PubMed

Rescue of Munc18-1 and -2 Double Knockdown Reveals the Essential Functions of Interaction between Munc18 and Closed Syntaxin in PC12 Cells.

Han L, Jiang T, Han GA, Malintan NT, Xie L, Wang L, Tse FW, Gaisano HY, Collins BM, Meunier FA, Sugita S.

Mol Biol Cell. 2009 Oct 7. [Epub ahead of print]PMID: 19812250 [PubMed - as supplied by publisher]Related articlesFree article

Deletion of Fas in the pancreatic beta-cells leads to enhanced insulin secretion.

Choi D, Radziszewska A, Schroer SA, Liadis N, Liu Y, Zhang Y, Lam PP, Sheu L, Hao Z, Gaisano HY, Woo M.

Am J Physiol Endocrinol Metab. 2009 Dec;297(6):E1304-12. Epub 2009 Sep 15.PMID: 19755672 [PubMed - in process]Related articles

Characterization of Erg K+ channels in alpha- and beta-cells of mouse and human islets.

Hardy AB, Fox JE, Giglou PR, Wijesekara N, Bhattacharjee A, Sultan S, Gyulkhandanyan AV, Gaisano HY, MacDonald PE, Wheeler MB.

J Biol Chem. 2009 Oct 30;284(44):30441-52. Epub 2009 Aug 18.PMID: 19690348 [PubMed - in process]Related articles

Functional characterization of hyperpolarization-activated cyclic nucleotide-gated channels in rat pancreatic beta cells.

Zhang Y, Liu Y, Qu J, Hardy A, Zhang N, Diao J, Strijbos PJ, Tsushima R, Robinson RB, Gaisano HY, Wang Q, Wheeler MB.

J Endocrinol. 2009 Oct;203(1):45-53. Epub 2009 Aug 4.PMID: 19654142 [PubMed - indexed for MEDLINE]Related articles

POU homeodomain protein Oct-1 functions as a sensor for cyclic AMP.

Wang P, Wang Q, Sun J, Wu J, Li H, Zhang N, Huang Y, Su B, Li RK, Liu L, Zhang Y, Elsholtz HP, Hu J, Gaisano HY, Jin T.

J Biol Chem. 2009 Sep 25;284(39):26456-65. Epub 2009 Jul 18.PMID: 19617623 [PubMed - indexed for MEDLINE]Related articles

Truncation of SNAP-25 reduces the stimulatory action of cAMP on rapid exocytosis in insulin-secreting cells.

Vikman J, Svensson H, Huang YC, Kang Y, Andersson SA, Gaisano HY, Eliasson L.

Am J Physiol Endocrinol Metab. 2009 Aug;297(2):E452-61. Epub 2009 Jun 9.PMID: 19509185 [PubMed - indexed for MEDLINE]Related articles

Cab45b, a Munc18b-interacting partner, regulates exocytosis in pancreatic beta-cells.

Zhang Y, Kang YH, Chang N, Lam PP, Liu Y, Olkkonen VM, Gaisano HY.

J Biol Chem. 2009 Jul 31;284(31):20840-7. Epub 2009 Jun 1.PMID: 19487699 [PubMed - indexed for MEDLINE]Related articles

New insights into the mechanisms of pancreatitis.

Gaisano HY, Gorelick FS.

Gastroenterology. 2009 Jun;136(7):2040-4. Epub 2009 Apr 18. Review. No abstract available. PMID: 19379751 [PubMed - indexed for MEDLINE]Related articles

High beta-cell mass prevents streptozotocin-induced diabetes in thioredoxin-interacting protein-deficient mice.

Masson E, Koren S, Razik F, Goldberg H, Kwan EP, Sheu L, Gaisano HY, Fantus IG.

Am J Physiol Endocrinol Metab. 2009 Jun;296(6):E1251-61. Epub 2009 Feb 17.PMID: 19223654 [PubMed - indexed for MEDLINE]Related articles

Rescuing the subprime meltdown in insulin exocytosis in diabetes.

Kwan EP, Gaisano HY.

