PubMed

Substrate utilization by the failing human heart by direct quantification using arterio-venous blood sampling.

Funada J, Betts TR, Hodson L, Humphreys SM, Timperley J, Frayn KN, Karpe F.

PLoS One. 2009 Oct 21;4(10):e7533.PMID: 19844574 [PubMed - in process]Related articlesFree article

Dietary Approaches to Stop Hypertension (DASH) diet: applicability and acceptability to a UK population.

Harnden KE, Frayn KN, Hodson L.

J Hum Nutr Diet. 2009 Oct 15. [Epub ahead of print]PMID: 19843201 [PubMed - as supplied by publisher]Related articles

Addition of n-3 fatty acids to a 4-hour lipid infusion does not affect insulin sensitivity, insulin secretion, or markers of oxidative stress in subjects with type 2 diabetes mellitus.

Mostad IL, Bjerve KS, Basu S, Sutton P, Frayn KN, Grill V.

Metabolism. 2009 Dec;58(12):1753-61. Epub 2009 Aug 27.PMID: 19716144 [PubMed - in process]Related articles

Does the DASH diet lower blood pressure by altering peripheral vascular function?

Hodson L, Harnden KE, Roberts R, Dennis AL, Frayn KN.

J Hum Hypertens. 2009 Aug 6. [Epub ahead of print]PMID: 19657359 [PubMed - as supplied by publisher]Related articles

Liver fat and lipid oxidation in humans.

Kotronen A, Seppälä-Lindroos A, Vehkavaara S, Bergholm R, Frayn KN, Fielding BA, Yki-Järvinen H.

Liver Int. 2009 Oct;29(9):1439-46. Epub 2009 Jul 7.PMID: 19602132 [PubMed - indexed for MEDLINE]Related articles

Markers of de novo lipogenesis in adipose tissue: associations with small adipocytes and insulin sensitivity in humans.

Roberts R, Hodson L, Dennis AL, Neville MJ, Humphreys SM, Harnden KE, Micklem KJ, Frayn KN.

Diabetologia. 2009 May;52(5):882-90. Epub 2009 Feb 28.PMID: 19252892 [PubMed - indexed for MEDLINE]Related articles

Fasted to fed trafficking of Fatty acids in human adipose tissue reveals a novel regulatory step for enhanced fat storage.

Ruge T, Hodson L, Cheeseman J, Dennis AL, Fielding BA, Humphreys SM, Frayn KN, Karpe F.

J Clin Endocrinol Metab. 2009 May;94(5):1781-8. Epub 2009 Feb 17.PMID: 19223522 [PubMed - indexed for MEDLINE]Related articles

Transcriptional control of human adipose tissue blood flow.

Perez-Matute P, Neville MJ, Tan GD, Frayn KN, Karpe F.

Obesity (Silver Spring). 2009 Apr;17(4):681-8. Epub 2009 Jan 22.PMID: 19165164 [PubMed - indexed for MEDLINE]Related articles

Elevated expression of osteopontin may be related to adipose tissue macrophage accumulation and liver steatosis in morbid obesity.

Bertola A, Deveaux V, Bonnafous S, Rousseau D, Anty R, Wakkach A, Dahman M, Tordjman J, Clément K, McQuaid SE, Frayn KN, Huet PM, Gugenheim J, Lotersztajn S, Le Marchand-Brustel Y, Tran A, Gual P.

Diabetes. 2009 Jan;58(1):125-33. Epub 2008 Oct 24.PMID: 18952835 [PubMed - indexed for MEDLINE]Related articlesFree article

Differences in partitioning of meal fatty acids into blood lipid fractions: a comparison of linoleate, oleate, and palmitate.

Hodson L, McQuaid SE, Karpe F, Frayn KN, Fielding BA.

Am J Physiol Endocrinol Metab. 2009 Jan;296(1):E64-71. Epub 2008 Oct 21.PMID: 18940935 [PubMed - indexed for MEDLINE]Related articles

Fatty acid metabolism in patients with PPARgamma mutations.

Tan GD, Savage DB, Fielding BA, Collins J, Hodson L, Humphreys SM, O'Rahilly S, Chatterjee K, Frayn KN, Karpe F.

J Clin Endocrinol Metab. 2008 Nov;93(11):4462-70. Epub 2008 Aug 19.PMID: 18713822 [PubMed - indexed for MEDLINE]Related articlesFree article

Adipose tissue fatty acid metabolism in insulin-resistant men.

Bickerton AS, Roberts R, Fielding BA, Tornqvist H, Blaak EE, Wagenmakers AJ, Gilbert M, Humphreys SM, Karpe F, Frayn KN.

