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    Results: 1 to 50 of 57

    1.

    Hip Geometry Variation is Associated With Bone Mineralization Pathway Gene Variants: The Framingham Study.

    Cheung CL, Livshits G, Zhou Y, Meigs JB, McAteer JB, Florez JC, Cupples LA, Demissie S, Kiel DP, Karasik D.

    J Bone Miner Res. 2009 Nov 5. [Epub ahead of print]PMID: 19888898 [PubMed - as supplied by publisher]Related articles

    2.

    The clinical application of genetic testing in type 2 diabetes: a patient and physician survey.

    Grant RW, Hivert M, Pandiscio JC, Florez JC, Nathan DM, Meigs JB.

    Diabetologia. 2009 Sep 2. [Epub ahead of print]PMID: 19727660 [PubMed - as supplied by publisher]Related articles

    3.

    Genomics of type 2 diabetes mellitus: implications for the clinician.

    Stolerman ES, Florez JC.

    Nat Rev Endocrinol. 2009 Aug;5(8):429-36. Epub 2009 Jun 30. Review.PMID: 19564886 [PubMed - indexed for MEDLINE]Related articles

    4.

    Strong association of socioeconomic status with genetic ancestry in Latinos: implications for admixture studies of type 2 diabetes.

    Florez JC, Price AL, Campbell D, Riba L, Parra MV, Yu F, Duque C, Saxena R, Gallego N, Tello-Ruiz M, Franco L, Rodríguez-Torres M, Villegas A, Bedoya G, Aguilar-Salinas CA, Tusié-Luna MT, Ruiz-Linares A, Reich D.

    Diabetologia. 2009 Aug;52(8):1528-36. Epub 2009 Jun 13.PMID: 19526211 [PubMed - indexed for MEDLINE]Related articles

    5.

    Genetic architecture of type 2 diabetes: recent progress and clinical implications.

    Grant RW, Moore AF, Florez JC.

    Diabetes Care. 2009 Jun;32(6):1107-14. No abstract available. PMID: 19460916 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    The dawn of prospective pharmacogenetic testing in type 2 diabetes.

    Florez JC.

    Curr Diab Rep. 2009 Apr;9(2):95-7. No abstract available. PMID: 19323951 [PubMed]Related articles

    7.

    Clinical translation of genetic predictors for type 2 diabetes.

    Majithia AR, Florez JC.

    Curr Opin Endocrinol Diabetes Obes. 2009 Apr;16(2):100-6. Review.PMID: 19306524 [PubMed - indexed for MEDLINE]Related articles

    8.

    TCF7L2 variants are associated with increased proinsulin/insulin ratios but not obesity traits in the Framingham Heart Study.

    Stolerman ES, Manning AK, McAteer JB, Fox CS, Dupuis J, Meigs JB, Florez JC.

    Diabetologia. 2009 Apr;52(4):614-20. Epub 2009 Jan 31.PMID: 19183934 [PubMed - indexed for MEDLINE]Related articles

    9.

    Variants in the CNR1 and the FAAH genes and adiposity traits in the community.

    Lieb W, Manning AK, Florez JC, Dupuis J, Cupples LA, McAteer JB, Vasan RS, Hoffmann U, O'Donnell CJ, Meigs JB, Fox CS.

    Obesity (Silver Spring). 2009 Apr;17(4):755-60. Epub 2009 Jan 22.PMID: 19165169 [PubMed - indexed for MEDLINE]Related articles

    10.

    The role of HSP70 on ENPP1 expression and insulin-receptor activation.

    Marucci A, Miscio G, Padovano L, Boonyasrisawat W, Florez JC, Doria A, Trischitta V, Di Paola R.

    J Mol Med. 2009 Feb;87(2):139-44. Epub 2008 Dec 16.PMID: 19083193 [PubMed - indexed for MEDLINE]Related articles

    11.

    Association of variants in RETN with plasma resistin levels and diabetes-related traits in the Framingham Offspring Study.

    Hivert MF, Manning AK, McAteer JB, Dupuis J, Fox CS, Cupples LA, Meigs JB, Florez JC.

