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Hyperinsulinemia predicts survival in a hyperglycemic mouse model of critical illness.

Woodske ME, Yokoe T, Zou B, Romano LC, Rosa TC, Garcia-Ocana A, Alonso LC, O'Donnell CP, McVerry BJ.

Crit Care Med. 2009 Sep;37(9):2596-603.PMID: 19623043 [PubMed - indexed for MEDLINE]Related articles

Marginal mass islet transplantation with autologous mesenchymal stem cells promotes long-term islet allograft survival and sustained normoglycemia.

Solari MG, Srinivasan S, Boumaza I, Unadkat J, Harb G, Garcia-Ocana A, Feili-Hariri M.

J Autoimmun. 2009 Mar;32(2):116-24. Epub 2009 Feb 12.PMID: 19217258 [PubMed - indexed for MEDLINE]Related articles

Autologous bone marrow-derived rat mesenchymal stem cells promote PDX-1 and insulin expression in the islets, alter T cell cytokine pattern and preserve regulatory T cells in the periphery and induce sustained normoglycemia.

Boumaza I, Srinivasan S, Witt WT, Feghali-Bostwick C, Dai Y, Garcia-Ocana A, Feili-Hariri M.

J Autoimmun. 2009 Feb;32(1):33-42. Epub 2008 Dec 4.PMID: 19062254 [PubMed - indexed for MEDLINE]Related articles

Hepatocyte growth factor enhances engraftment and function of nonhuman primate islets.

Fiaschi-Taesch NM, Berman DM, Sicari BM, Takane KK, Garcia-Ocaña A, Ricordi C, Kenyon NS, Stewart AF.

Diabetes. 2008 Oct;57(10):2745-54.PMID: 18820214 [PubMed - indexed for MEDLINE]Related articlesFree article

Hepatocyte Growth Factor (HGF) Enhances Engraftment and Function of Non-Human Primate Islets.

Fiaschi-Taesch NM, Berman DM, Sicari BM, Takane KK, Garcia-Ocaña A, Ricordi C, Kenyon NS, Stewart AF.

Diabetes. 2008 Jul 15. [Epub ahead of print]PMID: 18633102 [PubMed - as supplied by publisher]Related articles

Hepatocyte growth factor is a novel stimulator of glucose uptake and metabolism in skeletal muscle cells.

Perdomo G, Martinez-Brocca MA, Bhatt BA, Brown NF, O'Doherty RM, Garcia-Ocaña A.

J Biol Chem. 2008 May 16;283(20):13700-6. Epub 2008 Mar 24.PMID: 18362143 [PubMed - indexed for MEDLINE]Related articlesFree article

Intermittent hypoxia reverses the diurnal glucose rhythm and causes pancreatic beta-cell replication in mice.

Yokoe T, Alonso LC, Romano LC, Rosa TC, O'Doherty RM, Garcia-Ocana A, Minoguchi K, O'Donnell CP.

J Physiol. 2008 Feb 1;586(3):899-911. Epub 2007 Nov 22.PMID: 18033815 [PubMed - indexed for MEDLINE]Related articlesFree article

Improving islet transplantation by gene delivery of hepatocyte growth factor (HGF) and its downstream target, protein kinase B (PKB)/Akt.

Fiaschi-Taesch N, Stewart AF, Garcia-Ocaña A.

Cell Biochem Biophys. 2007;48(2-3):191-9. Review.PMID: 17709889 [PubMed - indexed for MEDLINE]Related articles

Protein kinase C-zeta activation markedly enhances beta-cell proliferation: an essential role in growth factor mediated beta-cell mitogenesis.

Vasavada RC, Wang L, Fujinaka Y, Takane KK, Rosa TC, Mellado-Gil JM, Friedman PA, Garcia-Ocaña A.

Diabetes. 2007 Nov;56(11):2732-43. Epub 2007 Aug 8.PMID: 17686945 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose infusion in mice: a new model to induce beta-cell replication.

Alonso LC, Yokoe T, Zhang P, Scott DK, Kim SK, O'Donnell CP, Garcia-Ocaña A.

