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Year Number of Results
1992 1
1995 1
1997 2
1998 3
1999 3
2000 3
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2002 9
2003 3
2004 7
2005 11
2006 5
2007 7
2008 12
2009 10
2010 11
2011 11
2012 9
2013 6
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2015 18
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263 results

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Page 1
FZD2 regulates limb development by mediating beta-catenin-dependent and -independent Wnt signaling pathways.
Zhu X, Xu M, Leu NA, Morrisey EE, Millar SE. Zhu X, et al. Dis Model Mech. 2023 Mar 1;16(3):dmm049876. doi: 10.1242/dmm.049876. Epub 2023 Mar 24. Dis Model Mech. 2023. PMID: 36867021 Free PMC article.
Human Robinow syndrome (RS) and dominant omodysplasia type 2 (OMOD2), characterized by skeletal limb and craniofacial defects, are associated with heterozygous mutations in the Wnt receptor FZD2. However, as FZD2 can activate both canonical and non-canonical Wnt pat …
Human Robinow syndrome (RS) and dominant omodysplasia type 2 (OMOD2), characterized by skeletal limb and craniofacial defects, are associate …
FZD2 Regulates Murine Hair Follicle Function and Maintenance.
Brennan-Crispi DM, Frankfurter M, Murphy C, Sheng E, Xu M, Morrisey EE, Millar SE, Leung TH. Brennan-Crispi DM, et al. J Invest Dermatol. 2022 Aug;142(8):2260-2263.e2. doi: 10.1016/j.jid.2022.01.004. Epub 2022 Jan 17. J Invest Dermatol. 2022. PMID: 35051380 Free PMC article.
Fzd2 is required for hair follicle function and maintenance in mice....
Fzd2 is required for hair follicle function and maintenance in mice....
FZD2 regulates cell proliferation and invasion in tongue squamous cell carcinoma.
Huang L, Luo EL, Xie J, Gan RH, Ding LC, Su BH, Zhao Y, Lin LS, Zheng DL, Lu YG. Huang L, et al. Int J Biol Sci. 2019 Aug 24;15(11):2330-2339. doi: 10.7150/ijbs.33881. eCollection 2019. Int J Biol Sci. 2019. PMID: 31595151 Free PMC article.
Knockdown of FZD2 inhibited the proliferation, migration and invasion of CAL-27 and TCA-8113 cells, whereas overexpression of FZD2 led to the opposite results. ...These results indicated that FZD2 may act as an oncogene in tongue squamous cell carcinoma. Ther …
Knockdown of FZD2 inhibited the proliferation, migration and invasion of CAL-27 and TCA-8113 cells, whereas overexpression of FZD2 …
FZD2 promotes TGF-beta-induced epithelial-to-mesenchymal transition in breast cancer via activating notch signaling pathway.
Tuluhong D, Chen T, Wang J, Zeng H, Li H, Dunzhu W, Li Q, Wang S. Tuluhong D, et al. Cancer Cell Int. 2021 Apr 8;21(1):199. doi: 10.1186/s12935-021-01866-3. Cancer Cell Int. 2021. PMID: 33832493 Free PMC article.
Xenograft tumorigenicity assay was performed to assess the effect of FZD2 on tumor growth in vivo. RESULTS: FZD2 mRNA and protein expression was abundant in BC tissues. ...Animal study further demonstrated that FZD2 silencing inhibited BC cell growth in vivo. …
Xenograft tumorigenicity assay was performed to assess the effect of FZD2 on tumor growth in vivo. RESULTS: FZD2 mRNA and prot …
Fzd2 Contributes to Breast Cancer Cell Mesenchymal-Like Stemness and Drug Resistance.
Yin P, Wang W, Gao J, Bai Y, Wang Z, Na L, Sun Y, Zhao C. Yin P, et al. Oncol Res. 2020 May 29;28(3):273-284. doi: 10.3727/096504020X15783052025051. Epub 2020 Jan 6. Oncol Res. 2020. PMID: 31907106 Free PMC article.
Fzd2 was overexpressed in human BC tissues, and Fzd2 overexpression was associated with an unfavorable outcome. ...These data indicate that Fzd2 contributes to BC cell mesenchymal-like stemness; targeting Fzd2 may inhibit BC recurrence, metastasis, and …
Fzd2 was overexpressed in human BC tissues, and Fzd2 overexpression was associated with an unfavorable outcome. ...These data …
WNT2-Mediated FZD2 Stabilization Regulates Esophageal Cancer Metastasis via STAT3 Signaling.
Fu Y, Zheng Q, Mao Y, Jiang X, Chen X, Liu P, Lv B, Huang T, Yang J, Cheng Y, Dai X, Dai C, Wang X, Yin Y, Song T, Jin W, Zou C, Chen T, Fu L, Chen Z. Fu Y, et al. Front Oncol. 2020 Jul 16;10:1168. doi: 10.3389/fonc.2020.01168. eCollection 2020. Front Oncol. 2020. PMID: 32766155 Free PMC article.

