PubMed

A new approach to study in vivo cellular metabolism using a modellistic analysis of magnetic resonance spectra.

Gastaldelli A, Martini S, Donati A, Marchettini N, Rossi C, Bastianoni S.

Math Biosci. 2009 Nov;222(1):36-41. Epub 2009 Aug 23.PMID: 19706297 [PubMed - in process]Related articles

Importance of changes in adipose tissue insulin resistance to histological response during thiazolidinedione treatment of patients with nonalcoholic steatohepatitis.

Gastaldelli A, Harrison SA, Belfort-Aguilar R, Hardies LJ, Balas B, Schenker S, Cusi K.

Hepatology. 2009 Oct;50(4):1087-93.PMID: 19670459 [PubMed - indexed for MEDLINE]Related articles

Pancreatic islet amyloidosis, beta-cell apoptosis, and alpha-cell proliferation are determinants of islet remodeling in type-2 diabetic baboons.

Guardado-Mendoza R, Davalli AM, Chavez AO, Hubbard GB, Dick EJ, Majluf-Cruz A, Tene-Perez CE, Goldschmidt L, Hart J, Perego C, Comuzzie AG, Tejero ME, Finzi G, Placidi C, La Rosa S, Capella C, Halff G, Gastaldelli A, DeFronzo RA, Folli F.

Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):13992-7. Epub 2009 Jul 30.PMID: 19666551 [PubMed - indexed for MEDLINE]Related articlesFree article

Sites and mechanisms of insulin resistance in nonobese, nondiabetic patients with chronic hepatitis C.

Vanni E, Abate ML, Gentilcore E, Hickman I, Gambino R, Cassader M, Smedile A, Ferrannini E, Rizzetto M, Marchesini G, Gastaldelli A, Bugianesi E.

Hepatology. 2009 Sep;50(3):697-706.PMID: 19582803 [PubMed - indexed for MEDLINE]Related articles

Improved tolerance to sequential glucose loading (Staub-Traugott effect): size and mechanisms.

Bonuccelli S, Muscelli E, Gastaldelli A, Barsotti E, Astiarraga BD, Holst JJ, Mari A, Ferrannini E.

Am J Physiol Endocrinol Metab. 2009 Aug;297(2):E532-7. Epub 2009 Jun 16.PMID: 19531643 [PubMed - indexed for MEDLINE]Related articles

Decreased whole body lipolysis as a mechanism of the lipid-lowering effect of pioglitazone in type 2 diabetic patients.

Gastaldelli A, Casolaro A, Ciociaro D, Frascerra S, Nannipieri M, Buzzigoli E, Ferrannini E.

Am J Physiol Endocrinol Metab. 2009 Jul;297(1):E225-30. Epub 2009 May 5.PMID: 19417125 [PubMed - indexed for MEDLINE]Related articles

Predictive models of insulin resistance derived from simple morphometric and biochemical indices related to obesity and the metabolic syndrome in baboons.

Chavez AO, Gastaldelli A, Guardado-Mendoza R, Lopez-Alvarenga JC, Leland MM, Tejero ME, Sorice G, Casiraghi F, Davalli A, Bastarrachea RA, Comuzzie AG, DeFronzo RA, Folli F.

Cardiovasc Diabetol. 2009 Apr 23;8:22.PMID: 19389241 [PubMed - in process]Related articlesFree article

Imaging and laboratory biomarkers in cardiovascular disease.

Andreassi MG, Gastaldelli A, Clerico A, Salvadori PA, Sicari R, Picano E.

Curr Pharm Des. 2009;15(10):1131-41. Review.PMID: 19355954 [PubMed - indexed for MEDLINE]Related articles

Fatty liver is associated with insulin resistance, risk of coronary heart disease, and early atherosclerosis in a large European population.

Gastaldelli A, Kozakova M, Højlund K, Flyvbjerg A, Favuzzi A, Mitrakou A, Balkau B; RISC Investigators.

Hepatology. 2009 May;49(5):1537-44.PMID: 19291789 [PubMed - indexed for MEDLINE]Related articles

Accurate segmentation of subcutaneous and intermuscular adipose tissue from MR images of the thigh.

Positano V, Christiansen T, Santarelli MF, Ringgaard S, Landini L, Gastaldelli A.

J Magn Reson Imaging. 2009 Mar;29(3):677-84.PMID: 19243051 [PubMed - indexed for MEDLINE]Related articles

The L-4F mimetic peptide prevents insulin resistance through increased levels of HO-1, pAMPK, and pAKT in obese mice.

