PubMed

Losartan metabolite EXP3179 blocks NADPH oxidase-mediated superoxide production by inhibiting protein kinase C: potential clinical implications in hypertension.

Fortuño A, Bidegain J, Robador PA, Hermida J, López-Sagaseta J, Beloqui O, Díez J, Zalba G.

Hypertension. 2009 Oct;54(4):744-50. Epub 2009 Aug 17.PMID: 19687351 [PubMed - indexed for MEDLINE]Related articles

Insulin-induced NADPH oxidase activation promotes proliferation and matrix metalloproteinase activation in monocytes/macrophages.

San José G, Bidegain J, Robador PA, Díez J, Fortuño A, Zalba G.

Free Radic Biol Med. 2009 Apr 15;46(8):1058-67. Epub 2009 Jan 21.PMID: 19439231 [PubMed - indexed for MEDLINE]Related articles

Increased CD74 expression in human atherosclerotic plaques: contribution to inflammatory responses in vascular cells.

Martín-Ventura JL, Madrigal-Matute J, Muñoz-Garcia B, Blanco-Colio LM, Van Oostrom M, Zalba G, Fortuño A, Gomez-Guerrero C, Ortega L, Ortiz A, Diez J, Egido J.

Cardiovasc Res. 2009 Aug 1;83(3):586-94. Epub 2009 May 7.PMID: 19423618 [PubMed - indexed for MEDLINE]Related articles

Insulin resistance determines phagocytic nicotinamide adenine dinucleotide phosphate oxidase overactivation in metabolic syndrome patients.

Fortuño A, Bidegain J, San José G, Robador PA, Landecho MF, Beloqui O, Díez J, Zalba G.

J Hypertens. 2009 Jul;27(7):1420-30.PMID: 19357530 [PubMed - indexed for MEDLINE]Related articles

Molecular mechanisms of atherosclerosis in metabolic syndrome: role of reduced IRS2-dependent signaling.

González-Navarro H, Vinué A, Vila-Caballer M, Fortuño A, Beloqui O, Zalba G, Burks D, Díez J, Andrés V.

Arterioscler Thromb Vasc Biol. 2008 Dec;28(12):2187-94. Epub 2008 Sep 18.PMID: 18802016 [PubMed - indexed for MEDLINE]Related articlesFree article

The angiotensin-converting enzyme insertion/deletion polymorphism is associated with phagocytic NADPH oxidase-dependent superoxide generation: potential implication in hypertension.

San José G, Fortuño A, Moreno MU, Robador PA, Bidegain J, Varo N, Beloqui O, Díez J, Zalba G.

Clin Sci (Lond). 2009 Feb;116(3):233-40.PMID: 18647135 [PubMed - indexed for MEDLINE]Related articles

NADPH oxidase CYBA polymorphisms, oxidative stress and cardiovascular diseases.

San José G, Fortuño A, Beloqui O, Díez J, Zalba G.

Clin Sci (Lond). 2008 Feb;114(3):173-82. Review.PMID: 18184111 [PubMed - indexed for MEDLINE]Related articles

Oxidative stress, endothelial dysfunction and cerebrovascular disease.

Zalba G, Fortuño A, San José G, Moreno MU, Beloqui O, Díez J.

Cerebrovasc Dis. 2007;24 Suppl 1:24-9. Epub 2007 Nov 1. Review.PMID: 17971636 [PubMed - indexed for MEDLINE]Related articles

A novel CYBA variant, the -675A/T polymorphism, is associated with essential hypertension.

Moreno MU, San José G, Fortuño A, Beloqui O, Redón J, Chaves FJ, Corella D, Díez J, Zalba G.

J Hypertens. 2007 Aug;25(8):1620-6.PMID: 17620958 [PubMed - indexed for MEDLINE]Related articles

Phagocytic NADPH oxidase-dependent superoxide production stimulates matrix metalloproteinase-9: implications for human atherosclerosis.

Zalba G, Fortuño A, Orbe J, San José G, Moreno MU, Belzunce M, Rodríguez JA, Beloqui O, Páramo JA, Díez J.

Arterioscler Thromb Vasc Biol. 2007 Mar;27(3):587-93. Epub 2006 Dec 28.PMID: 17194891 [PubMed - indexed for MEDLINE]Related articlesFree article

The inhibitory effect of leptin on angiotensin II-induced vasoconstriction in vascular smooth muscle cells is mediated via a nitric oxide-dependent mechanism.

Rodríguez A, Fortuño A, Gómez-Ambrosi J, Zalba G, Díez J, Frühbeck G.

