PubMed

Direct detection and quantification of abasic sites for in vivo studies of DNA damage and repair.

Wang Y, Liu L, Wu C, Bulgar A, Somoza E, Zhu W, Gerson SL.

Nucl Med Biol. 2009 Nov;36(8):975-83. Epub 2009 Oct 3.PMID: 19875055 [PubMed - in process]Related articles

Phase I trial of fludarabine, bortezomib and rituximab for relapsed and refractory indolent and mantle cell non-Hodgkin lymphoma.

Barr PM, Fu P, Lazarus HM, Horvath N, Gerson SL, Koc ON, Bahlis NJ, Snell MR, Dowlati A, Cooper BW.

Br J Haematol. 2009 Oct;147(1):89-96. Epub 2009 Jun 29.PMID: 19656151 [PubMed - in process]Related articles

Elevated AF1q expression is a poor prognostic marker for adult acute myeloid leukemia patients with normal cytogenetics.

Strunk CJ, Platzbecker U, Thiede C, Schaich M, Illmer T, Kang Z, Leahy P, Li C, Xie X, Laughlin MJ, Lazarus HM, Gerson SL, Bunting KD, Ehninger G, Tse W.

Am J Hematol. 2009 May;84(5):308-9.PMID: 19396856 [PubMed - indexed for MEDLINE]Related articles

DNA repair modulates the vulnerability of the developing brain to alkylating agents.

Kisby GE, Olivas A, Park T, Churchwell M, Doerge D, Samson LD, Gerson SL, Turker MS.

DNA Repair (Amst). 2009 Mar 1;8(3):400-12. Epub 2009 Jan 21.PMID: 19162564 [PubMed - indexed for MEDLINE]Related articles

Transcriptional profiling of human mesenchymal stem cells transduced with reporter genes for imaging.

Wang F, Dennis JE, Awadallah A, Solchaga LA, Molter J, Kuang Y, Salem N, Lin Y, Tian H, Kolthammer JA, Kim Y, Love ZB, Gerson SL, Lee Z.

Physiol Genomics. 2009 Mar 3;37(1):23-34. Epub 2008 Dec 30.PMID: 19116247 [PubMed - indexed for MEDLINE]Related articles

Synergistic actions of hematopoietic and mesenchymal stem/progenitor cells in vascularizing bioengineered tissues.

Moioli EK, Clark PA, Chen M, Dennis JE, Erickson HP, Gerson SL, Mao JJ.

PLoS One. 2008;3(12):e3922. Epub 2008 Dec 15.PMID: 19081793 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of 6-benzylthioinosine as a myeloid leukemia differentiation-inducing compound.

Wald DN, Vermaat HM, Zang S, Lavik A, Kang Z, Peleg G, Gerson SL, Bunting KD, Agarwal ML, Roth BL, Tse W.

Cancer Res. 2008 Jun 1;68(11):4369-76.PMID: 18519698 [PubMed - indexed for MEDLINE]Related articlesFree article

Imaging stem cell implant for cellular-based therapies.

Lee Z, Dennis JE, Gerson SL.

Exp Biol Med (Maywood). 2008 Aug;233(8):930-40. Epub 2008 May 14. Review.PMID: 18480418 [PubMed - indexed for MEDLINE]Related articlesFree article

Bioluminescence imaging of hematopoietic stem cell repopulation in murine models.

Lin Y, Molter J, Lee Z, Gerson SL.

Methods Mol Biol. 2008;430:295-306.PMID: 18370307 [PubMed - indexed for MEDLINE]Related articles

Phase I trial of VNP40101M (Cloretazine) in children with recurrent brain tumors: a pediatric brain tumor consortium study.

Gururangan S, Turner CD, Stewart CF, O'Shaughnessy M, Kocak M, Poussaint TY, Phillips PC, Goldman S, Packer R, Pollack IF, Blaney SM, Karsten V, Gerson SL, Boyett JM, Friedman HS, Kun LE.

