PubMed

Engineering prolonged-acting prodrugs employing an albumin-binding probe that undergoes slow hydrolysis at physiological conditions.

Sasson K, Marcus Y, Lev-Goldman V, Rubinraut S, Fridkin M, Shechter Y.

J Control Release. 2009 Oct 30. [Epub ahead of print]PMID: 19883707 [PubMed - as supplied by publisher]Related articles

Restoration of Nigrostriatal Dopamine Neurons in Post-MPTP Treatment by the Novel Multifunctional Brain-Permeable Iron Chelator-Monoamine Oxidase Inhibitor Drug, M30.

Gal S, Zheng H, Fridkin M, Youdim MB.

Neurotox Res. 2009 Jul 16. [Epub ahead of print]PMID: 19609632 [PubMed - as supplied by publisher]Related articles

Site-activated multifunctional chelator with acetylcholinesterase and neuroprotective-neurorestorative moieties for Alzheimer's therapy.

Zheng H, Youdim MB, Fridkin M.

J Med Chem. 2009 Jul 23;52(14):4095-8.PMID: 19485411 [PubMed - indexed for MEDLINE]Related articles

Restrain of bone growth by estrogen-mimetic peptide-1 (EMP-1): a micro-computed tomographic study.

Kasher R, Bajayo A, Gabet Y, Nevo N, Fridkin M, Katchalski-Katzir E, Kohen F, Bab I.

Peptides. 2009 Jun;30(6):1181-6. Epub 2009 Mar 14.PMID: 19463753 [PubMed - indexed for MEDLINE]Related articles

The amyloidogenic domains of the human serum amyloid A protein--new insights.

Perugia E, Monticelli E, Rubinraut S, Kapitkovsky A, Fridkin M.

Adv Exp Med Biol. 2009;611:69-70. No abstract available. PMID: 19400097 [PubMed - indexed for MEDLINE]Related articles

Turning low-molecular-weight drugs into prolonged acting prodrugs by reversible pegylation: a study with gentamicin.

Marcus Y, Sasson K, Fridkin M, Shechter Y.

J Med Chem. 2008 Jul 24;51(14):4300-5. Epub 2008 Jun 25.PMID: 18578475 [PubMed - indexed for MEDLINE]Related articles

Conjugates of gonadotropin releasing hormone (GnRH) with carminic acid: Synthesis, generation of reactive oxygen species (ROS) and biological evaluation.

Lev-Goldman V, Mester B, Ben-Aroya N, Hanoch T, Rupp B, Stanoeva T, Gescheidt G, Seger R, Koch Y, Weiner L, Fridkin M.

Bioorg Med Chem. 2008 Jul 15;16(14):6789-98. Epub 2008 Jun 19.PMID: 18571926 [PubMed - indexed for MEDLINE]Related articles

Reversible pegylation of insulin facilitates its prolonged action in vivo.

Shechter Y, Mironchik M, Rubinraut S, Tsubery H, Sasson K, Marcus Y, Fridkin M.

Eur J Pharm Biopharm. 2008 Sep;70(1):19-28. Epub 2008 Apr 7.PMID: 18495444 [PubMed - indexed for MEDLINE]Related articles

The molecular and cellular basis of exostosis formation in hereditary multiple exostoses.

Trebicz-Geffen M, Robinson D, Evron Z, Glaser T, Fridkin M, Kollander Y, Vlodavsky I, Ilan N, Law KF, Cheah KS, Chan D, Werner H, Nevo Z.

Int J Exp Pathol. 2008 Oct;89(5):321-31. Epub 2008 Apr 30.PMID: 18452536 [PubMed - indexed for MEDLINE]Related articles

Chirality of amyloid suprastructures.

Rubin N, Perugia E, Goldschmidt M, Fridkin M, Addadi L.

J Am Chem Soc. 2008 Apr 9;130(14):4602-3. Epub 2008 Mar 14.PMID: 18338897 [PubMed - indexed for MEDLINE]Related articlesFree article

Pneumococcal capsular polysaccharide is immunogenic when present on the surface of macrophages and dendritic cells: TLR4 signaling induced by a conjugate vaccine or by lipopolysaccharide is conducive.