Ann N Y Acad Sci. 2009 Jan;1152:154-64. Review.PMID: 19161386 [PubMed - indexed for MEDLINE]Related articles

Epac is involved in cAMP-stimulated proglucagon expression and hormone production but not hormone secretion in pancreatic alpha- and intestinal L-cell lines.

Islam D, Zhang N, Wang P, Li H, Brubaker PL, Gaisano HY, Wang Q, Jin T.

Am J Physiol Endocrinol Metab. 2009 Jan;296(1):E174-81. Epub 2008 Oct 14.PMID: 18854429 [PubMed - indexed for MEDLINE]Related articles

Presence of functional hyperpolarisation-activated cyclic nucleotide-gated channels in clonal alpha cell lines and rat islet alpha cells.

Zhang Y, Zhang N, Gyulkhandanyan AV, Xu E, Gaisano HY, Wheeler MB, Wang Q.

Diabetologia. 2008 Dec;51(12):2290-8. Epub 2008 Oct 11.PMID: 18850083 [PubMed - indexed for MEDLINE]Related articles

Syntaxin-1A inhibition of P-1075, cromakalim, and diazoxide actions on mouse cardiac ATP-sensitive potassium channel.

Ng B, Kang Y, Xie H, Sun H, Gaisano HY.

Cardiovasc Res. 2008 Dec 1;80(3):365-74. Epub 2008 Aug 14.PMID: 18703534 [PubMed - indexed for MEDLINE]Related articles

Inhibition of cholesterol biosynthesis impairs insulin secretion and voltage-gated calcium channel function in pancreatic beta-cells.

Xia F, Xie L, Mihic A, Gao X, Chen Y, Gaisano HY, Tsushima RG.

Endocrinology. 2008 Oct;149(10):5136-45. Epub 2008 Jul 3.PMID: 18599549 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of Rac1 decreases the severity of pancreatitis and pancreatitis-associated lung injury in mice.

Binker MG, Binker-Cosen AA, Gaisano HY, Cosen-Binker LI.

Exp Physiol. 2008 Oct;93(10):1091-103. Epub 2008 Jun 20.PMID: 18567599 [PubMed - indexed for MEDLINE]Related articlesFree article

VAMP8 is the v-SNARE that mediates basolateral exocytosis in a mouse model of alcoholic pancreatitis.

Cosen-Binker LI, Binker MG, Wang CC, Hong W, Gaisano HY.

J Clin Invest. 2008 Jul;118(7):2535-51.PMID: 18535671 [PubMed - indexed for MEDLINE]Related articlesFree article

Pancreatic islet alpha cell commands itself: secrete more glucagon!

Gaisano HY, Leung YM.

Cell Metab. 2008 Jun;7(6):474-5. Review.PMID: 18522828 [PubMed - indexed for MEDLINE]Related articles

The RalA GTPase is a central regulator of insulin exocytosis from pancreatic islet beta cells.

Lopez JA, Kwan EP, Xie L, He Y, James DE, Gaisano HY.

J Biol Chem. 2008 Jun 27;283(26):17939-45. Epub 2008 Apr 21.PMID: 18426794 [PubMed - indexed for MEDLINE]Related articlesFree article

Munc18/SNARE proteins' regulation of exocytosis in guinea pig duodenal Brunner's gland acini.

Cosen-Binker LI, Morris GP, Vanner S, Gaisano HY.

World J Gastroenterol. 2008 Apr 21;14(15):2314-22.PMID: 18416456 [PubMed - indexed for MEDLINE]Related articlesFree article

Elevation in intracellular long-chain acyl-coenzyme A esters lead to reduced beta-cell excitability via activation of adenosine 5'-triphosphate-sensitive potassium channels.

Webster NJ, Searle GJ, Lam PP, Huang YC, Riedel MJ, Harb G, Gaisano HY, Holt A, Light PE.

Endocrinology. 2008 Jul;149(7):3679-87. Epub 2008 Mar 27.PMID: 18372336 [PubMed - indexed for MEDLINE]Related articlesFree article

Botulinum neurotoxin A and neurotoxin E cleavage products of synaptosome-associated protein of 25 kd exhibit distinct actions on pancreatic islet beta-cell Kv2.1 channel gating.

