PubMed

Modulation of Exaggerated-IgE Allergic Responses by Gene Transfer-mediated Antagonism of IL-13 and IL-17e.

Mueller C, Keeler A, Braag S, Menz T, Tang Q, Flotte TR.

Mol Ther. 2009 Nov 24. [Epub ahead of print]PMID: 19935781 [PubMed - as supplied by publisher]

In vitro and in vivo functional characterization of gutless recombinant SV40-derived CFTR vectors.

Mueller C, Strayer MS, Sirninger J, Braag S, Branco F, Louboutin JP, Flotte TR, Strayer DS.

Gene Ther. 2009 Nov 5. [Epub ahead of print]PMID: 19890354 [PubMed - as supplied by publisher]Related articles

Dual Reporter Comparative Indexing of rAAV Pseudotyped Vectors in Chimpanzee Airway.

Flotte TR, Fischer AC, Goetzmann J, Mueller C, Cebotaru L, Yan Z, Wang L, Wilson JM, Guggino WB, Engelhardt JF.

Mol Ther. 2009 Oct 13. [Epub ahead of print]PMID: 19826405 [PubMed - as supplied by publisher]Related articles

Sustained transgene expression despite T lymphocyte responses in a clinical trial of rAAV1-AAT gene therapy.

Brantly ML, Chulay JD, Wang L, Mueller C, Humphries M, Spencer LT, Rouhani F, Conlon TJ, Calcedo R, Betts MR, Spencer C, Byrne BJ, Wilson JM, Flotte TR.

Proc Natl Acad Sci U S A. 2009 Sep 22;106(38):16363-8. Epub 2009 Aug 12. Erratum in: Proc Natl Acad Sci U S A. 2009 Oct 13;106(41):17606. PMID: 19706466 [PubMed - indexed for MEDLINE]Related articles

Endocrine parameters of cystic fibrosis: Back to basics.

Stalvey MS, Flotte TR.

J Cell Biochem. 2009 Oct 1;108(2):353-61.PMID: 19670266 [PubMed - in process]Related articles

Melanocytic nevus-like hyperplasia and melanoma in transgenic BRAFV600E mice.

Goel VK, Ibrahim N, Jiang G, Singhal M, Fee S, Flotte T, Westmoreland S, Haluska FS, Hinds PW, Haluska FG.

Oncogene. 2009 Jun 11;28(23):2289-98. Epub 2009 Apr 27.PMID: 19398955 [PubMed - indexed for MEDLINE]Related articles

Metastatic malignant melanoma.

Markovic SN, Erickson LA, Flotte TJ, Kottschade LA, McWilliams RR, Jakub JW, Farley DR, Tran NV, Schild SE, Olivier KR, Vuk-Pavlovic S, Sekulic A, Weenig RH, Pulido JS, Quevedo JF, Vile RG, Wiseman GA, Stoian I, Pittelkow MR; Melanoma Study Group of the Mayo Clinic Cancer Center.

G Ital Dermatol Venereol. 2009 Feb;144(1):1-26. Review.PMID: 19218908 [PubMed - indexed for MEDLINE]Related articles

Defective acid sphingomyelinase pathway with Pseudomonas aeruginosa infection in cystic fibrosis.

Yu H, Zeidan YH, Wu BX, Jenkins RW, Flotte TR, Hannun YA, Virella-Lowell I.

Am J Respir Cell Mol Biol. 2009 Sep;41(3):367-75. Epub 2009 Jan 23.PMID: 19168701 [PubMed - indexed for MEDLINE]Related articles

Murine model for cystic fibrosis bone disease demonstrates osteopenia and sex-related differences in bone formation.

Pashuck TD, Franz SE, Altman MK, Wasserfall CH, Atkinson MA, Wronski TJ, Flotte TR, Stalvey MS.

Pediatr Res. 2009 Mar;65(3):311-6.PMID: 19047917 [PubMed - indexed for MEDLINE]Related articles

Recombinant AAV serotype and capsid mutant comparison for pulmonary gene transfer of alpha-1-antitrypsin using invasive and noninvasive delivery.

Liqun Wang R, McLaughlin T, Cossette T, Tang Q, Foust K, Campbell-Thompson M, Martino A, Cruz P, Loiler S, Mueller C, Flotte TR.