Cohen N, Stolarsky-Bennun M, Amir-Kroll H, Margalit R, Nussbaum G, Cohen-Sfady M, Pevsner-Fischer M, Fridkin M, Bercovier H, Eisenbach L, Jung S, Cohen IR.

J Immunol. 2008 Feb 15;180(4):2409-18.PMID: 18250450 [PubMed - indexed for MEDLINE]Related articlesFree article

Novel multifunctional anti-Alzheimer drugs with various CNS neurotransmitter targets and neuroprotective moieties.

Van der Schyf CJ, Mandel S, Geldenhuys WJ, Amit T, Avramovich Y, Zheng H, Fridkin M, Gal S, Weinreb O, Bar Am O, Sagi Y, Youdim MB.

Curr Alzheimer Res. 2007 Dec;4(5):522-36. Review.PMID: 18220515 [PubMed - indexed for MEDLINE]Related articles

A Novel iron-chelating derivative of the neuroprotective peptide NAPVSIPQ shows superior antioxidant and antineurodegenerative capabilities.

Blat D, Weiner L, Youdim MB, Fridkin M.

J Med Chem. 2008 Jan 10;51(1):126-34. Epub 2007 Dec 14.PMID: 18078312 [PubMed - indexed for MEDLINE]Related articles

'1-8 interferon inducible gene family': putative colon carcinoma-associated antigens.

Tirosh B, Daniel-Carmi V, Carmon L, Paz A, Lugassy G, Vadai E, Machlenkin A, Bar-Haim E, Do MS, Ahn IS, Fridkin M, Tzehoval E, Eisenbach L.

Br J Cancer. 2007 Dec 17;97(12):1655-63. Epub 2007 Dec 11.PMID: 18071348 [PubMed - indexed for MEDLINE]Related articlesFree article

Reversible pegylation prolongs the hypotensive effect of atrial natriuretic peptide.

Nesher M, Vachutinsky Y, Fridkin G, Schwarz Y, Sasson K, Fridkin M, Shechter Y, Lichtstein D.

Bioconjug Chem. 2008 Jan;19(1):342-8. Epub 2007 Dec 11.PMID: 18069777 [PubMed - indexed for MEDLINE]Related articles

Novel glycosylated VIP analogs: synthesis, biological activity, and metabolic stability.

Dangoor D, Biondi B, Gobbo M, Vachutinski Y, Fridkin M, Gozes I, Rocchi R.

J Pept Sci. 2008 Mar;14(3):321-8.PMID: 17924396 [PubMed - indexed for MEDLINE]Related articles

Neurorescue activity, APP regulation and amyloid-beta peptide reduction by novel multi-functional brain permeable iron- chelating- antioxidants, M-30 and green tea polyphenol, EGCG.

Avramovich-Tirosh Y, Reznichenko L, Mit T, Zheng H, Fridkin M, Weinreb O, Mandel S, Youdim MB.

Curr Alzheimer Res. 2007 Sep;4(4):403-11.PMID: 17908043 [PubMed - indexed for MEDLINE]Related articles

Prevention and restoration of lactacystin-induced nigrostriatal dopamine neuron degeneration by novel brain-permeable iron chelators.

Zhu W, Xie W, Pan T, Xu P, Fridkin M, Zheng H, Jankovic J, Youdim MB, Le W.

FASEB J. 2007 Dec;21(14):3835-44. Epub 2007 Aug 9.PMID: 17690154 [PubMed - indexed for MEDLINE]Related articlesFree article

The efficacy of specific IVIG anti-idiotypic antibodies in antiphospholipid syndrome (APS): trophoblast invasiveness and APS animal model.

Blank M, Anafi L, Zandman-Goddard G, Krause I, Goldman S, Shalev E, Cervera R, Font J, Fridkin M, Thiesen HJ, Shoenfeld Y.