Diabetes. 2007 Jul;56(7):1792-801. Epub 2007 Mar 30.PMID: 17400928 [PubMed - indexed for MEDLINE]Related articlesFree article

Intermittent hypoxia causes insulin resistance in lean mice independent of autonomic activity.

Iiyori N, Alonso LC, Li J, Sanders MH, Garcia-Ocana A, O'Doherty RM, Polotsky VY, O'Donnell CP.

Am J Respir Crit Care Med. 2007 Apr 15;175(8):851-7. Epub 2007 Feb 1.PMID: 17272786 [PubMed - indexed for MEDLINE]Related articlesFree article

Leptin increases proliferation of human steosarcoma cells through activation of PI(3)-K and MAPK pathways.

Burguera B, Brunetto A, Garcia-Ocana A, Teijeiro R, Esplen J, Thomas T, Couce ME, Zhao A.

Med Sci Monit. 2006 Nov;12(11):BR341-9.PMID: 17072262 [PubMed - indexed for MEDLINE]Related articlesFree article

Molecular control of cell cycle progression in the pancreatic beta-cell.

Cozar-Castellano I, Fiaschi-Taesch N, Bigatel TA, Takane KK, Garcia-Ocaña A, Vasavada R, Stewart AF.

Endocr Rev. 2006 Jun;27(4):356-70. Epub 2006 Apr 25. Review.PMID: 16638909 [PubMed - indexed for MEDLINE]Related articlesFree article

Growth factors and beta cell replication.

Vasavada RC, Gonzalez-Pertusa JA, Fujinaka Y, Fiaschi-Taesch N, Cozar-Castellano I, Garcia-Ocaña A.

Int J Biochem Cell Biol. 2006;38(5-6):931-50. Epub 2005 Aug 31. Review.PMID: 16168703 [PubMed - indexed for MEDLINE]Related articles

Continuous PTH and PTHrP infusion causes suppression of bone formation and discordant effects on 1,25(OH)2 vitamin D.

Horwitz MJ, Tedesco MB, Sereika SM, Syed MA, Garcia-Ocaña A, Bisello A, Hollis BW, Rosen CJ, Wysolmerski JJ, Dann P, Gundberg C, Stewart AF.

J Bone Miner Res. 2005 Oct;20(10):1792-803. Epub 2005 Jun 6.PMID: 16160737 [PubMed - indexed for MEDLINE]Related articles

Safety and tolerability of subcutaneous PTHrP(1-36) in healthy human volunteers: a dose escalation study.

Horwitz MJ, Tedesco MB, Sereika SM, Garcia-Ocaña A, Bisello A, Hollis BW, Gundberg C, Stewart AF.

Osteoporos Int. 2006 Feb;17(2):225-30. Epub 2005 Sep 7.PMID: 16151606 [PubMed - indexed for MEDLINE]Related articles

Targeted inactivation of hepatocyte growth factor receptor c-met in beta-cells leads to defective insulin secretion and GLUT-2 downregulation without alteration of beta-cell mass.

Roccisana J, Reddy V, Vasavada RC, Gonzalez-Pertusa JA, Magnuson MA, Garcia-Ocaña A.

Diabetes. 2005 Jul;54(7):2090-102.PMID: 15983210 [PubMed - indexed for MEDLINE]Related articlesFree article

Gene transfer of constitutively active Akt markedly improves human islet transplant outcomes in diabetic severe combined immunodeficient mice.

Rao P, Roccisana J, Takane KK, Bottino R, Zhao A, Trucco M, García-Ocaña A.

Diabetes. 2005 Jun;54(6):1664-75.PMID: 15919787 [PubMed - indexed for MEDLINE]Related articlesFree article

Characterization of mice doubly transgenic for parathyroid hormone-related protein and murine placental lactogen: a novel role for placental lactogen in pancreatic beta-cell survival.

Fujinaka Y, Sipula D, Garcia-Ocaña A, Vasavada RC.

