PubMed

ENPP1 Q121 variant, increased pulse pressure and reduced insulin signaling, and nitric oxide synthase activity in endothelial cells.

Bacci S, Di Paola R, Menzaghi C, Di Fulvio P, Di Silvestre S, Pellegrini F, Baratta R, Marucci A, Mastroianno S, Fini G, Formoso G, Consoli A, Perticone F, Frittitta L, Pandolfi A, Trischitta V.

Arterioscler Thromb Vasc Biol. 2009 Oct;29(10):1678-83. Epub 2009 Aug 13.PMID: 19679831 [PubMed - indexed for MEDLINE]Related articles

Re: Insulin, insulin-like growth factor-I, and risk of breast cancer in postmenopausal women.

Vigneri R, Frasca F, Sciacca L, Vigneri P, Frittitta L.

J Natl Cancer Inst. 2009 Jul 15;101(14):1030-1; author reply 1031-2. Epub 2009 Jun 22. No abstract available. PMID: 19546433 [PubMed - indexed for MEDLINE]Related articles

Role of the ENPP1 K121Q polymorphism in glucose homeostasis.

Baratta R, Rossetti P, Prudente S, Barbetti F, Sudano D, Nigro A, Farina MG, Pellegrini F, Trischitta V, Frittitta L.

Diabetes. 2008 Dec;57(12):3360-4. Epub 2008 Sep 5.PMID: 18776139 [PubMed - indexed for MEDLINE]Related articlesFree article

Loss-of-function mutation of the GPR40 gene associates with abnormal stimulated insulin secretion by acting on intracellular calcium mobilization.

Vettor R, Granzotto M, De Stefani D, Trevellin E, Rossato M, Farina MG, Milan G, Pilon C, Nigro A, Federspil G, Vigneri R, Vitiello L, Rizzuto R, Baratta R, Frittitta L.

J Clin Endocrinol Metab. 2008 Sep;93(9):3541-50. Epub 2008 Jun 26.PMID: 18583466 [PubMed - indexed for MEDLINE]Related articlesFree article

The role of membrane glycoprotein plasma cell antigen 1/ectonucleotide pyrophosphatase phosphodiesterase 1 in the pathogenesis of insulin resistance and related abnormalities.

Goldfine ID, Maddux BA, Youngren JF, Reaven G, Accili D, Trischitta V, Vigneri R, Frittitta L.

Endocr Rev. 2008 Feb;29(1):62-75. Epub 2008 Jan 16. Review. Erratum in: Endocr Rev. 2009 Feb;30(1):117. PMID: 18199690 [PubMed - indexed for MEDLINE]Related articlesFree article

Hyperinsulinemia and insulin resistance are independently associated with plasma lipids, uric acid and blood pressure in non-diabetic subjects. The GISIR database.

Bonora E, Capaldo B, Perin PC, Del Prato S, De Mattia G, Frittitta L, Frontoni S, Leonetti F, Luzi L, Marchesini G, Marini MA, Natali A, Paolisso G, Piatti PM, Pujia A, Solini A, Vettor R, Bonadonna RC; Group of Italian Scientists of Insulin Resistance (GISIR).

Nutr Metab Cardiovasc Dis. 2008 Nov;18(9):624-31. Epub 2007 Dec 3.PMID: 18060751 [PubMed - indexed for MEDLINE]Related articles

Correspondence between the International Diabetes Federation criteria for metabolic syndrome and insulin resistance in a cohort of Italian nondiabetic Caucasians: the GISIR database.

Sesti G, Capaldo B, Cavallo Perin P, Del Prato S, Frittitta L, Frontoni S, Hribal ML, Marchesini G, Paolisso G, Piatti PM, Solini A, Bonora E; Group of Italian Scientists of Insulin Resistance.

Diabetes Care. 2007 May;30(5):e33. No abstract available. PMID: 17468362 [PubMed - indexed for MEDLINE]Related articlesFree article

A functional variant of the adipocyte glycerol channel aquaporin 7 gene is associated with obesity and related metabolic abnormalities.

Prudente S, Flex E, Morini E, Turchi F, Capponi D, De Cosmo S, Tassi V, Guida V, Avogaro A, Folli F, Maiani F, Frittitta L, Dallapiccola B, Trischitta V.