Endocrinology. 2007 Jan;148(1):324-31. Epub 2006 Oct 12.PMID: 17038553 [PubMed - indexed for MEDLINE]Related articlesFree article

The inhibitory effect of leptin on angiotensin II-induced vasoconstriction is blunted in spontaneously hypertensive rats.

Rodríguez A, Frühbeck G, Gómez-Ambrosi J, Catalán V, Sáinz N, Díez J, Zalba G, Fortuño A.

J Hypertens. 2006 Aug;24(8):1589-97.PMID: 16877962 [PubMed - indexed for MEDLINE]Related articles

Oxidative stress and atherosclerosis in early chronic kidney disease.

Zalba G, Fortuño A, Díez J.

Nephrol Dial Transplant. 2006 Oct;21(10):2686-90. Epub 2006 Jul 22. Review. No abstract available. PMID: 16861737 [PubMed - indexed for MEDLINE]Related articlesFree article

The C242T CYBA polymorphism of NADPH oxidase is associated with essential hypertension.

Moreno MU, San José G, Fortuño A, Beloqui O, Díez J, Zalba G.

J Hypertens. 2006 Jul;24(7):1299-306.PMID: 16794479 [PubMed - indexed for MEDLINE]Related articles

Oxidative stress-related markers and langerhans cells in a hairless rat model exposed to UV radiation.

Mulero M, Romeu M, Giralt M, Folch J, Nogués MR, Fortuño A, Sureda FX, Linares V, Cabré M, Paternáin JL, Mallol J.

J Toxicol Environ Health A. 2006 Jul;69(14):1371-85.PMID: 16760142 [PubMed - indexed for MEDLINE]Related articles

Phagocytic NADPH oxidase overactivity underlies oxidative stress in metabolic syndrome.

Fortuño A, San José G, Moreno MU, Beloqui O, Díez J, Zalba G.

Diabetes. 2006 Jan;55(1):209-15.PMID: 16380495 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased phagocytic nicotinamide adenine dinucleotide phosphate oxidase-dependent superoxide production in patients with early chronic kidney disease.

Fortuño A, Beloqui O, San José G, Moreno MU, Zalba G, Díez J.

Kidney Int Suppl. 2005 Dec;(99):S71-5.PMID: 16336581 [PubMed - indexed for MEDLINE]Related articles

NADPH oxidase-mediated oxidative stress: genetic studies of the p22(phox) gene in hypertension.

Zalba G, San José G, Moreno MU, Fortuño A, Díez J.

Antioxid Redox Signal. 2005 Sep-Oct;7(9-10):1327-36. Review.PMID: 16115038 [PubMed - indexed for MEDLINE]Related articles

Oxidative stress and vascular remodelling.

Fortuño A, San José G, Moreno MU, Díez J, Zalba G.

Exp Physiol. 2005 Jul;90(4):457-62. Epub 2005 May 12. Review.PMID: 15890797 [PubMed - indexed for MEDLINE]Related articlesFree article

NADPH oxidase-dependent superoxide production is associated with carotid intima-media thickness in subjects free of clinical atherosclerotic disease.

Zalba G, Beloqui O, San José G, Moreno MU, Fortuño A, Díez J.

Arterioscler Thromb Vasc Biol. 2005 Jul;25(7):1452-7. Epub 2005 Apr 28.PMID: 15860744 [PubMed - indexed for MEDLINE]Related articlesFree article

Association of increased phagocytic NADPH oxidase-dependent superoxide production with diminished nitric oxide generation in essential hypertension.

Fortuño A, Oliván S, Beloqui O, San José G, Moreno MU, Díez J, Zalba G.

J Hypertens. 2004 Nov;22(11):2169-75.PMID: 15480102 [PubMed - indexed for MEDLINE]Related articles

[Oxidative stress in hypertension: from the SNPs to the clinical phenotype]

Zalba G, Fortuño A, San José G, Moreno MU, Oliván S, Beloqui O, Díez J.

Nefrologia. 2004;24 Suppl 4:25-8. Spanish. No abstract available. PMID: 15279382 [PubMed - indexed for MEDLINE]Related articles

Functional effect of the p22phox -930A/G polymorphism on p22phox expression and NADPH oxidase activity in hypertension.

San José G, Moreno MU, Oliván S, Beloqui O, Fortuño A, Díez J, Zalba G.

Hypertension. 2004 Aug;44(2):163-9. Epub 2004 Jun 21.PMID: 15210651 [PubMed - indexed for MEDLINE]Related articlesFree article

Adipose tissue as an endocrine organ: role of leptin and adiponectin in the pathogenesis of cardiovascular diseases.

