PubMed

Direct bone formation during distraction osteogenesis does not require TNFalpha receptors and elevated serum TNFalpha fails to inhibit bone formation in TNFR1 deficient mice.

Wahl EC, Aronson J, Liu L, Skinner RA, Miller MJ, Cockrell GE, Fowlkes JL, Thrailkill KM, Bunn RC, Ronis MJ, Lumpkin CK Jr.

Bone. 2009 Sep 17. [Epub ahead of print]PMID: 19772956 [PubMed - as supplied by publisher]Related articles

Restoration of Regenerative Osteoblastogenesis in Aged Mice: Modulation of TNF.

Wahl EC, Aronson J, Liu L, Fowlkes JL, Thrailkill KM, Bunn RC, Skinner RA, Miller MJ, Cockrell GE, Clark LM, Ou Y, Isales CM, Badger TM, Ronis MJ, Sims J, Lumpkin CK.

J Bone Miner Res. 2009 Jul 6. [Epub ahead of print]PMID: 19580462 [PubMed - as supplied by publisher]Related articles

Microalbuminuria in type 1 diabetes is associated with enhanced excretion of the endocytic multiligand receptors megalin and cubilin.

Thrailkill KM, Nimmo T, Bunn RC, Cockrell GE, Moreau CS, Mackintosh S, Edmondson RD, Fowlkes JL.

Diabetes Care. 2009 Jul;32(7):1266-8. Epub 2009 Apr 14.PMID: 19366958 [PubMed - indexed for MEDLINE]Related articlesFree article

Matrix metalloproteinases: their potential role in the pathogenesis of diabetic nephropathy.

Thrailkill KM, Clay Bunn R, Fowlkes JL.

Endocrine. 2009 Feb;35(1):1-10. Epub 2008 Oct 30. Review.PMID: 18972226 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulinlike growth factor-binding protein proteolysis an emerging paradigm in insulinlike growth factor physiology.

Fowlkes JL.

Trends Endocrinol Metab. 1997 Oct;8(8):299-306.PMID: 18406818 [PubMed - in process]Related articles

Runt-related transcription factor 2 (RUNX2) and RUNX2-related osteogenic genes are down-regulated throughout osteogenesis in type 1 diabetes mellitus.

Fowlkes JL, Bunn RC, Liu L, Wahl EC, Coleman HN, Cockrell GE, Perrien DS, Lumpkin CK Jr, Thrailkill KM.

Endocrinology. 2008 Apr;149(4):1697-704. Epub 2007 Dec 27.PMID: 18162513 [PubMed - indexed for MEDLINE]Related articlesFree article

Rabson-Mendenhall syndrome: medullary sponge kidney, a new component.

Harris AM, Hall B, Kriss VM, Fowlkes JL, Kiessling SG.

Pediatr Nephrol. 2007 Dec;22(12):2141-4. Epub 2007 Sep 12.PMID: 17849153 [PubMed - indexed for MEDLINE]Related articles

Matrix metalloproteinase-2 dysregulation in type 1 diabetes.

Thrailkill KM, Bunn RC, Moreau CS, Cockrell GE, Simpson PM, Coleman HN, Frindik JP, Kemp SF, Fowlkes JL.

Diabetes Care. 2007 Sep;30(9):2321-6. Epub 2007 Jun 11. Erratum in: Diabetes Care. 2007 Dec;30(12):3154. PMID: 17563344 [PubMed - indexed for MEDLINE]Related articlesFree article

Severe deficiencies of IGF-I, IGF-II, IGFBP-3, ALS and paradoxically high-normal bone mass in a child with insulin-resistance syndrome (Rabson-Mendenhall type).

Fowlkes JL, Bunn RC, Coleman HN, Hall B, Reid MC, Thrailkill KM.

Growth Horm IGF Res. 2007 Oct;17(5):399-407. Epub 2007 Jun 7.PMID: 17560154 [PubMed - indexed for MEDLINE]Related articles

A novel rat model for the study of deficits in bone formation in type-2 diabetes.

Liu Z, Aronson J, Wahl EC, Liu L, Perrien DS, Kern PA, Fowlkes JL, Thrailkill KM, Bunn RC, Cockrell GE, Skinner RA, Lumpkin CK Jr.

Acta Orthop. 2007 Feb;78(1):46-55.PMID: 17453392 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of systemic and local administration of recombinant human IGF-I (rhIGF-I) on de novo bone formation in an aged mouse model.

Fowlkes JL, Thrailkill KM, Liu L, Wahl EC, Bunn RC, Cockrell GE, Perrien DS, Aronson J, Lumpkin CK Jr.

J Bone Miner Res. 2006 Sep;21(9):1359-66.PMID: 16939394 [PubMed - indexed for MEDLINE]Related articlesFree article

Efficacy and safety of mecasermin rinfabate.

Kemp SF, Fowlkes JL, Thrailkill KM.