    Diabetes. 2009 Mar;58(3):750-6. Epub 2008 Dec 15.PMID: 19074981 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    Variants in MTNR1B influence fasting glucose levels.

    Prokopenko I, Langenberg C, Florez JC, Saxena R, Soranzo N, Thorleifsson G, Loos RJ, Manning AK, Jackson AU, Aulchenko Y, Potter SC, Erdos MR, Sanna S, Hottenga JJ, Wheeler E, Kaakinen M, Lyssenko V, Chen WM, Ahmadi K, Beckmann JS, Bergman RN, Bochud M, Bonnycastle LL, Buchanan TA, Cao A, Cervino A, Coin L, Collins FS, Crisponi L, de Geus EJ, Dehghan A, Deloukas P, Doney AS, Elliott P, Freimer N, Gateva V, Herder C, Hofman A, Hughes TE, Hunt S, Illig T, Inouye M, Isomaa B, Johnson T, Kong A, Krestyaninova M, Kuusisto J, Laakso M, Lim N, Lindblad U, Lindgren CM, McCann OT, Mohlke KL, Morris AD, Naitza S, Orrù M, Palmer CN, Pouta A, Randall J, Rathmann W, Saramies J, Scheet P, Scott LJ, Scuteri A, Sharp S, Sijbrands E, Smit JH, Song K, Steinthorsdottir V, Stringham HM, Tuomi T, Tuomilehto J, Uitterlinden AG, Voight BF, Waterworth D, Wichmann HE, Willemsen G, Witteman JC, Yuan X, Zhao JH, Zeggini E, Schlessinger D, Sandhu M, Boomsma DI, Uda M, Spector TD, Penninx BW, Altshuler D, Vollenweider P, Jarvelin MR, Lakatta E, Waeber G, Fox CS, Peltonen L, Groop LC, Mooser V, Cupples LA, Thorsteinsdottir U, Boehnke M, Barroso I, Van Duijn C, Dupuis J, Watanabe RM, Stefansson K, McCarthy MI, Wareham NJ, Meigs JB, Abecasis GR.

    Nat Genet. 2009 Jan;41(1):77-81. Epub 2008 Dec 7.PMID: 19060907 [PubMed - indexed for MEDLINE]Related articles

    13.

    Genotype score in addition to common risk factors for prediction of type 2 diabetes.

    Meigs JB, Shrader P, Sullivan LM, McAteer JB, Fox CS, Dupuis J, Manning AK, Florez JC, Wilson PW, D'Agostino RB Sr, Cupples LA.

    N Engl J Med. 2008 Nov 20;359(21):2208-19. Erratum in: N Engl J Med. 2009 Feb 5;360(6):648. PMID: 19020323 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    The association of ENPP1 K121Q with diabetes incidence is abolished by lifestyle modification in the diabetes prevention program.

    Moore AF, Jablonski KA, Mason CC, McAteer JB, Arakaki RF, Goldstein BJ, Kahn SE, Kitabchi AE, Hanson RL, Knowler WC, Florez JC; Diabetes Prevention Program Research Group.

    J Clin Endocrinol Metab. 2009 Feb;94(2):449-55. Epub 2008 Nov 18.PMID: 19017751 [PubMed - indexed for MEDLINE]Related articles

    15.

    Assessing gene-treatment interactions at the FTO and INSIG2 loci on obesity-related traits in the Diabetes Prevention Program.

    Franks PW, Jablonski KA, Delahanty LM, McAteer JB, Kahn SE, Knowler WC, Florez JC; Diabetes Prevention Program Research Group.

    Diabetologia. 2008 Dec;51(12):2214-23. Epub 2008 Oct 7. Erratum in: Diabetologia. 2009 Jul;52(7):1456. PMID: 18839134 [PubMed - indexed for MEDLINE]Related articles

    16.

    Clinical review: the genetics of type 2 diabetes: a realistic appraisal in 2008.

    Florez JC.

    J Clin Endocrinol Metab. 2008 Dec;93(12):4633-42. Epub 2008 Sep 9. Review.PMID: 18782870 [PubMed - indexed for MEDLINE]Related articles

    17.

