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    Results: 1 to 50 of 133

    1.

    Genetic evidence that raised Sex Hormone Binding Globulin (SHBG) levels reduce the risk of type 2 diabetes.

    Perry JR, Weedon MN, Langenberg C, Jackson AU, Lyssenko V, Sparsø T, Thorleifsson G, Grallert H, Ferrucci L, Maggio M, Paolisso G, Walker M, Palmer CN, Payne F, Young E, Herder C, Narisu N, Morken MA, Bonnycastle LL, Owen KR, Shields B, Knight B, Bennett A, Groves CJ, Ruokonen A, Jarvelin MR, Pearson E, Pascoe L, Ferrannini E, Bornstein SR, Stringham HM, Scott LJ, Kuusisto J, Nilsson P, Neptin M, Gjesing AP, Pisinger C, Lauritzen T, Sandbaek A, Sampson M; MAGIC, Zeggini E, Lindgren CM, Steinthorsdottir V, Thorsteinsdottir U, Hansen T, Schwarz P, Illig T, Laakso M, Stefansson K, Morris AD, Groop L, Pedersen O, Boehnke M, Barroso I, Wareham NJ, Hattersley AT, McCarthy MI, Frayling TM.

    Hum Mol Genet. 2009 Nov 18. [Epub ahead of print]PMID: 19933169 [PubMed - as supplied by publisher]

    2.

    Genetic association analysis of LARS2 with type 2 diabetes.

    Reiling E, Jafar-Mohammadi B, van 't Riet E, Weedon MN, van Vliet-Ostaptchouk JV, Hansen T, Saxena R, van Haeften TW, Arp PA, Das S, Nijpels G, Groenewoud MJ, van Hove EC, Uitterlinden AG, Smit JW, Morris AD, Doney AS, Palmer CN, Guiducci C, Hattersley AT, Frayling TM, Pedersen O, Slagboom PE, Altshuler DM, Groop L, Romijn JA, Maassen JA, Hofker MH, Dekker JM, McCarthy MI, 't Hart LM.

    Diabetologia. 2009 Oct 22. [Epub ahead of print]PMID: 19847392 [PubMed - as supplied by publisher]Related articles

    3.

    Phosphodiesterase 8B gene polymorphism is associated with subclinical hypothyroidism in pregnancy.

    Shields BM, Freathy RM, Knight BA, Hill A, Weedon MN, Frayling TM, Hattersley AT, Vaidya B.

    J Clin Endocrinol Metab. 2009 Nov;94(11):4608-12. Epub 2009 Oct 9.PMID: 19820008 [PubMed - in process]Related articles

    4.

    Polygenic Risk Variants for Type 2 Diabetes Susceptibility Modify Age at Diagnosis in Monogenic HNF1A Diabetes.

    Lango Allen H, Johansson S, Ellard S, Shields B, Hertel JK, Ræder H, Colclough K, Molven A, Frayling TM, Njølstad PR, Hattersley AT, Weedon MN.

    Diabetes. 2009 Sep 30. [Epub ahead of print]PMID: 19794065 [PubMed - as supplied by publisher]Related articles

    5.

    Low frequency variants in the exons only encoding isoform A of HNF1A do not contribute to susceptibility to type 2 diabetes.

    Jafar-Mohammadi B, Groves CJ, Owen KR, Frayling TM, Hattersley AT, McCarthy MI, Gloyn AL.

    PLoS One. 2009 Aug 12;4(8):e6615.PMID: 19672314 [PubMed - in process]Related articlesFree article

    6.

    Circulating beta-carotene levels and type 2 diabetes-cause or effect?

    Perry JR, Ferrucci L, Bandinelli S, Guralnik J, Semba RD, Rice N, Melzer D; DIAGRAM Consortium, Saxena R, Scott LJ, McCarthy MI, Hattersley AT, Zeggini E, Weedon MN, Frayling TM.

    Diabetologia. 2009 Oct;52(10):2117-21. Epub 2009 Aug 7.PMID: 19662379 [PubMed - in process]Related articles

    7.

    The paraoxonase (PON1) Q192R polymorphism is not associated with poor health status or depression in the ELSA or INCHIANTI studies.

    Rice NE, Bandinelli S, Corsi AM, Ferrucci L, Guralnik JM, Miller MA, Kumari M, Murray A, Frayling TM, Melzer D.

    Int J Epidemiol. 2009 Oct;38(5):1374-9. Epub 2009 Aug 3.PMID: 19651761 [PubMed - in process]Related articles

    8.

    Interleukin-18 polymorphism and physical functioning in older people: a replication study and meta-analysis.

    Thomas K, Rafiq S, Frayling TM, Ebrahim S, Kumari M, Gallacher J, Ferrucci L, Bandinelli S, Wallace RB, Melzer D, Martin RM, Ben-Shlomo Y.