Clin Cancer Res. 2008 Feb 15;14(4):1124-30.PMID: 18281546 [PubMed - indexed for MEDLINE]Related articlesFree article

Targets of small interfering RNA restriction during human immunodeficiency virus type 1 replication.

Gao Y, Lobritz MA, Roth J, Abreha M, Nelson KN, Nankya I, Moore-Dudley DM, Abraha A, Gerson SL, Arts EJ.

J Virol. 2008 Mar;82(6):2938-51. Epub 2008 Jan 16.PMID: 18199654 [PubMed - indexed for MEDLINE]Related articlesFree article

Bone marrow-derived cells exhibiting lung epithelial cell characteristics are enriched in vivo using methylguanine DNA methyltransferase-mediated drug resistance.

Reese JS, Roth JC, Gerson SL.

Stem Cells. 2008 Mar;26(3):675-81. Epub 2008 Jan 10.PMID: 18192231 [PubMed - indexed for MEDLINE]Related articlesFree article

The role of DNA damage repair in aging of adult stem cells.

Kenyon J, Gerson SL.

Nucleic Acids Res. 2007;35(22):7557-65. Epub 2007 Dec 26. Review.PMID: 18160407 [PubMed - indexed for MEDLINE]Related articlesFree article

DNA repair in stem cell maintenance and conversion to cancer stem cells.

Gerson SL, Reese J, Kenyon J.

Ernst Schering Found Symp Proc. 2006;(5):231-44. Review.PMID: 17939304 [PubMed - indexed for MEDLINE]Related articles

Time-dependent effect of non-Hodgkin's lymphoma grade on disease-free survival of relapsed/refractory patients treated with high-dose chemotherapy plus autotransplantation.

Fu P, van Heeckeren WJ, Wadhwa PD, Bajor DJ, Creger RJ, Xu Z, Cooper BW, Laughlin MJ, Gerson SL, Koç ON, Lazarus HM.

Contemp Clin Trials. 2008 Mar;29(2):157-64. Epub 2007 Jul 19.PMID: 17707140 [PubMed - indexed for MEDLINE]Related articles

O6-benzylguanine and BCNU in multiple myeloma: a phase II trial.

Batts ED, Maisel C, Kane D, Liu L, Fu P, O'Brien T, Remick S, Bahlis N, Gerson SL.

Cancer Chemother Pharmacol. 2007 Aug;60(3):415-21. Epub 2007 Mar 13.PMID: 17354015 [PubMed - indexed for MEDLINE]Related articles

Combined treatment with temozolomide and methoxyamine: blocking apurininc/pyrimidinic site repair coupled with targeting topoisomerase IIalpha.

Yan L, Bulgar A, Miao Y, Mahajan V, Donze JR, Gerson SL, Liu L.

Clin Cancer Res. 2007 Mar 1;13(5):1532-9.PMID: 17332299 [PubMed - indexed for MEDLINE]Related articlesFree article

Pre-mobilization therapy blood CD34+ cell count predicts the likelihood of successful hematopoietic stem cell mobilization.

Fu P, Bagai RK, Meyerson H, Kane D, Fox RM, Creger RJ, Cooper BW, Gerson SL, Laughlin MJ, Koc ON, Lazarus HM.

Bone Marrow Transplant. 2006 Aug;38(3):189-96.PMID: 16850032 [PubMed - indexed for MEDLINE]Related articles

Peritransplant use of ultraviolet-B irradiation (UV-B) therapy is detrimental to allogeneic stem cell transplantation outcome.

Yüksel M, Baron E, Camouse M, Cooper BW, Lazarus HM, Gerson SL, Laughlin MJ, Cooper KD, Gilliam A, Fu P, Stevens S, Koç ON.

Biol Blood Marrow Transplant. 2006 Jun;12(6):665-71.PMID: 16737940 [PubMed - indexed for MEDLINE]Related articles

Clozapine alone versus clozapine and risperidone for refractory schizophrenia.