Peterson SJ, Kim DH, Li M, Positano V, Vanella L, Rodella LF, Piccolomini F, Puri N, Gastaldelli A, Kusmic C, L'Abbate A, Abraham NG.

J Lipid Res. 2009 Jul;50(7):1293-304. Epub 2009 Feb 17.PMID: 19224872 [PubMed - in process]Related articlesFree article

Heme oxygenase-1 induction remodels adipose tissue and improves insulin sensitivity in obesity-induced diabetic rats.

Nicolai A, Li M, Kim DH, Peterson SJ, Vanella L, Positano V, Gastaldelli A, Rezzani R, Rodella LF, Drummond G, Kusmic C, L'Abbate A, Kappas A, Abraham NG.

Hypertension. 2009 Mar;53(3):508-15. Epub 2009 Jan 26.PMID: 19171794 [PubMed - indexed for MEDLINE]Related articlesFree article

Hepatic fat is not associated with beta-cell function or postprandial free fatty acid response.

Rijkelijkhuizen JM, Doesburg T, Girman CJ, Mari A, Rhodes T, Gastaldelli A, Nijpels G, Dekker JM.

Metabolism. 2009 Feb;58(2):196-203.PMID: 19154952 [PubMed - indexed for MEDLINE]Related articles

The crosstalk between insulin and renin-angiotensin-aldosterone signaling systems and its effect on glucose metabolism and diabetes prevention.

Muscogiuri G, Chavez AO, Gastaldelli A, Perego L, Tripathy D, Saad MJ, Velloso L, Folli F.

Curr Vasc Pharmacol. 2008 Oct;6(4):301-12. Review.PMID: 18855718 [PubMed - indexed for MEDLINE]Related articles

Elevated concentrations of liver enzymes and ferritin identify a new phenotype of insulin resistance: effect of weight loss after gastric banding.

Gastaldelli A, Perego L, Paganelli M, Sesti G, Hribal M, Chavez AO, Defronzo RA, Pontiroli A, Folli F.

Obes Surg. 2009 Jan;19(1):80-6. Epub 2008 Sep 24.PMID: 18820980 [PubMed - indexed for MEDLINE]Related articles

Automatic correction of intensity inhomogeneities improves unsupervised assessment of abdominal fat by MRI.

Positano V, Cusi K, Santarelli MF, Sironi A, Petz R, Defronzo R, Landini L, Gastaldelli A.

J Magn Reson Imaging. 2008 Aug;28(2):403-10.PMID: 18666138 [PubMed - indexed for MEDLINE]Related articles

Abdominal fat: does it predict the development of type 2 diabetes?

Gastaldelli A.

Am J Clin Nutr. 2008 May;87(5):1118-9. No abstract available. PMID: 18469227 [PubMed - indexed for MEDLINE]Related articlesFree article

Molecular basis and mechanisms of progression of non-alcoholic steatohepatitis.

Marra F, Gastaldelli A, Svegliati Baroni G, Tell G, Tiribelli C.

Trends Mol Med. 2008 Feb;14(2):72-81. Epub 2008 Jan 22. Review.PMID: 18218340 [PubMed - indexed for MEDLINE]Related articles

Early hypertension is associated with reduced regional cardiac function, insulin resistance, epicardial, and visceral fat.

Sironi AM, Pingitore A, Ghione S, De Marchi D, Scattini B, Positano V, Muscelli E, Ciociaro D, Lombardi M, Ferrannini E, Gastaldelli A.

Hypertension. 2008 Feb;51(2):282-8. Epub 2008 Jan 2.PMID: 18172058 [PubMed - indexed for MEDLINE]Related articlesFree article

Separate impact of obesity and glucose tolerance on the incretin effect in normal subjects and type 2 diabetic patients.

Muscelli E, Mari A, Casolaro A, Camastra S, Seghieri G, Gastaldelli A, Holst JJ, Ferrannini E.

Diabetes. 2008 May;57(5):1340-8. Epub 2007 Dec 27.PMID: 18162504 [PubMed - indexed for MEDLINE]Related articlesFree article

Loss of 50% of excess weight using a very low energy diet improves insulin-stimulated glucose disposal and skeletal muscle insulin signalling in obese insulin-treated type 2 diabetic patients.