    Common variants in the adiponectin gene (ADIPOQ) associated with plasma adiponectin levels, type 2 diabetes, and diabetes-related quantitative traits: the Framingham Offspring Study.

    Hivert MF, Manning AK, McAteer JB, Florez JC, Dupuis J, Fox CS, O'Donnell CJ, Cupples LA, Meigs JB.

    Diabetes. 2008 Dec;57(12):3353-9. Epub 2008 Sep 5.PMID: 18776141 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    Ordered stratification to reduce heterogeneity in linkage to diabetes-related quantitative traits.

    Meigs JB, Manning AK, Dupuis J, Liu C, Florez JC, Cupples LA.

    Obesity (Silver Spring). 2008 Oct;16(10):2314-22. Epub 2008 Jul 24.PMID: 18719643 [PubMed - indexed for MEDLINE]Related articles

    19.

    A genetic link between type 2 diabetes and prostate cancer.

    Frayling TM, Colhoun H, Florez JC.

    Diabetologia. 2008 Oct;51(10):1757-60. Epub 2008 Aug 12.PMID: 18696045 [PubMed - indexed for MEDLINE]Related articles

    20.

    TCF7L2 variants associate with CKD progression and renal function in population-based cohorts.

    Köttgen A, Hwang SJ, Rampersaud E, Coresh J, North KE, Pankow JS, Meigs JB, Florez JC, Parsa A, Levy D, Boerwinkle E, Shuldiner AR, Fox CS, Kao WH.

    J Am Soc Nephrol. 2008 Oct;19(10):1989-99. Epub 2008 Jul 23.PMID: 18650481 [PubMed - indexed for MEDLINE]Related articlesFree article

    21.

    Extension of type 2 diabetes genome-wide association scan results in the diabetes prevention program.

    Moore AF, Jablonski KA, McAteer JB, Saxena R, Pollin TI, Franks PW, Hanson RL, Shuldiner AR, Knowler WC, Altshuler D, Florez JC; Diabetes Prevention Program Research Group.

    Diabetes. 2008 Sep;57(9):2503-10. Epub 2008 Jun 10.PMID: 18544707 [PubMed - indexed for MEDLINE]Related articlesFree article

    22.

    Newly identified loci highlight beta cell dysfunction as a key cause of type 2 diabetes: where are the insulin resistance genes?

    Florez JC.

    Diabetologia. 2008 Jul;51(7):1100-10. Epub 2008 May 27. Review.PMID: 18504548 [PubMed - indexed for MEDLINE]Related articles

    23.

    The prevention of type 2 diabetes.

    Crandall JP, Knowler WC, Kahn SE, Marrero D, Florez JC, Bray GA, Haffner SM, Hoskin M, Nathan DM; Diabetes Prevention Program Research Group.

    Nat Clin Pract Endocrinol Metab. 2008 Jul;4(7):382-93. Epub 2008 May 20. Review.PMID: 18493227 [PubMed - indexed for MEDLINE]Related articlesFree article

    24.

    Haplotype structure of the ENPP1 Gene and Nominal Association of the K121Q missense single nucleotide polymorphism with glycemic traits in the Framingham Heart Study.

    Stolerman ES, Manning AK, McAteer JB, Dupuis J, Fox CS, Cupples LA, Meigs JB, Florez JC.

    Diabetes. 2008 Jul;57(7):1971-7. Epub 2008 Apr 21.PMID: 18426862 [PubMed - indexed for MEDLINE]Related articlesFree article

    25.

    The ENPP1 K121Q polymorphism is associated with type 2 diabetes in European populations: evidence from an updated meta-analysis in 42,042 subjects.

    McAteer JB, Prudente S, Bacci S, Lyon HN, Hirschhorn JN, Trischitta V, Florez JC; ENPP1 Consortium.

    Diabetes. 2008 Apr;57(4):1125-30. Epub 2007 Dec 10.PMID: 18071025 [PubMed - indexed for MEDLINE]Related articlesFree article

    26.