Int Immunol. 2007 Jul;19(7):857-65. Epub 2007 Jun 18.PMID: 17576752 [PubMed - indexed for MEDLINE]Related articlesFree article

Novel analogs of VIP with multiple C-terminal domains.

Dangoor D, Rubinraut S, Fridkin M, Gozes I.

Peptides. 2007 Sep;28(9):1622-30. Epub 2007 Mar 30.PMID: 17481779 [PubMed - indexed for MEDLINE]Related articles

Novel neuroprotective neurotrophic NAP analogs targeting metal toxicity and oxidative stress: potential candidates for the control of neurodegenerative diseases.

Zheng H, Blat D, Fridkin M.

J Neural Transm Suppl. 2006;(71):163-72.PMID: 17447427 [PubMed - indexed for MEDLINE]Related articles

Therapeutic targets and potential of the novel brain- permeable multifunctional iron chelator-monoamine oxidase inhibitor drug, M-30, for the treatment of Alzheimer's disease.

Avramovich-Tirosh Y, Amit T, Bar-Am O, Zheng H, Fridkin M, Youdim MB.

J Neurochem. 2007 Jan;100(2):490-502. Epub 2006 Nov 27.PMID: 17144902 [PubMed - indexed for MEDLINE]Related articles

[Luliberin analogues exhibiting a cytotoxic effect on tumor cells in vitro]

Burov SV, Iablokova TV, Dorosh MIu, Shkarubskaia ZP, Blank M, Epshteĭn N, Fridkin M.

Bioorg Khim. 2006 Sep-Oct;32(5):459-66. Russian. PMID: 17042263 [PubMed - indexed for MEDLINE]Related articles

M30, a novel multifunctional neuroprotective drug with potent iron chelating and brain selective monoamine oxidase-ab inhibitory activity for Parkinson's disease.

Gal S, Fridkin M, Amit T, Zheng H, Youdim MB.

J Neural Transm Suppl. 2006;(70):447-56.PMID: 17017567 [PubMed - indexed for MEDLINE]Related articles

Novel extended and branched N-terminal analogs of VIP.

Dangoor D, Rubinraut S, Fridkin M, Gozes I.

Regul Pept. 2006 Nov 15;137(1-2):42-9. Epub 2006 Sep 8.PMID: 16962672 [PubMed - indexed for MEDLINE]Related articles

Synthesis and active oxygen generation by new emodin derivatives and their gonadotropin-releasing hormone conjugates.

Lev-Goldman V, Mester B, Ben-Aroya N, Koch Y, Weiner L, Fridkin M.

Bioconjug Chem. 2006 Jul-Aug;17(4):1008-16.PMID: 16848409 [PubMed - indexed for MEDLINE]Related articles

The substrate-binding domain of 21-hydroxylase, the main autoantigen in autoimmune Addison's disease, is an immunodominant T cell epitope.

Husebye ES, Bratland E, Bredholt G, Fridkin M, Dayan M, Mozes E.

Endocrinology. 2006 May;147(5):2411-6. Epub 2006 Feb 23.PMID: 16497795 [PubMed - indexed for MEDLINE]Related articlesFree article

Subtle differences in structural transitions between poly-L- and poly-D-amino acids of equal length in water.

Scolnik Y, Portnaya I, Cogan U, Tal S, Haimovitz R, Fridkin M, Elitzur AC, Deamer DW, Shinitzky M.

Phys Chem Chem Phys. 2006 Jan 21;8(3):333-9. Epub 2005 Dec 5.PMID: 16482275 [PubMed - indexed for MEDLINE]Related articlesFree article

Novel potential neuroprotective agents with both iron chelating and amino acid-based derivatives targeting central nervous system neurons.

Zheng H, Youdim MB, Weiner LM, Fridkin M.

Biochem Pharmacol. 2005 Nov 25;70(11):1642-52. Epub 2005 Oct 13.PMID: 16226724 [PubMed - indexed for MEDLINE]Related articles

Novel multifunctional neuroprotective iron chelator-monoamine oxidase inhibitor drugs for neurodegenerative diseases. In vivo selective brain monoamine oxidase inhibition and prevention of MPTP-induced striatal dopamine depletion.