Diabetes. 2007 May;56(5):1468-74. Epub 2007 Mar 9.PMID: 17351148 [PubMed - indexed for MEDLINE]Related articlesFree article

The Q121/Q121 genotype of ENPP1/PC-1 is associated with lower BMI in non-diabetic whites.

Prudente S, Chandalia M, Morini E, Baratta R, Dallapiccola B, Abate N, Frittitta L, Trischitta V.

Obesity (Silver Spring). 2007 Jan;15(1):1-4.PMID: 17228024 [PubMed - indexed for MEDLINE]Related articles

High prevalence of overweight and obesity in 11-15-year-old children from Sicily.

Baratta R, Degano C, Leonardi D, Vigneri R, Frittitta L.

Nutr Metab Cardiovasc Dis. 2006 May;16(4):249-55. Epub 2006 Jan 18.PMID: 16679216 [PubMed - indexed for MEDLINE]Related articles

Obesity and cancer.

Vigneri P, Frasca F, Sciacca L, Frittitta L, Vigneri R.

Nutr Metab Cardiovasc Dis. 2006 Jan;16(1):1-7. No abstract available. PMID: 16399485 [PubMed - indexed for MEDLINE]Related articles

Adiponectin relationship with lipid metabolism is independent of body fat mass: evidence from both cross-sectional and intervention studies.

Baratta R, Amato S, Degano C, Farina MG, Patanè G, Vigneri R, Frittitta L.

J Clin Endocrinol Metab. 2004 Jun;89(6):2665-71.PMID: 15181039 [PubMed - indexed for MEDLINE]Related articlesFree article

The allelic variant of LAR gene promoter -127 bp T-->A is associated with reduced risk of obesity and other features related to insulin resistance.

Miscio G, Tassi V, Coco A, Soccio T, Di Paola R, Prudente S, Baratta R, Frittitta L, Ludovico O, Padovano L, Dallapiccola B, Di Mario U, De Cosmo S, Trischitta V.

J Mol Med. 2004 Jul;82(7):459-66. Epub 2004 May 19.PMID: 15150650 [PubMed - indexed for MEDLINE]Related articles

Evidence for genetic epistasis in human insulin resistance: the combined effect of PC-1 (K121Q) and PPARgamma2 (P12A) polymorphisms.

Baratta R, Di Paola R, Spampinato D, Fini G, Marucci A, Coco A, Vigneri R, Frittitta L, Trischitta V.

J Mol Med. 2003 Nov;81(11):718-23. Epub 2003 Oct 22.PMID: 14574455 [PubMed - indexed for MEDLINE]Related articles

Rats that are made insulin resistant by glucosamine treatment have impaired skeletal muscle insulin receptor phosphorylation.

Spampinato D, Giaccari A, Trischitta V, Costanzo BV, Morviducci L, Buongiorno A, Di Mario U, Vigneri R, Frittitta L.

Metabolism. 2003 Sep;52(9):1092-5.PMID: 14506612 [PubMed - indexed for MEDLINE]Related articles

Polymorphisms of the insulin receptor substrate-2 in patients with type 2 diabetes.

D'Alfonso R, Marini MA, Frittitta L, Sorge R, Frontoni S, Porzio O, Mariani LM, Lauro D, Gambardella S, Trischitta V, Federici M, Lauro R, Sesti G.

J Clin Endocrinol Metab. 2003 Jan;88(1):317-22.PMID: 12519871 [PubMed - indexed for MEDLINE]Related articlesFree article

An ATG repeat in the 3'-untranslated region of the human resistin gene is associated with a decreased risk of insulin resistance.

Pizzuti A, Argiolas A, Di Paola R, Baratta R, Rauseo A, Bozzali M, Vigneri R, Dallapiccola B, Trischitta V, Frittitta L.

J Clin Endocrinol Metab. 2002 Sep;87(9):4403-6.PMID: 12213907 [PubMed - indexed for MEDLINE]Related articlesFree article

The role of PC-1 and ACE genes in diabetic nephropathy in type 1 diabetic patients: evidence for a polygenic control of kidney disease progression.

De Cosmo S, Miscio G, Zucaro L, Margaglione M, Argiolas A, Thomas S, Piras G, Trevisan R, Perin PC, Bacci S, Frittitta L, Pizzuti A, Tassi V, Di Minno G, Viberti G, Trischitta V.