    Testing of diabetes-associated WFS1 polymorphisms in the Diabetes Prevention Program.

    Florez JC, Jablonski KA, McAteer J, Sandhu MS, Wareham NJ, Barroso I, Franks PW, Altshuler D, Knowler WC; Diabetes Prevention Program Research Group.

    Diabetologia. 2008 Mar;51(3):451-7. Epub 2007 Dec 4.PMID: 18060660 [PubMed - indexed for MEDLINE]Related articlesFree article

    27.

    Genetic susceptibility to type 2 diabetes and implications for antidiabetic therapy.

    Moore AF, Florez JC.

    Annu Rev Med. 2008;59:95-111. Review.PMID: 17937592 [PubMed - indexed for MEDLINE]Related articles

    28.

    Genome-wide association with diabetes-related traits in the Framingham Heart Study.

    Meigs JB, Manning AK, Fox CS, Florez JC, Liu C, Cupples LA, Dupuis J.

    BMC Med Genet. 2007 Sep 19;8 Suppl 1:S16.PMID: 17903298 [PubMed - indexed for MEDLINE]Related articlesFree article

    29.

    A piece of my mind. Knowledge is power.

    Florez JC.

    JAMA. 2007 Oct 3;298(13):1489-90. No abstract available. PMID: 17911487 [PubMed - indexed for MEDLINE]Related articles

    30.

    Patent foramen ovale and hypercoagulability as combined risk factors for stroke.

    Florez JC, Ay H, Van Cott EM, Buonanno FS.

    J Stroke Cerebrovasc Dis. 2003 May-Jun;12(3):114-8.PMID: 17903914 [PubMed]Related articles

    31.

    The Pro12Ala variant at the peroxisome proliferator-activated receptor gamma gene and change in obesity-related traits in the Diabetes Prevention Program.

    Franks PW, Jablonski KA, Delahanty L, Hanson RL, Kahn SE, Altshuler D, Knowler WC, Florez JC; Diabetes Prevention Program Research Group.

    Diabetologia. 2007 Dec;50(12):2451-60. Epub 2007 Sep 27.PMID: 17898990 [PubMed - indexed for MEDLINE]Related articlesFree article

    32.

    Introduction to genetic association studies.

    Tsao H, Florez JC.

    J Invest Dermatol. 2007 Oct;127(10):2283-7. No abstract available. PMID: 17853910 [PubMed - indexed for MEDLINE]Related articlesFree article

    33.

    A 100K genome-wide association scan for diabetes and related traits in the Framingham Heart Study: replication and integration with other genome-wide datasets.

    Florez JC, Manning AK, Dupuis J, McAteer J, Irenze K, Gianniny L, Mirel DB, Fox CS, Cupples LA, Meigs JB.

    Diabetes. 2007 Dec;56(12):3063-74. Epub 2007 Sep 11.PMID: 17848626 [PubMed - indexed for MEDLINE]Related articlesFree article

    34.

    The new type 2 diabetes gene TCF7L2.

    Florez JC.

    Curr Opin Clin Nutr Metab Care. 2007 Jul;10(4):391-6. Review.PMID: 17563454 [PubMed - indexed for MEDLINE]Related articles

    35.

    Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels.

    Diabetes Genetics Initiative of Broad Institute of Harvard and MIT, Lund University, and Novartis Institutes of BioMedical Research, Saxena R, Voight BF, Lyssenko V, Burtt NP, de Bakker PI, Chen H, Roix JJ, Kathiresan S, Hirschhorn JN, Daly MJ, Hughes TE, Groop L, Altshuler D, Almgren P, Florez JC, Meyer J, Ardlie K, Bengtsson Boström K, Isomaa B, Lettre G, Lindblad U, Lyon HN, Melander O, Newton-Cheh C, Nilsson P, Orho-Melander M, Råstam L, Speliotes EK, Taskinen MR, Tuomi T, Guiducci C, Berglund A, Carlson J, Gianniny L, Hackett R, Hall L, Holmkvist J, Laurila E, Sjögren M, Sterner M, Surti A, Svensson M, Svensson M, Tewhey R, Blumenstiel B, Parkin M, Defelice M, Barry R, Brodeur W, Camarata J, Chia N, Fava M, Gibbons J, Handsaker B, Healy C, Nguyen K, Gates C, Sougnez C, Gage D, Nizzari M, Gabriel SB, Chirn GW, Ma Q, Parikh H, Richardson D, Ricke D, Purcell S.