Diabetologia. 2008 Aug;51(8):1466-74. Epub 2008 May 27. Erratum in: Diabetologia. 2008 Oct;51(10):1936. PMID: 18504545 [PubMed - indexed for MEDLINE]Related articles

Reduced oxidation of dietary fat after a short term high-carbohydrate diet.

Roberts R, Bickerton AS, Fielding BA, Blaak EE, Wagenmakers AJ, Chong MF, Gilbert M, Karpe F, Frayn KN.

Am J Clin Nutr. 2008 Apr;87(4):824-31.PMID: 18400703 [PubMed - indexed for MEDLINE]Related articlesFree article

Parallel activation of de novo lipogenesis and stearoyl-CoA desaturase activity after 3 d of high-carbohydrate feeding.

Chong MF, Hodson L, Bickerton AS, Roberts R, Neville M, Karpe F, Frayn KN, Fielding BA.

Am J Clin Nutr. 2008 Apr;87(4):817-23.PMID: 18400702 [PubMed - indexed for MEDLINE]Related articlesFree article

Remodeling phenotype of human subcutaneous adipose tissue macrophages.

Bourlier V, Zakaroff-Girard A, Miranville A, De Barros S, Maumus M, Sengenes C, Galitzky J, Lafontan M, Karpe F, Frayn KN, Bouloumié A.

Circulation. 2008 Feb 12;117(6):806-15. Epub 2008 Jan 28.PMID: 18227385 [PubMed - indexed for MEDLINE]Related articlesFree article

Leukocyte activation by triglyceride-rich lipoproteins.

Alipour A, van Oostrom AJ, Izraeljan A, Verseyden C, Collins JM, Frayn KN, Plokker TW, Elte JW, Castro Cabezas M.

Arterioscler Thromb Vasc Biol. 2008 Apr;28(4):792-7. Epub 2008 Jan 24.PMID: 18218988 [PubMed - indexed for MEDLINE]Related articlesFree article

Fatty acid-induced mitochondrial uncoupling in adipocytes is not a promising target for treatment of insulin resistance unless adipocyte oxidative capacity is increased.

Frayn KN, Langin D, Karpe F.

Diabetologia. 2008 Mar;51(3):394-7. Epub 2007 Dec 21.PMID: 18097647 [PubMed - indexed for MEDLINE]Related articles

Effects of short-term low- and high-carbohydrate diets on postprandial metabolism in non-diabetic and diabetic subjects.

Culling KS, Neil HA, Gilbert M, Frayn KN.

Nutr Metab Cardiovasc Dis. 2009 Jun;19(5):345-51. Epub 2007 Dec 20.PMID: 18083355 [PubMed - indexed for MEDLINE]Related articles

Effect of beta-adrenergic stimulation on whole-body and abdominal subcutaneous adipose tissue lipolysis in lean and obese men.

Jocken JW, Goossens GH, van Hees AM, Frayn KN, van Baak M, Stegen J, Pakbiers MT, Saris WH, Blaak EE.

Diabetologia. 2008 Feb;51(2):320-7. Epub 2007 Dec 5.PMID: 18060661 [PubMed - indexed for MEDLINE]Related articlesFree article

Activation of peroxisome proliferator-activated receptor (PPAR)delta promotes reversal of multiple metabolic abnormalities, reduces oxidative stress, and increases fatty acid oxidation in moderately obese men.

Risérus U, Sprecher D, Johnson T, Olson E, Hirschberg S, Liu A, Fang Z, Hegde P, Richards D, Sarov-Blat L, Strum JC, Basu S, Cheeseman J, Fielding BA, Humphreys SM, Danoff T, Moore NR, Murgatroyd P, O'Rahilly S, Sutton P, Willson T, Hassall D, Frayn KN, Karpe F.

Diabetes. 2008 Feb;57(2):332-9. Epub 2007 Nov 16.PMID: 18024853 [PubMed - indexed for MEDLINE]Related articlesFree article

Adipose tissue: a key target for diabetes pathophysiology and treatment?

Frayn KN, Tan GD, Karpe F.

Horm Metab Res. 2007 Oct;39(10):739-42. Review.PMID: 17952837 [PubMed - indexed for MEDLINE]Related articles

The contribution of splanchnic fat to VLDL triglyceride is greater in insulin-resistant than insulin-sensitive men and women: studies in the postprandial state.

Hodson L, Bickerton AS, McQuaid SE, Roberts R, Karpe F, Frayn KN, Fielding BA.

Diabetes. 2007 Oct;56(10):2433-41. Epub 2007 Jun 29.PMID: 17601988 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanisms for the acute effect of fructose on postprandial lipemia.

Chong MF, Fielding BA, Frayn KN.

