PubMed

Affinity chromatography of native SUMO proteins using His-tagged recombinant UBC9 bound to Co2+-charged talon resin.

Bohren KM, Gabbay KH, Owerbach D.

Protein Expr Purif. 2007 Aug;54(2):289-94. Epub 2007 Mar 27.PMID: 17459725 [PubMed - indexed for MEDLINE]Related articles

A proline-90 residue unique to SUMO-4 prevents maturation and sumoylation.

Owerbach D, McKay EM, Yeh ET, Gabbay KH, Bohren KM.

Biochem Biophys Res Commun. 2005 Nov 18;337(2):517-20. Epub 2005 Sep 22.PMID: 16198310 [PubMed - indexed for MEDLINE]Related articles

The structure of Apo R268A human aldose reductase: hinges and latches that control the kinetic mechanism.

Bohren KM, Brownlee JM, Milne AC, Gabbay KH, Harrison DH.

Biochim Biophys Acta. 2005 May 15;1748(2):201-12.PMID: 15769597 [PubMed - indexed for MEDLINE]Related articles

Aldose reductase inhibition in the treatment of diabetic neuropathy: where are we in 2004?

Gabbay KH.

Curr Diab Rep. 2004 Dec;4(6):405-8. Review.PMID: 15539002 [PubMed - indexed for MEDLINE]Related articles

Association of a CAG/CAA repeat sequence in the TBP gene with type I diabetes.

Owerbach D, Piña L, Gabbay KH.

Biochem Biophys Res Commun. 2004 Oct 22;323(3):865-9.PMID: 15381080 [PubMed - indexed for MEDLINE]Related articles

A 212-kb region on chromosome 6q25 containing the TAB2 gene is associated with susceptibility to type 1 diabetes.

Owerbach D, Piña L, Gabbay KH.

Diabetes. 2004 Jul;53(7):1890-3.PMID: 15220215 [PubMed - indexed for MEDLINE]Related articlesFree article

A M55V polymorphism in a novel SUMO gene (SUMO-4) differentially activates heat shock transcription factors and is associated with susceptibility to type I diabetes mellitus.

Bohren KM, Nadkarni V, Song JH, Gabbay KH, Owerbach D.

J Biol Chem. 2004 Jun 25;279(26):27233-8. Epub 2004 Apr 29.PMID: 15123604 [PubMed - indexed for MEDLINE]Related articlesFree article

Human aldehyde reductase promoter allows simultaneous expression of two genes in opposite directions.

Barski OA, Siller-Lopez F, Bohren KM, Gabbay KH, Aguilar-Cordova E.

Biotechniques. 2004 Mar;36(3):382-4, 386, 388. No abstract available. PMID: 15038151 [PubMed - indexed for MEDLINE]Related articles

Regulation of aldehyde reductase expression by STAF and CHOP.

Barski OA, Papusha VZ, Kunkel GR, Gabbay KH.

Genomics. 2004 Jan;83(1):119-29.PMID: 14667815 [PubMed - indexed for MEDLINE]Related articles

Cyclosporine A inhibits the adaptive responses to hypertonicity: a potential mechanism of nephrotoxicity.

Sheikh-Hamad D, Nadkarni V, Choi YJ, Truong LD, Wideman C, Hodjati R, Gabbay KH.

J Am Soc Nephrol. 2001 Dec;12(12):2732-41.PMID: 11729242 [PubMed - indexed for MEDLINE]Related articlesFree article

Characterization of the human aldehyde reductase gene and promoter.

Barski OA, Gabbay KH, Bohren KM.

Genomics. 1999 Sep 1;60(2):188-98.PMID: 10486210 [PubMed - indexed for MEDLINE]Related articles

Osmotic response element enhancer activity. Regulation through p38 kinase and mitogen-activated extracellular signal-regulated kinase kinase.

Nadkarni V, Gabbay KH, Bohren KM, Sheikh-Hamad D.

J Biol Chem. 1999 Jul 16;274(29):20185-90.PMID: 10400634 [PubMed - indexed for MEDLINE]Related articlesFree article

Factors affecting counteraction by methylamines of urea effects on aldose reductase.

