PubMed

Long-term treatment of patients with Alzheimer's disease in primary and secondary care: results from an international survey.

Froelich L, Andreasen N, Tsolaki M, Foucher A, Kavanagh S, Baelen BV, Schwalen S.

Curr Med Res Opin. 2009 Dec;25(12):3059-68.PMID: 19852697 [PubMed - in process]Related articles

Creating a transatlantic research enterprise for preventing Alzheimer's disease.

Khachaturian ZS, Camí J, Andrieu S, Avila J, Boada Rovira M, Breteler M, Froelich L, Gauthier S, Gómez-Isla T, Khachaturian AS, Kuller LH, Larson EB, Lopez OL, Martinez-Lage JM, Petersen RC, Schellenberg GD, Sunyer J, Vellas B, Bain LJ.

Alzheimers Dement. 2009 Jul;5(4):361-6.PMID: 19560106 [PubMed - indexed for MEDLINE]Related articles

Methodological issues in primary prevention trials for neurodegenerative dementia.

Andrieu S, Coley N, Aisen P, Carrillo MC, DeKosky S, Durga J, Fillit H, Frisoni GB, Froelich L, Gauthier S, Jones R, Jönsson L, Khachaturian Z, Morris JC, Orgogozo JM, Ousset PJ, Robert P, Salmon E, Sampaio C, Verhey F, Wilcock G, Vellas B.

J Alzheimers Dis. 2009 Feb;16(2):235-70. Review.PMID: 19221415 [PubMed - indexed for MEDLINE]Related articles

Multi-center comparison of medial temporal atrophy in patients with Alzheimer's disease--data from the ICTUS study.

Galluzzi S, Talassi E, Belussi M, Scheltens P, van de Pol L, Nobili F, Rodriguez G, Froelich L, Damian M, Martinez-Lage P, Gomez-Isla T, Reynish E, Ousset PJ, Vellas B, Frisoni GB.

Dement Geriatr Cogn Disord. 2008;26(4):314-22. Epub 2008 Oct 8.PMID: 18841016 [PubMed - indexed for MEDLINE]Related articles

Investigation of the terminal P4 domain in a series of D-phenylglycinamide-based factor Xa inhibitors.

Franciskovich JB, Masters JJ, Weber WW, Klimkowski VJ, Chouinard M, Sipes PR, Johnson LM, Snyder DW, Chastain MK, Craft TJ, Towner RD, Gifford-Moore DS, Froelich LL, Smallwood JK, Foster RS, Smith GF, Liebeschuetz JW, Murray CW, Young SC.

Bioorg Med Chem Lett. 2007 Dec 15;17(24):6910-3. Epub 2007 Oct 24.PMID: 17976987 [PubMed - indexed for MEDLINE]Related articles

The ICTUS Study: A Prospective longitudinal observational study of 1,380 AD patients in Europe. Study design and baseline characteristics of the cohort.

Reynish E, Cortes F, Andrieu S, Cantet C, Olde Rikkert M, Melis R, Froelich L, Frisoni GB, Jönsson L, Visser PJ, Ousset PJ, Vellas B; ICTUS Study Group.

Neuroepidemiology. 2007;29(1-2):29-38. Epub 2007 Sep 24.PMID: 17898521 [PubMed - indexed for MEDLINE]Related articles

Anthranilamide inhibitors of factor Xa.

Mendel D, Marquart AL, Joseph S, Waid P, Yee YK, Tebbe AL, Ratz AM, Herron DK, Goodson T, Masters JJ, Franciskovich JB, Tinsley JM, Wiley MR, Weir LC, Kyle JA, Klimkowski VJ, Smith GF, Towner RD, Froelich LL, Buben J, Craft TJ.

Bioorg Med Chem Lett. 2007 Sep 1;17(17):4832-6. Epub 2007 Jun 20.PMID: 17624775 [PubMed - indexed for MEDLINE]Related articles

Commentary on "Health economics and the value of therapy in Alzheimer's disease." Value therapy for Alzheimer's disease-A European perspective.

Vellas B, Froelich L, Sampaio C.

Alzheimers Dement. 2007 Jul;3(3):152-6.PMID: 19595930 [PubMed - in process]Related articles

White matter lesions - age-adjusted values for cognitively healthy and demented subjects.

