1 associated with polycystic kidney disease in the rat.

    Kaisaki PJ, Bergmann C, Brown JH, Outeda P, Lens XM, Peters DJ, Gretz N, Gauguier D, Bihoreau MT.

    Eur J Med Genet. 2008 Jul-Aug;51(4):325-31. Epub 2008 Mar 16.PMID: 18434273 [PubMed - indexed for MEDLINE]Related articles

    11.

    Phylometabonomic patterns of adaptation to high fat diet feeding in inbred mice.

    Fearnside JF, Dumas ME, Rothwell AR, Wilder SP, Cloarec O, Toye A, Blancher C, Holmes E, Tatoud R, Barton RH, Scott J, Nicholson JK, Gauguier D.

    PLoS One. 2008 Feb 27;3(2):e1668.PMID: 18301746 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    Pancreatic ectopic fat is characterized by adipocyte infiltration and altered lipid composition.

    Pinnick KE, Collins SC, Londos C, Gauguier D, Clark A, Fielding BA.

    Obesity (Silver Spring). 2008 Mar;16(3):522-30. Epub 2008 Jan 17.PMID: 18239594 [PubMed - indexed for MEDLINE]Related articles

    13.

    [Genetic mapping of metabolic profiles: genomic and metagenomic influences]

    Gauguier D, Dumas ME.

    Med Sci (Paris). 2007 Dec;23(12):1091-4. French. No abstract available. PMID: 18154710 [PubMed - indexed for MEDLINE]Related articles

    14.

    Aryl hydrocarbon receptor nuclear translocator-like (BMAL1) is associated with susceptibility to hypertension and type 2 diabetes.

    Woon PY, Kaisaki PJ, Bragança J, Bihoreau MT, Levy JC, Farrall M, Gauguier D.

    Proc Natl Acad Sci U S A. 2007 Sep 4;104(36):14412-7. Epub 2007 Aug 29.PMID: 17728404 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    European rational approach for the genetics of diabetic complications--EURAGEDIC: patient populations and strategy.

    Tarnow L, Groop PH, Hadjadj S, Kazeem G, Cambien F, Marre M, Forsblom C, Parving HH, Trégouët D, Thévard A, Farrall M, Gut I, Gauguier D, Cox R, Matsuda F, Lathrop M, Vionnet N; EURAGEDIC Consortium.

    Nephrol Dial Transplant. 2008 Jan;23(1):161-8. Epub 2007 Aug 17.PMID: 17704113 [PubMed - indexed for MEDLINE]Related articles

    16.

    Subtle metabolic and liver gene transcriptional changes underlie diet-induced fatty liver susceptibility in insulin-resistant mice.

    Toye AA, Dumas ME, Blancher C, Rothwell AR, Fearnside JF, Wilder SP, Bihoreau MT, Cloarec O, Azzouzi I, Young S, Barton RH, Holmes E, McCarthy MI, Tatoud R, Nicholson JK, Scott J, Gauguier D.

    Diabetologia. 2007 Sep;50(9):1867-79. Epub 2007 Jul 6.PMID: 17618414 [PubMed - indexed for MEDLINE]Related articles

    17.

    Genetic association analysis of inositol polyphosphate phosphatase-like 1 (INPPL1, SHIP2) variants with essential hypertension.

    Marçano AC, Burke B, Gungadoo J, Wallace C, Kaisaki PJ, Woon PY, Farrall M, Clayton D, Brown M, Dominiczak A, Connell JM, Webster J, Lathrop M, Caulfield M, Samani N, Gauguier D, Munroe PB.

    J Med Genet. 2007 Sep;44(9):603-5. Epub 2007 Jun 8.PMID: 17557929 [PubMed - indexed for MEDLINE]Related articles

    18.

    Direct quantitative trait locus mapping of mammalian metabolic phenotypes in diabetic and normoglycemic rat models.

    Dumas ME, Wilder SP, Bihoreau MT, Barton RH, Fearnside JF, Argoud K, D'Amato L, Wallis RH, Blancher C, Keun HC, Baunsgaard D, Scott J, Sidelmann UG, Nicholson JK, Gauguier D.

    Nat Genet. 2007 May;39(5):666-72. Epub 2007 Apr 15.PMID: 17435758 [PubMed - indexed for MEDLINE]Related articles

    19.

    Association between angiotensin-converting enzyme gene polymorphisms and diabetic nephropathy: case-control, haplotype, and family-based study in three European populations.

    Hadjadj S, Tarnow L, Forsblom C, Kazeem G, Marre M, Groop PH, Parving HH, Cambien F, Tregouet DA, Gut IG, Théva A, Gauguier D, Farrall M, Cox R, Matsuda F, Lathrop M, Hager-Vionnet N; EURAGEDIC (European Rational Approach for Genetics of Diabetic Complications) Study Group.

