PubMed

Apolipoprotein A-V modulates insulin secretion in pancreatic beta-cells through its interaction with midkine.

Helleboid-Chapman A, Nowak M, Helleboid S, Moitrot E, Rommens C, Dehondt H, Héliot L, Drobecq H, Fruchart-Najib J, Fruchart JC.

Cell Physiol Biochem. 2009;24(5-6):451-60. Epub 2009 Nov 4.PMID: 19910685 [PubMed - in process]Related articles

Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity.

Alberti KG, Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, Donato KA, Fruchart JC, James WP, Loria CM, Smith SC Jr; International Diabetes Federation Task Force on Epidemiology and Prevention; Hational Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; International Association for the Study of Obesity.

Circulation. 2009 Oct 20;120(16):1640-5. Epub 2009 Oct 5.PMID: 19805654 [PubMed - indexed for MEDLINE]Related articles

Peroxisome proliferator-activated receptor-alpha (PPARalpha): at the crossroads of obesity, diabetes and cardiovascular disease.

Fruchart JC.

Atherosclerosis. 2009 Jul;205(1):1-8. Epub 2009 Mar 20. Review.PMID: 19386311 [PubMed - indexed for MEDLINE]Related articles

Tissue-specific roles of ABCA1 influence susceptibility to atherosclerosis.

Brunham LR, Singaraja RR, Duong M, Timmins JM, Fievet C, Bissada N, Kang MH, Samra A, Fruchart JC, McManus B, Staels B, Parks JS, Hayden MR.

Arterioscler Thromb Vasc Biol. 2009 Apr;29(4):548-54. Epub 2009 Feb 5.PMID: 19201688 [PubMed - indexed for MEDLINE]Related articles

The Residual Risk Reduction Initiative: a call to action to reduce residual vascular risk in patients with dyslipidemia.

Fruchart JC, Sacks F, Hermans MP, Assmann G, Brown WV, Ceska R, Chapman MJ, Dodson PM, Fioretto P, Ginsberg HN, Kadowaki T, Lablanche JM, Marx N, Plutzky J, Reiner Z, Rosenson RS, Staels B, Stock JK, Sy R, Wanner C, Zambon A, Zimmet P.

Am J Cardiol. 2008 Nov 17;102(10 Suppl):1K-34K. Review.PMID: 19068318 [PubMed - indexed for MEDLINE]Related articles

The Residual Risk Reduction Initiative: a call to action to reduce residual vascular risk in dyslipidaemic patient.

Fruchart JC, Sacks FM, Hermans MP, Assmann G, Brown WV, Ceska R, Chapman MJ, Dodson PM, Fioretto P, Ginsberg HN, Kadowaki T, Lablanche JM, Marx N, Plutzky J, Reiner Z, Rosenson RS, Staels B, Stock JK, Sy R, Wanner C, Zambon A, Zimmet P; Residual Risk Reduction Initiative (R3I).

Diab Vasc Dis Res. 2008 Nov;5(4):319-35. Review.PMID: 18958843 [PubMed - indexed for MEDLINE]Related articles

Liver X receptor activation induces the uptake of cholesteryl esters from high density lipoproteins in primary human macrophages.

Bultel S, Helin L, Clavey V, Chinetti-Gbaguidi G, Rigamonti E, Colin M, Fruchart JC, Staels B, Lestavel S.

Arterioscler Thromb Vasc Biol. 2008 Dec;28(12):2288-95. Epub 2008 Sep 18.PMID: 18802017 [PubMed - indexed for MEDLINE]Related articles

Phosphorylation of farnesoid X receptor by protein kinase C promotes its transcriptional activity.

Gineste R, Sirvent A, Paumelle R, Helleboid S, Aquilina A, Darteil R, Hum DW, Fruchart JC, Staels B.

Mol Endocrinol. 2008 Nov;22(11):2433-47. Epub 2008 Aug 28.PMID: 18755856 [PubMed - indexed for MEDLINE]Related articlesFree article

Atheroprotective effect of human apolipoprotein A5 in a mouse model of mixed dyslipidemia.

Mansouri RM, Baugé E, Gervois P, Fruchart-Najib J, Fiévet C, Staels B, Fruchart JC.