Diabetes. 2004 Dec;53(12):3120-30.PMID: 15561942 [PubMed - indexed for MEDLINE]Related articlesFree article

Hepatocyte growth factor gene therapy for islet transplantation.

Rao P, Cozar-Castellano I, Roccisana J, Vasavada RC, Garcia-Ocaña A.

Expert Opin Biol Ther. 2004 Apr;4(4):507-18. Review.PMID: 15102600 [PubMed - indexed for MEDLINE]Related articles

Prevention of acute ischemic renal failure by targeted delivery of growth factors to the proximal tubule in transgenic mice: the efficacy of parathyroid hormone-related protein and hepatocyte growth factor.

Fiaschi-Taesch NM, Santos S, Reddy V, Van Why SK, Philbrick WF, Ortega A, Esbrit P, Orloff JJ, Garcia-Ocaña A.

J Am Soc Nephrol. 2004 Jan;15(1):112-25.PMID: 14694163 [PubMed - indexed for MEDLINE]Related articlesFree article

Hepatocyte growth factor gene therapy for pancreatic islets in diabetes: reducing the minimal islet transplant mass required in a glucocorticoid-free rat model of allogeneic portal vein islet transplantation.

Lopez-Talavera JC, Garcia-Ocaña A, Sipula I, Takane KK, Cozar-Castellano I, Stewart AF.

Endocrinology. 2004 Feb;145(2):467-74. Epub 2003 Oct 9.PMID: 14551233 [PubMed - indexed for MEDLINE]Related articlesFree article

Direct comparison of sustained infusion of human parathyroid hormone-related protein-(1-36) [hPTHrP-(1-36)] versus hPTH-(1-34) on serum calcium, plasma 1,25-dihydroxyvitamin D concentrations, and fractional calcium excretion in healthy human volunteers.

Horwitz MJ, Tedesco MB, Sereika SM, Hollis BW, Garcia-Ocaña A, Stewart AF.

J Clin Endocrinol Metab. 2003 Apr;88(4):1603-9.PMID: 12679445 [PubMed - indexed for MEDLINE]Related articlesFree article

Short-term, high-dose parathyroid hormone-related protein as a skeletal anabolic agent for the treatment of postmenopausal osteoporosis.

Horwitz MJ, Tedesco MB, Gundberg C, Garcia-Ocana A, Stewart AF.

J Clin Endocrinol Metab. 2003 Feb;88(2):569-75.PMID: 12574182 [PubMed - indexed for MEDLINE]Related articlesFree article

Adenovirus-mediated hepatocyte growth factor expression in mouse islets improves pancreatic islet transplant performance and reduces beta cell death.

Garcia-Ocana A, Takane KK, Reddy VT, Lopez-Talavera JC, Vasavada RC, Stewart AF.

J Biol Chem. 2003 Jan 3;278(1):343-51. Epub 2002 Oct 25.PMID: 12403787 [PubMed - indexed for MEDLINE]Related articlesFree article

Overexpression of parathyroid hormone-related protein inhibits pancreatic beta-cell death in vivo and in vitro.

Cebrian A, García-Ocaña A, Takane KK, Sipula D, Stewart AF, Vasavada RC.

Diabetes. 2002 Oct;51(10):3003-13.PMID: 12351440 [PubMed - indexed for MEDLINE]Related articlesFree article

Transgenic overexpression of hepatocyte growth factor in the beta-cell markedly improves islet function and islet transplant outcomes in mice.

García-Ocaña A, Vasavada RC, Cebrian A, Reddy V, Takane KK, López-Talavera JC, Stewart AF.

Diabetes. 2001 Dec;50(12):2752-62.PMID: 11723058 [PubMed - indexed for MEDLINE]Related articlesFree article

Parathyroid hormone-related protein-(1--36) stimulates renal tubular calcium reabsorption in normal human volunteers: implications for the pathogenesis of humoral hypercalcemia of malignancy.

Syed MA, Horwitz MJ, Tedesco MB, Garcia-Ocaña A, Wisniewski SR, Stewart AF.

