PubMed

C/EBP transcription factors regulate SREBP1c gene expression during adipogenesis.

Payne VA, Au WS, Lowe CE, Rahman SM, Friedman JE, O'Rahilly S, Rochford JJ.

Biochem J. 2009 Oct 8. [Epub ahead of print]PMID: 19811452 [PubMed - as supplied by publisher]Related articlesFree article

The lipophilic zinc chelator DP-b99 prevents zinc induced neuronal death.

Barkalifa R, Hershfinkel M, Friedman JE, Kozak A, Sekler I.

Eur J Pharmacol. 2009 Sep 15;618(1-3):15-21. Epub 2009 Jul 19.PMID: 19622352 [PubMed - in process]Related articles

In vivo knockdown of p85alpha with an antisense oligonucleotide improves insulin sensitivity in Lep(ob/ob) and diet-induced obese mice.

Moriarty MW, McCurdy CE, Janssen RC, Shaw T, Leitner JW, Friedman JE, Draznin B.

Horm Metab Res. 2009 Oct;41(10):757-61. Epub 2009 Jul 13.PMID: 19598077 [PubMed - in process]Related articles

Fenofibrate and PBA prevent fatty acid-induced loss of adiponectin receptor and pAMPK in human hepatoma cells and in hepatitis C virus-induced steatosis.

Rahman SM, Qadri I, Janssen RC, Friedman JE.

J Lipid Res. 2009 Jun 5. [Epub ahead of print]PMID: 19502591 [PubMed - as supplied by publisher]Related articlesFree article

Intrauterine growth restriction increases fetal hepatic gluconeogenic capacity and reduces messenger ribonucleic acid translation initiation and nutrient sensing in fetal liver and skeletal muscle.

Thorn SR, Regnault TR, Brown LD, Rozance PJ, Keng J, Roper M, Wilkening RB, Hay WW Jr, Friedman JE.

Endocrinology. 2009 Jul;150(7):3021-30. Epub 2009 Apr 2.PMID: 19342452 [PubMed - indexed for MEDLINE]Related articles

Maternal high-fat diet triggers lipotoxicity in the fetal livers of nonhuman primates.

McCurdy CE, Bishop JM, Williams SM, Grayson BE, Smith MS, Friedman JE, Grove KL.

J Clin Invest. 2009 Feb;119(2):323-35. doi: 10.1172/JCI32661. Epub 2009 Jan 19.PMID: 19147984 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of cyclin D1 and Wnt10b gene expression by cAMP-responsive element-binding protein during early adipogenesis involves differential promoter methylation.

Fox KE, Colton LA, Erickson PF, Friedman JE, Cha HC, Keller P, MacDougald OA, Klemm DJ.

J Biol Chem. 2008 Dec 12;283(50):35096-105. Epub 2008 Oct 27.PMID: 18957421 [PubMed - indexed for MEDLINE]Related articles

Skeletal muscle-specific deletion of lipoprotein lipase enhances insulin signaling in skeletal muscle but causes insulin resistance in liver and other tissues.

Wang H, Knaub LA, Jensen DR, Young Jung D, Hong EG, Ko HJ, Coates AM, Goldberg IJ, de la Houssaye BA, Janssen RC, McCurdy CE, Rahman SM, Soo Choi C, Shulman GI, Kim JK, Friedman JE, Eckel RH.

Diabetes. 2009 Jan;58(1):116-24. Epub 2008 Oct 24.PMID: 18952837 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin is required for amino acid stimulation of dual pathways for translational control in skeletal muscle in the late-gestation ovine fetus.

Brown LD, Rozance PJ, Barry JS, Friedman JE, Hay WW Jr.

Am J Physiol Endocrinol Metab. 2009 Jan;296(1):E56-63. Epub 2008 Oct 21.PMID: 18940943 [PubMed - indexed for MEDLINE]Related articles

Structure-activity relationship of ortho- and meta-phenol based LFA-1 ICAM inhibitors.

Lin EY, Guckian KM, Silvian L, Chin D, Boriack-Sjodin PA, van Vlijmen H, Friedman JE, Scott DM.

Bioorg Med Chem Lett. 2008 Oct 1;18(19):5245-8. Epub 2008 Aug 22.PMID: 18783948 [PubMed - indexed for MEDLINE]Related articles

Design and synthesis of a series of meta aniline-based LFA-1 ICAM inhibitors.