He Y, Elias CL, Huang YC, Gao X, Leung YM, Kang Y, Xie H, Chaddock JA, Tsushima RG, Gaisano HY.

Pancreas. 2008 Jan;36(1):10-7.PMID: 18192874 [PubMed - indexed for MEDLINE]Related articles

Munc18-1 is critical for plasma membrane localization of syntaxin1 but not of SNAP-25 in PC12 cells.

Arunachalam L, Han L, Tassew NG, He Y, Wang L, Xie L, Fujita Y, Kwan E, Davletov B, Monnier PP, Gaisano HY, Sugita S.

Mol Biol Cell. 2008 Feb;19(2):722-34. Epub 2007 Dec 12.PMID: 18077557 [PubMed - indexed for MEDLINE]Related articlesFree article

New insights into the molecular mechanisms of priming of insulin exocytosis.

Kwan EP, Gaisano HY.

Diabetes Obes Metab. 2007 Nov;9 Suppl 2:99-108.PMID: 17919184 [PubMed - indexed for MEDLINE]Related articles

Activation of exchange protein directly activated by cyclic adenosine monophosphate and protein kinase A regulate common and distinct steps in promoting plasma membrane exocytic and granule-to-granule fusions in rat islet beta cells.

Kwan EP, Gao X, Leung YM, Gaisano HY.

Pancreas. 2007 Oct;35(3):e45-54.PMID: 17895835 [PubMed - indexed for MEDLINE]Related articles

SNAREing voltage-gated K+ and ATP-sensitive K+ channels: tuning beta-cell excitability with syntaxin-1A and other exocytotic proteins.

Leung YM, Kwan EP, Ng B, Kang Y, Gaisano HY.

Endocr Rev. 2007 Oct;28(6):653-63. Epub 2007 Sep 18. Review.PMID: 17878408 [PubMed - indexed for MEDLINE]Related articlesFree article

Dynamin is functionally coupled to insulin granule exocytosis.

Min L, Leung YM, Tomas A, Watson RT, Gaisano HY, Halban PA, Pessin JE, Hou JC.

J Biol Chem. 2007 Nov 16;282(46):33530-6. Epub 2007 Sep 11.PMID: 17848579 [PubMed - indexed for MEDLINE]Related articlesFree article

Interaction of syntaxin 1A with the N-terminus of Kv4.2 modulates channel surface expression and gating.

Yamakawa T, Saith S, Li Y, Gao X, Gaisano HY, Tsushima RG.

Biochemistry. 2007 Sep 25;46(38):10942-9. Epub 2007 Aug 29.PMID: 17725325 [PubMed - indexed for MEDLINE]Related articles

Interaction between Munc13-1 and RIM is critical for glucagon-like peptide-1 mediated rescue of exocytotic defects in Munc13-1 deficient pancreatic beta-cells.

Kwan EP, Xie L, Sheu L, Ohtsuka T, Gaisano HY.

Diabetes. 2007 Oct;56(10):2579-88. Epub 2007 Jul 16.PMID: 17639022 [PubMed - indexed for MEDLINE]Related articlesFree article

Distinct in vivo roles of caspase-8 in beta-cells in physiological and diabetes models.

Liadis N, Salmena L, Kwan E, Tajmir P, Schroer SA, Radziszewska A, Li X, Sheu L, Eweida M, Xu S, Gaisano HY, Hakem R, Woo M.

Diabetes. 2007 Sep;56(9):2302-11. Epub 2007 Jun 11.PMID: 17563067 [PubMed - indexed for MEDLINE]Related articlesFree article

Ca2+-dependent activator protein for secretion 1 is critical for constitutive and regulated exocytosis but not for loading of transmitters into dense core vesicles.

Fujita Y, Xu A, Xie L, Arunachalam L, Chou TC, Jiang T, Chiew SK, Kourtesis J, Wang L, Gaisano HY, Sugita S.

J Biol Chem. 2007 Jul 20;282(29):21392-403. Epub 2007 May 31.PMID: 17540763 [PubMed - indexed for MEDLINE]Related articlesFree article

Modulation of the K(v)4.3 channel by syntaxin 1A.