Mol Ther. 2009 Jan;17(1):81-7. Epub 2008 Oct 21.PMID: 18941444 [PubMed - indexed for MEDLINE]Related articles

The pros and cons of immunomodulatory IL-10 gene therapy with recombinant AAV in a Cftr-/- -dependent allergy mouse model.

Mueller C, Braag SA, Martino AT, Tang Q, Campbell-Thompson M, Flotte TR.

Gene Ther. 2009 Feb;16(2):172-83. Epub 2008 Sep 25.PMID: 18818669 [PubMed - in process]Related articles

Human gene therapy for RPE65 isomerase deficiency activates the retinoid cycle of vision but with slow rod kinetics.

Cideciyan AV, Aleman TS, Boye SL, Schwartz SB, Kaushal S, Roman AJ, Pang JJ, Sumaroka A, Windsor EA, Wilson JM, Flotte TR, Fishman GA, Heon E, Stone EM, Byrne BJ, Jacobson SG, Hauswirth WW.

Proc Natl Acad Sci U S A. 2008 Sep 30;105(39):15112-7. Epub 2008 Sep 22.PMID: 18809924 [PubMed - indexed for MEDLINE]Related articlesFree article

CFTR mutations impart elevated immune reactivity in a murine model of cystic fibrosis related diabetes.

Stalvey MS, Brusko TM, Mueller C, Wasserfall CH, Schatz DA, Atkinson MA, Flotte TR.

Cytokine. 2008 Oct;44(1):154-9. Epub 2008 Sep 7.PMID: 18778952 [PubMed - indexed for MEDLINE]Related articles

Treatment of leber congenital amaurosis due to RPE65 mutations by ocular subretinal injection of adeno-associated virus gene vector: short-term results of a phase I trial.

Hauswirth WW, Aleman TS, Kaushal S, Cideciyan AV, Schwartz SB, Wang L, Conlon TJ, Boye SL, Flotte TR, Byrne BJ, Jacobson SG.

Hum Gene Ther. 2008 Oct;19(10):979-90.PMID: 18774912 [PubMed - indexed for MEDLINE]Related articles

Recombinant adeno-associated virus-mediated gene delivery of long chain acyl coenzyme A dehydrogenase (LCAD) into LCAD-deficient mice.

Beattie SG, Goetzman E, Tang Q, Conlon T, Campbell-Thompson M, Matern D, Vockley J, Flotte TR.

J Gene Med. 2008 Oct;10(10):1113-23.PMID: 18720429 [PubMed - indexed for MEDLINE]Related articles

Gene therapy for cystic fibrosis.

Mueller C, Flotte TR.

Clin Rev Allergy Immunol. 2008 Dec;35(3):164-78. Review.PMID: 18600482 [PubMed - indexed for MEDLINE]Related articles

Towards a rAAV-based gene therapy for ADA-SCID: from ADA deficiency to current and future treatment strategies.

Silver JN, Flotte TR.

Pharmacogenomics. 2008 Jul;9(7):947-68. Review.PMID: 18597656 [PubMed - indexed for MEDLINE]Related articles

Apparently nonspecific enzyme elevations after portal vein delivery of recombinant adeno-associated virus serotype 2 vector in hepatitis C virus-infected chimpanzees.

Flotte TR, Goetzmann J, Caridi J, Paolillo J, Conlon TJ, Potter M, Mueller C, Byrne BJ.

Hum Gene Ther. 2008 Jul;19(7):681-9.PMID: 18588426 [PubMed - indexed for MEDLINE]Related articles

Case records of the Massachusetts General Hospital. Case 20-2008. A 57-year-old woman with abdominal pain and weakness after gastric bypass surgery.

Bonkovsky HL, Siao P, Roig Z, Hedley-Whyte ET, Flotte TJ.

N Engl J Med. 2008 Jun 26;358(26):2813-25. No abstract available. Erratum in: N Engl J Med. 2008 Oct 23;359(17):1859. PMID: 18579817 [PubMed - indexed for MEDLINE]Related articles

Cystic fibrosis transmembrane regulator missing the first four transmembrane segments increases wild type and DeltaF508 processing.