Guckian KM, Lin EY, Silvian L, Friedman JE, Chin D, Scott DM.

Bioorg Med Chem Lett. 2008 Oct 1;18(19):5249-51. Epub 2008 Aug 22.PMID: 18778938 [PubMed - indexed for MEDLINE]Related articles

Hepatitis C virus infection: molecular pathways to metabolic syndrome.

Sheikh MY, Choi J, Qadri I, Friedman JE, Sanyal AJ.

Hepatology. 2008 Jun;47(6):2127-33. Review.PMID: 18446789 [PubMed - indexed for MEDLINE]Related articles

SM16, an orally active TGF-beta type I receptor inhibitor prevents myofibroblast induction and vascular fibrosis in the rat carotid injury model.

Fu K, Corbley MJ, Sun L, Friedman JE, Shan F, Papadatos JL, Costa D, Lutterodt F, Sweigard H, Bowes S, Choi M, Boriack-Sjodin PA, Arduini RM, Sun D, Newman MN, Zhang X, Mead JN, Chuaqui CE, Cheung HK, Zhang X, Cornebise M, Carter MB, Josiah S, Singh J, Lee WC, Gill A, Ling LE.

Arterioscler Thromb Vasc Biol. 2008 Apr;28(4):665-71. Epub 2008 Jan 17.PMID: 18202322 [PubMed - indexed for MEDLINE]Related articlesFree article

The dual burden of infectious and non-communicable diseases in the Asia-Pacific region: examples from the Philippines and the Samoan Islands.

Friedman JE, Kurtis JD, McGarvey ST.

Med Health R I. 2007 Nov;90(11):346-50. Review. No abstract available. PMID: 18092484 [PubMed - indexed for MEDLINE]Related articles

Increased skeletal muscle tumor necrosis factor-alpha and impaired insulin signaling persist in obese women with gestational diabetes mellitus 1 year postpartum.

Friedman JE, Kirwan JP, Jing M, Presley L, Catalano PM.

Diabetes. 2008 Mar;57(3):606-13. Epub 2007 Dec 14.PMID: 18083784 [PubMed - indexed for MEDLINE]Related articlesFree article

Gouty attacks occur frequently in postoperative gastric bypass patients.

Friedman JE, Dallal RM, Lord JL.

Surg Obes Relat Dis. 2008 Jan-Feb;4(1):11-3. Epub 2007 Dec 11.PMID: 18065292 [PubMed - indexed for MEDLINE]Related articles

Chronic late-gestation hypoglycemia upregulates hepatic PEPCK associated with increased PGC1alpha mRNA and phosphorylated CREB in fetal sheep.

Rozance PJ, Limesand SW, Barry JS, Brown LD, Thorn SR, LoTurco D, Regnault TR, Friedman JE, Hay WW Jr.

Am J Physiol Endocrinol Metab. 2008 Feb;294(2):E365-70. Epub 2007 Dec 4.PMID: 18056789 [PubMed - indexed for MEDLINE]Related articlesFree article

Complete distal femoral metaphyseal fractures: a harbinger of child abuse before walking age.

Arkader A, Friedman JE, Warner WC Jr, Wells L.

J Pediatr Orthop. 2007 Oct-Nov;27(7):751-3.PMID: 17878779 [PubMed - indexed for MEDLINE]Related articles

The lipophilic metal chelators DP-109 and DP-460 are neuroprotective in a transgenic mouse model of amyotrophic lateral sclerosis.

Petri S, Calingasan NY, Alsaied OA, Wille E, Kiaei M, Friedman JE, Baranova O, Chavez JC, Beal MF.

J Neurochem. 2007 Aug;102(3):991-1000.PMID: 17630988 [PubMed - indexed for MEDLINE]Related articles

DP-155, a lecithin derivative of indomethacin, is a novel nonsteroidal antiinflammatory drug for analgesia and Alzheimer's disease therapy.

Dvir E, Elman A, Simmons D, Shapiro I, Duvdevani R, Dahan A, Hoffman A, Friedman JE.

CNS Drug Rev. 2007 Summer;13(2):260-77. Review.PMID: 17627676 [PubMed - indexed for MEDLINE]Related articles

Cellular mechanisms for insulin resistance in normal pregnancy and gestational diabetes.

Barbour LA, McCurdy CE, Hernandez TL, Kirwan JP, Catalano PM, Friedman JE.