Ahmed I, Cosen-Binker LI, Leung YM, Gaisano HY, Diamant NE.

Biochem Biophys Res Commun. 2007 Jul 6;358(3):789-95. Epub 2007 May 4.PMID: 17506992 [PubMed - indexed for MEDLINE]Related articles

The actions of a novel potent islet beta-cell specific ATP-sensitive K+ channel opener can be modulated by syntaxin-1A acting on sulfonylurea receptor 1.

Ng B, Kang Y, Elias CL, He Y, Xie H, Hansen JB, Wahl P, Gaisano HY.

Diabetes. 2007 Aug;56(8):2124-34. Epub 2007 May 11.PMID: 17496234 [PubMed - indexed for MEDLINE]Related articlesFree article

Alcohol redirects CCK-mediated apical exocytosis to the acinar basolateral membrane in alcoholic pancreatitis.

Lam PP, Cosen Binker LI, Lugea A, Pandol SJ, Gaisano HY.

Traffic. 2007 May;8(5):605-17.PMID: 17451559 [PubMed - indexed for MEDLINE]Related articles

A cytosolic splice variant of Cab45 interacts with Munc18b and impacts on amylase secretion by pancreatic acini.

Lam PP, Hyvärinen K, Kauppi M, Cosen-Binker L, Laitinen S, Keränen S, Gaisano HY, Olkkonen VM.

Mol Biol Cell. 2007 Jul;18(7):2473-80. Epub 2007 Apr 18.PMID: 17442889 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of palmitate on insulin secretion and exocytotic proteins in islets of diabetic Goto-Kakizaki rats.

Ostenson CG, Chen J, Sheu L, Gaisano HY.

Pancreas. 2007 Apr;34(3):359-63.PMID: 17414060 [PubMed - indexed for MEDLINE]Related articles

Alcohol-induced protein kinase Calpha phosphorylation of Munc18c in carbachol-stimulated acini causes basolateral exocytosis.

Cosen-Binker LI, Lam PP, Binker MG, Gaisano HY.

Gastroenterology. 2007 Apr;132(4):1527-45. Epub 2007 Jan 26.PMID: 17408632 [PubMed - indexed for MEDLINE]Related articles

Alcohol/cholecystokinin-evoked pancreatic acinar basolateral exocytosis is mediated by protein kinase C alpha phosphorylation of Munc18c.

Cosen-Binker LI, Lam PP, Binker MG, Reeve J, Pandol S, Gaisano HY.

J Biol Chem. 2007 Apr 27;282(17):13047-58. Epub 2007 Feb 26.PMID: 17324928 [PubMed - indexed for MEDLINE]Related articlesFree article

Targeting of voltage-gated K+ and Ca2+ channels and soluble N-ethylmaleimide-sensitive factor attachment protein receptor proteins to cholesterol-rich lipid rafts in pancreatic alpha-cells: effects on glucagon stimulus-secretion coupling.

Xia F, Leung YM, Gaisano G, Gao X, Chen Y, Fox JE, Bhattacharjee A, Wheeler MB, Gaisano HY, Tsushima RG.

Endocrinology. 2007 May;148(5):2157-67. Epub 2007 Feb 15.PMID: 17303668 [PubMed - indexed for MEDLINE]Related articlesFree article

Distinct modulation of Kv1.2 channel gating by wild type, but not open form, of syntaxin-1A.

Neshatian L, Leung YM, Kang Y, Gao X, Xie H, Tsushima RG, Gaisano HY, Diamant NE.

Am J Physiol Gastrointest Liver Physiol. 2007 May;292(5):G1233-42. Epub 2007 Jan 18.PMID: 17234891 [PubMed - indexed for MEDLINE]Related articlesFree article

Recent insights into the cellular mechanisms of acute pancreatitis.

Cosen-Binker LI, Gaisano HY.

Can J Gastroenterol. 2007 Jan;21(1):19-24. Review.PMID: 17225878 [PubMed - indexed for MEDLINE]Related articlesFree article

Target soluble N-ethylmaleimide-sensitive factor attachment protein receptors (t-SNAREs) differently regulate activation and inactivation gating of Kv2.2 and Kv2.1: Implications on pancreatic islet cell Kv channels.