    J Am Soc Nephrol. 2007 Apr;18(4):1284-91. Epub 2007 Mar 21.PMID: 17376814 [PubMed - indexed for MEDLINE]Related articlesFree article

    20.

    Analysis of 14 candidate genes for diabetic nephropathy on chromosome 3q in European populations: strongest evidence for association with a variant in the promoter region of the adiponectin gene.

    Vionnet N, Tregouët D, Kazeem G, Gut I, Groop PH, Tarnow L, Parving HH, Hadjadj S, Forsblom C, Farrall M, Gauguier D, Cox R, Matsuda F, Heath S, Thévard A, Rousseau R, Cambien F, Marre M, Lathrop M.

    Diabetes. 2006 Nov;55(11):3166-74.PMID: 17065357 [PubMed - indexed for MEDLINE]Related articlesFree article

    21.

    Genetic control of plasma lipid levels in a cross derived from normoglycaemic Brown Norway and spontaneously diabetic Goto-Kakizaki rats.

    Argoud K, Wilder SP, McAteer MA, Bihoreau MT, Ouali F, Woon PY, Wallis RH, Ktorza A, Gauguier D.

    Diabetologia. 2006 Nov;49(11):2679-88. Epub 2006 Sep 16.PMID: 16983556 [PubMed - indexed for MEDLINE]Related articles

    22.

    Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulin-resistant mice.

    Dumas ME, Barton RH, Toye A, Cloarec O, Blancher C, Rothwell A, Fearnside J, Tatoud R, Blanc V, Lindon JC, Mitchell SC, Holmes E, McCarthy MI, Scott J, Gauguier D, Nicholson JK.

    Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12511-6. Epub 2006 Aug 8.PMID: 16895997 [PubMed - indexed for MEDLINE]Related articlesFree article

    23.

    Genetic and environmental effects on complex traits in mice.

    Valdar W, Solberg LC, Gauguier D, Cookson WO, Rawlins JN, Mott R, Flint J.

    Genetics. 2006 Oct;174(2):959-84. Epub 2006 Aug 3.PMID: 16888333 [PubMed - indexed for MEDLINE]Related articlesFree article

    24.

    Genome-wide genetic association of complex traits in heterogeneous stock mice.

    Valdar W, Solberg LC, Gauguier D, Burnett S, Klenerman P, Cookson WO, Taylor MS, Rawlins JN, Mott R, Flint J.

    Nat Genet. 2006 Aug;38(8):879-87. Epub 2006 Jul 9.PMID: 16832355 [PubMed - indexed for MEDLINE]Related articles

    25.

    Mapping diabetes QTL in an intercross derived from a congenic strain of the Brown Norway and Goto-Kakizaki rats.

    Collins SC, Wallis RH, Wilder SP, Wallace KJ, Argoud K, Kaisaki PJ, Bihoreau MT, Gauguier D.

    Mamm Genome. 2006 Jun;17(6):538-47. Epub 2006 Jun 12.PMID: 16783636 [PubMed - indexed for MEDLINE]Related articles

    26.

    Glycomics investigation into insulin action.

    Parry S, Hadaschik D, Blancher C, Kumaran MK, Bochkina N, Morris HR, Richardson S, Aitman TJ, Gauguier D, Siddle K, Scott J, Dell A.

    Biochim Biophys Acta. 2006 Apr;1760(4):652-68. Epub 2006 Jan 10.PMID: 16473469 [PubMed - indexed for MEDLINE]Related articles

    27.

    A protocol for high-throughput phenotyping, suitable for quantitative trait analysis in mice.

    Solberg LC, Valdar W, Gauguier D, Nunez G, Taylor A, Burnett S, Arboledas-Hita C, Hernandez-Pliego P, Davidson S, Burns P, Bhattacharya S, Hough T, Higgs D, Klenerman P, Cookson WO, Zhang Y, Deacon RM, Rawlins JN, Mott R, Flint J.

    Mamm Genome. 2006 Feb;17(2):129-46. Epub 2006 Feb 6.PMID: 16465593 [PubMed - indexed for MEDLINE]Related articles

    28.

    Diabetes quantitative trait locus research: from physiology to genetics and back.

    Gauguier D.

    Diabetologia. 2006 Mar;49(3):431-3. Epub 2006 Jan 31. No abstract available. PMID: 16447055 [PubMed - indexed for MEDLINE]Related articles

    29.

    Killer cell lectin-like receptors and the natural killer cell gene complex.