Nephrol Dial Transplant. 2002 Aug;17(8):1402-7.PMID: 12147786 [PubMed - indexed for MEDLINE]Related articlesFree article

A variation in 3' UTR of hPTP1B increases specific gene expression and associates with insulin resistance.

Di Paola R, Frittitta L, Miscio G, Bozzali M, Baratta R, Centra M, Spampinato D, Santagati MG, Ercolino T, Cisternino C, Soccio T, Mastroianno S, Tassi V, Almgren P, Pizzuti A, Vigneri R, Trischitta V.

Am J Hum Genet. 2002 Mar;70(3):806-12. Epub 2002 Feb 6. Erratum in: Am J Hum Genet 2002 May;70(5):1388. PMID: 11833006 [PubMed - indexed for MEDLINE]Related articlesFree article

The Q121 PC-1 variant and obesity have additive and independent effects in causing insulin resistance.

Frittitta L, Baratta R, Spampinato D, Di Paola R, Pizzuti A, Vigneri R, Trischitta V.

J Clin Endocrinol Metab. 2001 Dec;86(12):5888-91.PMID: 11739459 [PubMed - indexed for MEDLINE]Related articlesFree article

Chronic exposure to high leucine impairs glucose-induced insulin release by lowering the ATP-to-ADP ratio.

Anello M, Ucciardello V, Piro S, Patané G, Frittitta L, Calabrese V, Giuffrida Stella AM, Vigneri R, Purrello F, Rabuazzo AM.

Am J Physiol Endocrinol Metab. 2001 Nov;281(5):E1082-7.PMID: 11595666 [PubMed - indexed for MEDLINE]Related articlesFree article

A cluster of three single nucleotide polymorphisms in the 3'-untranslated region of human glycoprotein PC-1 gene stabilizes PC-1 mRNA and is associated with increased PC-1 protein content and insulin resistance-related abnormalities.

Frittitta L, Ercolino T, Bozzali M, Argiolas A, Graci S, Santagati MG, Spampinato D, Di Paola R, Cisternino C, Tassi V, Vigneri R, Pizzuti A, Trischitta V.

Diabetes. 2001 Aug;50(8):1952-5.PMID: 11473061 [PubMed - indexed for MEDLINE]Related articlesFree article

The Q allele variant (GLN121) of membrane glycoprotein PC-1 interacts with the insulin receptor and inhibits insulin signaling more effectively than the common K allele variant (LYS121).

Costanzo BV, Trischitta V, Di Paola R, Spampinato D, Pizzuti A, Vigneri R, Frittitta L.

Diabetes. 2001 Apr;50(4):831-6.PMID: 11289049 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin/insulin-like growth factor I hybrid receptors overexpression is not an early defect in insulin-resistant subjects.

Spampinato D, Pandini G, Iuppa A, Trischitta V, Vigneri R, Frittitta L.

J Clin Endocrinol Metab. 2000 Nov;85(11):4219-23.PMID: 11095457 [PubMed - indexed for MEDLINE]Related articlesFree article

The K121Q variant of the human PC-1 gene is not associated with insulin resistance or type 2 diabetes among Danish Caucasians.

Rasmussen SK, Urhammer SA, Pizzuti A, Echwald SM, Ekstrøm CT, Hansen L, Hansen T, Borch-Johnsen K, Frittitta L, Trischitta V, Pedersen O.

Diabetes. 2000 Sep;49(9):1608-11.PMID: 10969849 [PubMed - indexed for MEDLINE]Related articlesFree article

Association between the human glycoprotein PC-1 gene and elevated glucose and insulin levels in a paired-sibling analysis.

Gu HF, Almgren P, Lindholm E, Frittitta L, Pizzuti A, Trischitta V, Groop LC.

Diabetes. 2000 Sep;49(9):1601-3.PMID: 10969847 [PubMed - indexed for MEDLINE]Related articlesFree article

A PC-1 amino acid variant (K121Q) is associated with faster progression of renal disease in patients with type 1 diabetes and albuminuria.

De Cosmo S, Argiolas A, Miscio G, Thomas S, Piras GP, Trevisan R, Perin PC, Bacci S, Zucaro L, Margaglione M, Frittitta L, Pizzuti A, Tassi V, Viberti GC, Trischitta V.

Diabetes. 2000 Mar;49(3):521-4.PMID: 10868979 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of PC-1 in the etiology of insulin resistance.