Fortuño A, Rodríguez A, Gómez-Ambrosi J, Frühbeck G, Díez J.

J Physiol Biochem. 2003 Mar;59(1):51-60. Review.PMID: 12903905 [PubMed - indexed for MEDLINE]Related articles

Persistence of the nitric oxide pathway in the aorta of hypercholesterolemic apolipoprotein-E-deficient mice.

Villeneuve N, Fortuno A, Sauvage M, Fournier N, Breugnot C, Jacquemin C, Petit C, Gosgnach W, Carpentier N, Vanhoutte P, Vilaine JP.

J Vasc Res. 2003 Mar-Apr;40(2):87-96.PMID: 12808344 [PubMed - indexed for MEDLINE]Related articles

Leptin inhibits angiotensin II-induced intracellular calcium increase and vasoconstriction in the rat aorta.

Fortuño A, Rodríguez A, Gómez-Ambrosi J, Muñiz P, Salvador J, Díez J, Frühbeck G.

Endocrinology. 2002 Sep;143(9):3555-60.PMID: 12193570 [PubMed - indexed for MEDLINE]Related articlesFree article

Parameters related to oxygen free radicals in erythrocytes, plasma and epidermis of the hairless rat.

Romeu M, Mulero M, Giralt M, Folch J, Nogués MR, Torres A, Fortuño A, Sureda FX, Cabré M, Paternáin JL, Mallol J.

Life Sci. 2002 Aug 30;71(15):1739-49.PMID: 12151052 [PubMed - indexed for MEDLINE]Related articles

Cardiomyocyte apoptotic cell death in arterial hypertension: mechanisms and potential management.

Fortuño MA, Ravassa S, Fortuño A, Zalba G, Díez J.

Hypertension. 2001 Dec 1;38(6):1406-12. Review.PMID: 11751726 [PubMed - indexed for MEDLINE]Related articlesFree article

Oxidative stress in arterial hypertension: role of NAD(P)H oxidase.

Zalba G, San José G, Moreno MU, Fortuño MA, Fortuño A, Beaumont FJ, Díez J.

Hypertension. 2001 Dec 1;38(6):1395-9. Review.PMID: 11751724 [PubMed - indexed for MEDLINE]Related articlesFree article

[Vascular oxidative stress and endothelial dysfunction]

Zalba G, González A, Beaumont J, San José G, Moreno U, López B, Ravassa S, Muñiz P, Fortuño A, Fortuño MA, Díez J.

Nefrologia. 2001;21 Suppl 1:61-6. Review. Spanish. No abstract available. PMID: 11382102 [PubMed - indexed for MEDLINE]Related articles

The loop diuretic torasemide interferes with endothelin-1 actions in the aorta of hypertensive rats.

Fortuño A, Muñiz P, Zalba G, Fortuño MA, Díez J.

Nephrol Dial Transplant. 2001;16 Suppl 1:18-21.PMID: 11369815 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of loop diuretics on angiotensin II-stimulated vascular smooth muscle cell growth.

Muñiz P, Fortuño A, Zalba G, Fortuño MA, Díez J.

Nephrol Dial Transplant. 2001;16 Suppl 1:14-7.PMID: 11369814 [PubMed - indexed for MEDLINE]Related articlesFree article

Is the balance between nitric oxide and superoxide altered in spontaneously hypertensive rats with endothelial dysfunction?

Zalba G, Beaumont FJ, San José G, Fortuño A, Fortuño MA, Díez J.

Nephrol Dial Transplant. 2001;16 Suppl 1:2-5.PMID: 11369811 [PubMed - indexed for MEDLINE]Related articlesFree article

Polymorphisms and promoter overactivity of the p22(phox) gene in vascular smooth muscle cells from spontaneously hypertensive rats.

Zalba G, San José G, Beaumont FJ, Fortuño MA, Fortuño A, Díez J.

Circ Res. 2001 Feb 2;88(2):217-22.PMID: 11157675 [PubMed - indexed for MEDLINE]Related articlesFree article

Vascular oxidant stress: molecular mechanisms and pathophysiological implications.

Zalba G, Beaumont J, San José G, Fortuño A, Fortuño MA, Díez J.

J Physiol Biochem. 2000 Mar;56(1):57-64. Review.PMID: 10879682 [PubMed - indexed for MEDLINE]Related articles

Vascular NADH/NADPH oxidase is involved in enhanced superoxide production in spontaneously hypertensive rats.

