PubMed

Diabetic macular oedema and visual loss: relationship to location, severity and duration.

Gardner TW, Larsen M, Girach A, Zhi X; on behalf of the Protein Kinase C Diabetic Retinopathy Study (PKC-DRS2) Study Group*.

Acta Ophthalmol. 2009 Oct 8. [Epub ahead of print]PMID: 19817721 [PubMed - as supplied by publisher]Related articles

Subconjunctivally implantable hydrogels with degradable and thermoresponsive properties for sustained release of insulin to the retina.

Misra GP, Singh RS, Aleman TS, Jacobson SG, Gardner TW, Lowe TL.

Biomaterials. 2009 Nov;30(33):6541-7. Epub 2009 Aug 25.PMID: 19709741 [PubMed - in process]Related articles

Neuroprotection for diabetic retinopathy.

Imai H, Singh RS, Fort PE, Gardner TW.

Dev Ophthalmol. 2009;44:56-68. Epub 2009 Jun 3.PMID: 19494653 [PubMed - in process]Related articles

Diabetes and obesity: a challenge for every ophthalmologist.

Gardner TW, Gabbay RA.

Arch Ophthalmol. 2009 Mar;127(3):328-9. No abstract available. PMID: 19273798 [PubMed - indexed for MEDLINE]Related articles

Phosphorylation site mapping of endogenous proteins: a combined MS and bioinformatics approach.

Sundstrom JM, Sundstrom CJ, Sundstrom SA, Fort PE, Rauscher RL, Gardner TW, Antonetti DA.

J Proteome Res. 2009 Feb;8(2):798-807.PMID: 19125583 [PubMed - indexed for MEDLINE]Related articles

The retinal proteome in experimental diabetic retinopathy: up-regulation of crystallins and reversal by systemic and periocular insulin.

Fort PE, Freeman WM, Losiewicz MK, Singh RS, Gardner TW.

Mol Cell Proteomics. 2009 Apr;8(4):767-79. Epub 2008 Dec 1.PMID: 19049959 [PubMed - indexed for MEDLINE]Related articles

Effect of IL-1beta on survival and energy metabolism of R28 and RGC-5 retinal neurons.

Abcouwer SF, Shanmugam S, Gomez PF, Shushanov S, Barber AJ, Lanoue KF, Quinn PG, Kester M, Gardner TW.

Invest Ophthalmol Vis Sci. 2008 Dec;49(12):5581-92.PMID: 19037001 [PubMed - indexed for MEDLINE]Related articles

Novel potential mechanisms for diabetic macular edema: leveraging new investigational approaches.

Gardner TW, Antonetti DA.

Curr Diab Rep. 2008 Aug;8(4):263-9. Review.PMID: 18631437 [PubMed - indexed for MEDLINE]Related articles

Whole genome assessment of the retinal response to diabetes reveals a progressive neurovascular inflammatory response.

Brucklacher RM, Patel KM, VanGuilder HD, Bixler GV, Barber AJ, Antonetti DA, Lin CM, LaNoue KF, Gardner TW, Bronson SK, Freeman WM.

BMC Med Genomics. 2008 Jun 13;1:26.PMID: 18554398 [PubMed]Related articlesFree article

PDGF- and insulin/IGF-1-specific distinct modes of class IA PI 3-kinase activation in normal rat retinas and RGC-5 retinal ganglion cells.

Biswas SK, Zhao Y, Nagalingam A, Gardner TW, Sandirasegarane L.

Invest Ophthalmol Vis Sci. 2008 Aug;49(8):3687-98. Epub 2008 Apr 17.PMID: 18421086 [PubMed - indexed for MEDLINE]Related articlesFree article

Whole genome assessment of the retinal response to diabetes reveals a progressive neurovascular inflammatory response.

Brucklacher RM, Patel KM, VanGuilder HD, Bixler GV, Barber AJ, Antonetti DA, Lin CM, LaNoue KF, Gardner TW, Bronson SK, Freeman WM.

BMC Med Genomics. 2008;1:26.PMID: 19623761 [PubMed]Related articlesFree article

TELEMAM: a cluster randomised trial to assess the use of telemedicine in multi-disciplinary breast cancer decision making.

Kunkler IH, Prescott RJ, Lee RJ, Brebner JA, Cairns JA, Fielding RG, Bowman A, Neades G, Walls AD, Chetty U, Dixon JM, Smith ME, Gardner TW, Macnab M, Swann S, Maclean JR.

