PubMed

Evolution in Health and Medicine Sackler Colloquium: Making evolutionary biology a basic science for medicine.

Nesse RM, Bergstrom CT, Ellison PT, Flier JS, Gluckman P, Govindaraju DR, Niethammer D, Omenn GS, Perlman RL, Schwartz MD, Thomas MG, Stearns SC, Valle D.

Proc Natl Acad Sci U S A. 2009 Nov 16. [Epub ahead of print]PMID: 19918069 [PubMed - as supplied by publisher]Related articles

Fibroblast growth factor 21-deficient mice demonstrate impaired adaptation to ketosis.

Badman MK, Koester A, Flier JS, Kharitonenkov A, Maratos-Flier E.

Endocrinology. 2009 Nov;150(11):4931-40. Epub 2009 Oct 9.PMID: 19819944 [PubMed - indexed for MEDLINE]Related articles

Adipose triglyceride lipase deficiency causes tissue-specific changes in insulin signaling.

Kienesberger PC, Lee D, Pulinilkunnil T, Brenner DS, Cai L, Magnes C, Koefeler HC, Streith IE, Rechberger GN, Haemmerle G, Flier JS, Zechner R, Kim YB, Kershaw EE.

J Biol Chem. 2009 Oct 30;284(44):30218-29. Epub 2009 Aug 31.PMID: 19723629 [PubMed - in process]Related articles

Reduced adiposity and high-fat diet-induced adipose inflammation in mice deficient for phosphodiesterase 4B.

Zhang R, Maratos-Flier E, Flier JS.

Endocrinology. 2009 Jul;150(7):3076-82. Epub 2009 Apr 9.PMID: 19359377 [PubMed - indexed for MEDLINE]Related articles

Curative and beta cell regenerative effects of alpha1-antitrypsin treatment in autoimmune diabetic NOD mice.

Koulmanda M, Bhasin M, Hoffman L, Fan Z, Qipo A, Shi H, Bonner-Weir S, Putheti P, Degauque N, Libermann TA, Auchincloss H Jr, Flier JS, Strom TB.

Proc Natl Acad Sci U S A. 2008 Oct 21;105(42):16242-7. Epub 2008 Oct 13.PMID: 18852471 [PubMed - indexed for MEDLINE]Related articlesFree article

Selective inactivation of Socs3 in SF1 neurons improves glucose homeostasis without affecting body weight.

Zhang R, Dhillon H, Yin H, Yoshimura A, Lowell BB, Maratos-Flier E, Flier JS.

Endocrinology. 2008 Nov;149(11):5654-61. Epub 2008 Jul 31.PMID: 18669597 [PubMed - indexed for MEDLINE]Related articlesFree article

Evidence for constitutive neural cell proliferation in the adult murine hypothalamus.

Kokoeva MV, Yin H, Flier JS.

J Comp Neurol. 2007 Nov 10;505(2):209-20.PMID: 17853440 [PubMed - indexed for MEDLINE]Related articles

PPARgamma regulates adipose triglyceride lipase in adipocytes in vitro and in vivo.

Kershaw EE, Schupp M, Guan HP, Gardner NP, Lazar MA, Flier JS.

Am J Physiol Endocrinol Metab. 2007 Dec;293(6):E1736-45. Epub 2007 Sep 11.PMID: 17848638 [PubMed - indexed for MEDLINE]Related articlesFree article

What fuels fat.

Flier JS, Maratos-Flier E.

Sci Am. 2007 Sep;297(3):72-81. No abstract available. PMID: 17784627 [PubMed - indexed for MEDLINE]Related articles

Modification of adverse inflammation is required to cure new-onset type 1 diabetic hosts.

Koulmanda M, Budo E, Bonner-Weir S, Qipo A, Putheti P, Degauque N, Shi H, Fan Z, Flier JS, Auchincloss H Jr, Zheng XX, Strom TB.

Proc Natl Acad Sci U S A. 2007 Aug 7;104(32):13074-9. Epub 2007 Aug 1.PMID: 17670937 [PubMed - indexed for MEDLINE]Related articlesFree article

Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states.

Badman MK, Pissios P, Kennedy AR, Koukos G, Flier JS, Maratos-Flier E.