Zalba G, Beaumont FJ, San José G, Fortuño A, Fortuño MA, Etayo JC, Díez J.

Hypertension. 2000 May;35(5):1055-61.PMID: 10818064 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanisms of increased susceptibility to angiotensin II-induced apoptosis in ventricular cardiomyocytes of spontaneously hypertensive rats.

Ravassa S, Fortuño MA, González A, López B, Zalba G, Fortuño A, Díez J.

Hypertension. 2000 Dec;36(6):1065-71.PMID: 11116126 [PubMed - indexed for MEDLINE]Related articlesFree article

CCK-mediated response in the activation of 5-HT receptor types in the guinea-pig ileum.

Fortuño A, Ballaz S, Del Río J, Barber A.

J Physiol Biochem. 1999 Jun;55(2):85-92.PMID: 10517265 [PubMed - indexed for MEDLINE]Related articles

Torasemide inhibits angiotensin II-induced vasoconstriction and intracellular calcium increase in the aorta of spontaneously hypertensive rats.

Fortuño A, Muñiz P, Ravassa S, Rodriguez JA, Fortuño MA, Zalba G, Díez J.

Hypertension. 1999 Jul;34(1):138-43.PMID: 10406837 [PubMed - indexed for MEDLINE]Related articlesFree article

p53-mediated upregulation of BAX gene transcription is not involved in Bax-alpha protein overexpression in the left ventricle of spontaneously hypertensive rats.

Fortuño MA, Zalba G, Ravassa S, D'Elom E, Beaumont FJ, Fortuño A, Díez J.

Hypertension. 1999 Jun;33(6):1348-52.PMID: 10373214 [PubMed - indexed for MEDLINE]Related articlesFree article

Altered regulation of smooth muscle cell proliferation and apoptosis in small arteries of spontaneously hypertensive rats.

Díez J, Fortuño MA, Zalba G, Etayo JC, Fortuño A, Ravassa S, Beaumont J.

Eur Heart J. 1998 Jul;19 Suppl G:G29-33.PMID: 9717053 [PubMed - indexed for MEDLINE]Related articles

Synthesis and stereochemical structure-activity relationships of 1,3-dioxoperhydropyrido[1,2-c]pyrimidine derivatives: potent and selective cholecystokinin-A receptor antagonists.

Martín-Martínez M, Bartolomé-Nebreda JM, Gómez-Monterrey I, González-Muñiz R, García-López MT, Ballaz S, Barber A, Fortuño A, Del Río J, Herranz R.

J Med Chem. 1997 Oct 10;40(21):3402-7.PMID: 9341915 [PubMed - indexed for MEDLINE]Related articles

Pharmacological evaluation of IQM-95,333, a highly selective CCKA receptor antagonist with anxiolytic-like activity in animal models.

Ballaz S, Barber A, Fortuño A, Del Río J, Martin-Martínez M, Gómez-Monterrey I, Herranz R, González-Muñiz R, García-López MT.

Br J Pharmacol. 1997 Jun;121(4):759-67.PMID: 9208145 [PubMed - indexed for MEDLINE]Related articlesFree article

2,5-Diketopiperidine derivatives as non-peptide ligands for cholecystokinin receptors.

González-Muñiz RG, Domínguez MJ, Herranz R, García-López MT, Ballaz SJ, Fortuño A, Del Río J.

Farmaco. 1997 Apr;52(4):243-6.PMID: 9241830 [PubMed - indexed for MEDLINE]Related articles

Angiotensin converting enzyme inhibition corrects Na+/H+ exchanger overactivity in essential hypertension.

Fortuño A, Tisaire J, López R, Bueno J, Díez J.

Am J Hypertens. 1997 Jan;10(1):84-93.PMID: 9008252 [PubMed - indexed for MEDLINE]Related articles

Enhanced Na(+)-H+ exchanger activity and NHE-1 mRNA expression in lymphocytes from patients with essential hypertension.

Garciandia A, López R, Tisaire J, Arrázola A, Fortuño A, Bueno J, Diez J.

Hypertension. 1995 Mar;25(3):356-64.PMID: 7875760 [PubMed - indexed for MEDLINE]Related articlesFree article

Association of increased erythrocyte Na+/H+ exchanger with renal Na+ retention in patients with essential hypertension.

Díez J, Alonso A, Garciandía A, López R, Gómez-Alamillo C, Arrázola A, Fortuño A.

Am J Hypertens. 1995 Feb;8(2):124-32.PMID: 7755940 [PubMed - indexed for MEDLINE]Related articles