Cebotaru L, Vij N, Ciobanu I, Wright J, Flotte T, Guggino WB.

J Biol Chem. 2008 Aug 8;283(32):21926-33. Epub 2008 May 28.PMID: 18508776 [PubMed - indexed for MEDLINE]Related articlesFree article

Biochemical correction of short-chain acyl-coenzyme A dehydrogenase deficiency after portal vein injection of rAAV8-SCAD.

Beattie SG, Goetzman E, Conlon T, Germain S, Walter G, Campbell-Thompson M, Matern D, Vockley J, Flotte TR.

Hum Gene Ther. 2008 Jun;19(6):579-88.PMID: 18500942 [PubMed - indexed for MEDLINE]Related articles

In utero efficacy of cystic fibrosis gene therapy: difficult studies, positive or negative.

Flotte TR.

Mol Ther. 2008 May;16(5):806-7. No abstract available. PMID: 18432269 [PubMed - indexed for MEDLINE]Related articles

Clinical gene therapy using recombinant adeno-associated virus vectors.

Mueller C, Flotte TR.

Gene Ther. 2008 Jun;15(11):858-63. Epub 2008 Apr 17. Review.PMID: 18418415 [PubMed - indexed for MEDLINE]Related articles

Case records of the Massachusetts General Hospital. Case 3-2008. An 80-year-old woman with cutaneous basal-cell carcinomas and cysts of the jaws.

Epstein EH, Shepard JA, Flotte TJ.

N Engl J Med. 2008 Jan 24;358(4):393-401. No abstract available. PMID: 18216361 [PubMed - indexed for MEDLINE]Related articles

Transverse sectioning of the scalp (Headington technique) in the 19th century.

Flotte TJ.

J Cutan Pathol. 2008 Jan;35(1):82-5.PMID: 18096001 [PubMed - indexed for MEDLINE]Related articles

Recombinant adeno-associated virus-mediated global anterograde delivery of glial cell line-derived neurotrophic factor to the spinal cord: comparison of rubrospinal and corticospinal tracts in the rat.

Foust KD, Flotte TR, Reier PJ, Mandel RJ.

Hum Gene Ther. 2008 Jan;19(1):71-82.PMID: 18072858 [PubMed - indexed for MEDLINE]Related articles

Neonatal intraperitoneal or intravenous injections of recombinant adeno-associated virus type 8 transduce dorsal root ganglia and lower motor neurons.

Foust KD, Poirier A, Pacak CA, Mandel RJ, Flotte TR.

Hum Gene Ther. 2008 Jan;19(1):61-70.PMID: 18052722 [PubMed - indexed for MEDLINE]Related articles

Partial correction of the CFTR-dependent ABPA mouse model with recombinant adeno-associated virus gene transfer of truncated CFTR gene.

Mueller C, Torrez D, Braag S, Martino A, Clarke T, Campbell-Thompson M, Flotte TR.

J Gene Med. 2008 Jan;10(1):51-60.PMID: 18023072 [PubMed - indexed for MEDLINE]Related articles

The promise of gene therapy for the treatment of alpha-1 antitrypsin deficiency.

Cruz PE, Mueller C, Flotte TR.

Pharmacogenomics. 2007 Sep;8(9):1191-8. Review.PMID: 17924834 [PubMed - indexed for MEDLINE]Related articles

Progress and prospects: gene therapy clinical trials (part 1).

Alexander BL, Ali RR, Alton EW, Bainbridge JW, Braun S, Cheng SH, Flotte TR, Gaspar HB, Grez M, Griesenbach U, Kaplitt MG, Ott MG, Seger R, Simons M, Thrasher AJ, Thrasher AZ, Ylä-Herttuala S.

Gene Ther. 2007 Oct;14(20):1439-47. Review. Erratum in: Gene Ther. 2007 Dec;14(24):1754. multiple author names added. PMID: 17909539 [PubMed - indexed for MEDLINE]Related articles

In vivo post-transcriptional gene silencing of alpha-1 antitrypsin by adeno-associated virus vectors expressing siRNA.

