PubMed

Evidence for oxazepam as an in vivo probe of UGT2B15: oxazepam clearance is reduced by UGT2B15 D85Y polymorphism but unaffected by UGT2B17 deletion.

He X, Hesse LM, Hazarika S, Masse G, Harmatz JS, Greenblatt DJ, Court MH.

Br J Clin Pharmacol. 2009 Nov;68(5):721-30.PMID: 19916996 [PubMed - in process]Related articles

Drug-drug noninteractions.

Greenblatt DJ.

Cardiovasc Ther. 2009 Winter;27(4):226-9.PMID: 19903185 [PubMed - in process]Related articles

Pharmacokinetics, bioavailability and effects on electrocardiographic parameters of oral fludarabine phosphate.

Yin W, Karyagina EV, Lundberg AS, Greenblatt DJ, Lister-James J.

Biopharm Drug Dispos. 2009 Oct 26. [Epub ahead of print]PMID: 19862681 [PubMed - as supplied by publisher]Related articles

Analysis of drug interactions involving fruit beverages and organic anion-transporting polypeptides.

Greenblatt DJ.

J Clin Pharmacol. 2009 Dec;49(12):1403-7. Epub 2009 Sep 29.PMID: 19789373 [PubMed - in process]Related articles

The absence of an interaction between warfarin and cranberry juice: a randomized, double-blind trial.

Ansell J, McDonough M, Zhao Y, Harmatz JS, Greenblatt DJ.

J Clin Pharmacol. 2009 Jul;49(7):824-30.PMID: 19553405 [PubMed - indexed for MEDLINE]Related articles

Propofol clearance and volume of distribution are increased in patients with major burns.

Han TH, Greenblatt DJ, Martyn JA.

J Clin Pharmacol. 2009 Jul;49(7):768-72.PMID: 19553403 [PubMed - indexed for MEDLINE]Related articles

Short-term clarithromycin administration impairs clearance and enhances pharmacodynamic effects of trazodone but not of zolpidem.

Farkas D, Volak LP, Harmatz JS, von Moltke LL, Court MH, Greenblatt DJ.

Clin Pharmacol Ther. 2009 Jun;85(6):644-50. Epub 2009 Feb 25.PMID: 19242403 [PubMed - indexed for MEDLINE]Related articles

Ritonavir greatly impairs CYP3A activity in HIV infection with chronic viral hepatitis.

Knox TA, Oleson L, von Moltke LL, Kaufman RC, Wanke CA, Greenblatt DJ.

J Acquir Immune Defic Syndr. 2008 Dec 1;49(4):358-68.PMID: 19186349 [PubMed - indexed for MEDLINE]Related articles

Ritonavir Greatly Impairs CYP3A Activity in HIV Infection With Chronic Viral Hepatitis.

Knox TA, Oleson L, von Moltke LL, Kaufman RC, Wanke CA, Greenblatt DJ.

J Acquir Immune Defic Syndr. 2008 Oct 16. [Epub ahead of print]PMID: 18931633 [PubMed - as supplied by publisher]Related articles

Role of NADPH-cytochrome P450 reductase and cytochrome-b5/NADH-b5 reductase in variability of CYP3A activity in human liver microsomes.

Gan L, von Moltke LL, Trepanier LA, Harmatz JS, Greenblatt DJ, Court MH.

Drug Metab Dispos. 2009 Jan;37(1):90-6. Epub 2008 Oct 6.PMID: 18838505 [PubMed - indexed for MEDLINE]Related articles

Pharmacologic consideration for the use of antiretroviral agents in the elderly.

Rhee MS, Greenblatt DJ.

J Clin Pharmacol. 2008 Oct;48(10):1212-25. Review.PMID: 18812611 [PubMed - indexed for MEDLINE]Related articles

Gender has a small but statistically significant effect on clearance of CYP3A substrate drugs.

Greenblatt DJ, von Moltke LL.