Goldfine ID, Maddux BA, Youngren JF, Trischitta V, Frittitta L.

Ann N Y Acad Sci. 1999 Nov 18;892:204-22. Review.PMID: 10842664 [PubMed - indexed for MEDLINE]Related articles

High insulin levels do not influence PC-1 gene expression and protein content in human muscle tissue and hepatoma cells.

Frittitta L, Sbraccia P, Costanzo BV, Tassi V, D'Adamo M, Spampinato D, Ercolino T, Purrello F, Tamburrano G, Vigneri R, Trischitta V.

Diabetes Metab Res Rev. 2000 Jan-Feb;16(1):26-32.PMID: 10707036 [PubMed - indexed for MEDLINE]Related articles

A soluble PC-1 circulates in human plasma: relationship with insulin resistance and associated abnormalities.

Frittitta L, Camastra S, Baratta R, Costanzo BV, D'Adamo M, Graci S, Spampinato D, Maddux BA, Vigneri R, Ferrannini E, Trischitta V.

J Clin Endocrinol Metab. 1999 Oct;84(10):3620-5.PMID: 10523005 [PubMed - indexed for MEDLINE]Related articlesFree article

A polymorphism (K121Q) of the human glycoprotein PC-1 gene coding region is strongly associated with insulin resistance.

Pizzuti A, Frittitta L, Argiolas A, Baratta R, Goldfine ID, Bozzali M, Ercolino T, Scarlato G, Iacoviello L, Vigneri R, Tassi V, Trischitta V.

Diabetes. 1999 Sep;48(9):1881-4.PMID: 10480624 [PubMed - indexed for MEDLINE]Related articlesFree article

The intravenous insulin tolerance test is an accurate method for screening a general population for insulin resistance and related abnormalities.

Graci S, Baratta R, Degano C, Luppa A, Vigneri R, Frittitta L, Trischitta V.

J Endocrinol Invest. 1999 Jun;22(6):472-5.PMID: 10435858 [PubMed - indexed for MEDLINE]Related articles

Functional insulin receptors are overexpressed in thyroid tumors: is this an early event in thyroid tumorigenesis?

Frittitta L, Sciacca L, Catalfamo R, Ippolito A, Gangemi P, Pezzino V, Filetti S, Vigneri R.

Cancer. 1999 Jan 15;85(2):492-8.PMID: 10023720 [PubMed - indexed for MEDLINE]Related articlesFree article

Elevated PC-1 content in cultured skin fibroblasts correlates with decreased in vivo and in vitro insulin action in nondiabetic subjects: evidence that PC-1 may be an intrinsic factor in impaired insulin receptor signaling.

Frittitta L, Spampinato D, Solini A, Nosadini R, Goldfine ID, Vigneri R, Trischitta V.

Diabetes. 1998 Jul;47(7):1095-100.PMID: 9648833 [PubMed - indexed for MEDLINE]Related articlesFree article

Membrane glycoprotein PC-1 and insulin resistance.

Goldfine ID, Maddux BA, Youngren JF, Frittitta L, Trischitta V, Dohm GL.

Mol Cell Biochem. 1998 May;182(1-2):177-84. Review.PMID: 9609127 [PubMed - indexed for MEDLINE]Related articles

The insulin receptor content is increased in breast cancers initiated by three different oncogenes in transgenic mice.

Frittitta L, Cerrato A, Sacco MG, Weidner N, Goldfine ID, Vigneri R.

Breast Cancer Res Treat. 1997 Sep;45(2):141-7.PMID: 9342439 [PubMed - indexed for MEDLINE]Related articles

Early molecular defects in human insulin resistance: studies in healthy subjects with low insulin sensitivity.

Trischitta V, Frittitta L, Vigneri R.

Diabetes Metab Rev. 1997 Sep;13(3):147-62. Review. No abstract available. PMID: 9307888 [PubMed - indexed for MEDLINE]Related articles

Increased adipose tissue PC-1 protein content, but not tumour necrosis factor-alpha gene expression, is associated with a reduction of both whole body insulin sensitivity and insulin receptor tyrosine-kinase activity.

Frittitta L, Youngren JF, Sbraccia P, D'Adamo M, Buongiorno A, Vigneri R, Goldfine ID, Trischitta V.

