PubMed

Neutrophil elastase inhibitor improves survival of rats with clinically relevant sepsis.

Suda K, Takeuchi H, Hagiwara T, Miyasho T, Okamoto M, Kawasako K, Yamada S, Suganuma K, Wada N, Saikawa Y, Fukunaga K, Funakoshi Y, Hashimoto S, Yokota H, Maruyama I, Ishizaka A, Kitagawa Y.

Shock. 2009 Nov 26. [Epub ahead of print]PMID: 19953005 [PubMed - as supplied by publisher]Related articles

Inhibition of dystrophin breakdown and endothelial nitric oxide synthase uncoupling accounts for cytoprotection by 3-[2-[4-(3-Chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole Dihydrochloride 3.5 Hydrate (DY-9760e) in left ventricular hypertrophied mice.

Han F, Lu YM, Hasegawa H, Kanai H, Hachimura E, Shirasaki Y, Fukunaga K.

J Pharmacol Exp Ther. 2009 Nov 4. [Epub ahead of print]PMID: 19889795 [PubMed - as supplied by publisher]Related articlesFree article

Generation and characterization of conditional heparin-binding EGF-like growth factor knockout mice.

Oyagi A, Oida Y, Kakefuda K, Shimazawa M, Shioda N, Moriguchi S, Kitaichi K, Nanba D, Yamaguchi K, Furuta Y, Fukunaga K, Higashiyama S, Hara H.

PLoS One. 2009 Oct 14;4(10):e7461.PMID: 19829704 [PubMed - in process]Related articlesFree article

Beta-amyloid accumulation in neurovascular units following brain embolism.

Han F, Fukunaga K.

J Pharmacol Sci. 2009 Oct;111(2):101-9. Epub 2009 Sep 26.PMID: 19783863 [PubMed - in process]Related articlesFree article

Stimulation of Sigma-1 receptor signaling by dehydroepiandrosterone ameliorates pressure overload-induced hypertrophy and dysfunctions in ovariectomized rats.

Bhuiyan MS, Fukunaga K.

Expert Opin Ther Targets. 2009 Nov;13(11):1253-65.PMID: 19769544 [PubMed - in process]Related articles

Characterization of an animal model of postmenopausal cardiac hypertrophy and novel mechanisms responsible for cardiac decompensation using ovariectomized pressure-overloaded rats.

Bhuiyan MS, Fukunaga K.

Menopause. 2009 Sep 8. [Epub ahead of print]PMID: 19741553 [PubMed - as supplied by publisher]Related articles

Effects of dietary fish protein on serum and liver lipid concentrations in rats and the expression of hepatic genes involved in lipid metabolism.

Hosomi R, Fukunaga K, Arai H, Nishiyama T, Yoshida M.

J Agric Food Chem. 2009 Oct 14;57(19):9256-62.PMID: 19739642 [PubMed - in process]Related articles

An open-label prospective randomized multicenter study shows very rapid remission of ulcerative colitis by intensive granulocyte and monocyte adsorptive apheresis as compared with routine weekly treatment.

Sakuraba A, Motoya S, Watanabe K, Nishishita M, Kanke K, Matsui T, Suzuki Y, Oshima T, Kunisaki R, Matsumoto T, Hanai H, Fukunaga K, Yoshimura N, Chiba T, Funakoshi S, Aoyama N, Andoh A, Nakase H, Mizuta Y, Suzuki R, Akamatsu T, Iizuka M, Ashida T, Hibi T.

Am J Gastroenterol. 2009 Dec;104(12):2990-5. Epub 2009 Sep 1.PMID: 19724269 [PubMed - in process]Related articles

Impact of pharmacokinetics and pharmacogenetics on the efficacy of pranlukast in Japanese asthmatics.

Asano K, Nakade S, Shiomi T, Nakajima T, Suzuki Y, Fukunaga K, Oguma T, Sayama K, Fujita H, Tanigawara Y, Ishizaka A.

Respirology. 2009 Aug;14(6):822-7.PMID: 19703064 [PubMed - in process]Related articles

Ca2+/calmodulin-dependent protein kinase IV-mediated LIM kinase activation is critical for calcium signal-induced neurite outgrowth.

Takemura M, Mishima T, Wang Y, Kasahara J, Fukunaga K, Ohashi K, Mizuno K.