Burg MB, Peters EM, Bohren KM, Gabbay KH.

Proc Natl Acad Sci U S A. 1999 May 25;96(11):6517-22.PMID: 10339620 [PubMed - indexed for MEDLINE]Related articlesFree article

The alrestatin double-decker: binding of two inhibitor molecules to human aldose reductase reveals a new specificity determinant.

Harrison DH, Bohren KM, Petsko GA, Ringe D, Gabbay KH.

Biochemistry. 1997 Dec 23;36(51):16134-40.PMID: 9405046 [PubMed - indexed for MEDLINE]Related articles

Linkage analyses in type I diabetes mellitus using CASPAR, a software and statistical program for conditional analysis of polygenic diseases.

Buhler J, Owerbach D, Schäffer AA, Kimmel M, Gabbay KH.

Hum Hered. 1997 Jul-Aug;47(4):211-22.PMID: 9239508 [PubMed - indexed for MEDLINE]Related articles

Identification and characterization of multiple osmotic response sequences in the human aldose reductase gene.

Ko BC, Ruepp B, Bohren KM, Gabbay KH, Chung SS.

J Biol Chem. 1997 Jun 27;272(26):16431-7.PMID: 9195951 [PubMed - indexed for MEDLINE]Related articlesFree article

Analysis of candidate genes for susceptibility to type I diabetes: a case-control and family-association study of genes on chromosome 2q31-35.

Owerbach D, Naya FJ, Tsai MJ, Allander SV, Powell DR, Gabbay KH.

Diabetes. 1997 Jun;46(6):1069-74.PMID: 9166681 [PubMed - indexed for MEDLINE]Related articles

Characterization of an element resembling an androgen response element (ARE) in the human aldose reductase promoter.

Ruepp BU, Bohren KM, Gabbay KH.

Adv Exp Med Biol. 1997;414:515-9. No abstract available. PMID: 9059657 [PubMed - indexed for MEDLINE]Related articles

Characterization of a novel murine aldo-keto reductase.

Bohren KM, Barski OA, Gabbay KH.

Adv Exp Med Biol. 1997;414:455-64. No abstract available. PMID: 9059651 [PubMed - indexed for MEDLINE]Related articles

Aldehyde reductase. Catalytic mechanism and substrate recognition.

Barski OA, Gabbay KH, Bohren KM.

Adv Exp Med Biol. 1997;414:443-51. No abstract available. PMID: 9059649 [PubMed - indexed for MEDLINE]Related articles

The C-terminal loop of aldehyde reductase determines the substrate and inhibitor specificity.

Barski OA, Gabbay KH, Bohren KM.

Biochemistry. 1996 Nov 12;35(45):14276-80.PMID: 8916913 [PubMed - indexed for MEDLINE]Related articles

Characterization of the osmotic response element of the human aldose reductase gene promoter.

Ruepp B, Bohren KM, Gabbay KH.

Proc Natl Acad Sci U S A. 1996 Aug 6;93(16):8624-9.PMID: 8710921 [PubMed - indexed for MEDLINE]Related articlesFree article

The search for IDDM susceptibility genes: the next generation.

Owerbach D, Gabbay KH.

Diabetes. 1996 May;45(5):544-51. Review.PMID: 8621001 [PubMed - indexed for MEDLINE]Related articles

Human aldose reductase: pK of tyrosine 48 reveals the preferred ionization state for catalysis and inhibition.

Grimshaw CE, Bohren KM, Lai CJ, Gabbay KH.

Biochemistry. 1995 Nov 7;34(44):14374-84.PMID: 7578041 [PubMed - indexed for MEDLINE]Related articles

Human aldose reductase: subtle effects revealed by rapid kinetic studies of the C298A mutant enzyme.

Grimshaw CE, Bohren KM, Lai CJ, Gabbay KH.

Biochemistry. 1995 Nov 7;34(44):14366-73.PMID: 7578040 [PubMed - indexed for MEDLINE]Related articles

Human aldose reductase: rate constants for a mechanism including interconversion of ternary complexes by recombinant wild-type enzyme.