J Clin Pharmacol. 2008 Nov;48(11):1350-5. Epub 2008 Aug 29. Review.PMID: 18757784 [PubMed - indexed for MEDLINE]Related articles

Pharmacokinetics of efavirenz when co-administered with rifampin in TB/HIV co-infected patients: pharmacogenetic effect of CYP2B6 variation.

Kwara A, Lartey M, Sagoe KW, Xexemeku F, Kenu E, Oliver-Commey J, Boima V, Sagoe A, Boamah I, Greenblatt DJ, Court MH.

J Clin Pharmacol. 2008 Sep;48(9):1032-40.PMID: 18728241 [PubMed - indexed for MEDLINE]Related articlesFree article

Preparation of scientific reports on pharmacokinetic drug interaction studies.

Greenblatt DJ.

J Clin Psychopharmacol. 2008 Aug;28(4):369-73. No abstract available. PMID: 18626262 [PubMed - indexed for MEDLINE]Related articles

Influence of fruit juices on drug disposition: discrepancies between in vitro and clinical studies.

Farkas D, Greenblatt DJ.

Expert Opin Drug Metab Toxicol. 2008 Apr;4(4):381-93. Review.PMID: 18433343 [PubMed - indexed for MEDLINE]Related articles

Induction of P-glycoprotein expression and activity by ritonavir in bovine brain microvessel endothelial cells.

Perloff MD, von Moltke LL, Fahey JM, Greenblatt DJ.

J Pharm Pharmacol. 2007 Jul;59(7):947-53.PMID: 17637189 [PubMed - indexed for MEDLINE]Related articles

Pharmacokinetic and pharmacodynamic interactions between zolpidem and caffeine.

Cysneiros RM, Farkas D, Harmatz JS, von Moltke LL, Greenblatt DJ.

Clin Pharmacol Ther. 2007 Jul;82(1):54-62. Epub 2007 Apr 18.PMID: 17443132 [PubMed - indexed for MEDLINE]Related articles

Fentanyl clearance and volume of distribution are increased in patients with major burns.

Han T, Harmatz JS, Greenblatt DJ, Martyn JA.

J Clin Pharmacol. 2007 Jun;47(6):674-80. Epub 2007 Apr 11.PMID: 17428913 [PubMed - indexed for MEDLINE]Related articles

Role of CYP3A and CYP2E1 in alcohol-mediated increases in acetaminophen hepatotoxicity: comparison of wild-type and Cyp2e1(-/-) mice.

Wolf KK, Wood SG, Allard JL, Hunt JA, Gorman N, Walton-Strong BW, Szakacs JG, Duan SX, Hao Q, Court MH, von Moltke LL, Greenblatt DJ, Kostrubsky V, Jeffery EH, Wrighton SA, Gonzalez FJ, Sinclair PR, Sinclair JF.

Drug Metab Dispos. 2007 Jul;35(7):1223-31. Epub 2007 Mar 28.PMID: 17392391 [PubMed - indexed for MEDLINE]Related articlesFree article

Age and gender effects on the pharmacokinetics and pharmacodynamics of ramelteon, a hypnotic agent acting via melatonin receptors MT1 and MT2.

Greenblatt DJ, Harmatz JS, Karim A.

J Clin Pharmacol. 2007 Apr;47(4):485-96.PMID: 17389558 [PubMed - indexed for MEDLINE]Related articles

Pomegranate juice does not impair clearance of oral or intravenous midazolam, a probe for cytochrome P450-3A activity: comparison with grapefruit juice.

Farkas D, Oleson LE, Zhao Y, Harmatz JS, Zinny MA, Court MH, Greenblatt DJ.

J Clin Pharmacol. 2007 Mar;47(3):286-94.PMID: 17322140 [PubMed - indexed for MEDLINE]Related articles

Comparison of duloxetine, escitalopram, and sertraline effects on cytochrome P450 2D6 function in healthy volunteers.