Jazet IM, Schaart G, Gastaldelli A, Ferrannini E, Hesselink MK, Schrauwen P, Romijn JA, Maassen JA, Pijl H, Ouwens DM, Meinders AE.

Diabetologia. 2008 Feb;51(2):309-19. Epub 2007 Dec 14.PMID: 18080107 [PubMed - indexed for MEDLINE]Related articles

Impaired myocardial metabolic reserve and substrate selection flexibility during stress in patients with idiopathic dilated cardiomyopathy.

Neglia D, De Caterina A, Marraccini P, Natali A, Ciardetti M, Vecoli C, Gastaldelli A, Ciociaro D, Pellegrini P, Testa R, Menichetti L, L'Abbate A, Stanley WC, Recchia FA.

Am J Physiol Heart Circ Physiol. 2007 Dec;293(6):H3270-8. Epub 2007 Oct 5.PMID: 17921325 [PubMed - indexed for MEDLINE]Related articlesFree article

Model-based assessment of insulin sensitivity of glucose disposal and endogenous glucose production from double-tracer oral glucose tolerance test.

Thomaseth K, Pavan A, Berria R, Glass L, DeFronzo R, Gastaldelli A.

Comput Methods Programs Biomed. 2008 Feb;89(2):132-40. Epub 2007 Aug 13.PMID: 17706318 [PubMed - indexed for MEDLINE]Related articles

Relationship between hepatic/visceral fat and hepatic insulin resistance in nondiabetic and type 2 diabetic subjects.

Gastaldelli A, Cusi K, Pettiti M, Hardies J, Miyazaki Y, Berria R, Buzzigoli E, Sironi AM, Cersosimo E, Ferrannini E, Defronzo RA.

Gastroenterology. 2007 Aug;133(2):496-506. Epub 2007 May 1.PMID: 17681171 [PubMed - indexed for MEDLINE]Related articles

Pioglitazone treatment increases whole body fat but not total body water in patients with non-alcoholic steatohepatitis.

Balas B, Belfort R, Harrison SA, Darland C, Finch J, Schenker S, Gastaldelli A, Cusi K.

J Hepatol. 2007 Oct;47(4):565-70. Epub 2007 May 24.PMID: 17560678 [PubMed - indexed for MEDLINE]Related articles

Effect of a daily supplement of soy protein on body composition and insulin secretion in postmenopausal women.

Sites CK, Cooper BC, Toth MJ, Gastaldelli A, Arabshahi A, Barnes S.

Fertil Steril. 2007 Dec;88(6):1609-17. Epub 2007 Apr 6.PMID: 17412329 [PubMed - indexed for MEDLINE]Related articlesFree article

Early-onset type 2 diabetes in obese white subjects is characterised by a marked defect in beta cell insulin secretion, severe insulin resistance and a lack of response to aerobic exercise training.

Burns N, Finucane FM, Hatunic M, Gilman M, Murphy M, Gasparro D, Mari A, Gastaldelli A, Nolan JJ.

Diabetologia. 2007 Jul;50(7):1500-8. Epub 2007 Mar 29.PMID: 17393133 [PubMed - indexed for MEDLINE]Related articles

Reduction in hematocrit and hemoglobin following pioglitazone treatment is not hemodilutional in Type II diabetes mellitus.

Berria R, Glass L, Mahankali A, Miyazaki Y, Monroy A, De Filippis E, Cusi K, Cersosimo E, Defronzo RA, Gastaldelli A.

Clin Pharmacol Ther. 2007 Sep;82(3):275-81. Epub 2007 Mar 14.PMID: 17361126 [PubMed - indexed for MEDLINE]Related articles

Effects on insulin secretion and insulin action of a 48-h reduction of plasma free fatty acids with acipimox in nondiabetic subjects genetically predisposed to type 2 diabetes.

Cusi K, Kashyap S, Gastaldelli A, Bajaj M, Cersosimo E.

Am J Physiol Endocrinol Metab. 2007 Jun;292(6):E1775-81. Epub 2007 Feb 13.PMID: 17299078 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of pioglitazone on the metabolic and hormonal response to a mixed meal in type II diabetes.

Gastaldelli A, Casolaro A, Pettiti M, Nannipieri M, Ciociaro D, Frascerra S, Buzzigoli E, Baldi S, Mari A, Ferrannini E.