    Science. 2007 Jun 1;316(5829):1331-6. Epub 2007 Apr 26.PMID: 17463246 [PubMed - indexed for MEDLINE]Related articlesFree article

    36.

    Association testing of common variants in the insulin receptor substrate-1 gene (IRS1) with type 2 diabetes.

    Florez JC, Sjögren M, Agapakis CM, Burtt NP, Almgren P, Lindblad U, Berglund G, Tuomi T, Gaudet D, Daly MJ, Ardlie KG, Hirschhorn JN, Altshuler D, Groop L.

    Diabetologia. 2007 Jun;50(6):1209-17. Epub 2007 Apr 19.PMID: 17443311 [PubMed - indexed for MEDLINE]Related articles

    37.

    Type 2 diabetes-associated missense polymorphisms KCNJ11 E23K and ABCC8 A1369S influence progression to diabetes and response to interventions in the Diabetes Prevention Program.

    Florez JC, Jablonski KA, Kahn SE, Franks PW, Dabelea D, Hamman RF, Knowler WC, Nathan DM, Altshuler D.

    Diabetes. 2007 Feb;56(2):531-6.PMID: 17259403 [PubMed - indexed for MEDLINE]Related articlesFree article

    38.

    Effects of the type 2 diabetes-associated PPARG P12A polymorphism on progression to diabetes and response to troglitazone.

    Florez JC, Jablonski KA, Sun MW, Bayley N, Kahn SE, Shamoon H, Hamman RF, Knowler WC, Nathan DM, Altshuler D; Diabetes Prevention Program Research Group.

    J Clin Endocrinol Metab. 2007 Apr;92(4):1502-9. Epub 2007 Jan 9.PMID: 17213274 [PubMed - indexed for MEDLINE]Related articlesFree article

    39.

    The Krüppel-like factor 11 (KLF11) Q62R polymorphism is not associated with type 2 diabetes in 8,676 people.

    Florez JC, Saxena R, Winckler W, Burtt NP, Almgren P, Bengtsson Boström K, Tuomi T, Gaudet D, Ardlie KG, Daly MJ, Altshuler D, Hirschhorn JN, Groop L.

    Diabetes. 2006 Dec;55(12):3620-4.PMID: 17130512 [PubMed - indexed for MEDLINE]Related articlesFree article

    40.

    Common variants in the ENPP1 gene are not reproducibly associated with diabetes or obesity.

    Lyon HN, Florez JC, Bersaglieri T, Saxena R, Winckler W, Almgren P, Lindblad U, Tuomi T, Gaudet D, Zhu X, Cooper R, Ardlie KG, Daly MJ, Altshuler D, Groop L, Hirschhorn JN.

    Diabetes. 2006 Nov;55(11):3180-4.PMID: 17065359 [PubMed - indexed for MEDLINE]Related articlesFree article

    41.

    Common single nucleotide polymorphisms in TCF7L2 are reproducibly associated with type 2 diabetes and reduce the insulin response to glucose in nondiabetic individuals.

    Saxena R, Gianniny L, Burtt NP, Lyssenko V, Giuducci C, Sjögren M, Florez JC, Almgren P, Isomaa B, Orho-Melander M, Lindblad U, Daly MJ, Tuomi T, Hirschhorn JN, Ardlie KG, Groop LC, Altshuler D.

    Diabetes. 2006 Oct;55(10):2890-5.PMID: 17003358 [PubMed - indexed for MEDLINE]Related articlesFree article

    42.

    TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program.

    Florez JC, Jablonski KA, Bayley N, Pollin TI, de Bakker PI, Shuldiner AR, Knowler WC, Nathan DM, Altshuler D; Diabetes Prevention Program Research Group.