J Clin Endocrinol Metab. 2001 Apr;86(4):1525-31.PMID: 11297578 [PubMed - indexed for MEDLINE]Related articlesFree article

Using beta-cell growth factors to enhance human pancreatic Islet transplantation.

García-Ocaña A, Vasavada RC, Takane KK, Cebrian A, Lopez-Talavera JC, Stewart AF.

J Clin Endocrinol Metab. 2001 Mar;86(3):984-8. Review.PMID: 11238473 [PubMed - indexed for MEDLINE]Related articlesFree article

Characterization of parathyroid hormone/parathyroid hormone-related protein receptor and signaling in hypercalcemic Walker 256 tumor cells.

Esbrit P, Benítez-Verguizas J, de Miguel F, Valín A, García-Ocaña A.

J Endocrinol. 2000 Jul;166(1):11-20.PMID: 10856878 [PubMed - indexed for MEDLINE]Related articlesFree article

Targeted expression of placental lactogen in the beta cells of transgenic mice results in beta cell proliferation, islet mass augmentation, and hypoglycemia.

Vasavada RC, Garcia-Ocaña A, Zawalich WS, Sorenson RL, Dann P, Syed M, Ogren L, Talamantes F, Stewart AF.

J Biol Chem. 2000 May 19;275(20):15399-406.PMID: 10809775 [PubMed - indexed for MEDLINE]Related articlesFree article

Hepatocyte growth factor overexpression in the islet of transgenic mice increases beta cell proliferation, enhances islet mass, and induces mild hypoglycemia.

Garcia-Ocaña A, Takane KK, Syed MA, Philbrick WM, Vasavada RC, Stewart AF.

J Biol Chem. 2000 Jan 14;275(2):1226-32.PMID: 10625667 [PubMed - indexed for MEDLINE]Related articlesFree article

Parathyroid hormone-related protein (107-139) decreases alkaline phosphatase in osteoblastic osteosarcoma cells UMR 106 by a protein kinase C-dependent pathway.

Valín A, de Miguel F, García-Ocaña A, Esbrit P.

Calcif Tissue Int. 1999 Aug;65(2):148-51.PMID: 10430649 [PubMed - indexed for MEDLINE]Related articles

Expression and role of parathyroid hormone-related protein in human renal proximal tubule cells during recovery from ATP depletion.

García-Ocaña A, Galbraith SC, Van Why SK, Yang K, Golovyan L, Dann P, Zager RA, Stewart AF, Siegel NJ, Orloff JJ.

J Am Soc Nephrol. 1999 Feb;10(2):238-44.PMID: 10215322 [PubMed - indexed for MEDLINE]Related articlesFree article

Parathyroid hormone-related protein in the pancreatic islet and the cardiovascular system.

Vasavada RC, Garcia-Ocana A, Massfelder T, Dann P, Stewart AF.

Recent Prog Horm Res. 1998;53:305-38; discussion 338-40. Review.PMID: 9769713 [PubMed - indexed for MEDLINE]Related articles

Progressive pancreatic islet hyperplasia in the islet-targeted, parathyroid hormone-related protein-overexpressing mouse.

Porter SE, Sorenson RL, Dann P, Garcia-Ocana A, Stewart AF, Vasavada RC.

Endocrinology. 1998 Sep;139(9):3743-51.PMID: 9724026 [PubMed - indexed for MEDLINE]Related articlesFree article

Parathyroid hormone-related protein increases DNA synthesis in proximal tubule cells by cyclic AMP- and protein kinase C-dependent pathways.

García-Ocaña A, Gómez-Casero E, Peñaranda C, Esbrit P.

Life Sci. 1998;62(25):2267-73.PMID: 9651115 [PubMed - indexed for MEDLINE]Related articles

Cyclosporine increases renal parathyroid hormone-related protein expression in vivo in the rat.

Garcia-Ocaña A, Gomez-Casero E, Peñaranda C, Sarasa JL, Esbrit P.