Grimshaw CE, Bohren KM, Lai CJ, Gabbay KH.

Biochemistry. 1995 Nov 7;34(44):14356-65.PMID: 7578039 [PubMed - indexed for MEDLINE]Related articles

Mechanism of human aldehyde reductase: characterization of the active site pocket.

Barski OA, Gabbay KH, Grimshaw CE, Bohren KM.

Biochemistry. 1995 Sep 5;34(35):11264-75.PMID: 7669785 [PubMed - indexed for MEDLINE]Related articles

The HOXD8 locus (2q31) is linked to type I diabetes. Interaction with chromosome 6 and 11 disease susceptibility genes.

Owerbach D, Gabbay KH.

Diabetes. 1995 Jan;44(1):132-6.PMID: 7813807 [PubMed - indexed for MEDLINE]Related articles

Expression, crystallization and preliminary crystallographic analysis of human carbonyl reductase.

Bohren KM, Wermuth B, Harrison D, Ringe D, Petsko GA, Gabbay KH.

J Mol Biol. 1994 Dec 16;244(5):659-64.PMID: 7990149 [PubMed - indexed for MEDLINE]Related articles

Mechanism of aldose reductase inhibition: binding of NADP+/NADPH and alrestatin-like inhibitors.

Ehrig T, Bohren KM, Prendergast FG, Gabbay KH.

Biochemistry. 1994 Jun 14;33(23):7157-65.PMID: 8003482 [PubMed - indexed for MEDLINE]Related articles

Retinal circulatory abnormalities in type 1 diabetes.

Feke GT, Buzney SM, Ogasawara H, Fujio N, Goger DG, Spack NP, Gabbay KH.

Invest Ophthalmol Vis Sci. 1994 Jun;35(7):2968-75.PMID: 8206714 [PubMed - indexed for MEDLINE]Related articlesFree article

Linkage of the VNTR/insulin-gene and type I diabetes mellitus: increased gene sharing in affected sibling pairs.

Owerbach D, Gabbay KH.

Am J Hum Genet. 1994 May;54(5):909-12.PMID: 7909987 [PubMed - indexed for MEDLINE]Related articlesFree article

Tyrosine-48 is the proton donor and histidine-110 directs substrate stereochemical selectivity in the reduction reaction of human aldose reductase: enzyme kinetics and crystal structure of the Y48H mutant enzyme.

Bohren KM, Grimshaw CE, Lai CJ, Harrison DH, Ringe D, Petsko GA, Gabbay KH.

Biochemistry. 1994 Mar 1;33(8):2021-32.PMID: 8117659 [PubMed - indexed for MEDLINE]Related articles

An anion binding site in human aldose reductase: mechanistic implications for the binding of citrate, cacodylate, and glucose 6-phosphate.

Harrison DH, Bohren KM, Ringe D, Petsko GA, Gabbay KH.

Biochemistry. 1994 Mar 1;33(8):2011-20.PMID: 8117658 [PubMed - indexed for MEDLINE]Related articles

Localization of a type I diabetes susceptibility locus to the variable tandem repeat region flanking the insulin gene.

Owerbach D, Gabbay KH.

Diabetes. 1993 Dec;42(12):1708-14.PMID: 8243816 [PubMed - indexed for MEDLINE]Related articles

Characterization of the human aldose reductase gene promoter.

Wang K, Bohren KM, Gabbay KH.

J Biol Chem. 1993 Jul 25;268(21):16052-8.PMID: 8340427 [PubMed - indexed for MEDLINE]Related articlesFree article

Cys298 is responsible for reversible thiol-induced variation in aldose reductase activity.

Bohren KM, Gabbay KH.

Adv Exp Med Biol. 1993;328:267-77. No abstract available. PMID: 8493903 [PubMed - indexed for MEDLINE]Related articles

Catalytic effectiveness of human aldose reductase. Critical role of C-terminal domain.

Bohren KM, Grimshaw CE, Gabbay KH.

J Biol Chem. 1992 Oct 15;267(29):20965-70.PMID: 1400412 [PubMed - indexed for MEDLINE]Related articlesFree article

An unlikely sugar substrate site in the 1.65 A structure of the human aldose reductase holoenzyme implicated in diabetic complications.