J Biol Chem. 2009 Oct 16;284(42):28554-62. Epub 2009 Aug 20.PMID: 19696021 [PubMed - in process]Related articles

Nobiletin improves brain ischemia-induced learning and memory deficits through stimulation of CaMKII and CREB phosphorylation.

Yamamoto Y, Shioda N, Han F, Moriguchi S, Nakajima A, Yokosuka A, Mimaki Y, Sashida Y, Yamakuni T, Ohizumi Y, Fukunaga K.

Brain Res. 2009 Oct 27;1295:218-29. Epub 2009 Jul 30.PMID: 19646972 [PubMed - in process]Related articles

In vivo comparison of wear particles between highly crosslinked polyethylene and conventional polyethylene in the same design of total knee arthroplasties.

Iwakiri K, Minoda Y, Kobayashi A, Sugama R, Iwaki H, Inori F, Hashimoto Y, Ohashi H, Ohta Y, Fukunaga K, Takaoka K.

J Biomed Mater Res B Appl Biomater. 2009 Nov;91(2):799-804.PMID: 19637367 [PubMed - in process]Related articles

Prandial increase of leptin in the brain activates spatial learning and memory.

Oomura Y, Aou S, Fukunaga K.

Pathophysiology. 2009 Jul 14. [Epub ahead of print]PMID: 19608390 [PubMed - as supplied by publisher]Related articles

Role of Akt and ERK signaling in the neurogenesis following brain ischemia.

Shioda N, Han F, Fukunaga K.

Int Rev Neurobiol. 2009;85:375-87. Review.PMID: 19607982 [PubMed - indexed for MEDLINE]Related articles

Down-regulation of Bcl-2 enhances autophagy activation and cell death induced by mitochondrial dysfunction in rat striatum.

Zhang XD, Wang Y, Wu JC, Lin F, Han R, Han F, Fukunaga K, Qin ZH.

J Neurosci Res. 2009 Dec;87(16):3600-10.PMID: 19565656 [PubMed - in process]Related articles

Therapeutic Effects of Various Initial Combination Chemotherapy Including Clarithromycin Against Mycobacterium avium Complex Pulmonary Disease.

Hasegawa N, Nishimura T, Ohtani S, Takeshita K, Fukunaga K, Tasaka S, Urano T, Ishii K, Miyairi M, Ishizaka A.

Chest. 2009 Jun 19. [Epub ahead of print]PMID: 19542259 [PubMed - as supplied by publisher]Related articles

Repair of experimentally induced large osteochondral defects in rabbit knee with various concentrations of Escherichia coli-derived recombinant human bone morphogenetic protein-2.

Tokuhara Y, Wakitani S, Imai Y, Kawaguchi A, Fukunaga K, Kim M, Kadoya Y, Takaoka K.

Int Orthop. 2009 Jun 16. [Epub ahead of print]PMID: 19529936 [PubMed - as supplied by publisher]Related articles

Prevention of leukocyte activation by the neutrophil elastase inhibitor, sivelestat, in the hepatic microcirculation after ischemia-reperfusion.

Nakano Y, Kondo T, Matsuo R, Murata S, Fukunaga K, Ohkohchi N.

J Surg Res. 2009 Aug;155(2):311-7. Epub 2008 Aug 27.PMID: 19482311 [PubMed - indexed for MEDLINE]Related articles

Nefiracetam activation of CaM kinase II and protein kinase C mediated by NMDA and metabotropic glutamate receptors in olfactory bulbectomized mice.

Moriguchi S, Han F, Shioda N, Yamamoto Y, Nakajima T, Nakagawasai O, Tadano T, Yeh JZ, Narahashi T, Fukunaga K.

J Neurochem. 2009 Jul;110(1):170-81. Epub 2009 Apr 27.PMID: 19457128 [PubMed - indexed for MEDLINE]Related articles

Cardioprotection by vanadium compounds targeting Akt-mediated signaling.

Bhuiyan MS, Fukunaga K.

J Pharmacol Sci. 2009 May;110(1):1-13. Epub 2009 May 8. Review.PMID: 19423951 [PubMed - indexed for MEDLINE]Related articlesFree article

Long-lasting enhancement of CYP activity after discontinuation of repeated administration of phenobarbital in dogs.