Preskorn SH, Greenblatt DJ, Flockhart D, Luo Y, Perloff ES, Harmatz JS, Baker B, Klick-Davis A, Desta Z, Burt T.

J Clin Psychopharmacol. 2007 Feb;27(1):28-34.PMID: 17224709 [PubMed - indexed for MEDLINE]Related articles

Dynamics and kinetics of a modified-release formulation of zolpidem: comparison with immediate-release standard zolpidem and placebo.

Greenblatt DJ, Legangneux E, Harmatz JS, Weinling E, Freeman J, Rice K, Zammit GK.

J Clin Pharmacol. 2006 Dec;46(12):1469-80.PMID: 17101746 [PubMed - indexed for MEDLINE]Related articles

The Bolger conference on PDE-5 inhibition and HIV risk: implications for health policy and prevention.

Rosen RC, Catania JA, Ehrhardt AA, Burnett AL, Lue TF, McKenna K, Heiman JR, Schwarcz S, Ostrow DG, Hirshfield S, Purcell DW, Fisher WA, Stall R, Halkitis PN, Latini DM, Elford J, Laumann EO, Sonenstein FL, Greenblatt DJ, Kloner RA, Lee J, Malebranche D, Janssen E, Diaz R, Klausner JD, Caplan AL, Jackson G, Shabsigh R, Khalsa JH, Stoff DM, Goldmeier D, Lamba H, Richardson D, Sadeghi-Nejad H.

J Sex Med. 2006 Nov;3(6):960-75; discussion 973-5.PMID: 17100928 [PubMed - indexed for MEDLINE]Related articles

Lorazepam concentrations, pharmacokinetics and pharmacodynamics in a cohort of mechanically ventilated ICU patients.

de Wit M, Best AM, Epstein SK, Greenblatt DJ.

Int J Clin Pharmacol Ther. 2006 Oct;44(10):466-73.PMID: 17063976 [PubMed - indexed for MEDLINE]Related articles

Human pregnane X receptor: genetic polymorphisms, alternative mRNA splice variants, and cytochrome P450 3A metabolic activity.

He P, Court MH, Greenblatt DJ, von Moltke LL.

J Clin Pharmacol. 2006 Nov;46(11):1356-69.PMID: 17050801 [PubMed - indexed for MEDLINE]Related articles

The effect of chronic lorazepam administration in aging mice.

Fahey JM, Pritchard GA, Reddi JM, Pratt JS, Grassi JM, Shader RI, Greenblatt DJ.

Brain Res. 2006 Nov 6;1118(1):13-24. Epub 2006 Sep 20.PMID: 16989785 [PubMed - indexed for MEDLINE]Related articles

Factors influencing midazolam hydroxylation activity in human liver microsomes.

He P, Court MH, Greenblatt DJ, von Moltke LL.

Drug Metab Dispos. 2006 Jul;34(7):1198-207. Epub 2006 Apr 25.PMID: 16638818 [PubMed - indexed for MEDLINE]Related articlesFree article

Ritonavir has minimal impact on the pharmacokinetic disposition of a single dose of bupropion administered to human volunteers.

Hesse LM, Greenblatt DJ, von Moltke LL, Court MH.

J Clin Pharmacol. 2006 May;46(5):567-76.PMID: 16638740 [PubMed - indexed for MEDLINE]Related articles

Balancing efficacy and safety in the use of oral sedation in dental outpatients.

Dionne RA, Yagiela JA, Coté CJ, Donaldson M, Edwards M, Greenblatt DJ, Haas D, Malviya S, Milgrom P, Moore PA, Shampaine G, Silverman M, Williams RL, Wilson S.

J Am Dent Assoc. 2006 Apr;137(4):502-13.PMID: 16637480 [PubMed - indexed for MEDLINE]Related articlesFree article

The novel UGT1A9 intronic I399 polymorphism appears as a predictor of 7-ethyl-10-hydroxycamptothecin glucuronidation levels in the liver.