    J Gerontol A Biol Sci Med Sci. 2009 Nov;64(11):1177-82. Epub 2009 Jul 24.PMID: 19633236 [PubMed - indexed for MEDLINE]Related articles

    9.

    Underlying genetic models of inheritance in established type 2 diabetes associations.

    Salanti G, Southam L, Altshuler D, Ardlie K, Barroso I, Boehnke M, Cornelis MC, Frayling TM, Grallert H, Grarup N, Groop L, Hansen T, Hattersley AT, Hu FB, Hveem K, Illig T, Kuusisto J, Laakso M, Langenberg C, Lyssenko V, McCarthy MI, Morris A, Morris AD, Palmer CN, Payne F, Platou CG, Scott LJ, Voight BF, Wareham NJ, Zeggini E, Ioannidis JP.

    Am J Epidemiol. 2009 Sep 1;170(5):537-45. Epub 2009 Jul 14.PMID: 19602701 [PubMed - indexed for MEDLINE]Related articles

    10.

    Commentary: A new dawn for genetic epidemiology?

    Frayling TM.

    Int J Epidemiol. 2009 Aug;38(4):975-7. Epub 2009 Jul 7. No abstract available. PMID: 19584124 [PubMed - indexed for MEDLINE]Related articles

    11.

    Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution.

    Lindgren CM, Heid IM, Randall JC, Lamina C, Steinthorsdottir V, Qi L, Speliotes EK, Thorleifsson G, Willer CJ, Herrera BM, Jackson AU, Lim N, Scheet P, Soranzo N, Amin N, Aulchenko YS, Chambers JC, Drong A, Luan J, Lyon HN, Rivadeneira F, Sanna S, Timpson NJ, Zillikens MC, Zhao JH, Almgren P, Bandinelli S, Bennett AJ, Bergman RN, Bonnycastle LL, Bumpstead SJ, Chanock SJ, Cherkas L, Chines P, Coin L, Cooper C, Crawford G, Doering A, Dominiczak A, Doney AS, Ebrahim S, Elliott P, Erdos MR, Estrada K, Ferrucci L, Fischer G, Forouhi NG, Gieger C, Grallert H, Groves CJ, Grundy S, Guiducci C, Hadley D, Hamsten A, Havulinna AS, Hofman A, Holle R, Holloway JW, Illig T, Isomaa B, Jacobs LC, Jameson K, Jousilahti P, Karpe F, Kuusisto J, Laitinen J, Lathrop GM, Lawlor DA, Mangino M, McArdle WL, Meitinger T, Morken MA, Morris AP, Munroe P, Narisu N, Nordström A, Nordström P, Oostra BA, Palmer CN, Payne F, Peden JF, Prokopenko I, Renström F, Ruokonen A, Salomaa V, Sandhu MS, Scott LJ, Scuteri A, Silander K, Song K, Yuan X, Stringham HM, Swift AJ, Tuomi T, Uda M, Vollenweider P, Waeber G, Wallace C, Walters GB, Weedon MN; Wellcome Trust Case Control Consortium, Witteman JC, Zhang C, Zhang W, Caulfield MJ, Collins FS, Davey Smith G, Day IN, Franks PW, Hattersley AT, Hu FB, Jarvelin MR, Kong A, Kooner JS, Laakso M, Lakatta E, Mooser V, Morris AD, Peltonen L, Samani NJ, Spector TD, Strachan DP, Tanaka T, Tuomilehto J, Uitterlinden AG, van Duijn CM, Wareham NJ, Hugh Watkins; Procardis Consortia, Waterworth DM, Boehnke M, Deloukas P, Groop L, Hunter DJ, Thorsteinsdottir U, Schlessinger D, Wichmann HE, Frayling TM, Abecasis GR, Hirschhorn JN, Loos RJ, Stefansson K, Mohlke KL, Barroso I, McCarthy MI; Giant Consortium.

    PLoS Genet. 2009 Jun;5(6):e1000508. Epub 2009 Jun 26. Erratum in: PLoS Genet. 2009 Jul;5(7). doi: 10.1371/annotation/b6e8f9f6-2496-4a40-b0e3-e1d1390c1928. PMID: 19557161 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    Is the thrifty genotype hypothesis supported by evidence based on confirmed type 2 diabetes- and obesity-susceptibility variants?

    Southam L, Soranzo N, Montgomery SB, Frayling TM, McCarthy MI, Barroso I, Zeggini E.

    Diabetologia. 2009 Sep;52(9):1846-51. Epub 2009 Jun 13.PMID: 19526209 [PubMed - in process]Related articlesFree article

    13.

    Common genetic variation in the melatonin receptor 1B gene (MTNR1B) is associated with decreased early-phase insulin response.

    Langenberg C, Pascoe L, Mari A, Tura A, Laakso M, Frayling TM, Barroso I, Loos RJ, Wareham NJ, Walker M; RISC Consortium.