Cell Metab. 2007 Jun;5(6):426-37.PMID: 17550778 [PubMed - indexed for MEDLINE]Related articles

The adipocyte as an active participant in energy balance and metabolism.

Badman MK, Flier JS.

Gastroenterology. 2007 May;132(6):2103-15. Review.PMID: 17498506 [PubMed - indexed for MEDLINE]Related articles

Absence of CC chemokine ligand 2 does not limit obesity-associated infiltration of macrophages into adipose tissue.

Inouye KE, Shi H, Howard JK, Daly CH, Lord GM, Rollins BJ, Flier JS.

Diabetes. 2007 Sep;56(9):2242-50. Epub 2007 May 1.PMID: 17473219 [PubMed - indexed for MEDLINE]Related articlesFree article

Xanthine oxidoreductase is a regulator of adipogenesis and PPARgamma activity.

Cheung KJ, Tzameli I, Pissios P, Rovira I, Gavrilova O, Ohtsubo T, Chen Z, Finkel T, Flier JS, Friedman JM.

Cell Metab. 2007 Feb;5(2):115-28.PMID: 17276354 [PubMed - indexed for MEDLINE]Related articles

TLR4 links innate immunity and fatty acid-induced insulin resistance.

Shi H, Kokoeva MV, Inouye K, Tzameli I, Yin H, Flier JS.

J Clin Invest. 2006 Nov;116(11):3015-25. Epub 2006 Oct 19.PMID: 17053832 [PubMed - indexed for MEDLINE]Related articlesFree article

Attenuation of leptin and insulin signaling by SOCS proteins.

Howard JK, Flier JS.

Trends Endocrinol Metab. 2006 Nov;17(9):365-71. Epub 2006 Sep 28. Review.PMID: 17010638 [PubMed - indexed for MEDLINE]Related articles

Leptin regulation of the mesoaccumbens dopamine pathway.

Fulton S, Pissios P, Manchon RP, Stiles L, Frank L, Pothos EN, Maratos-Flier E, Flier JS.

Neuron. 2006 Sep 21;51(6):811-22.PMID: 16982425 [PubMed - indexed for MEDLINE]Related articles

Enhanced leptin sensitivity and improved glucose homeostasis in mice lacking suppressor of cytokine signaling-3 in POMC-expressing cells.

Kievit P, Howard JK, Badman MK, Balthasar N, Coppari R, Mori H, Lee CE, Elmquist JK, Yoshimura A, Flier JS.

Cell Metab. 2006 Aug;4(2):123-32.PMID: 16890540 [PubMed - indexed for MEDLINE]Related articles

Neuroscience. Regulating energy balance: the substrate strikes back.

Flier JS.

Science. 2006 May 12;312(5775):861-4. No abstract available. PMID: 16690851 [PubMed - indexed for MEDLINE]Related articles

Overexpression of suppressor of cytokine signaling 3 in adipose tissue causes local but not systemic insulin resistance.

Shi H, Cave B, Inouye K, Bjørbaek C, Flier JS.

Diabetes. 2006 Mar;55(3):699-707.PMID: 16505233 [PubMed - indexed for MEDLINE]Related articlesFree article

Complex role of the vitamin D receptor and its ligand in adipogenesis in 3T3-L1 cells.

Blumberg JM, Tzameli I, Astapova I, Lam FS, Flier JS, Hollenberg AN.

J Biol Chem. 2006 Apr 21;281(16):11205-13. Epub 2006 Feb 8.PMID: 16467308 [PubMed - indexed for MEDLINE]Related articlesFree article

AgRP in energy balance: Will the real AgRP please stand up?

Flier JS.

Cell Metab. 2006 Feb;3(2):83-5. Review.PMID: 16459309 [PubMed - indexed for MEDLINE]Related articles

Adipose triglyceride lipase: function, regulation by insulin, and comparison with adiponutrin.

Kershaw EE, Hamm JK, Verhagen LA, Peroni O, Katic M, Flier JS.

Diabetes. 2006 Jan;55(1):148-57.PMID: 16380488 [PubMed - indexed for MEDLINE]Related articlesFree article

Neurogenesis in the hypothalamus of adult mice: potential role in energy balance.