Gerson SL.

N Engl J Med. 2006 Apr 27;354(17):1846-8; author reply 1846-8. No abstract available. PMID: 16642587 [PubMed - indexed for MEDLINE]Related articles

Long-term-infected telomerase-immortalized endothelial cells: a model for Kaposi's sarcoma-associated herpesvirus latency in vitro and in vivo.

An FQ, Folarin HM, Compitello N, Roth J, Gerson SL, McCrae KR, Fakhari FD, Dittmer DP, Renne R.

J Virol. 2006 May;80(10):4833-46.PMID: 16641275 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential competitive resistance to methylating versus chloroethylating agents among five O6-alkylguanine DNA alkyltransferases in human hematopoietic cells.

Fontes AM, Davis BM, Encell LP, Lingas K, Covas DT, Zago MA, Loeb LA, Pegg AE, Gerson SL.

Mol Cancer Ther. 2006 Jan;5(1):121-8.PMID: 16432170 [PubMed - indexed for MEDLINE]Related articlesFree article

Targeted modulation of MGMT: clinical implications.

Liu L, Gerson SL.

Clin Cancer Res. 2006 Jan 15;12(2):328-31. Review.PMID: 16428468 [PubMed - indexed for MEDLINE]Related articlesFree article

Randomised comparison of two B-cell purging protocols for patients with B-cell non-Hodgkin lymphoma: in vivo purging with rituximab versus ex vivo purging with CliniMACS CD34 cell enrichment device.

van Heeckeren WJ, Vollweiler J, Fu P, Cooper BW, Meyerson H, Lazarus HM, Simic A, Laughlin MJ, Gerson SL, Koç ON.

Br J Haematol. 2006 Jan;132(1):42-55.PMID: 16371019 [PubMed - indexed for MEDLINE]Related articles

Phase II trial of the O6-alkylguanine DNA alkyltransferase inhibitor O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea in advanced melanoma.

Gajewski TF, Sosman J, Gerson SL, Liu L, Dolan E, Lin S, Vokes EE.

Clin Cancer Res. 2005 Nov 1;11(21):7861-5.PMID: 16278409 [PubMed - indexed for MEDLINE]Related articlesFree article

N-benzoylstaurosporine (PKC412) inhibits Akt kinase inducing apoptosis in multiple myeloma cells.

Bahlis NJ, Miao Y, Koc ON, Lee K, Boise LH, Gerson SL.

Leuk Lymphoma. 2005 Jun;46(6):899-908.PMID: 16019536 [PubMed - indexed for MEDLINE]Related articles

Cotransplantation of HLA-identical sibling culture-expanded mesenchymal stem cells and hematopoietic stem cells in hematologic malignancy patients.

Lazarus HM, Koc ON, Devine SM, Curtin P, Maziarz RT, Holland HK, Shpall EJ, McCarthy P, Atkinson K, Cooper BW, Gerson SL, Laughlin MJ, Loberiza FR Jr, Moseley AB, Bacigalupo A.

Biol Blood Marrow Transplant. 2005 May;11(5):389-98.PMID: 15846293 [PubMed - indexed for MEDLINE]Related articles

DNA repair defects in stem cell function and aging.

Park Y, Gerson SL.

Annu Rev Med. 2005;56:495-508. Review.PMID: 15660524 [PubMed - indexed for MEDLINE]Related articles

High-dose carmustine, etoposide, and cisplatin for autologous stem cell transplantation with or without involved-field radiation for relapsed/refractory lymphoma: an effective regimen with low morbidity and mortality.

Wadhwa PD, Fu P, Koc ON, Cooper BW, Fox RM, Creger RJ, Bajor DL, Bedi T, Laughlin MJ, Payne J, Gerson SL, Lazarus HM.

Biol Blood Marrow Transplant. 2005 Jan;11(1):13-22.PMID: 15625540 [PubMed - indexed for MEDLINE]Related articles

A phase I and pharmacodynamic study of fludarabine, carboplatin, and topotecan in patients with relapsed, refractory, or high-risk acute leukemia.