Transplantation. 1998 Mar 27;65(6):860-3.PMID: 9580169 [PubMed - indexed for MEDLINE]Related articles

C-terminal parathyroid hormone-related protein inhibits proliferation and differentiation of human osteoblast-like cells.

Martínez ME, García-Ocaña A, Sánchez M, Medina S, del Campo T, Valin A, Sanchez-Cabezudo MJ, Esbrit P.

J Bone Miner Res. 1997 May;12(5):778-85.PMID: 9144344 [PubMed - indexed for MEDLINE]Related articles

Antiproliferative effect of the C-terminal fragments of parathyroid hormone-related protein, PTHrP-(107-111) and (107-139), on osteoblastic osteosarcoma cells.

Valín A, García-Ocaña A, De Miguel F, Sarasa JL, Esbrit P.

J Cell Physiol. 1997 Feb;170(2):209-15.PMID: 9009150 [PubMed - indexed for MEDLINE]Related articles

Transforming growth factor-beta and its receptors in rabbit renal proximal tubules after uninephrectomy.

García-Ocaña A, Peñaranda C, Esbrit P.

Exp Nephrol. 1996 Jul-Aug;4(4):231-40.PMID: 8864726 [PubMed - indexed for MEDLINE]Related articles

Comparison of antiproliferative effects of atrial natriuretic peptide and transforming growth factor beta on rabbit kidney proximal tubule cells.

García-Ocaña A, Peñaranda C, Esbrit P.

Life Sci. 1996;58(3):251-8.PMID: 9499166 [PubMed - indexed for MEDLINE]Related articles

Hypertrophy of rabbit proximal tubule cells is associated with overexpression of TGF beta.

Peñaranda C, García-Ocaña A, Sarasa JL, Esbrit P.

Life Sci. 1996;59(21):1773-82.PMID: 8937504 [PubMed - indexed for MEDLINE]Related articles

Parathyroid hormone-related protein is an autocrine modulator of rabbit proximal tubule cell growth.

García-Ocaña A, De Miguel F, Peñaranda C, Albar JP, Sarasa JL, Esbrit P.

J Bone Miner Res. 1995 Dec;10(12):1875-84.PMID: 8619367 [PubMed - indexed for MEDLINE]Related articles

Locally formed dopamine modulates renal Na-Pi co-transport through DA1 and DA2 receptors.

Perrichot R, Garcia-Ocaña A, Couette S, Comoy E, Amiel C, Friedlander G.

Biochem J. 1995 Dec 1;312 ( Pt 2):433-7.PMID: 8526852 [PubMed - indexed for MEDLINE]Related articlesFree article

Further studies on the characterization of a renotropic activity detected in uninephrectomized rat plasma.

García-Ocaña A, Esbrit P.

Exp Nephrol. 1994 Sep-Oct;2(5):286-93.PMID: 7812734 [PubMed - indexed for MEDLINE]Related articles

Partial purification of a renotropic activity from plasma of uninephrectomized human subjects.

García-Ocaña A, Ortega J, González-García Y, García-Cantón C, Esbrit P.

Nephron. 1993;64(4):547-51.PMID: 8366979 [PubMed - indexed for MEDLINE]Related articles

Role of kidney and liver in the renotropic activity generated in rats after uninephrectomy.

García-Ocaña A, Esbrit P.

Nephrol Dial Transplant. 1992;7(7):608-12.PMID: 1323070 [PubMed - indexed for MEDLINE]Related articles

Biological properties of a renotropic protein present in plasma of uninephrectomized rats.

Esbrit P, García-Ocaña A, García-Cañero R, Manzano F, Jiménez-Clavero MA.

Ren Physiol Biochem. 1991 Nov-Dec;14(6):224-35.PMID: 1720253 [PubMed - indexed for MEDLINE]Related articles

Partial purification and characterisation of a renal growth factor from plasma of uninephrectomised rats.

Manzano F, Esbrit P, García-Ocaña A, García-Cañero R, Jiménez-Clavero MA.

Nephrol Dial Transplant. 1989;4(5):334-8.PMID: 2505182 [PubMed - indexed for MEDLINE]Related articles