    N Engl J Med. 2006 Jul 20;355(3):241-50.PMID: 16855264 [PubMed - indexed for MEDLINE]Related articlesFree article

    43.

    Haplotype structures and large-scale association testing of the 5' AMP-activated protein kinase genes PRKAA2, PRKAB1, and PRKAB2 [corrected] with type 2 diabetes.

    Sun MW, Lee JY, de Bakker PI, Burtt NP, Almgren P, Råstam L, Tuomi T, Gaudet D, Daly MJ, Hirschhorn JN, Altshuler D, Groop L, Florez JC.

    Diabetes. 2006 Mar;55(3):849-55. Erratum in: Diabetes. 2006 Jun;55(6):1904. PMID: 16505254 [PubMed - indexed for MEDLINE]Related articlesFree article

    44.

    High-density haplotype structure and association testing of the insulin-degrading enzyme (IDE) gene with type 2 diabetes in 4,206 people.

    Florez JC, Wiltshire S, Agapakis CM, Burtt NP, de Bakker PI, Almgren P, Bengtsson Boström K, Tuomi T, Gaudet D, Daly MJ, Hirschhorn JN, McCarthy MI, Altshuler D, Groop L.

    Diabetes. 2006 Jan;55(1):128-35.PMID: 16380485 [PubMed - indexed for MEDLINE]Related articlesFree article

    45.

    Genetic susceptibility for polycystic ovary syndrome on chromosome 19: advances in the genetic dissection of complex reproductive traits.

    Florez JC.

    J Clin Endocrinol Metab. 2005 Dec;90(12):6732-4. Review. No abstract available. PMID: 16330807 [PubMed - indexed for MEDLINE]Related articlesFree article

    46.

    Hypercalcemia and local production of parathyroid hormone-related protein by a perisellar rhabdomyosarcoma after remote pituitary irradiation.

    Florez JC, Burton DW, Arnell PM, Deftos LJ, Klibanski A.

    Endocr Pract. 2005 May-Jun;11(3):184-9.PMID: 16239205 [PubMed - indexed for MEDLINE]Related articles

    47.

    Association testing of the protein tyrosine phosphatase 1B gene (PTPN1) with type 2 diabetes in 7,883 people.

    Florez JC, Agapakis CM, Burtt NP, Sun M, Almgren P, Råstam L, Tuomi T, Gaudet D, Hudson TJ, Daly MJ, Ardlie KG, Hirschhorn JN, Groop L, Altshuler D.

    Diabetes. 2005 Jun;54(6):1884-91.PMID: 15919813 [PubMed - indexed for MEDLINE]Related articlesFree article

    48.

    Association testing in 9,000 people fails to confirm the association of the insulin receptor substrate-1 G972R polymorphism with type 2 diabetes.

    Florez JC, Sjögren M, Burtt N, Orho-Melander M, Schayer S, Sun M, Almgren P, Lindblad U, Tuomi T, Gaudet D, Hudson TJ, Daly MJ, Ardlie KG, Hirschhorn JN, Altshuler D, Groop L.

    Diabetes. 2004 Dec;53(12):3313-8.PMID: 15561965 [PubMed - indexed for MEDLINE]Related articlesFree article

    49.

    Phenotypic consequences of the peroxisome proliferator-activated receptor-gamma Pro12Ala polymorphism: the weight of the evidence in genetic association studies.

    Florez JC.

    J Clin Endocrinol Metab. 2004 Sep;89(9):4234-7. No abstract available. PMID: 15356013 [PubMed - indexed for MEDLINE]Related articlesFree article

    50.

    Haplotype structure and genotype-phenotype correlations of the sulfonylurea receptor and the islet ATP-sensitive potassium channel gene region.

    Florez JC, Burtt N, de Bakker PI, Almgren P, Tuomi T, Holmkvist J, Gaudet D, Hudson TJ, Schaffner SF, Daly MJ, Hirschhorn JN, Groop L, Altshuler D.

    Diabetes. 2004 May;53(5):1360-8.PMID: 15111507 [PubMed - indexed for MEDLINE]Related articlesFree article

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