Gal S, Zheng H, Fridkin M, Youdim MB.

J Neurochem. 2005 Oct;95(1):79-88.PMID: 16181414 [PubMed - indexed for MEDLINE]Related articles

Novel multifunctional neuroprotective iron chelator-monoamine oxidase inhibitor drugs for neurodegenerative diseases: in vitro studies on antioxidant activity, prevention of lipid peroxide formation and monoamine oxidase inhibition.

Zheng H, Gal S, Weiner LM, Bar-Am O, Warshawsky A, Fridkin M, Youdim MB.

J Neurochem. 2005 Oct;95(1):68-78.PMID: 16181413 [PubMed - indexed for MEDLINE]Related articles

Synthesis and evaluation of peptidic metal chelators for neuroprotection in neurodegenerative diseases.

Zheng H, Youdim MB, Weiner LM, Fridkin M.

J Pept Res. 2005 Oct;66(4):190-203.PMID: 16138857 [PubMed - indexed for MEDLINE]Related articles

Novel cyclic azo-bridged analogs of gonadotropin-releasing hormone.

Fridkin G, Rahimipour S, Ben-Aroya N, Kapitkovsky A, Di-Segni S, Rosenberg M, Kustanovich I, Koch Y, Gilon C, Fridkin M.

J Pept Sci. 2006 Feb;12(2):106-15.PMID: 16059965 [PubMed - indexed for MEDLINE]Related articles

Neopeptide antibiotics that function as opsonins and membrane-permeabilizing agents for gram-negative bacteria.

Tsubery H, Yaakov H, Cohen S, Giterman T, Matityahou A, Fridkin M, Ofek I.

Antimicrob Agents Chemother. 2005 Aug;49(8):3122-8.PMID: 16048913 [PubMed - indexed for MEDLINE]Related articlesFree article

Albumin-insulin conjugate releasing insulin slowly under physiological conditions: a new concept for long-acting insulin.

Shechter Y, Mironchik M, Rubinraut S, Saul A, Tsubery H, Fridkin M.

Bioconjug Chem. 2005 Jul-Aug;16(4):913-20.PMID: 16029032 [PubMed - indexed for MEDLINE]Related articles

Neuropeptide receptor transcripts are expressed in the rat clitoris and oscillate during the estrus cycle in the rat vagina.

Dangoor D, Giladi E, Fridkin M, Gozes I.

Peptides. 2005 Dec;26(12):2579-84. Epub 2005 Jul 14.PMID: 16023261 [PubMed - indexed for MEDLINE]Related articles

Identification of Ser153 in ICL2 of the gonadotropin-releasing hormone (GnRH) receptor as a phosphorylation-independent site for inhibition of Gq coupling.

Shacham S, Cheifetz MN, Fridkin M, Pawson AJ, Millar RP, Naor Z.

J Biol Chem. 2005 Aug 12;280(32):28981-8. Epub 2005 Jun 17.PMID: 15964850 [PubMed - indexed for MEDLINE]Related articlesFree article

Reversible PEGylation of peptide YY3-36 prolongs its inhibition of food intake in mice.

Shechter Y, Tsubery H, Mironchik M, Rubinstein M, Fridkin M.

FEBS Lett. 2005 Apr 25;579(11):2439-44.PMID: 15848185 [PubMed - indexed for MEDLINE]Related articles

Design, synthesis, and evaluation of novel bifunctional iron-chelators as potential agents for neuroprotection in Alzheimer's, Parkinson's, and other neurodegenerative diseases.

Zheng H, Weiner LM, Bar-Am O, Epsztejn S, Cabantchik ZI, Warshawsky A, Youdim MB, Fridkin M.

Bioorg Med Chem. 2005 Feb 1;13(3):773-83.PMID: 15653345 [PubMed - indexed for MEDLINE]Related articles

Novel methyl helianthrones as photosensitizers: synthesis and biological evaluation.