Diabetes Care. 2007 Jul;30 Suppl 2:S112-9. No abstract available. Erratum in: Diabetes Care. 2007 Dec;30(12):3154. PMID: 17596458 [PubMed - indexed for MEDLINE]Related articlesFree article

Sequential regulation of diacylglycerol acyltransferase 2 expression by CAAT/enhancer-binding protein beta (C/EBPbeta) and C/EBPalpha during adipogenesis.

Payne VA, Au WS, Gray SL, Nora ED, Rahman SM, Sanders R, Hadaschik D, Friedman JE, O'rahilly S, Rochford JJ.

J Biol Chem. 2007 Jul 20;282(29):21005-14. Epub 2007 May 14.PMID: 17504763 [PubMed - indexed for MEDLINE]Related articlesFree article

Normal cervical spine range of motion in children 3-12 years old.

Arbogast KB, Gholve PA, Friedman JE, Maltese MR, Tomasello MF, Dormans JP.

Spine (Phila Pa 1976). 2007 May 1;32(10):E309-15.PMID: 17471079 [PubMed - indexed for MEDLINE]Related articles

CCAAT/enhancing binding protein beta deletion in mice attenuates inflammation, endoplasmic reticulum stress, and lipid accumulation in diet-induced nonalcoholic steatohepatitis.

Rahman SM, Schroeder-Gloeckler JM, Janssen RC, Jiang H, Qadri I, Maclean KN, Friedman JE.

Hepatology. 2007 May;45(5):1108-17.PMID: 17464987 [PubMed - indexed for MEDLINE]Related articles

CCAAT/enhancer-binding protein beta deletion reduces adiposity, hepatic steatosis, and diabetes in Lepr(db/db) mice.

Schroeder-Gloeckler JM, Rahman SM, Janssen RC, Qiao L, Shao J, Roper M, Fischer SJ, Lowe E, Orlicky DJ, McManaman JL, Palmer C, Gitomer WL, Huang W, O'Doherty RM, Becker TC, Klemm DJ, Jensen DR, Pulawa LK, Eckel RH, Friedman JE.

J Biol Chem. 2007 May 25;282(21):15717-29. Epub 2007 Mar 26.PMID: 17387171 [PubMed - indexed for MEDLINE]Related articlesFree article

Growth hormone regulation of p85alpha expression and phosphoinositide 3-kinase activity in adipose tissue: mechanism for growth hormone-mediated insulin resistance.

del Rincon JP, Iida K, Gaylinn BD, McCurdy CE, Leitner JW, Barbour LA, Kopchick JJ, Friedman JE, Draznin B, Thorner MO.

Diabetes. 2007 Jun;56(6):1638-46. Epub 2007 Mar 15.PMID: 17363744 [PubMed - indexed for MEDLINE]Related articlesFree article

Acetabular dysplasia with hip subluxation in Trevor's disease of the hip.

Arkader A, Friedman JE, Moroz L, Dormans JP.

Clin Orthop Relat Res. 2007 Apr;457:247-52.PMID: 17146363 [PubMed - indexed for MEDLINE]Related articles

A novel phospholipid derivative of indomethacin, DP-155 [mixture of 1-steroyl and 1-palmitoyl-2-{6-[1-(p-chlorobenzoyl)-5-methoxy-2-methyl-3-indolyl acetamido]hexanoyl}-sn-glycero-3-phosophatidyl [corrected] choline], shows superior safety and similar efficacy in reducing brain amyloid beta in an Alzheimer's disease model.

Dvir E, Friedman JE, Lee JY, Koh JY, Younis F, Raz S, Shapiro I, Hoffman A, Dahan A, Rosenberg G, Angel I, Kozak A, Duvdevani R.

J Pharmacol Exp Ther. 2006 Sep;318(3):1248-56. Epub 2006 Jun 8. Erratum in: J Pharmacol Exp Ther. 2006 Dec;319(3):1492. PMID: 16763096 [PubMed - indexed for MEDLINE]Related articlesFree article

Early foetal programming of hepatic gluconeogenesis: Glucocorticoids strike back.

McCurdy CE, Friedman JE.

Diabetologia. 2006 Jun;49(6):1138-41. No abstract available. PMID: 16680490 [PubMed - indexed for MEDLINE]Related articles

Developmental changes in ovine myocardial glucose transporters and insulin signaling following hyperthermia-induced intrauterine fetal growth restriction.