Diabetologia. 1997 Mar;40(3):282-9.PMID: 9084965 [PubMed - indexed for MEDLINE]Related articles

PC-1 content in skeletal muscle of non-obese, non-diabetic subjects: relationship to insulin receptor tyrosine kinase and whole body insulin sensitivity.

Frittitta L, Youngren J, Vigneri R, Maddux BA, Trischitta V, Goldfine ID.

Diabetologia. 1996 Oct;39(10):1190-5.PMID: 8897006 [PubMed - indexed for MEDLINE]Related articles

Insulin receptors in breast cancer.

Belfiore A, Frittitta L, Costantino A, Frasca F, Pandini G, Sciacca L, Goldfine ID, Vigneri R.

Ann N Y Acad Sci. 1996 Apr 30;784:173-88. Review. No abstract available. PMID: 8651567 [PubMed - indexed for MEDLINE]Related articles

Peptide-based radioimmunoassay for the two isoforms of the human insulin receptor.

Sesti G, D'Alfonso R, Vargas Punti MD, Frittitta L, Trischitta V, Liu YY, Borboni P, Longhi R, Montemurro A, Lauro R.

Diabetologia. 1995 Apr;38(4):445-53.PMID: 7796985 [PubMed - indexed for MEDLINE]Related articles

Insulin receptor overexpression in 184B5 human mammary epithelial cells induces a ligand-dependent transformed phenotype.

Frittitta L, Vigneri R, Stampfer MR, Goldfine ID.

J Cell Biochem. 1995 Apr;57(4):666-9.PMID: 7615651 [PubMed - indexed for MEDLINE]Related articles

Insulin receptor tyrosine-kinase activity is altered in both muscle and adipose tissue from non-obese normoglycaemic insulin-resistant subjects.

Grasso G, Frittitta L, Anello M, Russo P, Sesti G, Trischitta V.

Diabetologia. 1995 Jan;38(1):55-61.PMID: 7744230 [PubMed - indexed for MEDLINE]Related articles

Insulin receptor tyrosine kinase activity is reduced in monocytes from non-obese normoglycaemic insulin-resistant subjects.

Frittitta L, Grasso G, Munguira ME, Vigneri R, Trischitta V.

Diabetologia. 1993 Nov;36(11):1163-7.PMID: 8270131 [PubMed - indexed for MEDLINE]Related articles

Relationship between insulin receptor tyrosine kinase activity and internalization in monocytes of non-insulin-dependent diabetes mellitus patients.

Trischitta V, Giorgino F, Frittitta L, Scalisi R, Vigneri R.

Metabolism. 1993 Jul;42(7):882-7.PMID: 8393956 [PubMed - indexed for MEDLINE]Related articles

Structural and functional studies of insulin receptors in human breast cancer.

Frittitta L, Vigneri R, Papa V, Goldfine ID, Grasso G, Trischitta V.

Breast Cancer Res Treat. 1993;25(1):73-82.PMID: 8518410 [PubMed - indexed for MEDLINE]Related articles

Identification and initial characterization of insulin receptor-like immunoreactivity in human plasma.

Pezzino V, Papa V, Costantino A, Frittitta L, Russo P, Goldfine ID, Vigneri R.

J Clin Endocrinol Metab. 1992 May;74(5):1116-21.PMID: 1314845 [PubMed - indexed for MEDLINE]Related articles

Radioimmunoassay for human insulin-like growth factor-I receptor: applicability to breast carcinoma specimens and cell lines.

Pezzino V, Milazzo G, Frittitta L, Vigneri R, Ezaki O, Kasahara M, LeBon TR, Goldfine ID, Fujita-Yamaguchi Y.

Metabolism. 1991 Aug;40(8):861-5.PMID: 1650422 [PubMed - indexed for MEDLINE]Related articles

Elevated insulin receptor content in human breast cancer.

Papa V, Pezzino V, Costantino A, Belfiore A, Giuffrida D, Frittitta L, Vannelli GB, Brand R, Goldfine ID, Vigneri R.

J Clin Invest. 1990 Nov;86(5):1503-10.PMID: 2243127 [PubMed - indexed for MEDLINE]Related articlesFree article

Evaluation of albumin excretion rate in overnight versus 24-h urine.

Tomaselli L, Trischitta V, Vinci C, Frittitta L, Squatrito S, Vigneri R.

Diabetes Care. 1989 Sep;12(8):585-7.PMID: 2776588 [PubMed - indexed for MEDLINE]Related articles