    Nylenna O, Flornes LM, Westgaard IH, Woon PY, Naper C, Vaage JT, Gauguier D, Ryan JC, Dissen E, Fossum S.

    Adv Exp Med Biol. 2005;564:23-4. No abstract available. PMID: 16400803 [PubMed - indexed for MEDLINE]Related articles

    30.

    Genomic organization of the rat Clock gene and sequence analysis in inbred rat strains.

    Woon PY, Curtis AM, Kaisaki PJ, Argoud K, Wallace KJ, Bihoreau MT, FitzGerald GA, Gauguier D.

    Genomics. 2006 Feb;87(2):208-17. Epub 2006 Jan 11.PMID: 16376516 [PubMed - indexed for MEDLINE]Related articles

    31.

    Missense mutation in sterile alpha motif of novel protein SamCystin is associated with polycystic kidney disease in (cy/+) rat.

    Brown JH, Bihoreau MT, Hoffmann S, Kränzlin B, Tychinskaya I, Obermüller N, Podlich D, Boehn SN, Kaisaki PJ, Megel N, Danoy P, Copley RR, Broxholme J, Witzgall R, Lathrop M, Gretz N, Gauguier D.

    J Am Soc Nephrol. 2005 Dec;16(12):3517-26. Epub 2005 Oct 5.PMID: 16207829 [PubMed - indexed for MEDLINE]Related articlesFree article

    32.

    Medical Genetics: revenge of the thrift.

    Kaisaki PJ, Gauguier D.

    Heredity. 2005 Nov;95(5):337-8. No abstract available. PMID: 15999140 [PubMed - indexed for MEDLINE]Related articlesFree article

    33.

    Statistical total correlation spectroscopy: an exploratory approach for latent biomarker identification from metabolic 1H NMR data sets.

    Cloarec O, Dumas ME, Craig A, Barton RH, Trygg J, Hudson J, Blancher C, Gauguier D, Lindon JC, Holmes E, Nicholson J.

    Anal Chem. 2005 Mar 1;77(5):1282-9.PMID: 15732908 [PubMed - indexed for MEDLINE]Related articles

    34.

    Chromosomal mapping of quantitative trait loci controlling elastin content in rat aorta.

    Gauguier D, Behmoaras J, Argoud K, Wilder SP, Pradines C, Bihoreau MT, Osborne-Pellegrin M, Jacob MP.

    Hypertension. 2005 Mar;45(3):460-6. Epub 2005 Jan 24.PMID: 15668357 [PubMed - indexed for MEDLINE]Related articlesFree article

    35.

    The genes and gene organization of the Ly49 region of the rat natural killer cell gene complex.

    Nylenna O, Naper C, Vaage JT, Woon PY, Gauguier D, Dissen E, Ryan JC, Fossum S.

    Eur J Immunol. 2005 Jan;35(1):261-72.PMID: 15593300 [PubMed - indexed for MEDLINE]Related articles

    36.

    Characteristics of the aortic elastic network and related phenotypes in seven inbred rat strains.

    Behmoaras J, Osborne-Pellegrin M, Gauguier D, Jacob MP.

    Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H769-77. Epub 2004 Oct 7.PMID: 15471977 [PubMed - indexed for MEDLINE]Related articlesFree article

    37.

    Gender differences in hypertrophy, insulin resistance and ischemic injury in the aging type 2 diabetic rat heart.

    Desrois M, Sidell RJ, Gauguier D, Davey CL, Radda GK, Clarke K.

    J Mol Cell Cardiol. 2004 Aug;37(2):547-55.PMID: 15276024 [PubMed - indexed for MEDLINE]Related articles

    38.

    Chromosomal mapping of genetic loci controlling absence epilepsy phenotypes in the WAG/Rij rat.

    Gauguier D, van Luijtelaar G, Bihoreau MT, Wilder SP, Godfrey RF, Vossen J, Coenen A, Cox RD.

    Epilepsia. 2004 Aug;45(8):908-15.PMID: 15270755 [PubMed - indexed for MEDLINE]Related articles

    39.

    Quantitative trait locus dissection in congenic strains of the Goto-Kakizaki rat identifies a region conserved with diabetes loci in human chromosome 1q.

    Wallace KJ, Wallis RH, Collins SC, Argoud K, Kaisaki PJ, Ktorza A, Woon PY, Bihoreau MT, Gauguier D.

    Physiol Genomics. 2004 Sep 16;19(1):1-10. Epub 2004 Jul 20.PMID: 15266047 [PubMed - indexed for MEDLINE]Related articlesFree article

    40.

    Polymorphisms in type II SH2 domain-containing inositol 5-phosphatase (INPPL1, SHIP2) are associated with physiological abnormalities of the metabolic syndrome.