Circ Res. 2008 Aug 29;103(5):450-3. Epub 2008 Jul 24.PMID: 18658049 [PubMed - indexed for MEDLINE]Related articlesFree article

[PPAR receptors at the crossroads of obesity, diabetes and cardiovascular diseases]

Gilde A, Fruchart JC, Staels B.

Journ Annu Diabetol Hotel Dieu. 2007:21-38. Review. French. No abstract available. PMID: 18610756 [PubMed - indexed for MEDLINE]Related articles

Glucose regulates the expression of the apolipoprotein A5 gene.

Nowak M, Helleboid-Chapman A, Jakel H, Moitrot E, Rommens C, Pennacchio LA, Fruchart-Najib J, Fruchart JC.

J Mol Biol. 2008 Jul 25;380(5):789-98. Epub 2008 Apr 30.PMID: 18572192 [PubMed - indexed for MEDLINE]Related articles

The nuclear receptor Rev-erbalpha is a liver X receptor (LXR) target gene driving a negative feedback loop on select LXR-induced pathways in human macrophages.

Fontaine C, Rigamonti E, Pourcet B, Duez H, Duhem C, Fruchart JC, Chinetti-Gbaguidi G, Staels B.

Mol Endocrinol. 2008 Aug;22(8):1797-811. Epub 2008 May 29.PMID: 18511497 [PubMed - indexed for MEDLINE]Related articlesFree article

DTS-108, a novel peptidic prodrug of SN38: in vivo efficacy and toxicokinetic studies.

Meyer-Losic F, Nicolazzi C, Quinonero J, Ribes F, Michel M, Dubois V, de Coupade C, Boukaissi M, Chéné AS, Tranchant I, Arranz V, Zoubaa I, Fruchart JS, Ravel D, Kearsey J.

Clin Cancer Res. 2008 Apr 1;14(7):2145-53.PMID: 18381956 [PubMed - indexed for MEDLINE]Related articlesFree article

Novel peroxisome proliferator activated receptor-alpha agonists.

Fruchart JC.

Am J Cardiol. 2007 Dec 3;100(11 A):n41-6. Review.PMID: 18047852 [PubMed - indexed for MEDLINE]Related articles

FXR-deficiency confers increased susceptibility to torpor.

Cariou B, Bouchaert E, Abdelkarim M, Dumont J, Caron S, Fruchart JC, Burcelin R, Kuipers F, Staels B.

FEBS Lett. 2007 Nov 13;581(27):5191-8. Epub 2007 Oct 12.PMID: 17950284 [PubMed - indexed for MEDLINE]Related articles

In vivo characterization of human APOA5 haplotypes.

Ahituv N, Akiyama J, Chapman-Helleboid A, Fruchart J, Pennacchio LA.

Genomics. 2007 Dec;90(6):674-9. Epub 2007 Oct 23.PMID: 17936576 [PubMed - indexed for MEDLINE]Related articles

HDL cholesterol, very low levels of LDL cholesterol, and cardiovascular events.

Barter P, Gotto AM, LaRosa JC, Maroni J, Szarek M, Grundy SM, Kastelein JJ, Bittner V, Fruchart JC; Treating to New Targets Investigators.

N Engl J Med. 2007 Sep 27;357(13):1301-10.PMID: 17898099 [PubMed - indexed for MEDLINE]Related articlesFree article

Apolipoprotein A-V gene polymorphisms in subjects with metabolic syndrome.

Niculescu LS, Fruchart-Najib J, Fruchart JC, Sima A.

Clin Chem Lab Med. 2007;45(9):1133-9.PMID: 17635078 [PubMed - indexed for MEDLINE]Related articles

Enhanced VDUP-1 gene expression by PPARgamma agonist induces apoptosis in human macrophage.

Billiet L, Furman C, Larigauderie G, Copin C, Page S, Fruchart JC, Brand K, Rouis M.

J Cell Physiol. 2008 Jan;214(1):183-91.PMID: 17579352 [PubMed - indexed for MEDLINE]Related articles

The PPARalpha activator fenofibrate slows down the progression of the left ventricular dysfunction in porcine tachycardia-induced cardiomyopathy.

Brigadeau F, Gelé P, Wibaux M, Marquié C, Martin-Nizard F, Torpier G, Fruchart JC, Staels B, Duriez P, Lacroix D.