Am J Clin Nutr. 2007 Jun;85(6):1511-20.PMID: 17556686 [PubMed - indexed for MEDLINE]Related articlesFree article

Removal of triacylglycerols from chylomicrons and VLDL by capillary beds: the basis of lipoprotein remnant formation.

Karpe F, Bickerton AS, Hodson L, Fielding BA, Tan GD, Frayn KN.

Biochem Soc Trans. 2007 Jun;35(Pt 3):472-6. Review.PMID: 17511631 [PubMed - indexed for MEDLINE]Related articles

Tissue-specific stable isotope measurements of postprandial lipid metabolism in familial combined hyperlipidaemia.

Evans K, Burdge GC, Wootton SA, Collins JM, Clark ML, Tan GD, Karpe F, Frayn KN.

Atherosclerosis. 2008 Mar;197(1):164-70. Epub 2007 Apr 26.PMID: 17466309 [PubMed - indexed for MEDLINE]Related articles

Metabolic interaction of dietary sugars and plasma lipids with a focus on mechanisms and de novo lipogenesis.

Chong MF, Fielding BA, Frayn KN.

Proc Nutr Soc. 2007 Feb;66(1):52-9. Review.PMID: 17343772 [PubMed - indexed for MEDLINE]Related articles

Acute and selective regulation of glyceroneogenesis and cytosolic phosphoenolpyruvate carboxykinase in adipose tissue by thiazolidinediones in type 2 diabetes.

Cadoudal T, Blouin JM, Collinet M, Fouque F, Tan GD, Loizon E, Beale EG, Frayn KN, Karpe F, Vidal H, Benelli C, Forest C.

Diabetologia. 2007 Mar;50(3):666-75. Epub 2007 Jan 23.PMID: 17242918 [PubMed - indexed for MEDLINE]Related articles

Preferential uptake of dietary Fatty acids in adipose tissue and muscle in the postprandial period.

Bickerton AS, Roberts R, Fielding BA, Hodson L, Blaak EE, Wagenmakers AJ, Gilbert M, Karpe F, Frayn KN.

Diabetes. 2007 Jan;56(1):168-76.PMID: 17192479 [PubMed - indexed for MEDLINE]Related articlesFree article

Fatty acid metabolism in adipose tissue, muscle and liver in health and disease.

Frayn KN, Arner P, Yki-Järvinen H.

Essays Biochem. 2006;42:89-103. Review.PMID: 17144882 [PubMed - indexed for MEDLINE]Related articles

Dietary fatty acids make a rapid and substantial contribution to VLDL-triacylglycerol in the fed state.

Heath RB, Karpe F, Milne RW, Burdge GC, Wootton SA, Frayn KN.

Am J Physiol Endocrinol Metab. 2007 Mar;292(3):E732-9. Epub 2006 Nov 7.PMID: 17090753 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin sensitisation affects lipoprotein lipase transport in type 2 diabetes: role of adipose tissue and skeletal muscle in response to rosiglitazone.

Tan GD, Olivecrona G, Vidal H, Frayn KN, Karpe F.

Diabetologia. 2006 Oct;49(10):2412-8. Epub 2006 Aug 1.PMID: 16896939 [PubMed - indexed for MEDLINE]Related articles

Integration of substrate flow in vivo: some insights into metabolic control.

Frayn KN.

Clin Nutr. 1997 Dec;16(6):277-82. No abstract available. PMID: 16844609 [PubMed]Related articles

Angiotensin II: a major regulator of subcutaneous adipose tissue blood flow in humans.

Goossens GH, McQuaid SE, Dennis AL, van Baak MA, Blaak EE, Frayn KN, Saris WH, Karpe F.

J Physiol. 2006 Mar 1;571(Pt 2):451-60. Epub 2006 Jan 5.PMID: 16396927 [PubMed - indexed for MEDLINE]Related articlesFree article

Plasma non-esterified fatty acids: why are we not measuring them routinely?

Frayn KN.

Ann Clin Biochem. 2005 Nov;42(Pt 6):413-4. No abstract available. PMID: 16259791 [PubMed - indexed for MEDLINE]Related articles

Insulin-sensitizing effects of dietary resistant starch and effects on skeletal muscle and adipose tissue metabolism.

Robertson MD, Bickerton AS, Dennis AL, Vidal H, Frayn KN.

Am J Clin Nutr. 2005 Sep;82(3):559-67.PMID: 16155268 [PubMed - indexed for MEDLINE]Related articlesFree article

Changes in adiponectin receptor expression in muscle and adipose tissue of type 2 diabetic patients during rosiglitazone therapy.

Tan GD, Debard C, Funahashi T, Humphreys SM, Matsuzawa Y, Frayn KN, Karpe F, Vidal H.