Fukunaga K, Saito M, Matsuo E, Muto M, Mishima K, Fujiwara M, Orito K.

Res Vet Sci. 2009 Dec;87(3):455-7. Epub 2009 Apr 29.PMID: 19406444 [PubMed - in process]Related articles

Olomoucine inhibits cathepsin L nuclear translocation, activates autophagy and attenuates toxicity of 6-hydroxydopamine.

Fei XF, Qin ZH, Xiang B, Li LY, Han F, Fukunaga K, Liang ZQ.

Brain Res. 2009 Apr 6;1264:85-97. Epub 2009 Feb 6.PMID: 19368812 [PubMed - indexed for MEDLINE]Related articles

Mitochondrial serine protease HtrA2/Omi as a potential therapeutic target.

Bhuiyan MS, Fukunaga K.

Curr Drug Targets. 2009 Apr;10(4):372-83. Review.PMID: 19355862 [PubMed - indexed for MEDLINE]Related articles

The incidence of the patellar clunk syndrome in a recently designed mobile-bearing posteriorly stabilised total knee replacement.

Fukunaga K, Kobayashi A, Minoda Y, Iwaki H, Hashimoto Y, Takaoka K.

J Bone Joint Surg Br. 2009 Apr;91(4):463-8.PMID: 19336805 [PubMed - indexed for MEDLINE]Related articles

p53 mediates mitochondria dysfunction-triggered autophagy activation and cell death in rat striatum.

Zhang XD, Wang Y, Wang Y, Zhang X, Han R, Wu JC, Liang ZQ, Gu ZL, Han F, Fukunaga K, Qin ZH.

Autophagy. 2009 Apr 26;5(3). [Epub ahead of print]PMID: 19305162 [PubMed - as supplied by publisher]Related articles

The expression profile of functional regulatory T cells, CD4+CD25high+/forkhead box protein P3+, in patients with ulcerative colitis during active and quiescent disease.

Kamikozuru K, Fukunaga K, Hirota S, Hida N, Ohda Y, Yoshida K, Yokoyama Y, Tozawa K, Kawa K, Iimuro M, Nagase K, Saniabadi AR, Nakamura S, Miwa H, Matsumoto T.

Clin Exp Immunol. 2009 May;156(2):320-7. Epub 2009 Mar 9.PMID: 19292766 [PubMed - indexed for MEDLINE]Related articles

Nefiracetam and galantamine modulation of excitatory and inhibitory synaptic transmission via stimulation of neuronal nicotinic acetylcholine receptors in rat cortical neurons.

Moriguchi S, Zhao X, Marszalec W, Yeh JZ, Fukunaga K, Narahashi T.

Neuroscience. 2009 May 5;160(2):484-91. Epub 2009 Mar 9.PMID: 19272425 [PubMed - indexed for MEDLINE]Related articles

Galantamine enhancement of long-term potentiation is mediated by calcium/calmodulin-dependent protein kinase II and protein kinase C activation.

Moriguchi S, Shioda N, Han F, Yeh JZ, Narahashi T, Fukunaga K.

Hippocampus. 2009 Sep;19(9):844-54.PMID: 19253410 [PubMed - indexed for MEDLINE]Related articles

Radiofrequency ablation of the liver: determination of ablative margin at MR imaging with impaired clearance of ferucarbotran--feasibility study.

Mori K, Fukuda K, Asaoka H, Ueda T, Kunimatsu A, Okamoto Y, Nasu K, Fukunaga K, Morishita Y, Minami M.

Radiology. 2009 May;251(2):557-65. Epub 2009 Feb 27.PMID: 19251941 [PubMed - indexed for MEDLINE]Related articles

Chronic beta-AR activation-induced calpain activation and impaired eNOS-Akt signaling mediates cardiac injury in ovariectomized female rats.

Bhuiyan MS, Shioda N, Fukunaga K.

Expert Opin Ther Targets. 2009 Mar;13(3):275-86. Erratum in: Expert Opin Ther Targets. 2009 May;13(5):623. PMID: 19236150 [PubMed - indexed for MEDLINE]Related articles

Improvement of depressive behaviors by nefiracetam is associated with activation of CaM kinases in olfactory bulbectomized mice.

Han F, Nakano T, Yamamoto Y, Shioda N, Lu YM, Fukunaga K.