    Diabetologia. 2009 Aug;52(8):1537-42. Epub 2009 May 20.PMID: 19455304 [PubMed - indexed for MEDLINE]Related articles

    14.

    A common genetic variant in the 15q24 nicotinic acetylcholine receptor gene cluster (CHRNA5-CHRNA3-CHRNB4) is associated with a reduced ability of women to quit smoking in pregnancy.

    Freathy RM, Ring SM, Shields B, Galobardes B, Knight B, Weedon MN, Smith GD, Frayling TM, Hattersley AT.

    Hum Mol Genet. 2009 Aug 1;18(15):2922-7. Epub 2009 May 9.PMID: 19429911 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    Linkage disequilibrium mapping of the replicated type 2 diabetes linkage signal on chromosome 1q.

    Prokopenko I, Zeggini E, Hanson RL, Mitchell BD, Rayner NW, Akan P, Baier L, Das SK, Elliott KS, Fu M, Frayling TM, Groves CJ, Gwilliam R, Scott LJ, Voight BF, Hattersley AT, Hu C, Morris AD, Ng M, Palmer CN, Tello-Ruiz M, Vaxillaire M, Wang CR, Stein L, Chan J, Jia W, Froguel P, Elbein SC, Deloukas P, Bogardus C, Shuldiner AR, McCarthy MI; International Type 2 Diabetes 1q Consortium.

    Diabetes. 2009 Jul;58(7):1704-9. Epub 2009 Apr 23.PMID: 19389826 [PubMed - indexed for MEDLINE]Related articlesFree article

    16.

    FTO gene variation and measures of body mass in an African population.

    Hennig BJ, Fulford AJ, Sirugo G, Rayco-Solon P, Hattersley AT, Frayling TM, Prentice AM.

    BMC Med Genet. 2009 Mar 5;10:21.PMID: 19265514 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    Interrogating type 2 diabetes genome-wide association data using a biological pathway-based approach.

    Perry JR, McCarthy MI, Hattersley AT, Zeggini E; Wellcome Trust Case Control Consortium, Weedon MN, Frayling TM.

    Diabetes. 2009 Jun;58(6):1463-7. Epub 2009 Feb 27.PMID: 19252133 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    Type 2 diabetes risk alleles are associated with reduced size at birth.

    Freathy RM, Bennett AJ, Ring SM, Shields B, Groves CJ, Timpson NJ, Weedon MN, Zeggini E, Lindgren CM, Lango H, Perry JR, Pouta A, Ruokonen A, Hyppönen E, Power C, Elliott P, Strachan DP, Järvelin MR, Smith GD, McCarthy MI, Frayling TM, Hattersley AT.

    Diabetes. 2009 Jun;58(6):1428-33. Epub 2009 Feb 19.PMID: 19228808 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    Common variation in the DIO2 gene predicts baseline psychological well-being and response to combination thyroxine plus triiodothyronine therapy in hypothyroid patients.

    Panicker V, Saravanan P, Vaidya B, Evans J, Hattersley AT, Frayling TM, Dayan CM.

    J Clin Endocrinol Metab. 2009 May;94(5):1623-9. Epub 2009 Feb 3.PMID: 19190113 [PubMed - indexed for MEDLINE]Related articles

    20.

    Common variation in the beta-carotene 15,15'-monooxygenase 1 gene affects circulating levels of carotenoids: a genome-wide association study.

    Ferrucci L, Perry JR, Matteini A, Perola M, Tanaka T, Silander K, Rice N, Melzer D, Murray A, Cluett C, Fried LP, Albanes D, Corsi AM, Cherubini A, Guralnik J, Bandinelli S, Singleton A, Virtamo J, Walston J, Semba RD, Frayling TM.

    Am J Hum Genet. 2009 Feb;84(2):123-33. Epub 2009 Jan 29.PMID: 19185284 [PubMed - indexed for MEDLINE]Related articlesFree article

    21.

    Six new loci associated with body mass index highlight a neuronal influence on body weight regulation.