    Kaisaki PJ, Delépine M, Woon PY, Sebag-Montefiore L, Wilder SP, Menzel S, Vionnet N, Marion E, Riveline JP, Charpentier G, Schurmans S, Levy JC, Lathrop M, Farrall M, Gauguier D.

    Diabetes. 2004 Jul;53(7):1900-4.PMID: 15220217 [PubMed - indexed for MEDLINE]Related articlesFree article

    41.

    Enhanced insulin secretion and cholesterol metabolism in congenic strains of the spontaneously diabetic (Type 2) Goto Kakizaki rat are controlled by independent genetic loci in rat chromosome 8.

    Wallis RH, Wallace KJ, Collins SC, McAteer M, Argoud K, Bihoreau MT, Kaisaki PJ, Gauguier D.

    Diabetologia. 2004 Jun;47(6):1096-106. Epub 2004 May 26.PMID: 15164172 [PubMed - indexed for MEDLINE]Related articles

    42.

    Studies of congenic lines in the Brown Norway rat model of Th2-mediated immunopathological disorders show that the aurothiopropanol sulfonate-induced immunological disorder (Aiid3) locus on chromosome 9 plays a major role compared to Aiid2 on chromosome 10.

    Mas M, Cavaillès P, Colacios C, Subra JF, Lagrange D, Calise M, Christen MO, Druet P, Pelletier L, Gauguier D, Fournié GJ.

    J Immunol. 2004 May 15;172(10):6354-61.PMID: 15128826 [PubMed - indexed for MEDLINE]Related articlesFree article

    43.

    Integration of the rat recombination and EST maps in the rat genomic sequence and comparative mapping analysis with the mouse genome.

    Wilder SP, Bihoreau MT, Argoud K, Watanabe TK, Lathrop M, Gauguier D.

    Genome Res. 2004 Apr;14(4):758-65.PMID: 15060020 [PubMed - indexed for MEDLINE]Related articlesFree article

    44.

    Transforming growth factor-beta 1 production is correlated with genetically determined ACE expression in congenic rats: a possible link between ACE genotype and diabetic nephropathy.

    Pueyo ME, Challah M, Gauguier D, Louedec L, Philippe M, Gaertner R, Marre M, Michel JB, Jacob MP.

    Diabetes. 2004 Apr;53(4):1111-8.PMID: 15047629 [PubMed - indexed for MEDLINE]Related articlesFree article

    45.

    Polygenic control of idiopathic generalized epilepsy phenotypes in the genetic absence rats from Strasbourg (GAERS).

    Rudolf G, Thérèse Bihoreau M, F Godfrey R, P Wilder S, D Cox R, Lathrop M, Marescaux C, Gauguier D.

    Epilepsia. 2004 Apr;45(4):301-8.PMID: 15030491 [PubMed - indexed for MEDLINE]Related articles

    46.

    Initial steps of insulin signaling and glucose transport are defective in the type 2 diabetic rat heart.

    Desrois M, Sidell RJ, Gauguier D, King LM, Radda GK, Clarke K.

    Cardiovasc Res. 2004 Feb 1;61(2):288-96.PMID: 14736545 [PubMed - indexed for MEDLINE]Related articlesFree article

    47.

    Genetics and functional genomics of type 2 diabetes mellitus.

    Toye A, Gauguier D.

    Genome Biol. 2003;4(12):241. Epub 2003 Nov 24. Review.PMID: 14659011 [PubMed - indexed for MEDLINE]Related articlesFree article

    48.

    Marker-assisted congenic screening (MACS): a database tool for the efficient production and characterization of congenic lines.

    Collins SC, Wallis RH, Wallace K, Bihoreau MT, Gauguier D.

    Mamm Genome. 2003 May;14(5):350-6.PMID: 12856287 [PubMed - indexed for MEDLINE]Related articles

    49.

    Localization, cDNA sequence and genomic organization of the rat seipin gene (Bscl2) and sequence analysis in inbred rat models of Type 2 diabetes mellitus.

    Kaisaki PJ, Sebag-Montefiore LM, Brown JH, Magre J, Lathrop M, Capeau J, Gauguier D.

    Cytogenet Genome Res. 2002;98(1):71-4.PMID: 12584444 [PubMed - indexed for MEDLINE]Related articles

    50.

    Thymectomy and radiation-induced type 1 diabetes in nonlymphopenic BB rats.

    Ramanathan S, Bihoreau MT, Paterson AD, Marandi L, Gauguier D, Poussier P.

    Diabetes. 2002 Oct;51(10):2975-81.PMID: 12351436 [PubMed - indexed for MEDLINE]Related articlesFree article

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