Eur J Cancer. 2007 Nov;43(17):2506-14. Epub 2007 Oct 24.PMID: 17962011 [PubMed - indexed for MEDLINE]Related articles

Nonobese, insulin-deficient Ins2Akita mice develop type 2 diabetes phenotypes including insulin resistance and cardiac remodeling.

Hong EG, Jung DY, Ko HJ, Zhang Z, Ma Z, Jun JY, Kim JH, Sumner AD, Vary TC, Gardner TW, Bronson SK, Kim JK.

Am J Physiol Endocrinol Metab. 2007 Dec;293(6):E1687-96. Epub 2007 Oct 2.PMID: 17911348 [PubMed - indexed for MEDLINE]Related articlesFree article

Adolescent self-regulation as resilience: resistance to antisocial behavior within the deviant peer context.

Gardner TW, Dishion TJ, Connell AM.

J Abnorm Child Psychol. 2008 Feb;36(2):273-84. Epub 2007 Sep 25.PMID: 17899361 [PubMed - indexed for MEDLINE]Related articles

Energy sources for glutamate neurotransmission in the retina: absence of the aspartate/glutamate carrier produces reliance on glycolysis in glia.

Xu Y, Ola MS, Berkich DA, Gardner TW, Barber AJ, Palmieri F, Hutson SM, LaNoue KF.

J Neurochem. 2007 Apr;101(1):120-31.PMID: 17394462 [PubMed - indexed for MEDLINE]Related articles

A prize catch for diabetic retinopathy.

Gardner TW, Antonetti DA.

Nat Med. 2007 Feb;13(2):131-2. No abstract available. PMID: 17290269 [PubMed - indexed for MEDLINE]Related articles

Ruboxistaurin for diabetic retinopathy.

Gardner TW, Antonetti DA.

Ophthalmology. 2006 Dec;113(12):2135-6. No abstract available. PMID: 17157131 [PubMed - indexed for MEDLINE]Related articles

Diabetes alters sphingolipid metabolism in the retina: a potential mechanism of cell death in diabetic retinopathy.

Fox TE, Han X, Kelly S, Merrill AH 2nd, Martin RE, Anderson RE, Gardner TW, Kester M.

Diabetes. 2006 Dec;55(12):3573-80.PMID: 17130506 [PubMed - indexed for MEDLINE]Related articlesFree article

VEGF activation of protein kinase C stimulates occludin phosphorylation and contributes to endothelial permeability.

Harhaj NS, Felinski EA, Wolpert EB, Sundstrom JM, Gardner TW, Antonetti DA.

Invest Ophthalmol Vis Sci. 2006 Nov;47(11):5106-15.PMID: 17065532 [PubMed - indexed for MEDLINE]Related articlesFree article

Diabetic retinopathy: seeing beyond glucose-induced microvascular disease.

Antonetti DA, Barber AJ, Bronson SK, Freeman WM, Gardner TW, Jefferson LS, Kester M, Kimball SR, Krady JK, LaNoue KF, Norbury CC, Quinn PG, Sandirasegarane L, Simpson IA; JDRF Diabetic Retinopathy Center Group.

Diabetes. 2006 Sep;55(9):2401-11.PMID: 16936187 [PubMed - indexed for MEDLINE]Related articlesFree article

An extension of the Early Treatment Diabetic Retinopathy Study (ETDRS) system for grading of diabetic macular edema in the Astemizole Retinopathy Trial.

Gardner TW, Sander B, Larsen ML, Kunselman A, Tenhave T, Lund-Andersen H, Reimers J, Hubbard L, Blankenship GW, Quillen DA, Brod RD, Wilmarth MH, Post-Hansen H, Parving HH, Davis MD.

Curr Eye Res. 2006 Jun;31(6):535-47.PMID: 16769613 [PubMed - indexed for MEDLINE]Related articles

Diabetes reduces basal retinal insulin receptor signaling: reversal with systemic and local insulin.

Reiter CE, Wu X, Sandirasegarane L, Nakamura M, Gilbert KA, Singh RS, Fort PE, Antonetti DA, Gardner TW.

Diabetes. 2006 Apr;55(4):1148-56.PMID: 16567541 [PubMed - indexed for MEDLINE]Related articlesFree article

Analysis of glucose metabolism in diabetic rat retinas.

Ola MS, Berkich DA, Xu Y, King MT, Gardner TW, Simpson I, LaNoue KF.

Am J Physiol Endocrinol Metab. 2006 Jun;290(6):E1057-67. Epub 2005 Dec 27.PMID: 16380392 [PubMed - indexed for MEDLINE]Related articlesFree article

Retinal angiogenesis in development and disease.

Gariano RF, Gardner TW.