    Willer CJ, Speliotes EK, Loos RJ, Li S, Lindgren CM, Heid IM, Berndt SI, Elliott AL, Jackson AU, Lamina C, Lettre G, Lim N, Lyon HN, McCarroll SA, Papadakis K, Qi L, Randall JC, Roccasecca RM, Sanna S, Scheet P, Weedon MN, Wheeler E, Zhao JH, Jacobs LC, Prokopenko I, Soranzo N, Tanaka T, Timpson NJ, Almgren P, Bennett A, Bergman RN, Bingham SA, Bonnycastle LL, Brown M, Burtt NP, Chines P, Coin L, Collins FS, Connell JM, Cooper C, Smith GD, Dennison EM, Deodhar P, Elliott P, Erdos MR, Estrada K, Evans DM, Gianniny L, Gieger C, Gillson CJ, Guiducci C, Hackett R, Hadley D, Hall AS, Havulinna AS, Hebebrand J, Hofman A, Isomaa B, Jacobs KB, Johnson T, Jousilahti P, Jovanovic Z, Khaw KT, Kraft P, Kuokkanen M, Kuusisto J, Laitinen J, Lakatta EG, Luan J, Luben RN, Mangino M, McArdle WL, Meitinger T, Mulas A, Munroe PB, Narisu N, Ness AR, Northstone K, O'Rahilly S, Purmann C, Rees MG, Ridderstråle M, Ring SM, Rivadeneira F, Ruokonen A, Sandhu MS, Saramies J, Scott LJ, Scuteri A, Silander K, Sims MA, Song K, Stephens J, Stevens S, Stringham HM, Tung YC, Valle TT, Van Duijn CM, Vimaleswaran KS, Vollenweider P, Waeber G, Wallace C, Watanabe RM, Waterworth DM, Watkins N; Wellcome Trust Case Control Consortium, Witteman JC, Zeggini E, Zhai G, Zillikens MC, Altshuler D, Caulfield MJ, Chanock SJ, Farooqi IS, Ferrucci L, Guralnik JM, Hattersley AT, Hu FB, Jarvelin MR, Laakso M, Mooser V, Ong KK, Ouwehand WH, Salomaa V, Samani NJ, Spector TD, Tuomi T, Tuomilehto J, Uda M, Uitterlinden AG, Wareham NJ, Deloukas P, Frayling TM, Groop LC, Hayes RB, Hunter DJ, Mohlke KL, Peltonen L, Schlessinger D, Strachan DP, Wichmann HE, McCarthy MI, Boehnke M, Barroso I, Abecasis GR, Hirschhorn JN; Genetic Investigation of ANthropometric Traits Consortium.

    Nat Genet. 2009 Jan;41(1):25-34. Epub 2008 Dec 14.PMID: 19079261 [PubMed - indexed for MEDLINE]Related articlesFree article

    22.

    Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data.

    Timpson NJ, Lindgren CM, Weedon MN, Randall J, Ouwehand WH, Strachan DP, Rayner NW, Walker M, Hitman GA, Doney AS, Palmer CN, Morris AD, Hattersley AT, Zeggini E, Frayling TM, McCarthy MI.

    Diabetes. 2009 Feb;58(2):505-10. Epub 2008 Dec 3.PMID: 19056611 [PubMed - indexed for MEDLINE]Related articlesFree article

    23.

    The association of common genetic variants in the APOA5, LPL and GCK genes with longitudinal changes in metabolic and cardiovascular traits.

    Webster RJ, Warrington NM, Weedon MN, Hattersley AT, McCaskie PA, Beilby JP, Palmer LJ, Frayling TM.

    Diabetologia. 2009 Jan;52(1):106-14. Epub 2008 Nov 19.PMID: 19018513 [PubMed - indexed for MEDLINE]Related articles

    24.

    FTO gene variants are strongly associated with type 2 diabetes in South Asian Indians.

    Yajnik CS, Janipalli CS, Bhaskar S, Kulkarni SR, Freathy RM, Prakash S, Mani KR, Weedon MN, Kale SD, Deshpande J, Krishnaveni GV, Veena SR, Fall CH, McCarthy MI, Frayling TM, Hattersley AT, Chandak GR.

    Diabetologia. 2009 Feb;52(2):247-52. Epub 2008 Nov 13.PMID: 19005641 [PubMed - indexed for MEDLINE]Related articlesFree article

    25.

    Reaching new heights: insights into the genetics of human stature.

    Weedon MN, Frayling TM.

    Trends Genet. 2008 Dec;24(12):595-603. Epub 2008 Oct 22. Review.PMID: 18950892 [PubMed - indexed for MEDLINE]Related articles

    26.

    Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes.

    Yuan X, Waterworth D, Perry JR, Lim N, Song K, Chambers JC, Zhang W, Vollenweider P, Stirnadel H, Johnson T, Bergmann S, Beckmann ND, Li Y, Ferrucci L, Melzer D, Hernandez D, Singleton A, Scott J, Elliott P, Waeber G, Cardon L, Frayling TM, Kooner JS, Mooser V.

    Am J Hum Genet. 2008 Oct;83(4):520-8.PMID: 18940312 [PubMed - indexed for MEDLINE]Related articlesFree article

    27.

    Gene variants influencing measures of inflammation or predisposing to autoimmune and inflammatory diseases are not associated with the risk of type 2 diabetes.

    Rafiq S, Melzer D, Weedon MN, Lango H, Saxena R, Scott LJ; DIAGRAM Consortium, Palmer CN, Morris AD, McCarthy MI, Ferrucci L, Hattersley AT, Zeggini E, Frayling TM.

    Diabetologia. 2008 Dec;51(12):2205-13. Epub 2008 Oct 14.PMID: 18853133 [PubMed - indexed for MEDLINE]Related articles

    28.