J Cardiovasc Pharmacol. 2007 Jun;49(6):408-15.PMID: 17577106 [PubMed - indexed for MEDLINE]Related articles

Design and synthesis of highly potent and selective human peroxisome proliferator-activated receptor alpha agonists.

Yamazaki Y, Abe K, Toma T, Nishikawa M, Ozawa H, Okuda A, Araki T, Oda S, Inoue K, Shibuya K, Staels B, Fruchart JC.

Bioorg Med Chem Lett. 2007 Aug 15;17(16):4689-93. Epub 2007 May 24.PMID: 17553678 [PubMed - indexed for MEDLINE]Related articles

Liver X receptor activation potentiates the lipopolysaccharide response in human macrophages.

Fontaine C, Rigamonti E, Nohara A, Gervois P, Teissier E, Fruchart JC, Staels B, Chinetti-Gbaguidi G.

Circ Res. 2007 Jul 6;101(1):40-9. Epub 2007 May 31.PMID: 17540978 [PubMed - indexed for MEDLINE]Related articlesFree article

PON1, a new biomarker of cardiovascular disease, is low in patients with systemic vasculitis.

Quéméneur T, Martin-Nizard F, Kandoussi A, Kyndt X, Vanhille P, Hachulla E, Hatron PY, Fruchart JC, Duriez P, Lambert M.

Semin Arthritis Rheum. 2007 Dec;37(3):149-55. Epub 2007 May 21.PMID: 17512573 [PubMed - indexed for MEDLINE]Related articles

The increase of apolipoprotein A-V during postprandial lipemia parallels the response of triglyceride-rich lipoproteins in type 2 diabetes: no relationship between apoA-V and postheparin plasma lipolytic activity.

Kahri J, Fruchart-Najib J, Matikainen N, Fruchart JC, Vakkilainen J, Taskinen MR.

Diabetes Care. 2007 Aug;30(8):2083-5. Epub 2007 May 7. No abstract available. PMID: 17485571 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetically-engineered animals as research models for atherosclerosis: their use for the characterization of PPAR agonists in the treatment of cardiometabolic disorders.

Fievet C, Fruchart JC, Staels B.

Front Biosci. 2007 May 1;12:4132-56. Review.PMID: 17485363 [PubMed - indexed for MEDLINE]Related articles

Safety issues and prospects for future generations of PPAR modulators.

Rubenstrunk A, Hanf R, Hum DW, Fruchart JC, Staels B.

Biochim Biophys Acta. 2007 Aug;1771(8):1065-81. Epub 2007 Feb 24. Review.PMID: 17428730 [PubMed - indexed for MEDLINE]Related articles

Is lipoprotein(a) a clinically meaningful risk marker for cardiovascular events in healthy women?

Fruchart JC.

Nat Clin Pract Cardiovasc Med. 2007 May;4(5):242-3. Epub 2007 Mar 13. No abstract available. PMID: 17356519 [PubMed]Related articles

Drug Insight: mechanisms of action and therapeutic applications for agonists of peroxisome proliferator-activated receptors.

Gervois P, Fruchart JC, Staels B.

Nat Clin Pract Endocrinol Metab. 2007 Feb;3(2):145-56. Review.PMID: 17237841 [PubMed - indexed for MEDLINE]Related articles

[4-(2H-1,2,3-benzotriazol-2-yl)phenoxy]alkanoic acids as agonists of peroxisome proliferator-activated receptors (PPARs).

Sparatore A, Godio C, Perrino E, Romeo S, Staels B, Fruchart JC, Crestani M.

Chem Biodivers. 2006 Apr;3(4):385-95.PMID: 17193275 [PubMed - indexed for MEDLINE]Related articles

Effects of high-dose atorvastatin on cerebrovascular events in patients with stable coronary disease in the TNT (treating to new targets) study.

Waters DD, LaRosa JC, Barter P, Fruchart JC, Gotto AM Jr, Carter R, Breazna A, Kastelein JJ, Grundy SM.

J Am Coll Cardiol. 2006 Nov 7;48(9):1793-9. Epub 2006 Oct 17.PMID: 17084252 [PubMed - indexed for MEDLINE]Related articles

PPAR: a new pharmacological target for neuroprotection in stroke and neurodegenerative diseases.