Nature. 2005 Dec 15;438(7070):960-6. Review.PMID: 16355161 [PubMed - indexed for MEDLINE]Related articles

Dynamic intraocular pressure measurements during vitrectomy.

Moorhead LC, Gardner TW, Lambert HM, O'Malley RE, Willis AW, Meharg LS, Moorhead WD.

Arch Ophthalmol. 2005 Nov;123(11):1514-23.PMID: 16286613 [PubMed - indexed for MEDLINE]Related articles

Attention and adolescent tobacco use: A potential self-regulatory dynamic underlying nicotine addiction.

Gardner TW, Dishion TJ, Posner MI.

Addict Behav. 2006 Mar;31(3):531-6. Epub 2005 Jun 13.PMID: 15951129 [PubMed - indexed for MEDLINE]Related articles

The Ins2Akita mouse as a model of early retinal complications in diabetes.

Barber AJ, Antonetti DA, Kern TS, Reiter CE, Soans RS, Krady JK, Levison SW, Gardner TW, Bronson SK.

Invest Ophthalmol Vis Sci. 2005 Jun;46(6):2210-8.PMID: 15914643 [PubMed - indexed for MEDLINE]Related articlesFree article

Minocycline reduces proinflammatory cytokine expression, microglial activation, and caspase-3 activation in a rodent model of diabetic retinopathy.

Krady JK, Basu A, Allen CM, Xu Y, LaNoue KF, Gardner TW, Levison SW.

Diabetes. 2005 May;54(5):1559-65.PMID: 15855346 [PubMed - indexed for MEDLINE]Related articlesFree article

NFPA 99-an overview and discussion of recent changes.

Gardner TW; National Fire Protection Association.

Biomed Instrum Technol. 2005 Mar-Apr;39(2):123-4. No abstract available. PMID: 15810781 [PubMed - indexed for MEDLINE]Related articles

VEGF increases paracellular transport without altering the solvent-drag reflection coefficient.

DeMaio L, Antonetti DA, Scaduto RC Jr, Gardner TW, Tarbell JM.

Microvasc Res. 2004 Nov;68(3):295-302.PMID: 15501249 [PubMed - indexed for MEDLINE]Related articles

Retinopathy in diabetes.

Fong DS, Aiello L, Gardner TW, King GL, Blankenship G, Cavallerano JD, Ferris FL 3rd, Klein R; American Diabetes Association.

Diabetes Care. 2004 Jan;27 Suppl 1:S84-7. No abstract available. PMID: 14693935 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin promotes rat retinal neuronal cell survival in a p70S6K-dependent manner.

Wu X, Reiter CE, Antonetti DA, Kimball SR, Jefferson LS, Gardner TW.

J Biol Chem. 2004 Mar 5;279(10):9167-75. Epub 2003 Dec 5.PMID: 14660591 [PubMed - indexed for MEDLINE]Related articlesFree article

A transmural pressure gradient induces mechanical and biological adaptive responses in endothelial cells.

DeMaio L, Tarbell JM, Scaduto RC Jr, Gardner TW, Antonetti DA.

Am J Physiol Heart Circ Physiol. 2004 Feb;286(2):H731-41. Epub 2003 Oct 2.PMID: 14527936 [PubMed - indexed for MEDLINE]Related articlesFree article

Light scatter causes the grayness of detached retinas: implications for vision loss in retinal detachment.

Yin S, Gardner TW, Thomas TO, Kolanda K.

Arch Ophthalmol. 2003 Jul;121(7):1002-8.PMID: 12860805 [PubMed - indexed for MEDLINE]Related articles

An eye on insulin.

Bronson SK, Reiter CE, Gardner TW.

J Clin Invest. 2003 Jun;111(12):1817-9. Review.PMID: 12813016 [PubMed - indexed for MEDLINE]Related articlesFree article

Characterization of insulin signaling in rat retina in vivo and ex vivo.

Reiter CE, Sandirasegarane L, Wolpert EB, Klinger M, Simpson IA, Barber AJ, Antonetti DA, Kester M, Gardner TW.

Am J Physiol Endocrinol Metab. 2003 Oct;285(4):E763-74. Epub 2003 Jun 10.PMID: 12799319 [PubMed - indexed for MEDLINE]Related articlesFree article

Functions of insulin and insulin receptor signaling in retina: possible implications for diabetic retinopathy.

Reiter CE, Gardner TW.

Prog Retin Eye Res. 2003 Jul;22(4):545-62. Review.PMID: 12742394 [PubMed - indexed for MEDLINE]Related articles

Diabetic retinopathy: more than meets the eye.