    Polymorphisms in LMNA and near a SERPINA gene cluster are associated with cognitive function in older people.

    Cluett C, Brayne C, Clarke R, Evans G, Matthews F, Rubinsztein DC, Huppert F, Llewellyn DJ, Rice N, Henley W, Frayling TM, Murray A, Melzer D.

    Neurobiol Aging. 2008 Oct 8. [Epub ahead of print]PMID: 18848371 [PubMed - as supplied by publisher]Related articles

    29.

    The fat mass- and obesity-associated locus and dietary intake in children.

    Timpson NJ, Emmett PM, Frayling TM, Rogers I, Hattersley AT, McCarthy MI, Davey Smith G.

    Am J Clin Nutr. 2008 Oct;88(4):971-8.PMID: 18842783 [PubMed - indexed for MEDLINE]Related articlesFree article

    30.

    Filaggrin gene mutations are associated with asthma and eczema in later life.

    Rice NE, Patel BD, Lang IA, Kumari M, Frayling TM, Murray A, Melzer D.

    J Allergy Clin Immunol. 2008 Oct;122(4):834-6. Epub 2008 Aug 29. No abstract available. PMID: 18760831 [PubMed - indexed for MEDLINE]Related articlesFree article

    31.

    Population-specific risk of type 2 diabetes conferred by HNF4A P2 promoter variants: a lesson for replication studies.

    Barroso I, Luan J, Wheeler E, Whittaker P, Wasson J, Zeggini E, Weedon MN, Hunt S, Venkatesh R, Frayling TM, Delgado M, Neuman RJ, Zhao J, Sherva R, Glaser B, Walker M, Hitman G, McCarthy MI, Hattersley AT, Permutt MA, Wareham NJ, Deloukas P.

    Diabetes. 2008 Nov;57(11):3161-5. Epub 2008 Aug 26.PMID: 18728231 [PubMed - indexed for MEDLINE]Related articlesFree article

    32.

    Beta cell glucose sensitivity is decreased by 39% in non-diabetic individuals carrying multiple diabetes-risk alleles compared with those with no risk alleles.

    Pascoe L, Frayling TM, Weedon MN, Mari A, Tura A, Ferrannini E, Walker M; RISC Consortium.

    Diabetologia. 2008 Nov;51(11):1989-92. Epub 2008 Aug 22.PMID: 18719881 [PubMed - indexed for MEDLINE]Related articles

    33.

    A genetic link between type 2 diabetes and prostate cancer.

    Frayling TM, Colhoun H, Florez JC.

    Diabetologia. 2008 Oct;51(10):1757-60. Epub 2008 Aug 12.PMID: 18696045 [PubMed - indexed for MEDLINE]Related articles

    34.

    Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk.

    Lango H; UK Type 2 Diabetes Genetics Consortium, Palmer CN, Morris AD, Zeggini E, Hattersley AT, McCarthy MI, Frayling TM, Weedon MN.

    Diabetes. 2008 Nov;57(11):3129-35. Epub 2008 Jun 30.PMID: 18591388 [PubMed - indexed for MEDLINE]Related articlesFree article

    35.

    New gene variants alter type 2 diabetes risk predominantly through reduced beta-cell function.

    Perry JR, Frayling TM.

    Curr Opin Clin Nutr Metab Care. 2008 Jul;11(4):371-7. Review.PMID: 18541994 [PubMed - indexed for MEDLINE]Related articles

    36.

    A common variation in deiodinase 1 gene DIO1 is associated with the relative levels of free thyroxine and triiodothyronine.

    Panicker V, Cluett C, Shields B, Murray A, Parnell KS, Perry JR, Weedon MN, Singleton A, Hernandez D, Evans J, Durant C, Ferrucci L, Melzer D, Saravanan P, Visser TJ, Ceresini G, Hattersley AT, Vaidya B, Dayan CM, Frayling TM.

    J Clin Endocrinol Metab. 2008 Aug;93(8):3075-81. Epub 2008 May 20.PMID: 18492748 [PubMed - indexed for MEDLINE]Related articlesFree article

    37.

    A genome-wide association study identifies protein quantitative trait loci (pQTLs).

    Melzer D, Perry JR, Hernandez D, Corsi AM, Stevens K, Rafferty I, Lauretani F, Murray A, Gibbs JR, Paolisso G, Rafiq S, Simon-Sanchez J, Lango H, Scholz S, Weedon MN, Arepalli S, Rice N, Washecka N, Hurst A, Britton A, Henley W, van de Leemput J, Li R, Newman AB, Tranah G, Harris T, Panicker V, Dayan C, Bennett A, McCarthy MI, Ruokonen A, Jarvelin MR, Guralnik J, Bandinelli S, Frayling TM, Singleton A, Ferrucci L.