Hentschel F, Damian M, Krumm B, Froelich L.

Acta Neurol Scand. 2007 Mar;115(3):174-80.PMID: 17295712 [PubMed - indexed for MEDLINE]Related articles

Investigation of factor Xa inhibitors containing non-amidine S1 elements.

Franciskovich JB, Masters JJ, Tinsley JM, Craft TJ, Froelich LL, Gifford-Moore DS, Klimkowski VJ, Smallwood JK, Smith GF, Smith T, Towner RR, Weir LC, Wiley MR.

Bioorg Med Chem Lett. 2005 Nov 1;15(21):4838-41.PMID: 16140530 [PubMed - indexed for MEDLINE]Related articles

Controlled substance prescriptions: the ARNP perspective.

Froelich L.

Kans Nurse. 2005 Jan;80(1):16. No abstract available. PMID: 15757210 [PubMed - indexed for MEDLINE]Related articles

Donepezil for Alzheimer's disease in clinical practice--The DONALD Study. A multicenter 24-week clinical trial in Germany.

Froelich L, Gertz HJ, Heun R, Heuser I, Jendroska K, Kornhuber J, Kurz A, Mueller-Thomsen T, Ries F, Waechtler C, Metz M, Goebel C.

Dement Geriatr Cogn Disord. 2004;18(1):37-43. Epub 2004 Apr 6.PMID: 15084792 [PubMed - indexed for MEDLINE]Related articles

Non-amidine-containing 1,2-dibenzamidobenzene inhibitors of human factor Xa with potent anticoagulant and antithrombotic activity.

Masters JJ, Franciskovich JB, Tinsley JM, Campbell C, Campbell JB, Craft TJ, Froelich LL, Gifford-Moore DS, Hay LA, Herron DK, Klimkowski VJ, Kurz KD, Metz JT, Ratz AM, Shuman RT, Smith GF, Smith T, Towner RD, Wiley MR, Wilson A, Yee YK.

J Med Chem. 2000 Jun 1;43(11):2087-92. No abstract available. PMID: 10841787 [PubMed - indexed for MEDLINE]Related articles

Pharmacologic actions of the second generation leukotriene B4 receptor antagonist LY29311: in vivo pulmonary studies.

Silbaugh SA, Stengel PW, Cockerham SL, Froelich LL, Bendele AM, Spaethe SM, Sofia MJ, Sawyer JS, Jackson WT.

Naunyn Schmiedebergs Arch Pharmacol. 2000 Apr;361(4):397-404.PMID: 10763854 [PubMed - indexed for MEDLINE]Related articles

Structure-based design of potent, amidine-derived inhibitors of factor Xa: evaluation of selectivity, anticoagulant activity, and antithrombotic activity.

Wiley MR, Weir LC, Briggs S, Bryan NA, Buben J, Campbell C, Chirgadze NY, Conrad RC, Craft TJ, Ficorilli JV, Franciskovich JB, Froelich LL, Gifford-Moore DS, Goodson T Jr, Herron DK, Klimkowski VJ, Kurz KD, Kyle JA, Masters JJ, Ratz AM, Milot G, Shuman RT, Smith T, Smith GF, Tebbe AL, Tinsley JM.

J Med Chem. 2000 Mar 9;43(5):883-99.PMID: 10715155 [PubMed - indexed for MEDLINE]Related articles

Postnatal ontogeny of GTP binding protein in the human frontal cortex.

Ozawa H, Ukai W, Kornhuber J, Yamaguchi T, Froelich L, Ikeda H, Saito T, Riederer P.

Life Sci. 1999;65(22):2315-23.PMID: 10597886 [PubMed - indexed for MEDLINE]Related articles

Pharmacologic actions of the second-generation leukotriene B4 receptor antagonist LY293111: in vitro studies.

Jackson WT, Froelich LL, Boyd RJ, Schrementi JP, Saussy DL Jr, Schultz RM, Sawyer JS, Sofia MJ, Herron DK, Goodson T Jr, Snyder DW, Pechous PA, Spaethe SM, Roman CR, Fleisch JH.