Girard H, Villeneuve L, Court MH, Fortier LC, Caron P, Hao Q, von Moltke LL, Greenblatt DJ, Guillemette C.

Drug Metab Dispos. 2006 Jul;34(7):1220-8. Epub 2006 Apr 4.PMID: 16595709 [PubMed - indexed for MEDLINE]Related articlesFree article

Simple and rapid liquid chromatography method for determination of efavirenz in plasma.

Ramachandran G, Kumar AK, Swaminathan S, Venkatesan P, Kumaraswami V, Greenblatt DJ.

J Chromatogr B Analyt Technol Biomed Life Sci. 2006 May 1;835(1-2):131-5. Epub 2006 Mar 29.PMID: 16574512 [PubMed - indexed for MEDLINE]Related articles

Apparent active transport of MDMA is not mediated by P-glycoprotein: a comparison with MDCK and Caco-2 monolayers.

Bertelsen KM, Greenblatt DJ, von Moltke LL.

Biopharm Drug Dispos. 2006 Jul;27(5):219-27.PMID: 16552717 [PubMed - indexed for MEDLINE]Related articles

Dose-dependent retrograde facilitation of verbal memory in healthy elderly after acute oral lorazepam administration.

Pomara N, Facelle TM, Roth AE, Willoughby LM, Greenblatt DJ, Sidtis JJ.

Psychopharmacology (Berl). 2006 May;185(4):487-94. Epub 2006 Mar 9.PMID: 16525857 [PubMed - indexed for MEDLINE]Related articles

Effect of extended exposure to grapefruit juice on cytochrome P450 3A activity in humans: comparison with ritonavir.

Culm-Merdek KE, von Moltke LL, Gan L, Horan KA, Reynolds R, Harmatz JS, Court MH, Greenblatt DJ.

Clin Pharmacol Ther. 2006 Mar;79(3):243-54. Epub 2006 Feb 7.PMID: 16513448 [PubMed - indexed for MEDLINE]Related articles

In vitro interactions of water-soluble garlic components with human cytochromes p450.

Greenblatt DJ, Leigh-Pemberton RA, von Moltke LL.

J Nutr. 2006 Mar;136(3 Suppl):806S-809S.PMID: 16484569 [PubMed - indexed for MEDLINE]Related articlesFree article

Acute zolpidem administration produces pharmacodynamic and receptor occupancy changes at similar doses.

Fahey JM, Grassi JM, Reddi JM, Greenblatt DJ.

Pharmacol Biochem Behav. 2006 Jan;83(1):21-7. Epub 2006 Jan 24.PMID: 16439007 [PubMed - indexed for MEDLINE]Related articles

Ginkgo biloba does not alter clearance of flurbiprofen, a cytochrome P450-2C9 substrate.

Greenblatt DJ, von Moltke LL, Luo Y, Perloff ES, Horan KA, Bruce A, Reynolds RC, Harmatz JS, Avula B, Khan IA, Goldman P.

J Clin Pharmacol. 2006 Feb;46(2):214-21.PMID: 16432273 [PubMed - indexed for MEDLINE]Related articles

Pharmacokinetics and pharmacodynamics of multiple sublingual buprenorphine tablets in dose-escalation trials.

Ciraulo DA, Hitzemann RJ, Somoza E, Knapp CM, Rotrosen J, Sarid-Segal O, Ciraulo AM, Greenblatt DJ, Chiang CN.

J Clin Pharmacol. 2006 Feb;46(2):179-92.PMID: 16432270 [PubMed - indexed for MEDLINE]Related articles

Pharmacologic management of dental anxiety: conscious versus unconscious sedation.

Greenblatt DJ.

J Clin Psychopharmacol. 2006 Feb;26(1):1-3. No abstract available. PMID: 16415696 [PubMed - indexed for MEDLINE]Related articles

Interaction of flurbiprofen with cranberry juice, grape juice, tea, and fluconazole: in vitro and clinical studies.