    PLoS Genet. 2008 May 9;4(5):e1000072.PMID: 18464913 [PubMed - indexed for MEDLINE]Related articlesFree article

    38.

    Common variants near MC4R are associated with fat mass, weight and risk of obesity.

    Loos RJ, Lindgren CM, Li S, Wheeler E, Zhao JH, Prokopenko I, Inouye M, Freathy RM, Attwood AP, Beckmann JS, Berndt SI; Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial, Jacobs KB, Chanock SJ, Hayes RB, Bergmann S, Bennett AJ, Bingham SA, Bochud M, Brown M, Cauchi S, Connell JM, Cooper C, Smith GD, Day I, Dina C, De S, Dermitzakis ET, Doney AS, Elliott KS, Elliott P, Evans DM, Sadaf Farooqi I, Froguel P, Ghori J, Groves CJ, Gwilliam R, Hadley D, Hall AS, Hattersley AT, Hebebrand J, Heid IM; KORA, Lamina C, Gieger C, Illig T, Meitinger T, Wichmann HE, Herrera B, Hinney A, Hunt SE, Jarvelin MR, Johnson T, Jolley JD, Karpe F, Keniry A, Khaw KT, Luben RN, Mangino M, Marchini J, McArdle WL, McGinnis R, Meyre D, Munroe PB, Morris AD, Ness AR, Neville MJ, Nica AC, Ong KK, O'Rahilly S, Owen KR, Palmer CN, Papadakis K, Potter S, Pouta A, Qi L; Nurses' Health Study, Randall JC, Rayner NW, Ring SM, Sandhu MS, Scherag A, Sims MA, Song K, Soranzo N, Speliotes EK; Diabetes Genetics Initiative, Syddall HE, Teichmann SA, Timpson NJ, Tobias JH, Uda M; SardiNIA Study, Vogel CI, Wallace C, Waterworth DM, Weedon MN; Wellcome Trust Case Control Consortium, Willer CJ; FUSION, Wraight, Yuan X, Zeggini E, Hirschhorn JN, Strachan DP, Ouwehand WH, Caulfield MJ, Samani NJ, Frayling TM, Vollenweider P, Waeber G, Mooser V, Deloukas P, McCarthy MI, Wareham NJ, Barroso I, Jacobs KB, Chanock SJ, Hayes RB, Lamina C, Gieger C, Illig T, Meitinger T, Wichmann HE, Kraft P, Hankinson SE, Hunter DJ, Hu FB, Lyon HN, Voight BF, Ridderstrale M, Groop L, Scheet P, Sanna S, Abecasis GR, Albai G, Nagaraja R, Schlessinger D, Jackson AU, Tuomilehto J, Collins FS, Boehnke M, Mohlke KL.

    Nat Genet. 2008 Jun;40(6):768-75. Epub 2008 May 4.PMID: 18454148 [PubMed - indexed for MEDLINE]Related articlesFree article

    39.

    Genome-wide association analysis identifies 20 loci that influence adult height.

    Weedon MN, Lango H, Lindgren CM, Wallace C, Evans DM, Mangino M, Freathy RM, Perry JR, Stevens S, Hall AS, Samani NJ, Shields B, Prokopenko I, Farrall M, Dominiczak A; Diabetes Genetics Initiative; Wellcome Trust Case Control Consortium, Johnson T, Bergmann S, Beckmann JS, Vollenweider P, Waterworth DM, Mooser V, Palmer CN, Morris AD, Ouwehand WH; Cambridge GEM Consortium, Zhao JH, Li S, Loos RJ, Barroso I, Deloukas P, Sandhu MS, Wheeler E, Soranzo N, Inouye M, Wareham NJ, Caulfield M, Munroe PB, Hattersley AT, McCarthy MI, Frayling TM.

    Nat Genet. 2008 May;40(5):575-83. Epub 2008 Apr 6.PMID: 18391952 [PubMed - indexed for MEDLINE]Related articlesFree article

    40.

    Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes.

    Zeggini E, Scott LJ, Saxena R, Voight BF, Marchini JL, Hu T, de Bakker PI, Abecasis GR, Almgren P, Andersen G, Ardlie K, Boström KB, Bergman RN, Bonnycastle LL, Borch-Johnsen K, Burtt NP, Chen H, Chines PS, Daly MJ, Deodhar P, Ding CJ, Doney AS, Duren WL, Elliott KS, Erdos MR, Frayling TM, Freathy RM, Gianniny L, Grallert H, Grarup N, Groves CJ, Guiducci C, Hansen T, Herder C, Hitman GA, Hughes TE, Isomaa B, Jackson AU, Jørgensen T, Kong A, Kubalanza K, Kuruvilla FG, Kuusisto J, Langenberg C, Lango H, Lauritzen T, Li Y, Lindgren CM, Lyssenko V, Marvelle AF, Meisinger C, Midthjell K, Mohlke KL, Morken MA, Morris AD, Narisu N, Nilsson P, Owen KR, Palmer CN, Payne F, Perry JR, Pettersen E, Platou C, Prokopenko I, Qi L, Qin L, Rayner NW, Rees M, Roix JJ, Sandbaek A, Shields B, Sjögren M, Steinthorsdottir V, Stringham HM, Swift AJ, Thorleifsson G, Thorsteinsdottir U, Timpson NJ, Tuomi T, Tuomilehto J, Walker M, Watanabe RM, Weedon MN, Willer CJ; Wellcome Trust Case Control Consortium, Illig T, Hveem K, Hu FB, Laakso M, Stefansson K, Pedersen O, Wareham NJ, Barroso I, Hattersley AT, Collins FS, Groop L, McCarthy MI, Boehnke M, Altshuler D.