Cruz PE, Mueller C, Cossette TL, Golant A, Tang Q, Beattie SG, Brantly M, Campbell-Thompson M, Blomenkamp KS, Teckman JH, Flotte TR.

Lab Invest. 2007 Sep;87(9):893-902. Epub 2007 Jun 25.PMID: 17592477 [PubMed - indexed for MEDLINE]Related articlesFree article

Gene therapy: the first two decades and the current state-of-the-art.

Flotte TR.

J Cell Physiol. 2007 Nov;213(2):301-5. Review.PMID: 17577203 [PubMed - indexed for MEDLINE]Related articles

In vivo expression of human ATP:cob(I)alamin adenosyltransferase (ATR) using recombinant adeno-associated virus (rAAV) serotypes 2 and 8.

Erger KE, Conlon TJ, Leal NA, Zori R, Bobik TA, Flotte TR.

J Gene Med. 2007 Jun;9(6):462-9.PMID: 17471589 [PubMed - indexed for MEDLINE]Related articles

Adeno-associated viral vector-mediated interleukin-10 prolongs allograft survival in a rat kidney transplantation model.

Chen B, Kapturczak MH, Joseph R, George JF, Campbell-Thompson M, Wasserfall CH, Atkinson MA, Tisher CC, Flotte TR, Agarwal A, Chen S.

Am J Transplant. 2007 May;7(5):1112-20.PMID: 17456199 [PubMed - indexed for MEDLINE]Related articles

Preclinical characterization of a recombinant adeno-associated virus type 1-pseudotyped vector demonstrates dose-dependent injection site inflammation and dissemination of vector genomes to distant sites.

Flotte TR, Conlon TJ, Poirier A, Campbell-Thompson M, Byrne BJ.

Hum Gene Ther. 2007 Mar;18(3):245-56.PMID: 17376008 [PubMed - indexed for MEDLINE]Related articles

Fluorescence polarization of tetracycline derivatives as a technique for mapping nonmelanoma skin cancers.

Yaroslavsky AN, Salomatina EV, Neel V, Anderson R, Flotte T.

J Biomed Opt. 2007 Jan-Feb;12(1):014005.PMID: 17343480 [PubMed - indexed for MEDLINE]Related articles

Expression of a truncated cystic fibrosis transmembrane conductance regulator with an AAV5-pseudotyped vector in primates.

Fischer AC, Smith CI, Cebotaru L, Zhang X, Askin FB, Wright J, Guggino SE, Adams RJ, Flotte T, Guggino WB.

Mol Ther. 2007 Apr;15(4):756-63. Epub 2007 Feb 13.PMID: 17299412 [PubMed - indexed for MEDLINE]Related articles

Viral vector-mediated and cell-based therapies for treatment of cystic fibrosis.

Flotte TR, Ng P, Dylla DE, McCray PB Jr, Wang G, Kolls JK, Hu J.

Mol Ther. 2007 Feb;15(2):229-41. Review.PMID: 17235299 [PubMed - indexed for MEDLINE]Related articles

Improved staining method for determining the extent of thermal damage to cells.

Sherwood ME, Flotte TJ.

Lasers Surg Med. 2007 Feb;39(2):128-31.PMID: 17163480 [PubMed - indexed for MEDLINE]Related articles

Phase I trial of intramuscular injection of a recombinant adeno-associated virus serotype 2 alphal-antitrypsin (AAT) vector in AAT-deficient adults.

Brantly ML, Spencer LT, Humphries M, Conlon TJ, Spencer CT, Poirier A, Garlington W, Baker D, Song S, Berns KI, Muzyczka N, Snyder RO, Byrne BJ, Flotte TR.

Hum Gene Ther. 2006 Dec;17(12):1177-86.PMID: 17115945 [PubMed - indexed for MEDLINE]Related articles

alpha-1 antitrypsin inhibits caspase-3 activity, preventing lung endothelial cell apoptosis.

Petrache I, Fijalkowska I, Medler TR, Skirball J, Cruz P, Zhen L, Petrache HI, Flotte TR, Tuder RM.

Am J Pathol. 2006 Oct;169(4):1155-66.PMID: 17003475 [PubMed - indexed for MEDLINE]Related articlesFree article

Repeated intrathecal injections of plasmid DNA encoding interleukin-10 produce prolonged reversal of neuropathic pain.