Clin Pharmacol Ther. 2007 Feb;81(2):205-12.PMID: 17259945 [PubMed - indexed for MEDLINE]Related articles

Quantification of liver glucose metabolism by positron emission tomography: validation study in pigs.

Iozzo P, Jarvisalo MJ, Kiss J, Borra R, Naum GA, Viljanen A, Viljanen T, Gastaldelli A, Buzzigoli E, Guiducci L, Barsotti E, Savunen T, Knuuti J, Haaparanta-Solin M, Ferrannini E, Nuutila P.

Gastroenterology. 2007 Feb;132(2):531-42. Epub 2006 Dec 21.PMID: 17258736 [PubMed - indexed for MEDLINE]Related articles

A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis.

Belfort R, Harrison SA, Brown K, Darland C, Finch J, Hardies J, Balas B, Gastaldelli A, Tio F, Pulcini J, Berria R, Ma JZ, Dwivedi S, Havranek R, Fincke C, DeFronzo R, Bannayan GA, Schenker S, Cusi K.

N Engl J Med. 2006 Nov 30;355(22):2297-307.PMID: 17135584 [PubMed - indexed for MEDLINE]Related articlesFree article

Thiazolidinediones improve beta-cell function in type 2 diabetic patients.

Gastaldelli A, Ferrannini E, Miyazaki Y, Matsuda M, Mari A, DeFronzo RA.

Am J Physiol Endocrinol Metab. 2007 Mar;292(3):E871-83. Epub 2006 Nov 14.PMID: 17106061 [PubMed - indexed for MEDLINE]Related articlesFree article

Comparison of glargine insulin versus rosiglitazone addition in poorly controlled type 2 diabetic patients on metformin plus sulfonylurea.

Triplitt C, Glass L, Miyazaki Y, Wajcberg E, Gastaldelli A, De Filippis E, Cersosimo E, DeFronzo RA.

Diabetes Care. 2006 Nov;29(11):2371-7.PMID: 17065670 [PubMed - indexed for MEDLINE]Related articlesFree article

The effect of pioglitazone on the liver: role of adiponectin.

Gastaldelli A, Miyazaki Y, Mahankali A, Berria R, Pettiti M, Buzzigoli E, Ferrannini E, DeFronzo RA.

Diabetes Care. 2006 Oct;29(10):2275-81.PMID: 17003306 [PubMed - indexed for MEDLINE]Related articlesFree article

Circulating soluble receptor for advanced glycation end products is inversely associated with glycemic control and S100A12 protein.

Basta G, Sironi AM, Lazzerini G, Del Turco S, Buzzigoli E, Casolaro A, Natali A, Ferrannini E, Gastaldelli A.

J Clin Endocrinol Metab. 2006 Nov;91(11):4628-34. Epub 2006 Aug 22.PMID: 16926247 [PubMed - indexed for MEDLINE]Related articlesFree article

Reduction in hematocrit level after pioglitazone treatment is correlated with decreased plasma free testosterone level, not hemodilution, in women with polycystic ovary syndrome.

Berria R, Gastaldelli A, Lucidi S, Belfort R, De Filippis E, Easton C, Brytzki R, Cusi K, Jovanovic L, DeFronzo R.

Clin Pharmacol Ther. 2006 Aug;80(2):105-14. Epub 2006 Jun 30.PMID: 16890572 [PubMed - indexed for MEDLINE]Related articles

18F-FDG assessment of glucose disposal and production rates during fasting and insulin stimulation: a validation study.

Iozzo P, Gastaldelli A, Järvisalo MJ, Kiss J, Borra R, Buzzigoli E, Viljanen A, Naum G, Viljanen T, Oikonen V, Knuuti J, Savunen T, Salvadori PA, Ferrannini E, Nuutila P.

J Nucl Med. 2006 Jun;47(6):1016-22.PMID: 16741312 [PubMed - indexed for MEDLINE]Related articlesFree article

[11C]palmitate kinetics across the splanchnic bed in arterial, portal and hepatic venous plasma during fasting and euglycemic hyperinsulinemia.

Guiducci L, Järvisalo M, Kiss J, Någren K, Viljanen A, Naum AG, Gastaldelli A, Savunen T, Knuuti J, Salvadori PA, Ferrannini E, Nuutila P, Iozzo P.

Nucl Med Biol. 2006 May;33(4):521-8. Epub 2006 May 2.PMID: 16720244 [PubMed - indexed for MEDLINE]Related articles

The effect of rosiglitazone on the liver: decreased gluconeogenesis in patients with type 2 diabetes.