Expert Opin Biol Ther. 2006 May;6(5):533-8.PMID: 16610982 [PubMed - indexed for MEDLINE]Related articles

Physiological matrix metalloproteinase concentrations in serum during childhood and adolescence, using Luminex Multiplex technology.

Thrailkill KM, Moreau CS, Cockrell G, Simpson P, Goel R, North P, Fowlkes JL, Bunn RC.

Clin Chem Lab Med. 2005;43(12):1392-9.PMID: 16309379 [PubMed - indexed for MEDLINE]Related articlesFree article

Is insulin an anabolic agent in bone? Dissecting the diabetic bone for clues.

Thrailkill KM, Lumpkin CK Jr, Bunn RC, Kemp SF, Fowlkes JL.

Am J Physiol Endocrinol Metab. 2005 Nov;289(5):E735-45. Review.PMID: 16215165 [PubMed - indexed for MEDLINE]Related articlesFree article

Bone formation is impaired in a model of type 1 diabetes.

Thrailkill KM, Liu L, Wahl EC, Bunn RC, Perrien DS, Cockrell GE, Skinner RA, Hogue WR, Carver AA, Fowlkes JL, Aronson J, Lumpkin CK Jr.

Diabetes. 2005 Oct;54(10):2875-81.PMID: 16186388 [PubMed - indexed for MEDLINE]Related articlesFree article

Early developmental changes in IGF-I, IGF-II, IGF binding protein-1, and IGF binding protein-3 concentration in the cerebrospinal fluid of children.

Bunn RC, King WD, Winkler MK, Fowlkes JL.

Pediatr Res. 2005 Jul;58(1):89-93. Epub 2005 Mar 17.PMID: 15774848 [PubMed - indexed for MEDLINE]Related articles

IGFBP-4 degradation by pregnancy-associated plasma protein-A in MC3T3 osteoblasts.

Bunn RC, Green LD, Overgaard MT, Oxvig C, Fowlkes JL.

Biochem Biophys Res Commun. 2004 Dec 17;325(3):698-706.PMID: 15541345 [PubMed - indexed for MEDLINE]Related articles

The effects of co-therapy with recombinant human insulin-like growth factor I and insulin on serum leptin levels in adolescents with type 1 diabetes mellitus.

Thrailkill KM, Fowlkes JL, Hyde JF, Litton JC.

Pediatr Diabetes. 2001 Mar;2(1):25-9.PMID: 15016207 [PubMed]Related articles

Optic nerve aplasia in an infant with congenital hypopituitarism and posterior pituitary ectopia.

Brodsky MC, Atreides SP, Fowlkes JL, Sundin OH.

Arch Ophthalmol. 2004 Jan;122(1):125-6. No abstract available. PMID: 14718312 [PubMed - indexed for MEDLINE]Related articles

Regulation of insulin-like growth factor (IGF)-I action by matrix metalloproteinase-3 involves selective disruption of IGF-I/IGF-binding protein-3 complexes.

Fowlkes JL, Serra DM, Bunn RC, Thrailkill KM, Enghild JJ, Nagase H.

Endocrinology. 2004 Feb;145(2):620-6. Epub 2003 Nov 6.PMID: 14605000 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin-like growth factor binding protein proteolysis.

Bunn RC, Fowlkes JL.

Trends Endocrinol Metab. 2003 May-Jun;14(4):176-81. Review.PMID: 12714278 [PubMed - indexed for MEDLINE]Related articles

Exploring the interface between metallo-proteinase activity and growth factor and cytokine bioavailability.

Fowlkes JL, Winkler MK.

Cytokine Growth Factor Rev. 2002 Jun;13(3):277-87. Review.PMID: 12486879 [PubMed - indexed for MEDLINE]Related articles

Implications for matrix metalloproteinases as modulators of pediatric lung disease.

Winkler MK, Foldes JK, Bunn RC, Fowlkes JL.

Am J Physiol Lung Cell Mol Physiol. 2003 Apr;284(4):L557-65. Epub 2002 Nov 27.PMID: 12456387 [PubMed - indexed for MEDLINE]Related articlesFree article

Metalloproteinase and growth factor interactions: do they play a role in pulmonary fibrosis?

Winkler MK, Fowlkes JL.

Am J Physiol Lung Cell Mol Physiol. 2002 Jul;283(1):L1-11. Review.PMID: 12060555 [PubMed - indexed for MEDLINE]Related articlesFree article

Neonatal progeroid (Wiedemann-Rautenstrauch) syndrome: report of five new cases and review.

Pivnick EK, Angle B, Kaufman RA, Hall BD, Pitukcheewanont P, Hersh JH, Fowlkes JL, Sanders LP, O'Brien JM, Carroll GS, Gunther WM, Morrow HG, Burghen GA, Ward JC.

Am J Med Genet. 2000 Jan 17;90(2):131-40. Review.PMID: 10607952 [PubMed - indexed for MEDLINE]Related articles

Insulin-like growth factor II signaling in neoplastic proliferation is blocked by transgenic expression of the metalloproteinase inhibitor TIMP-1.