    Nat Genet. 2008 May;40(5):638-45. Epub 2008 Mar 30.PMID: 18372903 [PubMed - indexed for MEDLINE]Related articlesFree article

    41.

    Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMI.

    Freathy RM, Timpson NJ, Lawlor DA, Pouta A, Ben-Shlomo Y, Ruokonen A, Ebrahim S, Shields B, Zeggini E, Weedon MN, Lindgren CM, Lango H, Melzer D, Ferrucci L, Paolisso G, Neville MJ, Karpe F, Palmer CN, Morris AD, Elliott P, Jarvelin MR, Smith GD, McCarthy MI, Hattersley AT, Frayling TM.

    Diabetes. 2008 May;57(5):1419-26. Epub 2008 Mar 17.PMID: 18346983 [PubMed - indexed for MEDLINE]Related articlesFree article

    42.

    Exploring the developmental overnutrition hypothesis using parental-offspring associations and FTO as an instrumental variable.

    Lawlor DA, Timpson NJ, Harbord RM, Leary S, Ness A, McCarthy MI, Frayling TM, Hattersley AT, Smith GD.

    PLoS Med. 2008 Mar 11;5(3):e33.PMID: 18336062 [PubMed - indexed for MEDLINE]Related articlesFree article

    43.

    Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants.

    Wellcome Trust Case Control Consortium; Australo-Anglo-American Spondylitis Consortium (TASC), Burton PR, Clayton DG, Cardon LR, Craddock N, Deloukas P, Duncanson A, Kwiatkowski DP, McCarthy MI, Ouwehand WH, Samani NJ, Todd JA, Donnelly P, Barrett JC, Davison D, Easton D, Evans DM, Leung HT, Marchini JL, Morris AP, Spencer CC, Tobin MD, Attwood AP, Boorman JP, Cant B, Everson U, Hussey JM, Jolley JD, Knight AS, Koch K, Meech E, Nutland S, Prowse CV, Stevens HE, Taylor NC, Walters GR, Walker NM, Watkins NA, Winzer T, Jones RW, McArdle WL, Ring SM, Strachan DP, Pembrey M, Breen G, St Clair D, Caesar S, Gordon-Smith K, Jones L, Fraser C, Green EK, Grozeva D, Hamshere ML, Holmans PA, Jones IR, Kirov G, Moskivina V, Nikolov I, O'Donovan MC, Owen MJ, Collier DA, Elkin A, Farmer A, Williamson R, McGuffin P, Young AH, Ferrier IN, Ball SG, Balmforth AJ, Barrett JH, Bishop TD, Iles MM, Maqbool A, Yuldasheva N, Hall AS, Braund PS, Dixon RJ, Mangino M, Stevens S, Thompson JR, Bredin F, Tremelling M, Parkes M, Drummond H, Lees CW, Nimmo ER, Satsangi J, Fisher SA, Forbes A, Lewis CM, Onnie CM, Prescott NJ, Sanderson J, Matthew CG, Barbour J, Mohiuddin MK, Todhunter CE, Mansfield JC, Ahmad T, Cummings FR, Jewell DP, Webster J, Brown MJ, Lathrop MG, Connell J, Dominiczak A, Marcano CA, Burke B, Dobson R, Gungadoo J, Lee KL, Munroe PB, Newhouse SJ, Onipinla A, Wallace C, Xue M, Caulfield M, Farrall M, Barton A; Biologics in RA Genetics and Genomics Study Syndicate (BRAGGS) Steering Committee, Bruce IN, Donovan H, Eyre S, Gilbert PD, Hilder SL, Hinks AM, John SL, Potter C, Silman AJ, Symmons DP, Thomson W, Worthington J, Dunger DB, Widmer B, Frayling TM, Freathy RM, Lango H, Perry JR, Shields BM, Weedon MN, Hattersley AT, Hitman GA, Walker M, Elliott KS, Groves CJ, Lindgren CM, Rayner NW, Timpson NJ, Zeggini E, Newport M, Sirugo G, Lyons E, Vannberg F, Hill AV, Bradbury LA, Farrar C, Pointon JJ, Wordsworth P, Brown MA, Franklyn JA, Heward JM, Simmonds MJ, Gough SC, Seal S; Breast Cancer Susceptibility Collaboration (UK), Stratton MR, Rahman N, Ban M, Goris A, Sawcer SJ, Compston A, Conway D, Jallow M, Newport M, Sirugo G, Rockett KA, Bumpstead SJ, Chaney A, Downes K, Ghori MJ, Gwilliam R, Hunt SE, Inouye M, Keniry A, King E, McGinnis R, Potter S, Ravindrarajah R, Whittaker P, Widden C, Withers D, Cardin NJ, Davison D, Ferreira T, Pereira-Gale J, Hallgrimsdo'ttir IB, Howie BN, Su Z, Teo YY, Vukcevic D, Bentley D, Brown MA, Compston A, Farrall M, Hall AS, Hattersley AT, Hill AV, Parkes M, Pembrey M, Stratton MR, Mitchell SL, Newby PR, Brand OJ, Carr-Smith J, Pearce SH, McGinnis R, Keniry A, Deloukas P, Reveille JD, Zhou X, Sims AM, Dowling A, Taylor J, Doan T, Davis JC, Savage L, Ward MM, Learch TL, Weisman MH, Brown M.