Milligan ED, Sloane EM, Langer SJ, Hughes TS, Jekich BM, Frank MG, Mahoney JH, Levkoff LH, Maier SF, Cruz PE, Flotte TR, Johnson KW, Mahoney MM, Chavez RA, Leinwand LA, Watkins LR.

Pain. 2006 Dec 15;126(1-3):294-308. Epub 2006 Sep 1.PMID: 16949747 [PubMed - indexed for MEDLINE]Related articles

Safety in nonhuman primates of ocular AAV2-RPE65, a candidate treatment for blindness in Leber congenital amaurosis.

Jacobson SG, Boye SL, Aleman TS, Conlon TJ, Zeiss CJ, Roman AJ, Cideciyan AV, Schwartz SB, Komaromy AM, Doobrajh M, Cheung AY, Sumaroka A, Pearce-Kelling SE, Aguirre GD, Kaushal S, Maguire AM, Flotte TR, Hauswirth WW.

Hum Gene Ther. 2006 Aug;17(8):845-58.PMID: 16942444 [PubMed - indexed for MEDLINE]Related articles

Recent developments in the protection of pediatric research subjects.

Flotte TR, Frentzen B, Humphries MR, Rosenbloom AL.

J Pediatr. 2006 Sep;149(3):285-286. No abstract available. PMID: 16939731 [PubMed - indexed for MEDLINE]Related articles

The role of photosensitizer molecular charge and structure on the efficacy of photodynamic therapy against Leishmania parasites.

Akilov OE, Kosaka S, O'Riordan K, Song X, Sherwood M, Flotte TJ, Foley JW, Hasan T.

Chem Biol. 2006 Aug;13(8):839-47.PMID: 16931333 [PubMed - indexed for MEDLINE]Related articles

IL-10 regulation of lupus in the NZM2410 murine model.

Blenman KR, Duan B, Xu Z, Wan S, Atkinson MA, Flotte TR, Croker BP, Morel L.

Lab Invest. 2006 Nov;86(11):1136-48. Epub 2006 Aug 21.PMID: 16924244 [PubMed - indexed for MEDLINE]Related articlesFree article

Comparative oncogenomics identifies NEDD9 as a melanoma metastasis gene.

Kim M, Gans JD, Nogueira C, Wang A, Paik JH, Feng B, Brennan C, Hahn WC, Cordon-Cardo C, Wagner SN, Flotte TJ, Duncan LM, Granter SR, Chin L.

Cell. 2006 Jun 30;125(7):1269-81.PMID: 16814714 [PubMed - indexed for MEDLINE]Related articles

Cystic fibrosis transmembrane conductance regulator deficiency exacerbates islet cell dysfunction after beta-cell injury.

Stalvey MS, Muller C, Schatz DA, Wasserfall CH, Campbell-Thompson ML, Theriaque DW, Flotte TR, Atkinson MA.

Diabetes. 2006 Jul;55(7):1939-45.PMID: 16804061 [PubMed - indexed for MEDLINE]Related articlesFree article

Safety of recombinant adeno-associated virus type 2-RPE65 vector delivered by ocular subretinal injection.

Jacobson SG, Acland GM, Aguirre GD, Aleman TS, Schwartz SB, Cideciyan AV, Zeiss CJ, Komaromy AM, Kaushal S, Roman AJ, Windsor EA, Sumaroka A, Pearce-Kelling SE, Conlon TJ, Chiodo VA, Boye SL, Flotte TR, Maguire AM, Bennett J, Hauswirth WW.

Mol Ther. 2006 Jun;13(6):1074-84. Epub 2006 Apr 27.PMID: 16644289 [PubMed - indexed for MEDLINE]Related articles

In vivo complementation of complex I by the yeast Ndi1 enzyme. Possible application for treatment of Parkinson disease.

Seo BB, Nakamaru-Ogiso E, Flotte TR, Matsuno-Yagi A, Yagi T.

J Biol Chem. 2006 May 19;281(20):14250-5. Epub 2006 Mar 16.PMID: 16543240 [PubMed - indexed for MEDLINE]Related articlesFree article