Bordet R, Ouk T, Petrault O, Gelé P, Gautier S, Laprais M, Deplanque D, Duriez P, Staels B, Fruchart JC, Bastide M.

Biochem Soc Trans. 2006 Dec;34(Pt 6):1341-6. Review.PMID: 17073815 [PubMed - indexed for MEDLINE]Related articles

Transcriptional regulation of macrophage cholesterol trafficking by PPARalpha and LXR.

Chinetti G, Fruchart JC, Staels B.

Biochem Soc Trans. 2006 Dec;34(Pt 6):1128-31. Review. Erratum in: Biochem Soc Trans. 2007 Feb;35(Pt 1):165. PMID: 17073767 [PubMed - indexed for MEDLINE]Related articles

The RXR agonist bexarotene improves cholesterol homeostasis and inhibits atherosclerosis progression in a mouse model of mixed dyslipidemia.

Lalloyer F, Fiévet C, Lestavel S, Torpier G, van der Veen J, Touche V, Bultel S, Yous S, Kuipers F, Paumelle R, Fruchart JC, Staels B, Tailleux A.

Arterioscler Thromb Vasc Biol. 2006 Dec;26(12):2731-7. Epub 2006 Sep 28.PMID: 17008586 [PubMed - indexed for MEDLINE]Related articlesFree article

PPARalpha and PPARgamma dual agonists for the treatment of type 2 diabetes and the metabolic syndrome.

Fiévet C, Fruchart JC, Staels B.

Curr Opin Pharmacol. 2006 Dec;6(6):606-14. Epub 2006 Sep 14. Review.PMID: 16973418 [PubMed - indexed for MEDLINE]Related articles

Reduction of low-density lipoprotein cholesterol in patients with coronary heart disease and metabolic syndrome: analysis of the Treating to New Targets study.

Deedwania P, Barter P, Carmena R, Fruchart JC, Grundy SM, Haffner S, Kastelein JJ, LaRosa JC, Schachner H, Shepherd J, Waters DD; Treating to New Targets Investigators.

Lancet. 2006 Sep 9;368(9539):919-28.PMID: 16962881 [PubMed - indexed for MEDLINE]Related articles

Both hepatic and extrahepatic ABCA1 have discrete and essential functions in the maintenance of plasma high-density lipoprotein cholesterol levels in vivo.

Singaraja RR, Van Eck M, Bissada N, Zimetti F, Collins HL, Hildebrand RB, Hayden A, Brunham LR, Kang MH, Fruchart JC, Van Berkel TJ, Parks JS, Staels B, Rothblat GH, Fiévet C, Hayden MR.

Circulation. 2006 Sep 19;114(12):1301-9. Epub 2006 Aug 28.PMID: 16940190 [PubMed - indexed for MEDLINE]Related articlesFree article

Selective PPAR modulators, dual and pan PPAR agonists: multimodal drugs for the treatment of type 2 diabetes and atherosclerosis.

Pourcet B, Fruchart JC, Staels B, Glineur C.

Expert Opin Emerg Drugs. 2006 Sep;11(3):379-401. Review.PMID: 16939380 [PubMed - indexed for MEDLINE]Related articles

Apolipoprotein E knockout mice over-expressing human tissue inhibitor of metalloproteinase 1 are protected against aneurysm formation but not against atherosclerotic plaque development.

Cuaz-Pérolin C, Jguirim I, Larigauderie G, Jlassi A, Furman C, Moreau M, Chapman MJ, Fruchart JC, Slimane MN, Mezdour H, Rouis M.

J Vasc Res. 2006;43(6):493-501. Epub 2006 Aug 24.PMID: 16931892 [PubMed - indexed for MEDLINE]Related articles

Adipophilin increases triglyceride storage in human macrophages by stimulation of biosynthesis and inhibition of beta-oxidation.

Larigauderie G, Cuaz-Pérolin C, Younes AB, Furman C, Lasselin C, Copin C, Jaye M, Fruchart JC, Rouis M.

FEBS J. 2006 Aug;273(15):3498-510.PMID: 16884492 [PubMed - indexed for MEDLINE]Related articles

Glucose regulates LXRalpha subcellular localization and function in rat pancreatic beta-cells.

Helleboid-Chapman A, Helleboid S, Jakel H, Timmerman C, Sergheraert C, Pattou F, Fruchart-Najib J, Fruchart JC.