J Pharmacol Exp Ther. 1999 Jan;288(1):286-94.PMID: 9862783 [PubMed - indexed for MEDLINE]Related articlesFree article

Phosphatidylinositol 3-kinase activation is required for insulin-stimulated sodium transport in A6 cells.

Record RD, Froelich LL, Vlahos CJ, Blazer-Yost BL.

Am J Physiol. 1998 Apr;274(4 Pt 1):E611-7.PMID: 9575821 [PubMed - indexed for MEDLINE]Related articlesFree article

The discovery of LY293111, a novel, potent and orally active leukotriene B4 receptor antagonist of the biphenylphenol class.

Sofia MJ, Floreancig P, Bach N, Baker SR, Nelson K, Sawyer JS, Baldwin R, Cockerham SL, Fleisch JH, Froelich LL, Jackson WT, Marder P, Roman CR, Saussy DL Jr, Silbaugh SA, Spaethe SM, Stengel PW.

Adv Exp Med Biol. 1997;400A:381-6. No abstract available. PMID: 9547580 [PubMed - indexed for MEDLINE]Related articles

Inhibition of ex vivo neutrophil activation by oral LY293111, a novel leukotriene B4 receptor antagonist.

Marder P, Spaethe SM, Froelich LL, Cerimele BJ, Petersen BH, Tanner T, Lucas RA.

Br J Clin Pharmacol. 1996 Oct;42(4):457-64.PMID: 8904617 [PubMed - indexed for MEDLINE]Related articlesFree article

Aerosolized LTB4 produces delayed onset increases in pulmonary gas trapping.

Silbaugh SA, Stengel PW, Cockerham SL, Froelich LL, Bendele AM, Rippy MK, Baker SR, Sofia MJ, Jackson WT.

Prostaglandins Leukot Essent Fatty Acids. 1996 Feb;54(2):115-21.PMID: 8848430 [PubMed - indexed for MEDLINE]Related articles

Synthetic and structure/activity studies on acid-substituted 2-arylphenols: discovery of 2-[2-propyl-3-[3-[2-ethyl-4-(4-fluorophenyl)-5- hydroxyphenoxy]-propoxy]phenoxy]benzoic acid, a high-affinity leukotriene B4 receptor antagonist.

Sawyer JS, Bach NJ, Baker SR, Baldwin RF, Borromeo PS, Cockerham SL, Fleisch JH, Floreancig P, Froelich LL, Jackson WT, et al.

J Med Chem. 1995 Oct 27;38(22):4411-32.PMID: 7473568 [PubMed - indexed for MEDLINE]Related articles

Holeboard maze-learning deficits and brain monoaminergic neurotransmitter concentrations in rats after intracerebroventricular injection of 3-bromopyruvate.

Froelich L, Ding A, Hoyer S.

Pharmacol Biochem Behav. 1995 Aug;51(4):917-22.PMID: 7675877 [PubMed - indexed for MEDLINE]Related articles

Blockade of human neutrophil activation by 2-[2-propyl-3-[3-[2-ethyl-4-(4-fluorophenyl)-5- hydroxyphenoxy]propoxy]phenoxy]benzoic acid (LY293111), a novel leukotriene B4 receptor antagonist.

Marder P, Sawyer JS, Froelich LL, Mann LL, Spaethe SM.

Biochem Pharmacol. 1995 May 26;49(11):1683-90.PMID: 7786309 [PubMed - indexed for MEDLINE]Related articles

Leukotriene B4 (LTB4) receptor antagonists: a series of (hydroxyphenyl)pyrazoles.

Harper RW, Jackson WT, Froelich LL, Boyd RJ, Aldridge TE, Herron DK.

J Med Chem. 1994 Jul 22;37(15):2411-20.PMID: 8057289 [PubMed - indexed for MEDLINE]Related articles

Reduced sensitivity to ethanol of Gs alpha and Gi/o alpha in the cerebral cortex of alcoholic patients.

Ozawa H, Saito T, Hatta S, Hashimoto E, Froelich L, Ohshika H, Takahata N, Riederer P.

Alcohol Alcohol Suppl. 1994;29(1):93-7.PMID: 9063827 [PubMed - indexed for MEDLINE]Related articles

Biphenylyl-substituted xanthones: highly potent leukotriene B4 receptor antagonists.