Wolf-Goldberg T, Michaelevski I, Sheu L, Gaisano HY, Chikvashvili D, Lotan I.

Mol Pharmacol. 2006 Sep;70(3):818-28. Epub 2006 Jun 5.PMID: 16754785 [PubMed - indexed for MEDLINE]Related articlesFree article

The neuronal Ca2+ sensor protein visinin-like protein-1 is expressed in pancreatic islets and regulates insulin secretion.

Dai FF, Zhang Y, Kang Y, Wang Q, Gaisano HY, Braunewell KH, Chan CB, Wheeler MB.

J Biol Chem. 2006 Aug 4;281(31):21942-53. Epub 2006 May 26.PMID: 16731532 [PubMed - indexed for MEDLINE]Related articlesFree article

Two populations of pancreatic islet alpha-cells displaying distinct Ca2+ channel properties.

Leung YM, Ahmed I, Sheu L, Tsushima RG, Diamant NE, Gaisano HY.

Biochem Biophys Res Commun. 2006 Jun 23;345(1):340-4. Epub 2006 Apr 25.PMID: 16678791 [PubMed - indexed for MEDLINE]Related articles

Syntaxin-1A actions on sulfonylurea receptor 2A can block acidic pH-induced cardiac K(ATP) channel activation.

Kang Y, Ng B, Leung YM, He Y, Xie H, Lodwick D, Norman RI, Tinker A, Tsushima RG, Gaisano HY.

J Biol Chem. 2006 Jul 14;281(28):19019-28. Epub 2006 May 3.PMID: 16672225 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of the exchange protein directly activated by cyclic adenosine 5'-monophosphate (Epac) pathway in regulating proglucagon gene expression in intestinal endocrine L cells.

Lotfi S, Li Z, Sun J, Zuo Y, Lam PP, Kang Y, Rahimi M, Islam D, Wang P, Gaisano HY, Jin T.

Endocrinology. 2006 Aug;147(8):3727-36. Epub 2006 Apr 27.PMID: 16644915 [PubMed - indexed for MEDLINE]Related articlesFree article

Munc13-1 deficiency reduces insulin secretion and causes abnormal glucose tolerance.

Kwan EP, Xie L, Sheu L, Nolan CJ, Prentki M, Betz A, Brose N, Gaisano HY.

Diabetes. 2006 May;55(5):1421-9.PMID: 16644700 [PubMed - indexed for MEDLINE]Related articlesFree article

Involvement of VAMP-2 in exocytosis of IL-1 beta in turbot (Scophthalmus maximus) leukocytes after Vibrio anguillarum infection.

Chai Y, Huang X, Cong B, Liu S, Chen K, Li G, Gaisano HY.

Biochem Biophys Res Commun. 2006 Apr 7;342(2):509-13. Epub 2006 Feb 3.PMID: 16487935 [PubMed - indexed for MEDLINE]Related articles

Modulation of Kv2.1 channel gating and TEA sensitivity by distinct domains of SNAP-25.

He Y, Kang Y, Leung YM, Xia F, Gao X, Xie H, Gaisano HY, Tsushima RG.

Biochem J. 2006 Jun 1;396(2):363-9.PMID: 16478442 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin regulates islet alpha-cell function by reducing KATP channel sensitivity to adenosine 5'-triphosphate inhibition.

Leung YM, Ahmed I, Sheu L, Gao X, Hara M, Tsushima RG, Diamant NE, Gaisano HY.

Endocrinology. 2006 May;147(5):2155-62. Epub 2006 Feb 2.PMID: 16455778 [PubMed - indexed for MEDLINE]Related articlesFree article

Feline lower esophageal sphincter sling and circular muscles have different functional inhibitory neuronal responses.

L'Heureux MC, Muinuddin A, Gaisano HY, Diamant NE.

Am J Physiol Gastrointest Liver Physiol. 2006 Jan;290(1):G23-9. Epub 2005 Sep 15.PMID: 16166343 [PubMed - indexed for MEDLINE]Related articlesFree article