    Nat Genet. 2007 Nov;39(11):1329-37. Epub 2007 Oct 21.PMID: 17952073 [PubMed - indexed for MEDLINE]Related articlesFree article

    44.

    Commentary: Genetic association studies see light at the end of the tunnel.

    Frayling TM.

    Int J Epidemiol. 2008 Feb;37(1):133-5. Epub 2007 Oct 5. No abstract available. PMID: 17921192 [PubMed - indexed for MEDLINE]Related articlesFree article

    45.

    Genetic studies of diabetes following the advent of the genome-wide association study: where do we go from here?

    Frayling TM, McCarthy MI.

    Diabetologia. 2007 Nov;50(11):2229-33. No abstract available. PMID: 17909877 [PubMed - indexed for MEDLINE]Related articles

    46.

    Common variants of the novel type 2 diabetes genes CDKAL1 and HHEX/IDE are associated with decreased pancreatic beta-cell function.

    Pascoe L, Tura A, Patel SK, Ibrahim IM, Ferrannini E, Zeggini E, Weedon MN, Mari A, Hattersley AT, McCarthy MI, Frayling TM, Walker M; RISC Consortium; U.K. Type 2 Diabetes Genetics Consortium.

    Diabetes. 2007 Dec;56(12):3101-4. Epub 2007 Sep 5.PMID: 17804762 [PubMed - indexed for MEDLINE]Related articlesFree article

    47.

    A common variant of HMGA2 is associated with adult and childhood height in the general population.

    Weedon MN, Lettre G, Freathy RM, Lindgren CM, Voight BF, Perry JR, Elliott KS, Hackett R, Guiducci C, Shields B, Zeggini E, Lango H, Lyssenko V, Timpson NJ, Burtt NP, Rayner NW, Saxena R, Ardlie K, Tobias JH, Ness AR, Ring SM, Palmer CN, Morris AD, Peltonen L, Salomaa V; Diabetes Genetics Initiative; Wellcome Trust Case Control Consortium, Davey Smith G, Groop LC, Hattersley AT, McCarthy MI, Hirschhorn JN, Frayling TM.

    Nat Genet. 2007 Oct;39(10):1245-50. Epub 2007 Sep 2.PMID: 17767157 [PubMed - indexed for MEDLINE]Related articles

    48.

    The transcription factor 7-like 2 (TCF7L2) gene is associated with Type 2 diabetes in UK community-based cases, but the risk allele frequency is reduced compared with UK cases selected for genetic studies.

    De Silva NM, Steele A, Shields B, Knight B, Parnell K, Weedon MN, Hattersley AT, Frayling TM.

    Diabet Med. 2007 Oct;24(10):1067-72. Epub 2007 Aug 24.PMID: 17725629 [PubMed - indexed for MEDLINE]Related articles

    49.

    Genome-wide association studies provide new insights into type 2 diabetes aetiology.

    Frayling TM.

    Nat Rev Genet. 2007 Sep;8(9):657-62. Review.PMID: 17703236 [PubMed - indexed for MEDLINE]Related articles

    50.

    A common variant of the interleukin 6 receptor (IL-6r) gene increases IL-6r and IL-6 levels, without other inflammatory effects.

    Rafiq S, Frayling TM, Murray A, Hurst A, Stevens K, Weedon MN, Henley W, Ferrucci L, Bandinelli S, Corsi AM, Guralnik JM, Melzer D.

    Genes Immun. 2007 Oct;8(7):552-9. Epub 2007 Aug 2.PMID: 17671508 [PubMed - indexed for MEDLINE]Related articlesFree article

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