Cooper BW, Veal GJ, Radivoyevitch T, Tilby MJ, Meyerson HJ, Lazarus HM, Koc ON, Creger RJ, Pearson G, Nowell GM, Gosky D, Ingalls ST, Hoppel CL, Gerson SL.

Clin Cancer Res. 2004 Oct 15;10(20):6830-9.PMID: 15501959 [PubMed - indexed for MEDLINE]Related articlesFree article

Hematopoietic stem cell gene therapy of murine protoporphyria by methylguanine-DNA-methyltransferase-mediated in vivo drug selection.

Richard E, Robert E, Cario-André M, Ged C, Géronimi F, Gerson SL, de Verneuil H, Moreau-Gaudry F.

Gene Ther. 2004 Nov;11(22):1638-47.PMID: 15284838 [PubMed - indexed for MEDLINE]Related articles

Therapeutic impact of methoxyamine: blocking repair of abasic sites in the base excision repair pathway.

Liu L, Gerson SL.

Curr Opin Investig Drugs. 2004 Jun;5(6):623-7. Review.PMID: 15242251 [PubMed - indexed for MEDLINE]Related articles

Limited lentiviral transgene expression with increasing copy number in an MGMT selection model: lack of copy number selection by drug treatment.

Zielske SP, Lingas KT, Li Y, Gerson SL.

Mol Ther. 2004 Jun;9(6):923-31.PMID: 15194059 [PubMed - indexed for MEDLINE]Related articles

MGMT: its role in cancer aetiology and cancer therapeutics.

Gerson SL.

Nat Rev Cancer. 2004 Apr;4(4):296-307. Review. No abstract available. PMID: 15057289 [PubMed - indexed for MEDLINE]Related articles

A randomized phase I and pharmacological trial of sequences of 1,3-bis(2-chloroethyl)-1-nitrosourea and temozolomide in patients with advanced solid neoplasms.

Hammond LA, Eckardt JR, Kuhn JG, Gerson SL, Johnson T, Smith L, Drengler RL, Campbell E, Weiss GR, Von Hoff DD, Rowinsky EK.

Clin Cancer Res. 2004 Mar 1;10(5):1645-56.PMID: 15014015 [PubMed - indexed for MEDLINE]Related articlesFree article

Phase I and correlative study of combination bryostatin 1 and vincristine in relapsed B-cell malignancies.

Dowlati A, Lazarus HM, Hartman P, Jacobberger JW, Whitacre C, Gerson SL, Ksenich P, Cooper BW, Frisa PS, Gottlieb M, Murgo AJ, Remick SC.

Clin Cancer Res. 2003 Dec 1;9(16 Pt 1):5929-35.PMID: 14676117 [PubMed - indexed for MEDLINE]Related articlesFree article

In vivo selection of MGMT(P140K) lentivirus-transduced human NOD/SCID repopulating cells without pretransplant irradiation conditioning.

Zielske SP, Reese JS, Lingas KT, Donze JR, Gerson SL.

J Clin Invest. 2003 Nov;112(10):1561-70.PMID: 14617757 [PubMed - indexed for MEDLINE]Related articlesFree article

Blockage of abasic site repair enhances antitumor efficacy of 1,3-bis-(2-chloroethyl)-1-nitrosourea in colon tumor xenografts.

Liu L, Yan L, Donze JR, Gerson SL.

Mol Cancer Ther. 2003 Oct;2(10):1061-6.PMID: 14578471 [PubMed - indexed for MEDLINE]Related articlesFree article

Measurement of anti-cancer agent methoxyamine in plasma by tandem mass spectrometry with on-line sample extraction.

Yang S, Liu L, Gerson SL, Xu Y.