Diabetologia. 2005 Aug;48(8):1585-9. Epub 2005 Jul 1.PMID: 15991021 [PubMed - indexed for MEDLINE]Related articles

Adipose tissue fatty acid metabolism and cardiovascular disease.

Frayn KN, Fielding BA, Karpe F.

Curr Opin Lipidol. 2005 Aug;16(4):409-15. Review.PMID: 15990589 [PubMed - indexed for MEDLINE]Related articles

Glycaemic index methodology.

Brouns F, Bjorck I, Frayn KN, Gibbs AL, Lang V, Slama G, Wolever TM.

Nutr Res Rev. 2005 Jun;18(1):145-71.PMID: 19079901 [PubMed - in process]Related articles

Deficiency of PPARalpha disturbs the response of lipogenic flux and of lipogenic and cholesterogenic gene expression to dietary cholesterol in mouse white adipose tissue.

Islam KK, Knight BL, Frayn KN, Patel DD, Gibbons GF.

Biochim Biophys Acta. 2005 Jun 1;1734(3):259-68. Epub 2005 Apr 14.PMID: 15878692 [PubMed - indexed for MEDLINE]Related articles

Obesity and metabolic disease: is adipose tissue the culprit?

Frayn KN.

Proc Nutr Soc. 2005 Feb;64(1):7-13. Review.PMID: 15877917 [PubMed - indexed for MEDLINE]Related articles

Rosiglitazone increases indexes of stearoyl-CoA desaturase activity in humans: link to insulin sensitization and the role of dominant-negative mutation in peroxisome proliferator-activated receptor-gamma.

Risérus U, Tan GD, Fielding BA, Neville MJ, Currie J, Savage DB, Chatterjee VK, Frayn KN, O'Rahilly S, Karpe F.

Diabetes. 2005 May;54(5):1379-84.PMID: 15855323 [PubMed - indexed for MEDLINE]Related articlesFree article

Oscillations of fatty acid and glycerol release from human subcutaneous adipose tissue in vivo.

Karpe F, Fielding BA, Coppack SW, Lawrence VJ, Macdonald IA, Frayn KN.

Diabetes. 2005 May;54(5):1297-303.PMID: 15855313 [PubMed - indexed for MEDLINE]Related articlesFree article

Enhanced metabolic cycling in subjects after colonic resection for ulcerative colitis.

Robertson MD, Bickerton AS, Dennis AL, Vidal H, Jewell DP, Frayn KN.

J Clin Endocrinol Metab. 2005 May;90(5):2747-54. Epub 2005 Feb 15.PMID: 15713705 [PubMed - indexed for MEDLINE]Related articlesFree article

The effects of rosiglitazone on fatty acid and triglyceride metabolism in type 2 diabetes.

Tan GD, Fielding BA, Currie JM, Humphreys SM, Désage M, Frayn KN, Laville M, Vidal H, Karpe F.

Diabetologia. 2005 Jan;48(1):83-95. Epub 2004 Dec 24.PMID: 15619071 [PubMed - indexed for MEDLINE]Related articles

Lipid metabolism.

Fielding BA, Frayn KN.

Curr Opin Lipidol. 2004 Aug;15(4):483-5. No abstract available. PMID: 15243224 [PubMed - indexed for MEDLINE]Related articles

The nicotinic acid receptor--a new mechanism for an old drug.

Karpe F, Frayn KN.

Lancet. 2004 Jun 5;363(9424):1892-4. Review.PMID: 15183629 [PubMed - indexed for MEDLINE]Related articles

Vagal stimulation exaggerates the inhibitory ghrelin response to oral fat in humans.

Heath RB, Jones R, Frayn KN, Robertson MD.

J Endocrinol. 2004 Feb;180(2):273-81.PMID: 14765979 [PubMed - indexed for MEDLINE]Related articlesFree article

Coupling of metabolism and cardiovascular responses.

Frayn KN, Ardilouze JL, Fielding BA, Karpe F.

Clin Sci (Lond). 2004 May;106(5):547-8. No abstract available. PMID: 14686875 [PubMed - indexed for MEDLINE]Related articles

Nitric oxide and beta-adrenergic stimulation are major regulators of preprandial and postprandial subcutaneous adipose tissue blood flow in humans.

Ardilouze JL, Fielding BA, Currie JM, Frayn KN, Karpe F.

Circulation. 2004 Jan 6;109(1):47-52. Epub 2003 Dec 8.PMID: 14662716 [PubMed - indexed for MEDLINE]Related articlesFree article

The glucose-fatty acid cycle: a physiological perspective.

Frayn KN.

Biochem Soc Trans. 2003 Dec;31(Pt 6):1115-9. Review.PMID: 14641007 [PubMed - indexed for MEDLINE]Related articles