Brain Res. 2009 Apr 10;1265:205-14. Epub 2009 Feb 21.PMID: 19233146 [PubMed - indexed for MEDLINE]Related articles

Rif1 and rif2 inhibit localization of tel1 to DNA ends.

Hirano Y, Fukunaga K, Sugimoto K.

Mol Cell. 2009 Feb 13;33(3):312-22.PMID: 19217405 [PubMed - indexed for MEDLINE]Related articles

DY-9760e inhibits endothelin-1-induced cardiomyocyte hypertrophy through inhibition of CaMKII and ERK activities.

Lu YM, Shioda N, Han F, Kamata A, Shirasaki Y, Qin ZH, Fukunaga K.

Cardiovasc Ther. 2009 Spring;27(1):17-27.PMID: 19207476 [PubMed - indexed for MEDLINE]Related articles

[Role of heart-type fatty acid binding protein in the brain function]

Motohashi K, Yamamoto Y, Shioda N, Kondo H, Owada Y, Fukunaga K.

Yakugaku Zasshi. 2009 Feb;129(2):191-5. Review. Japanese. PMID: 19182446 [PubMed - indexed for MEDLINE]Related articlesFree article

Multivariate analysis for factors predicting rapid response of leukocytapheresis in patients with steroid-resistant ulcerative colitis: a multicenter prospective open-label study.

Matsumoto T, Andoh A, Okawa K, Ito H, Torii A, Yoshikawa S, Nakaoka R, Okuyama Y, Oshitani N, Nishishita M, Watanabe K, Fukunaga K, Ohnishi K, Kusaka T, Yokoyama Y, Sasaki M, Tsujikawa T, Aoki T, Kusaka T, Takeda Y, Umehara Y, Nakamura S, Fujiyama Y.

Ther Apher Dial. 2008 Dec;12(6):484-90.PMID: 19140847 [PubMed - indexed for MEDLINE]Related articles

Increase in ascorbate content of transgenic tobacco plants overexpressing the acerola (Malpighia glabra) phosphomannomutase gene.

Badejo AA, Eltelib HA, Fukunaga K, Fujikawa Y, Esaka M.

Plant Cell Physiol. 2009 Feb;50(2):423-8. Epub 2009 Jan 2.PMID: 19122187 [PubMed - indexed for MEDLINE]Related articles

Exacerbation of bleomycin-induced injury and fibrosis by pneumonectomy in the residual lung of mice.

Kakizaki T, Kohno M, Watanabe M, Tajima A, Izumi Y, Miyasho T, Tasaka S, Fukunaga K, Maruyama I, Ishizaka A, Kobayashi K.

J Surg Res. 2009 Jun 15;154(2):336-44. Epub 2008 Jul 15.PMID: 19118846 [PubMed - indexed for MEDLINE]Related articles

[Hyperthermic immuno-cellular therapy-basic and clinical study]

Takeda T, Fukunaga K, Miyazawa K, Takahashi T, Takeda H, Takeda Y, Tanigawa K, Morisaki T, Yamamoto I, Hasegawa T.

Gan To Kagaku Ryoho. 2008 Nov;35(12):2244-6. Japanese. PMID: 19106584 [PubMed - indexed for MEDLINE]Related articles

High-mobility group box 1 contributes to lethality of endotoxemia in heme oxygenase-1-deficient mice.

Takamiya R, Hung CC, Hall SR, Fukunaga K, Nagaishi T, Maeno T, Owen C, Macias AA, Fredenburgh LE, Ishizaka A, Blumberg RS, Baron RM, Perrella MA.

Am J Respir Cell Mol Biol. 2009 Aug;41(2):129-35. Epub 2008 Dec 18.PMID: 19097991 [PubMed - indexed for MEDLINE]Related articles

The postsynaptic density protein, IQ-ArfGEF/BRAG1, can interact with IRSp53 through its proline-rich sequence.

Sanda M, Kamata A, Katsumata O, Fukunaga K, Watanabe M, Kondo H, Sakagami H.

Brain Res. 2009 Jan 28;1251:7-15. Epub 2008 Dec 3.PMID: 19083995 [PubMed - indexed for MEDLINE]Related articles

Marine phosphatidylcholine suppresses 1,2-dimethylhydrazine-induced colon carcinogenesis in rats by inducing apoptosis.