Gardner TW, Antonetti DA, Barber AJ, LaNoue KF, Levison SW.

Surv Ophthalmol. 2002 Dec;47 Suppl 2:S253-62. Review.PMID: 12507627 [PubMed - indexed for MEDLINE]Related articles

Diabetic retinopathy.

Fong DS, Aiello L, Gardner TW, King GL, Blankenship G, Cavallerano JD, Ferris FL 3rd, Klein R; American Diabetes Association.

Diabetes Care. 2003 Jan;26(1):226-9. Review. No abstract available. PMID: 12502685 [PubMed - indexed for MEDLINE]Related articlesFree article

Diabetic retinopathy.

Fong DS, Aiello L, Gardner TW, King GL, Blankenship G, Cavallerano JD, Ferris FL 3rd, Klein R; American Diabetes Association.

Diabetes Care. 2003 Jan;26 Suppl 1:S99-S102. No abstract available. PMID: 12502630 [PubMed - indexed for MEDLINE]Related articlesFree article

Optic disk drusen, peripapillary choroidal neovascularization, and POEMS syndrome.

Diduszyn JM, Quillen DA, Cantore WA, Gardner TW.

Am J Ophthalmol. 2002 Feb;133(2):275-6.PMID: 11812439 [PubMed - indexed for MEDLINE]Related articles

Abnormal centrifugal axons in streptozotocin-diabetic rat retinas.

Gastinger MJ, Barber AJ, Khin SA, McRill CS, Gardner TW, Marshak DW.

Invest Ophthalmol Vis Sci. 2001 Oct;42(11):2679-85.PMID: 11581216 [PubMed - indexed for MEDLINE]Related articlesFree article

Excessive hexosamines block the neuroprotective effect of insulin and induce apoptosis in retinal neurons.

Nakamura M, Barber AJ, Antonetti DA, LaNoue KF, Robinson KA, Buse MG, Gardner TW.

J Biol Chem. 2001 Nov 23;276(47):43748-55. Epub 2001 Sep 17.PMID: 11560942 [PubMed - indexed for MEDLINE]Related articlesFree article

New insights into the pathophysiology of diabetic retinopathy: potential cell-specific therapeutic targets.

Gardner TW, Antonetti DA, Barber AJ, LaNoue KF, Nakamura M.

Diabetes Technol Ther. 2000 Winter;2(4):601-8. Review.PMID: 11469624 [PubMed - indexed for MEDLINE]Related articles

Insulin rescues retinal neurons from apoptosis by a phosphatidylinositol 3-kinase/Akt-mediated mechanism that reduces the activation of caspase-3.

Barber AJ, Nakamura M, Wolpert EB, Reiter CE, Seigel GM, Antonetti DA, Gardner TW.

J Biol Chem. 2001 Aug 31;276(35):32814-21. Epub 2001 Jul 6.PMID: 11443130 [PubMed - indexed for MEDLINE]Related articlesFree article

Shear stress regulates occludin content and phosphorylation.

DeMaio L, Chang YS, Gardner TW, Tarbell JM, Antonetti DA.

Am J Physiol Heart Circ Physiol. 2001 Jul;281(1):H105-13.PMID: 11406474 [PubMed - indexed for MEDLINE]Related articlesFree article

Retinal neurodegeneration: early pathology in diabetes.

Lieth E, Gardner TW, Barber AJ, Antonetti DA; Penn State Retina Research Group.

Clin Experiment Ophthalmol. 2000 Feb;28(1):3-8. Review.PMID: 11345341 [PubMed - indexed for MEDLINE]Related articles

Effect of shear stress on the hydraulic conductivity of cultured bovine retinal microvascular endothelial cell monolayers.

Lakshminarayanan S, Gardner TW, Tarbell JM.

Curr Eye Res. 2000 Dec;21(6):944-51.PMID: 11262618 [PubMed - indexed for MEDLINE]Related articles

Effect of VEGF on retinal microvascular endothelial hydraulic conductivity: the role of NO.

Lakshminarayanan S, Antonetti DA, Gardner TW, Tarbell JM.

Invest Ophthalmol Vis Sci. 2000 Dec;41(13):4256-61.PMID: 11095623 [PubMed - indexed for MEDLINE]Related articlesFree article

Altered expression of retinal occludin and glial fibrillary acidic protein in experimental diabetes. The Penn State Retina Research Group.

Barber AJ, Antonetti DA, Gardner TW.

Invest Ophthalmol Vis Sci. 2000 Oct;41(11):3561-8.PMID: 11006253 [PubMed - indexed for MEDLINE]Related articlesFree article