J Chromatogr B Analyt Technol Biomed Life Sci. 2003 Oct 5;795(2):295-307.PMID: 14522034 [PubMed - indexed for MEDLINE]Related articles

Drug selection of mutant methylguanine methyltransferase from different oncoretroviral backbones results in multilineage hematopoietic transgene expression in primary and secondary recipients.

Davis BM, Reese JS, Lingas K, Gerson SL.

J Hematother Stem Cell Res. 2003 Aug;12(4):375-87.PMID: 12965075 [PubMed - indexed for MEDLINE]Related articles

Pharmacokinetics of O6-benzylguanine (NSC637037) and its metabolite, 8-oxo-O6-benzylguanine.

Tserng KY, Ingalls ST, Boczko EM, Spiro TP, Li X, Majka S, Gerson SL, Willson JK, Hoppel CL.

J Clin Pharmacol. 2003 Aug;43(8):881-93.PMID: 12953345 [PubMed - indexed for MEDLINE]Related articles

A bicistronic SIN-lentiviral vector containing G156A MGMT allows selection and metabolic correction of hematopoietic protoporphyric cell lines.

Richard E, Géronimi F, Lalanne M, Ged C, Redonnet-Vernhet I, Lamrissi-Garcia I, Gerson SL, de Verneuil H, Moreau-Gaudry F.

J Gene Med. 2003 Sep;5(9):737-47.PMID: 12950064 [PubMed - indexed for MEDLINE]Related articles

Akt helps stem cells heal the heart.

Koç ON, Gerson SL.

Nat Med. 2003 Sep;9(9):1109-10. No abstract available. PMID: 12949518 [PubMed - indexed for MEDLINE]Related articles

Telomerase inhibition and telomere erosion: a two-pronged strategy in cancer therapy.

Odago FO, Gerson SL.

Trends Pharmacol Sci. 2003 Jul;24(7):328-31. Review. No abstract available. PMID: 12871663 [PubMed - indexed for MEDLINE]Related articles

SarCNU mediates selection of P140K methylguanine-DNA-methyltransferase transduced human CD34(+) cells in vitro.

Zielske SP, Gerson SL.

Blood Cells Mol Dis. 2003 Jul-Aug;31(1):48-50.PMID: 12850483 [PubMed - indexed for MEDLINE]Related articles

Myeloablation is not required to select and maintain expression of the drug-resistance gene, mutant MGMT, in primary and secondary recipients.

Bowman JE, Reese JS, Lingas KT, Gerson SL.

Mol Ther. 2003 Jul;8(1):42-50.PMID: 12842427 [PubMed - indexed for MEDLINE]Related articles

Hematopoietic stem cell gene therapy: progress toward therapeutic targets.

Vollweiler JL, Zielske SP, Reese JS, Gerson SL.

Bone Marrow Transplant. 2003 Jul;32(1):1-7. Review.PMID: 12815471 [PubMed - indexed for MEDLINE]Related articles

Repopulating defect of mismatch repair-deficient hematopoietic stem cells.

Reese JS, Liu L, Gerson SL.

Blood. 2003 Sep 1;102(5):1626-33. Epub 2003 May 1.PMID: 12730104 [PubMed - indexed for MEDLINE]Related articlesFree article

Marked inactivation of O6-alkylguanine-DNA alkyltransferase activity with protracted temozolomide schedules.

Tolcher AW, Gerson SL, Denis L, Geyer C, Hammond LA, Patnaik A, Goetz AD, Schwartz G, Edwards T, Reyderman L, Statkevich P, Cutler DL, Rowinsky EK.

Br J Cancer. 2003 Apr 7;88(7):1004-11.PMID: 12671695 [PubMed - indexed for MEDLINE]Related articlesFree article

Cytokines, including stem cell factor alone, enhance lentiviral transduction in nondividing human LTCIC and NOD/SCID repopulating cells.

Zielske SP, Gerson SL.

Mol Ther. 2003 Mar;7(3):325-33.PMID: 12668128 [PubMed - indexed for MEDLINE]Related articles