Sawyer JS, Baldwin RF, Sofia MJ, Floreancig P, Marder P, Saussy DL Jr, Froelich LL, Silbaugh SA, Stengel PW, Cockerham SL, et al.

J Med Chem. 1993 Nov 26;36(24):3982-4. No abstract available. PMID: 8254628 [PubMed - indexed for MEDLINE]Related articles

o-phenylphenols: potent and orally active leukotriene B4 receptor antagonists.

Sofia MJ, Floreancig P, Bach NJ, Baker SR, Cockerham SL, Fleisch JH, Froelich LL, Jackson WT, Marder P, Roman CR, et al.

J Med Chem. 1993 Nov 26;36(24):3978-81. No abstract available. PMID: 7902871 [PubMed - indexed for MEDLINE]Related articles

Alterations of guanine nucleotide-binding proteins in post-mortem human brain in alcoholics.

Ozawa H, Katamura Y, Hatta S, Saito T, Katada T, Gsell W, Froelich L, Takahata N, Riederer P.

Brain Res. 1993 Aug 20;620(1):174-9.PMID: 8402195 [PubMed - indexed for MEDLINE]Related articles

Design, synthesis, and pharmacological evaluation of potent xanthone dicarboxylic acid leukotriene B4 receptor antagonists.

Jackson WT, Boyd RJ, Froelich LL, Gapinski DM, Mallett BE, Sawyer JS.

J Med Chem. 1993 Jun 11;36(12):1726-34.PMID: 8389876 [PubMed - indexed for MEDLINE]Related articles

Segmentation of the spontaneous EEG in dementia of the Alzheimer type.

Ihl R, Dierks T, Froelich L, Martin EM, Maurer K.

Neuropsychobiology. 1993;27(4):231-6.PMID: 8232844 [PubMed - indexed for MEDLINE]Related articles

Specific inhibition of leukotriene B4-induced neutrophil activation by LY223982.

Jackson WT, Boyd RJ, Froelich LL, Mallett BE, Gapinski DM.

J Pharmacol Exp Ther. 1992 Dec;263(3):1009-14.PMID: 1335049 [PubMed - indexed for MEDLINE]Related articles

Leukotriene B4 receptor antagonists: the LY255283 series of hydroxyacetophenones.

Herron DK, Goodson T, Bollinger NG, Swanson-Bean D, Wright IG, Staten GS, Thompson AR, Froelich LL, Jackson WT.

J Med Chem. 1992 May 15;35(10):1818-28.PMID: 1316967 [PubMed - indexed for MEDLINE]Related articles

Binding of a novel radioiodinated thromboxane A2/prostaglandin H2 antagonist to guinea pig lung membranes.

Saussy DL Jr, Clark PD, Gunn DL, Mais DE, Froelich LL.

Eicosanoids. 1992;5(1):1-4.PMID: 1419073 [PubMed - indexed for MEDLINE]Related articles

Characterization of the spatial arrangement of the two acid-binding sites on the human neutrophil LTB4 receptor.

Chaney MO, Froelich LL, Gapinski DM, Mallett BE, Jackson WT.

Receptor. 1992 Fall;2(3):169-79.PMID: 1335328 [PubMed - indexed for MEDLINE]Related articles

Benzophenone dicarboxylic acid antagonists of leukotriene B4. 2. Structure-activity relationships of the lipophilic side chain.

Gapinski DM, Mallett BE, Froelich LL, Jackson WT.

J Med Chem. 1990 Oct;33(10):2807-13.PMID: 2170648 [PubMed - indexed for MEDLINE]Related articles

Benzophenone dicarboxylic acid antagonists of leukotriene B4. 1. Structure-activity relationships of the benzophenone nucleus.

Gapinski DM, Mallett BE, Froelich LL, Jackson WT.

J Med Chem. 1990 Oct;33(10):2798-807.PMID: 2170647 [PubMed - indexed for MEDLINE]Related articles

Demonstration of monoamine oxidase-A and -B in the human brainstem by a histochemical technique.

Konradi C, Kornhuber J, Froelich L, Fritze J, Heinsen H, Beckmann H, Schulz E, Riederer P.

Neuroscience. 1989;33(2):383-400.PMID: 2622533 [PubMed - indexed for MEDLINE]Related articles