Upregulated FZD2 expression was detected in 69% (69/100) of the primary ESCC cases examined, and increased FZD2 expression was significantly correlated with poor prognosis (P < 0.05). Mechanistically, FZD2 induced the migration and invasion of ESCC cells b

…
Upregulated FZD2 expression was detected in 69% (69/100) of the primary ESCC cases examined, and increased FZD2 expression was …
FZD2 inhibits the cell growth and migration of salivary adenoid cystic carcinomas.
Ding LC, Huang XY, Zheng FF, Xie J, She L, Feng Y, Su BH, Zheng DL, Lu YG. Ding LC, et al. Oncol Rep. 2016 Feb;35(2):1006-12. doi: 10.3892/or.2015.3811. Epub 2015 Feb 19. Oncol Rep. 2016. PMID: 25695658
Immunohistochemical staining was used to detect the expression of FZD2 in clinical SACC samples with or without metastasis. Cell proliferation and Transwell assays were performed to explore the effects of FZD2 on cell growth and migration following the silencing of …
Immunohistochemical staining was used to detect the expression of FZD2 in clinical SACC samples with or without metastasis. Cell prol …
Bioengineered BERA-Wnt5a siRNA Targeting Wnt5a/FZD2 Signaling Suppresses Advanced Prostate Cancer Tumor Growth and Enhances Enzalutamide Treatment.
Ning S, Liu C, Lou W, Yang JC, Lombard AP, D'Abronzo LS, Batra N, Yu AM, Leslie AR, Sharifi M, Evans CP, Gao AC. Ning S, et al. Mol Cancer Ther. 2022 Oct 7;21(10):1594-1607. doi: 10.1158/1535-7163.MCT-22-0216. Mol Cancer Ther. 2022. PMID: 35930737 Free PMC article.
Development of novel strategies targeting Wnt5a to overcome resistance is an urgent need. In this study, we demonstrated that Wnt5a/FZD2-mediated noncanonical Wnt pathway is overexpressed in enzalutamide-resistant prostate cancer. ...Blocking Wnt5a/FZD2 signal trans …
Development of novel strategies targeting Wnt5a to overcome resistance is an urgent need. In this study, we demonstrated that Wnt5a/FZD2 …
C. difficile intoxicates neurons and pericytes to drive neurogenic inflammation.
Manion J, Musser MA, Kuziel GA, Liu M, Shepherd A, Wang S, Lee PG, Zhao L, Zhang J, Marreddy RKR, Goldsmith JD, Yuan K, Hurdle JG, Gerhard R, Jin R, Rakoff-Nahoum S, Rao M, Dong M. Manion J, et al. Nature. 2023 Oct;622(7983):611-618. doi: 10.1038/s41586-023-06607-2. Epub 2023 Sep 12. Nature. 2023. PMID: 37699522
Here we report that TcdB induces neurogenic inflammation by targeting gut-innervating afferent neurons and pericytes through receptors, including the Frizzled receptors (FZD1, FZD2 and FZD7) in neurons and chondroitin sulfate proteoglycan 4 (CSPG4) in pericytes. ...
Here we report that TcdB induces neurogenic inflammation by targeting gut-innervating afferent neurons and pericytes through receptors, incl …
Noncanonical FZD2 Signaling Induces EMT and Tumor Progression.
[No authors listed] [No authors listed] Cancer Discov. 2015 Jan;5(1):OF17. doi: 10.1158/2159-8290.CD-RW2014-240. Epub 2014 Nov 20. Cancer Discov. 2015. PMID: 34450691
FZD2 and WNT5A drive EMT and metastasis via a noncanonical pathway involving FYN and STAT3....
FZD2 and WNT5A drive EMT and metastasis via a noncanonical pathway involving FYN and STAT3....
263 results