Martin DC, Fowlkes JL, Babic B, Khokha R.

J Cell Biol. 1999 Aug 23;146(4):881-92.PMID: 10459021 [PubMed - indexed for MEDLINE]Related articlesFree article

MMPs are IGFBP-degrading proteinases: implications for cell proliferation and tissue growth.

Fowlkes JL, Serra DM, Nagase H, Thrailkill KM.

Ann N Y Acad Sci. 1999 Jun 30;878:696-9. No abstract available. PMID: 10415811 [PubMed - indexed for MEDLINE]Related articles

Characterization of matrix metalloproteinases in human urine: alterations during adolescence.

Thrailkill KM, Kumar S, Rosenberg CK, Auten KJ, Fowlkes JL.

Pediatr Nephrol. 1999 Apr;13(3):223-9.PMID: 10353410 [PubMed - indexed for MEDLINE]Related articles

Characterization of insulin-like growth factor binding protein-3 (IGFBP-3) binding to human breast cancer cells: kinetics of IGFBP-3 binding and identification of receptor binding domain on the IGFBP-3 molecule.

Yamanaka Y, Fowlkes JL, Wilson EM, Rosenfeld RG, Oh Y.

Endocrinology. 1999 Mar;140(3):1319-28.PMID: 10067859 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin-like growth factor binding protein (IGFBP) substrate zymography. A new tool to identify and characterize IGFBP-degrading proteinases.

Fowlkes JL, Thrailkill KM, Serra DM, Nagase H.

Endocrine. 1997 Aug;7(1):33-6.PMID: 9449028 [PubMed - indexed for MEDLINE]Related articles

Heparin-binding, highly basic regions within the thyroglobulin type-1 repeat of insulin-like growth factor (IGF)-binding proteins (IGFBPs) -3, -5, and -6 inhibit IGFBP-4 degradation.

Fowlkes JL, Thrailkill KM, George-Nascimento C, Rosenberg CK, Serra DM.

Endocrinology. 1997 Jun;138(6):2280-5.PMID: 9165012 [PubMed - indexed for MEDLINE]Related articlesFree article

A rapid, non-radioactive method for the detection of insulin-like growth factor binding proteins by Western ligand blotting.

Fowlkes JL, Serra D.

Endocrinology. 1996 Dec;137(12):5751-4.PMID: 8940413 [PubMed - indexed for MEDLINE]Related articles

Characterization of glycosaminoglycan-binding domains present in insulin-like growth factor-binding protein-3.

Fowlkes JL, Serra DM.

J Biol Chem. 1996 Jun 21;271(25):14676-9.PMID: 8663298 [PubMed - indexed for MEDLINE]Related articlesFree article

Discordant expression of osteoblast markers in MC3T3-E1 cells that synthesize a high turnover matrix.

Wenstrup RJ, Fowlkes JL, Witte DP, Florer JB.

J Biol Chem. 1996 Apr 26;271(17):10271-6.PMID: 8626594 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3) functions as an IGF-reversible inhibitor of IGFBP-4 proteolysis.

Fowlkes JL, Serra DM, Rosenberg CK, Thrailkill KM.

J Biol Chem. 1995 Nov 17;270(46):27481-8.PMID: 7499205 [PubMed - indexed for MEDLINE]Related articlesFree article

Differentiation of MC3T3-E1 osteoblasts is associated with temporal changes in the expression of IGF-I and IGFBPs.

Thrailkill KM, Siddhanti SR, Fowlkes JL, Quarles LD.

Bone. 1995 Sep;17(3):307-13.PMID: 8541146 [PubMed - indexed for MEDLINE]Related articles

Characterization of insulin-like growth factor-binding protein 5-degrading proteases produced throughout murine osteoblast differentiation.

Thrailkill KM, Quarles LD, Nagase H, Suzuki K, Serra DM, Fowlkes JL.

Endocrinology. 1995 Aug;136(8):3527-33.PMID: 7543045 [PubMed - indexed for MEDLINE]Related articles

Matrix metalloproteinases as insulin-like growth factor binding protein-degrading proteinases.

Fowlkes JL, Thrailkill KM, Serra DM, Suzuki K, Nagase H.

Prog Growth Factor Res. 1995;6(2-4):255-63. Review.PMID: 8817668 [PubMed - indexed for MEDLINE]Related articles

Proteolysis of insulin-like growth factor binding protein-3 during rat pregnancy: a role for matrix metalloproteinases.

Fowlkes JL, Suzuki K, Nagase H, Thrailkill KM.

Endocrinology. 1994 Dec;135(6):2810-3.PMID: 7527335 [PubMed - indexed for MEDLINE]Related articles

Matrix metalloproteinases degrade insulin-like growth factor-binding protein-3 in dermal fibroblast cultures.

Fowlkes JL, Enghild JJ, Suzuki K, Nagase H.

J Biol Chem. 1994 Oct 14;269(41):25742-6.PMID: 7523391 [PubMed - indexed for MEDLINE]Related articlesFree article