Barry JS, Davidsen ML, Limesand SW, Galan HL, Friedman JE, Regnault TR, Hay WW Jr.

Exp Biol Med (Maywood). 2006 May;231(5):566-75.PMID: 16636305 [PubMed - indexed for MEDLINE]Related articlesFree article

Iodotyrosine deiodinase is the first mammalian member of the NADH oxidase/flavin reductase superfamily.

Friedman JE, Watson JA Jr, Lam DW, Rokita SE.

J Biol Chem. 2006 Feb 3;281(5):2812-9. Epub 2005 Nov 29.PMID: 16316988 [PubMed - indexed for MEDLINE]Related articlesFree article

Small-molecule inhibition of TNF-alpha.

He MM, Smith AS, Oslob JD, Flanagan WM, Braisted AC, Whitty A, Cancilla MT, Wang J, Lugovskoy AA, Yoburn JC, Fung AD, Farrington G, Eldredge JK, Day ES, Cruz LA, Cachero TG, Miller SK, Friedman JE, Choong IC, Cunningham BC.

Science. 2005 Nov 11;310(5750):1022-5.PMID: 16284179 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased P85alpha is a potent negative regulator of skeletal muscle insulin signaling and induces in vivo insulin resistance associated with growth hormone excess.

Barbour LA, Mizanoor Rahman S, Gurevich I, Leitner JW, Fischer SJ, Roper MD, Knotts TA, Vo Y, McCurdy CE, Yakar S, Leroith D, Kahn CR, Cantley LC, Friedman JE, Draznin B.

J Biol Chem. 2005 Nov 11;280(45):37489-94. Epub 2005 Sep 8.PMID: 16166093 [PubMed - indexed for MEDLINE]Related articlesFree article

A randomized clinical trial of valacyclovir in multiple sclerosis.

Friedman JE, Zabriskie JB, Plank C, Ablashi D, Whitman J, Shahan B, Edgell R, Shieh M, Rapalino O, Zimmerman R, Sheng D.

Mult Scler. 2005 Jun;11(3):286-95.PMID: 15957509 [PubMed - indexed for MEDLINE]Related articles

Reproduction and transplantation: report on the AST Consensus Conference on Reproductive Issues and Transplantation.

McKay DB, Josephson MA, Armenti VT, August P, Coscia LA, Davis CL, Davison JM, Easterling T, Friedman JE, Hou S, Karlix J, Lake KD, Lindheimer M, Matas AJ, Moritz MJ, Riely CA, Ross LF, Scott JR, Wagoner LE, Wrenshall L, Adams PL, Bumgardner GL, Fine RN, Goral S, Krams SM, Martinez OM, Tolkoff-Rubin N, Pavlakis M, Scantlebury V; Women's Health Committee of the American Society of Transplantation.

Am J Transplant. 2005 Jul;5(7):1592-9. Review.PMID: 15943616 [PubMed - indexed for MEDLINE]Related articles

C/EBPalpha regulates human adiponectin gene transcription through an intronic enhancer.

Qiao L, Maclean PS, Schaack J, Orlicky DJ, Darimont C, Pagliassotti M, Friedman JE, Shao J.

Diabetes. 2005 Jun;54(6):1744-54.PMID: 15919796 [PubMed - indexed for MEDLINE]Related articlesFree article

Fetoplacental transport and utilization of amino acids in IUGR--a review.

Regnault TR, Friedman JE, Wilkening RB, Anthony RV, Hay WW Jr.

Placenta. 2005 Apr;26 Suppl A:S52-62. Review.PMID: 15837069 [PubMed - indexed for MEDLINE]Related articles

Therapeutic actions of an insulin receptor activator and a novel peroxisome proliferator-activated receptor gamma agonist in the spontaneously hypertensive obese rat model of metabolic syndrome X.

Velliquette RA, Friedman JE, Shao J, Zhang BB, Ernsberger P.

J Pharmacol Exp Ther. 2005 Jul;314(1):422-30. Epub 2005 Apr 15.PMID: 15833894 [PubMed - indexed for MEDLINE]Related articlesFree article

Chronic hyperglycemia enhances PEPCK gene expression and hepatocellular glucose production via elevated liver activating protein/liver inhibitory protein ratio.

Shao J, Qiao L, Janssen RC, Pagliassotti M, Friedman JE.