Greenblatt DJ, von Moltke LL, Perloff ES, Luo Y, Harmatz JS, Zinny MA.

Clin Pharmacol Ther. 2006 Jan;79(1):125-33.PMID: 16413247 [PubMed - indexed for MEDLINE]Related articles

Clonazepam pharmacokinetics: comparison of subcutaneous microsphere injection with multiple-dose oral administration.

Greenblatt DJ, Blaskovich PD, Nuwayser ES, Harmatz JS, Chen G, Zinny MA.

J Clin Pharmacol. 2005 Nov;45(11):1288-93.PMID: 16239362 [PubMed - indexed for MEDLINE]Related articles

Fluvoxamine impairs single-dose caffeine clearance without altering caffeine pharmacodynamics.

Culm-Merdek KE, von Moltke LL, Harmatz JS, Greenblatt DJ.

Br J Clin Pharmacol. 2005 Nov;60(5):486-93.PMID: 16236038 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of the nuclear receptor pregnane X receptor in acetaminophen hepatotoxicity.

Wolf KK, Wood SG, Hunt JA, Walton-Strong BW, Yasuda K, Lan L, Duan SX, Hao Q, Wrighton SA, Jeffery EH, Evans RM, Szakacs JG, von Moltke LL, Greenblatt DJ, Court MH, Schuetz EG, Sinclair PR, Sinclair JF.

Drug Metab Dispos. 2005 Dec;33(12):1827-36. Epub 2005 Sep 1.PMID: 16141365 [PubMed - indexed for MEDLINE]Related articlesFree article

Pharmocokinetics and pharmacodynamics of single-dose triazolam: electroencephalography compared with the Digit-Symbol Substitution Test.

Greenblatt DJ, Gan L, Harmatz JS, Shader RI.

Br J Clin Pharmacol. 2005 Sep;60(3):244-8.PMID: 16120062 [PubMed - indexed for MEDLINE]Related articlesFree article

Sex-related elevation in cortisol during chronic treatment with alprazolam associated with enhanced cognitive performance.

Pomara N, Willoughby LM, Ritchie JC, Sidtis JJ, Greenblatt DJ, Nemeroff CB.

Psychopharmacology (Berl). 2005 Nov;182(3):414-9. Epub 2005 Oct 19.PMID: 16001108 [PubMed - indexed for MEDLINE]Related articles

UGT1A1 polymorphisms are important determinants of dietary carcinogen detoxification in the liver.

Girard H, Thibaudeau J, Court MH, Fortier LC, Villeneuve L, Caron P, Hao Q, von Moltke LL, Greenblatt DJ, Guillemette C.

Hepatology. 2005 Aug;42(2):448-57.PMID: 15986396 [PubMed - indexed for MEDLINE]Related articles

Genotype-phenotype associations of cytochrome P450 3A4 and 3A5 polymorphism with midazolam clearance in vivo.

He P, Court MH, Greenblatt DJ, Von Moltke LL.

Clin Pharmacol Ther. 2005 May;77(5):373-87.PMID: 15900284 [PubMed - indexed for MEDLINE]Related articles

Hyperforin plasma level as a marker of treatment adherence in the National Institutes of Health Hypericum Depression Trial.

Vitiello B, Shader RI, Parker CB, Ritz L, Harlan W, Greenblatt DJ, Gadde KM, Krishnan KR, Davidson JR.

J Clin Psychopharmacol. 2005 Jun;25(3):243-9.PMID: 15876903 [PubMed - indexed for MEDLINE]Related articles

Kinetics and dynamics of intravenous adinazolam, N-desmethyl adinazolam, and alprazolam in healthy volunteers.

Venkatakrishnan K, Culm KE, Ehrenberg BL, Harmatz JS, Corbett KE, Fleishaker JC, Greenblatt DJ.

J Clin Pharmacol. 2005 May;45(5):529-37.PMID: 15831776 [PubMed - indexed for MEDLINE]Related articles