Kokoeva MV, Yin H, Flier JS.

Science. 2005 Oct 28;310(5748):679-83.PMID: 16254185 [PubMed - indexed for MEDLINE]Related articlesFree article

Adipocyte-specific glucocorticoid inactivation protects against diet-induced obesity.

Kershaw EE, Morton NM, Dhillon H, Ramage L, Seckl JR, Flier JS.

Diabetes. 2005 Apr;54(4):1023-31.PMID: 15793240 [PubMed - indexed for MEDLINE]Related articlesFree article

The gut and energy balance: visceral allies in the obesity wars.

Badman MK, Flier JS.

Science. 2005 Mar 25;307(5717):1909-14. Review.PMID: 15790843 [PubMed - indexed for MEDLINE]Related articles

A good night's sleep: future antidote to the obesity epidemic?

Flier JS, Elmquist JK.

Ann Intern Med. 2004 Dec 7;141(11):885-6. No abstract available. PMID: 15583232 [PubMed - indexed for MEDLINE]Related articlesFree article

Region-specific leptin resistance within the hypothalamus of diet-induced obese mice.

Münzberg H, Flier JS, Bjørbaek C.

Endocrinology. 2004 Nov;145(11):4880-9. Epub 2004 Jul 22.PMID: 15271881 [PubMed - indexed for MEDLINE]Related articlesFree article

Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3.

Howard JK, Cave BJ, Oksanen LJ, Tzameli I, Bjørbaek C, Flier JS.

Nat Med. 2004 Jul;10(7):734-8. Epub 2004 Jun 27.PMID: 15220914 [PubMed - indexed for MEDLINE]Related articles

Regulated production of a peroxisome proliferator-activated receptor-gamma ligand during an early phase of adipocyte differentiation in 3T3-L1 adipocytes.

Tzameli I, Fang H, Ollero M, Shi H, Hamm JK, Kievit P, Hollenberg AN, Flier JS.

J Biol Chem. 2004 Aug 20;279(34):36093-102. Epub 2004 Jun 9.PMID: 15190061 [PubMed - indexed for MEDLINE]Related articlesFree article

Adipose tissue as an endocrine organ.

Kershaw EE, Flier JS.

J Clin Endocrinol Metab. 2004 Jun;89(6):2548-56. Review.PMID: 15181022 [PubMed - indexed for MEDLINE]Related articlesFree article

Suppressor of cytokine signaling 3 is a physiological regulator of adipocyte insulin signaling.

Shi H, Tzameli I, Bjørbaek C, Flier JS.

J Biol Chem. 2004 Aug 13;279(33):34733-40. Epub 2004 Jun 4.PMID: 15181014 [PubMed - indexed for MEDLINE]Related articlesFree article

Neuroscience. The fat-brain axis enters a new dimension.

Elmquist JK, Flier JS.

Science. 2004 Apr 2;304(5667):63-4. No abstract available. PMID: 15064411 [PubMed - indexed for MEDLINE]Related articles

Novel adipose tissue-mediated resistance to diet-induced visceral obesity in 11 beta-hydroxysteroid dehydrogenase type 1-deficient mice.

Morton NM, Paterson JM, Masuzaki H, Holmes MC, Staels B, Fievet C, Walker BR, Flier JS, Mullins JJ, Seckl JR.

Diabetes. 2004 Apr;53(4):931-8.PMID: 15047607 [PubMed - indexed for MEDLINE]Related articlesFree article

Ciliary neurotrophic factor and leptin induce distinct patterns of immediate early gene expression in the brain.

Kelly JF, Elias CF, Lee CE, Ahima RS, Seeley RJ, Bjørbaek C, Oka T, Saper CB, Flier JS, Elmquist JK.

Diabetes. 2004 Apr;53(4):911-20.PMID: 15047605 [PubMed - indexed for MEDLINE]Related articlesFree article

Obesity wars: molecular progress confronts an expanding epidemic.

Flier JS.

Cell. 2004 Jan 23;116(2):337-50. Review.PMID: 14744442 [PubMed - indexed for MEDLINE]Related articles

Tissue-specific glucocorticoid reactivating enzyme, 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1)--a promising drug target for the treatment of metabolic syndrome.