Wilson DK, Bohren KM, Gabbay KH, Quiocho FA.

Science. 1992 Jul 3;257(5066):81-4.PMID: 1621098 [PubMed - indexed for MEDLINE]Related articles

Expression of human aldose and aldehyde reductases. Site-directed mutagenesis of a critical lysine 262.

Bohren KM, Page JL, Shankar R, Henry SP, Gabbay KH.

J Biol Chem. 1991 Dec 15;266(35):24031-7.PMID: 1748675 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of puberty on insulinlike growth factor I and HbA1 in type I diabetes.

Rogers DG, Sherman LD, Gabbay KH.

Diabetes Care. 1991 Nov;14(11):1031-5.PMID: 1797483 [PubMed - indexed for MEDLINE]Related articles

Multigenic basis for type I diabetes. Association of HRAS1 polymorphism with HLA-DR3, DQw2/DR4, DQw8.

Owerbach D, Gunn S, Gabbay KH.

Diabetes. 1990 Dec;39(12):1504-9.PMID: 1978827 [PubMed - indexed for MEDLINE]Related articles

Two unrelated patients with familial hyperproinsulinemia due to a mutation substituting histidine for arginine at position 65 in the proinsulin molecule: identification of the mutation by direct sequencing of genomic deoxyribonucleic acid amplified by polymerase chain reaction.

Barbetti F, Raben N, Kadowaki T, Cama A, Accili D, Gabbay KH, Merenich JA, Taylor SI, Roth J.

J Clin Endocrinol Metab. 1990 Jul;71(1):164-9.PMID: 2196279 [PubMed - indexed for MEDLINE]Related articles

Primary association of HLA-DQw8 with type I diabetes in DR4 patients.

Owerbach D, Gunn S, Gabbay KH.

Diabetes. 1989 Jul;38(7):942-5.PMID: 2786821 [PubMed - indexed for MEDLINE]Related articles

The aldo-keto reductase superfamily. cDNAs and deduced amino acid sequences of human aldehyde and aldose reductases.

Bohren KM, Bullock B, Wermuth B, Gabbay KH.

J Biol Chem. 1989 Jun 5;264(16):9547-51.PMID: 2498333 [PubMed - indexed for MEDLINE]Related articlesFree article

Human carbonyl reductase. Nucleotide sequence analysis of a cDNA and amino acid sequence of the encoded protein.

Wermuth B, Bohren KM, Heinemann G, von Wartburg JP, Gabbay KH.

J Biol Chem. 1988 Nov 5;263(31):16185-8.PMID: 3141401 [PubMed - indexed for MEDLINE]Related articlesFree article

Oligonucleotide probes for HLA-DQA and DQB genes define susceptibility to type 1 (insulin-dependent) diabetes mellitus.

Owerbach D, Gunn S, Ty G, Wible L, Gabbay KH.

Diabetologia. 1988 Oct;31(10):751-7.PMID: 3240836 [PubMed - indexed for MEDLINE]Related articles

T-cell-defined DR4 subtypes as markers for type 1 diabetes.

Rowe JR, Mickelson EM, Hansen JA, MacDonald MJ, Allen CI, Gabbay KH, Yunis EJ, Sheehy MJ.

Hum Immunol. 1988 May;22(1):51-60.PMID: 3260586 [PubMed - indexed for MEDLINE]Related articles

Primary structure of aldehyde reductase from human liver.

Wermuth B, Omar A, Forster A, di Francesco C, Wolf M, von Wartburg JP, Bullock B, Gabbay KH.

Prog Clin Biol Res. 1987;232:297-307. No abstract available. PMID: 3615425 [PubMed - indexed for MEDLINE]Related articles

Secretion of an insulin-like growth factor-I-related protein by human breast cancer cells.

Huff KK, Kaufman D, Gabbay KH, Spencer EM, Lippman ME, Dickson RB.

Cancer Res. 1986 Sep;46(9):4613-9.PMID: 3731113 [PubMed - indexed for MEDLINE]Related articlesFree article