Diabetes. 2005 Apr;54(4):976-84.PMID: 15793235 [PubMed - indexed for MEDLINE]Related articlesFree article

Co-localization of human herpes virus 6 and tissue plasminogen activator in multiple sclerosis brain tissue.

Virtanen JO, Zabriskie JB, Sirén V, Friedman JE, Lyons MJ, Edgar M, Vaheri A, Koskiniemi M.

Med Sci Monit. 2005 Mar;11(3):BR84-7.PMID: 15735559 [PubMed - indexed for MEDLINE]Related articles

Effects of acute hyperinsulinemia on insulin signal transduction and glucose transporters in ovine fetal skeletal muscle.

Anderson MS, Thamotharan M, Kao D, Devaskar SU, Qiao L, Friedman JE, Hay WW Jr.

Am J Physiol Regul Integr Comp Physiol. 2005 Feb;288(2):R473-81. Epub 2004 Nov 11.PMID: 15539611 [PubMed - indexed for MEDLINE]Related articles

The lipophilic metal chelator DP-109 reduces amyloid pathology in brains of human beta-amyloid precursor protein transgenic mice.

Lee JY, Friedman JE, Angel I, Kozak A, Koh JY.

Neurobiol Aging. 2004 Nov-Dec;25(10):1315-21.PMID: 15465629 [PubMed - indexed for MEDLINE]Related articles

Reversal of insulin resistance postpartum is linked to enhanced skeletal muscle insulin signaling.

Kirwan JP, Varastehpour A, Jing M, Presley L, Shao J, Friedman JE, Catalano PM.

J Clin Endocrinol Metab. 2004 Sep;89(9):4678-84.PMID: 15356080 [PubMed - indexed for MEDLINE]Related articlesFree article

Human placental growth hormone increases expression of the p85 regulatory unit of phosphatidylinositol 3-kinase and triggers severe insulin resistance in skeletal muscle.

Barbour LA, Shao J, Qiao L, Leitner W, Anderson M, Friedman JE, Draznin B.

Endocrinology. 2004 Mar;145(3):1144-50. Epub 2003 Nov 21.PMID: 14633976 [PubMed - indexed for MEDLINE]Related articlesFree article

Prolactin, progesterone, and dexamethasone coordinately and adversely regulate glucokinase and cAMP/PDE cascades in MIN6 beta-cells.

Shao J, Qiao L, Friedman JE.

Am J Physiol Endocrinol Metab. 2004 Feb;286(2):E304-10. Epub 2003 Oct 14.PMID: 14559722 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of spontaneous gestational diabetes on fetal and postnatal hepatic insulin resistance in Lepr(db/+) mice.

Yamashita H, Shao J, Qiao L, Pagliassotti M, Friedman JE.

Pediatr Res. 2003 Mar;53(3):411-8.PMID: 12595588 [PubMed - indexed for MEDLINE]Related articles

Mechanisms of p75-mediated death of hippocampal neurons. Role of caspases.

Troy CM, Friedman JE, Friedman WJ.

J Biol Chem. 2002 Sep 13;277(37):34295-302. Epub 2002 Jul 3.PMID: 12097334 [PubMed - indexed for MEDLINE]Related articlesFree article

TNF-alpha is a predictor of insulin resistance in human pregnancy.

Kirwan JP, Hauguel-De Mouzon S, Lepercq J, Challier JC, Huston-Presley L, Friedman JE, Kalhan SC, Catalano PM.

Diabetes. 2002 Jul;51(7):2207-13.PMID: 12086951 [PubMed - indexed for MEDLINE]Related articlesFree article

Phosphoenolpyruvate carboxykinase overexpression selectively attenuates insulin signaling and hepatic insulin sensitivity in transgenic mice.

Sun Y, Liu S, Ferguson S, Wang L, Klepcyk P, Yun JS, Friedman JE.

J Biol Chem. 2002 Jun 28;277(26):23301-7. Epub 2002 Apr 18.PMID: 11964395 [PubMed - indexed for MEDLINE]Related articlesFree article

Human placental growth hormone causes severe insulin resistance in transgenic mice.

Barbour LA, Shao J, Qiao L, Pulawa LK, Jensen DR, Bartke A, Garrity M, Draznin B, Friedman JE.

Am J Obstet Gynecol. 2002 Mar;186(3):512-7.PMID: 11904616 [PubMed - indexed for MEDLINE]Related articles