Fukunaga K, Hossain Z, Takahashi K.

Nutr Res. 2008 Sep;28(9):635-40.PMID: 19083470 [PubMed - indexed for MEDLINE]Related articles

Activation of endothelial nitric oxide synthase by a vanadium compound ameliorates pressure overload-induced cardiac injury in ovariectomized rats.

Bhuiyan MS, Shioda N, Shibuya M, Iwabuchi Y, Fukunaga K.

Hypertension. 2009 Jan;53(1):57-63. Epub 2008 Nov 24.PMID: 19029487 [PubMed - indexed for MEDLINE]Related articles

Effects of trans and conjugated LC N-3 polyunsaturated fatty acids on lipid composition and abdominal fat weight in rats.

Okada T, Noguchi R, Hosokawa M, Fukunaga K, Nishiyama T, Zaima N, Hirata T, Miyashita K.

J Food Sci. 2008 Oct;73(8):H201-6.PMID: 19019116 [PubMed - indexed for MEDLINE]Related articles

Effects of urine pH modification on pharmacokinetics of phenobarbital in healthy dogs.

Fukunaga K, Saito M, Muto M, Mishima K, Fujiwara M, Orito K.

J Vet Pharmacol Ther. 2008 Oct;31(5):431-6.PMID: 19000262 [PubMed - indexed for MEDLINE]Related articles

Phenylephrine-induced cardiomyocyte injury is triggered by superoxide generation through uncoupled endothelial nitric-oxide synthase and ameliorated by 3-[2-[4-(3-chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxyindazole (DY-9836), a novel calmodulin antagonist.

Lu YM, Han F, Shioda N, Moriguchi S, Shirasaki Y, Qin ZH, Fukunaga K.

Mol Pharmacol. 2009 Jan;75(1):101-12. Epub 2008 Oct 24.PMID: 18952768 [PubMed - indexed for MEDLINE]Related articles

TP receptor-mediated release of eosinophil chemotactic activity from human bronchial smooth muscle cells.

Suzuki Y, Asano K, Niimi K, Miyata J, Shiraishi Y, Fukunaga K, Shiomi T, Nakajima T, Oguma T, Sayama K, Ishizaka A.

Eur J Pharmacol. 2008 Dec 14;600(1-3):133-9. Epub 2008 Oct 8.PMID: 18950617 [PubMed - indexed for MEDLINE]Related articles

Alpha-CaMKII deficiency causes immature dentate gyrus, a novel candidate endophenotype of psychiatric disorders.

Yamasaki N, Maekawa M, Kobayashi K, Kajii Y, Maeda J, Soma M, Takao K, Tanda K, Ohira K, Toyama K, Kanzaki K, Fukunaga K, Sudo Y, Ichinose H, Ikeda M, Iwata N, Ozaki N, Suzuki H, Higuchi M, Suhara T, Yuasa S, Miyakawa T.

Mol Brain. 2008 Sep 10;1(1):6.PMID: 18803808 [PubMed - in process]Related articlesFree article

Activation of HtrA2, a mitochondrial serine protease mediates apoptosis: current knowledge on HtrA2 mediated myocardial ischemia/reperfusion injury.

Bhuiyan MS, Fukunaga K.

Cardiovasc Ther. 2008 Fall;26(3):224-32. Review.PMID: 18786092 [PubMed - indexed for MEDLINE]Related articles

Targeting protein kinase B/Akt signaling with vanadium compounds for cardioprotection.

Bhuiyan MS, Shioda N, Fukunaga K.

Expert Opin Ther Targets. 2008 Oct;12(10):1217-27. Review.PMID: 18781821 [PubMed - indexed for MEDLINE]Related articles

Hyperthermic stimulation of blood increases the immunological effects of granulocyte and monocyte adsorption in vitro: relevance to extracorporeal immunomodulation.

Tozawa K, Fukunaga K, Kamikozuru K, Ohnishi K, Hida N, Ohda Y, Kusaka T, Yoshida K, Jinno Y, Nagase K, Nakamura S, Miwa H, Matsumoto T.

Transfus Apher Sci. 2008 Oct;39(2):129-35.PMID: 18762459 [PubMed - indexed for MEDLINE]Related articles