Rahimipour S, Litichever-Coslovsky N, Alaluf M, Freeman D, Ehrenberg B, Weiner L, Mazur Y, Fridkin M, Koch Y.

Photochem Photobiol. 2005 Mar-Apr;81(2):250-8.PMID: 15646998 [PubMed - indexed for MEDLINE]Related articles

beta-Sulfonamido gonadotropin-releasing hormone analogs: synthesis and evaluation of several parent hormone properties.

Di-Segni S, Giordano C, Rahimipour S, Ben-Aroya N, Koch Y, Fridkin M.

J Pept Sci. 2005 Jan;11(1):45-52.PMID: 15635726 [PubMed - indexed for MEDLINE]Related articles

Tuftsin-AZT conjugate: potential macrophage targeting for AIDS therapy.

Fridkin M, Tsubery H, Tzehoval E, Vonsover A, Biondi L, Filira F, Rocchi R.

J Pept Sci. 2005 Jan;11(1):37-44.PMID: 15635725 [PubMed - indexed for MEDLINE]Related articles

Bifunctional drug derivatives of MAO-B inhibitor rasagiline and iron chelator VK-28 as a more effective approach to treatment of brain ageing and ageing neurodegenerative diseases.

Youdim MB, Fridkin M, Zheng H.

Mech Ageing Dev. 2005 Feb;126(2):317-26. Review.PMID: 15621213 [PubMed - indexed for MEDLINE]Related articles

Novel bifunctional drugs targeting monoamine oxidase inhibition and iron chelation as an approach to neuroprotection in Parkinson's disease and other neurodegenerative diseases.

Youdim MB, Fridkin M, Zheng H.

J Neural Transm. 2004 Oct;111(10-11):1455-71. Epub 2004 Apr 20.PMID: 15480846 [PubMed - indexed for MEDLINE]Related articles

Design, synthesis, and evaluation of peptides with estrogen-like activity.

Kasher R, Gayer B, Kulik T, Somjen D, Venkatesh N, Fridkin M, Katchalski-Katzir E, Kohen F.

Biopolymers. 2004;76(5):404-20.PMID: 15468062 [PubMed - indexed for MEDLINE]Related articles

Backbone metal cyclization: novel 99mTc labeled GnRH analog as potential SPECT molecular imaging agent in cancer.

Barda Y, Cohen N, Lev V, Ben-Aroya N, Koch Y, Mishani E, Fridkin M, Gilon C.

Nucl Med Biol. 2004 Oct;31(7):921-33.PMID: 15464394 [PubMed - indexed for MEDLINE]Related articles

Reversible PEGylation: a novel technology to release native interferon alpha2 over a prolonged time period.

Peleg-Shulman T, Tsubery H, Mironchik M, Fridkin M, Schreiber G, Shechter Y.

J Med Chem. 2004 Sep 23;47(20):4897-904.PMID: 15369394 [PubMed - indexed for MEDLINE]Related articles

Prolonging the action of protein and peptide drugs by a novel approach of reversible polyethylene glycol modification.

Tsubery H, Mironchik M, Fridkin M, Shechter Y.

J Biol Chem. 2004 Sep 10;279(37):38118-24. Epub 2004 Jun 8.PMID: 15190059 [PubMed - indexed for MEDLINE]Related articlesFree article

A peptide that shares similarity with bacterial antigens reverses thrombogenic properties of antiphospholipid antibodies in vivo.

Pierangeli SS, Blank M, Liu X, Espinola R, Fridkin M, Ostertag MV, Roye-Green K, Harris EN, Shoenfeld Y.

J Autoimmun. 2004 May;22(3):217-25.PMID: 15041042 [PubMed - indexed for MEDLINE]Related articles

The binding site of acetylcholine receptor: from synthetic peptides to solution and crystal structure.

Fuchs S, Kasher R, Balass M, Scherf T, Harel M, Fridkin M, Sussman JL, Katchalski-Katzir E.

Ann N Y Acad Sci. 2003 Sep;998:93-100. Review.PMID: 14592866 [PubMed - indexed for MEDLINE]Related articles