Cell Res. 2006 Jul;16(7):661-70.PMID: 16773041 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of lowering LDL cholesterol substantially below currently recommended levels in patients with coronary heart disease and diabetes: the Treating to New Targets (TNT) study.

Shepherd J, Barter P, Carmena R, Deedwania P, Fruchart JC, Haffner S, Hsia J, Breazna A, LaRosa J, Grundy S, Waters D.

Diabetes Care. 2006 Jun;29(6):1220-6.PMID: 16731999 [PubMed - indexed for MEDLINE]Related articlesFree article

Peroxisome proliferator-activated receptor alpha improves pancreatic adaptation to insulin resistance in obese mice and reduces lipotoxicity in human islets.

Lalloyer F, Vandewalle B, Percevault F, Torpier G, Kerr-Conte J, Oosterveer M, Paumelle R, Fruchart JC, Kuipers F, Pattou F, Fiévet C, Staels B.

Diabetes. 2006 Jun;55(6):1605-13.PMID: 16731822 [PubMed - indexed for MEDLINE]Related articlesFree article

Paullinia pinnata extracts rich in polyphenols promote vascular relaxation via endothelium-dependent mechanisms.

Zamble A, Carpentier M, Kandoussi A, Sahpaz S, Petrault O, Ouk T, Hennuyer N, Fruchart JC, Staels B, Bordet R, Duriez P, Bailleul F, Martin-Nizard F.

J Cardiovasc Pharmacol. 2006 Apr;47(4):599-608.PMID: 16680075 [PubMed - indexed for MEDLINE]Related articles

Retinoic acid receptor-related orphan receptor alpha as a therapeutic target in the treatment of dyslipidemia and atherosclerosis.

Jakel H, Fruchart-Najib J, Fruchart JC.

Drug News Perspect. 2006 Mar;19(2):91-7. Review.PMID: 16628264 [PubMed - indexed for MEDLINE]Related articles

Fibrates.

Robillard R, Fontaine C, Chinetti G, Fruchart JC, Staels B.

Handb Exp Pharmacol. 2005;(170):389-406. Review.PMID: 16596808 [PubMed - indexed for MEDLINE]Related articles

Effect of very high-intensity statin therapy on regression of coronary atherosclerosis: the ASTEROID trial.

Nissen SE, Nicholls SJ, Sipahi I, Libby P, Raichlen JS, Ballantyne CM, Davignon J, Erbel R, Fruchart JC, Tardif JC, Schoenhagen P, Crowe T, Cain V, Wolski K, Goormastic M, Tuzcu EM; ASTEROID Investigators.

JAMA. 2006 Apr 5;295(13):1556-65. Epub 2006 Mar 13.PMID: 16533939 [PubMed - indexed for MEDLINE]Related articlesFree article

Mode of action of fibrates in the regulation of triglyceride and HDL-cholesterol metabolism.

Fruchart JC, Duriez P.

Drugs Today (Barc). 2006 Jan;42(1):39-64. Review.PMID: 16511610 [PubMed - indexed for MEDLINE]Related articles

Sorting out the roles of PPAR alpha in energy metabolism and vascular homeostasis.

Lefebvre P, Chinetti G, Fruchart JC, Staels B.

J Clin Invest. 2006 Mar;116(3):571-80. Review.PMID: 16511589 [PubMed - indexed for MEDLINE]Related articlesFree article

Characterization of a new mouse model for human apolipoprotein A-I/C-III/A-IV deficiency.

Mezdour H, Larigauderie G, Castro G, Torpier G, Fruchart J, Nowak M, Fruchart JC, Rouis M, Maeda N.

J Lipid Res. 2006 May;47(5):912-20. Epub 2006 Feb 23.PMID: 16497661 [PubMed - indexed for MEDLINE]Related articlesFree article

Different VLDL apo B, and HDL apo AI and apo AII metabolism in two heterozygous carriers of unrelated mutations in the lipoprotein lipase gene.

Pérez-Méndez O, Duhal N, Lacroix B, Bonte JP, Fruchart JC, Luc G.

Clin Chim Acta. 2006 Jun;368(1-2):149-54. Epub 2006 Feb 17.PMID: 16487502 [PubMed - indexed for MEDLINE]Related articles