Gastaldelli A, Miyazaki Y, Pettiti M, Santini E, Ciociaro D, Defronzo RA, Ferrannini E.

J Clin Endocrinol Metab. 2006 Mar;91(3):806-12. Epub 2005 Dec 13.PMID: 16352689 [PubMed - indexed for MEDLINE]Related articlesFree article

Visceral fat and beta cell function in non-diabetic humans.

Gastaldelli A, Sironi AM, Ciociaro D, Positano V, Buzzigoli E, Giannessi D, Lombardi M, Mari A, Ferrannini E.

Diabetologia. 2005 Oct;48(10):2090-6. Epub 2005 Aug 6.PMID: 16086140 [PubMed - indexed for MEDLINE]Related articles

beta-cell function in morbidly obese subjects during free living: long-term effects of weight loss.

Camastra S, Manco M, Mari A, Baldi S, Gastaldelli A, Greco AV, Mingrone G, Ferrannini E.

Diabetes. 2005 Aug;54(8):2382-9.PMID: 16046305 [PubMed - indexed for MEDLINE]Related articlesFree article

Beta-cell function in mild type 2 diabetic patients: effects of 6-month glucose lowering with nateglinide.

Mari A, Gastaldelli A, Foley JE, Pratley RE, Ferrannini E.

Diabetes Care. 2005 May;28(5):1132-8.PMID: 15855578 [PubMed - indexed for MEDLINE]Related articlesFree article

Plasma adiponectin in nonalcoholic fatty liver is related to hepatic insulin resistance and hepatic fat content, not to liver disease severity.

Bugianesi E, Pagotto U, Manini R, Vanni E, Gastaldelli A, de Iasio R, Gentilcore E, Natale S, Cassader M, Rizzetto M, Pasquali R, Marchesini G.

J Clin Endocrinol Metab. 2005 Jun;90(6):3498-504. Epub 2005 Mar 29.PMID: 15797948 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin resistance in non-diabetic patients with non-alcoholic fatty liver disease: sites and mechanisms.

Bugianesi E, Gastaldelli A, Vanni E, Gambino R, Cassader M, Baldi S, Ponti V, Pagano G, Ferrannini E, Rizzetto M.

Diabetologia. 2005 Apr;48(4):634-42. Epub 2005 Mar 4.PMID: 15747110 [PubMed - indexed for MEDLINE]Related articles

beta-cell function in obesity: effects of weight loss.

Ferrannini E, Camastra S, Gastaldelli A, Maria Sironi A, Natali A, Muscelli E, Mingrone G, Mari A.

Diabetes. 2004 Dec;53 Suppl 3:S26-33. Review.PMID: 15561918 [PubMed - indexed for MEDLINE]Related articlesFree article

Characterization of beta-cell function impairment in first-degree relatives of type 2 diabetic subjects: modeling analysis of 24-h triple-meal tests.

Mari A, Gastaldelli A, Natali A, Ostergard T, Schmitz O, Ferrannini E.

Am J Physiol Endocrinol Metab. 2005 Mar;288(3):E541-6. Epub 2004 Nov 2.PMID: 15522997 [PubMed - indexed for MEDLINE]Related articlesFree article

beta-Cell function in subjects spanning the range from normal glucose tolerance to overt diabetes: a new analysis.

Ferrannini E, Gastaldelli A, Miyazaki Y, Matsuda M, Mari A, DeFronzo RA.

J Clin Endocrinol Metab. 2005 Jan;90(1):493-500. Epub 2004 Oct 13.PMID: 15483086 [PubMed - indexed for MEDLINE]Related articlesFree article

An accurate and robust method for unsupervised assessment of abdominal fat by MRI.

Positano V, Gastaldelli A, Sironi AM, Santarelli MF, Lombardi M, Landini L.

J Magn Reson Imaging. 2004 Oct;20(4):684-9.PMID: 15390229 [PubMed - indexed for MEDLINE]Related articles

Separate contribution of diabetes, total fat mass, and fat topography to glucose production, gluconeogenesis, and glycogenolysis.

Gastaldelli A, Miyazaki Y, Pettiti M, Buzzigoli E, Mahankali S, Ferrannini E, DeFronzo RA.

J Clin Endocrinol Metab. 2004 Aug;89(8):3914-21.PMID: 15292327 [PubMed - indexed for MEDLINE]Related articlesFree article