Masuzaki H, Flier JS.

Curr Drug Targets Immune Endocr Metabol Disord. 2003 Dec;3(4):255-62. Review.PMID: 14683456 [PubMed - indexed for MEDLINE]Related articles

Melanin-concentrating hormone is a critical mediator of the leptin-deficient phenotype.

Segal-Lieberman G, Bradley RL, Kokkotou E, Carlson M, Trombly DJ, Wang X, Bates S, Myers MG Jr, Flier JS, Maratos-Flier E.

Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):10085-90. Epub 2003 Aug 1.PMID: 12897241 [PubMed - indexed for MEDLINE]Related articlesFree article

Transgenic amplification of glucocorticoid action in adipose tissue causes high blood pressure in mice.

Masuzaki H, Yamamoto H, Kenyon CJ, Elmquist JK, Morton NM, Paterson JM, Shinyama H, Sharp MG, Fleming S, Mullins JJ, Seckl JR, Flier JS.

J Clin Invest. 2003 Jul;112(1):83-90.PMID: 12840062 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin resistance and lipodystrophy in mice lacking ribosomal S6 kinase 2.

El-Haschimi K, Dufresne SD, Hirshman MF, Flier JS, Goodyear LJ, Bjørbaek C.

Diabetes. 2003 Jun;52(6):1340-6.PMID: 12765942 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of melanocortin-4 receptor signaling: agonist-mediated desensitization and internalization.

Shinyama H, Masuzaki H, Fang H, Flier JS.

Endocrinology. 2003 Apr;144(4):1301-14.PMID: 12639913 [PubMed - indexed for MEDLINE]Related articlesFree article

Physiology: is brain sympathetic to bone?

Flier JS.

Nature. 2002 Dec 12;420(6916):619, 621-22. No abstract available. PMID: 12478275 [PubMed - indexed for MEDLINE]Related articles

The stomach speaks--ghrelin and weight regulation.

Flier JS, Maratos-Flier E.

N Engl J Med. 2002 May 23;346(21):1662-3. No abstract available. PMID: 12024001 [PubMed - indexed for MEDLINE]Related articles

Effects of acute and chronic administration of the melanocortin agonist MTII in mice with diet-induced obesity.

Pierroz DD, Ziotopoulou M, Ungsunan L, Moschos S, Flier JS, Mantzoros CS.

Diabetes. 2002 May;51(5):1337-45.PMID: 11978628 [PubMed - indexed for MEDLINE]Related articlesFree article

Human obesity and type 2 diabetes are associated with alterations in SREBP1 isoform expression that are reproduced ex vivo by tumor necrosis factor-alpha.

Sewter C, Berger D, Considine RV, Medina G, Rochford J, Ciaraldi T, Henry R, Dohm L, Flier JS, O'Rahilly S, Vidal-Puig AJ.

Diabetes. 2002 Apr;51(4):1035-41.PMID: 11916923 [PubMed - indexed for MEDLINE]Related articlesFree article

Characterizaton of short isoforms of the leptin receptor in rat cerebral microvessels and of brain uptake of leptin in mouse models of obesity.

Hileman SM, Pierroz DD, Masuzaki H, Bjørbaek C, El-Haschimi K, Banks WA, Flier JS.

Endocrinology. 2002 Mar;143(3):775-83.PMID: 11861497 [PubMed - indexed for MEDLINE]Related articlesFree article

A transgenic model of visceral obesity and the metabolic syndrome.

Masuzaki H, Paterson J, Shinyama H, Morton NM, Mullins JJ, Seckl JR, Flier JS.

Science. 2001 Dec 7;294(5549):2166-70.PMID: 11739957 [PubMed - indexed for MEDLINE]Related articlesFree article

Synchronicity of frequently sampled thyrotropin (TSH) and leptin concentrations in healthy adults and leptin-deficient subjects: evidence for possible partial TSH regulation by leptin in humans.

Mantzoros CS, Ozata M, Negrao AB, Suchard MA, Ziotopoulou M, Caglayan S, Elashoff RM, Cogswell RJ, Negro P, Liberty V, Wong ML, Veldhuis J, Ozdemir IC, Gold PW, Flier JS, Licinio J.

J Clin Endocrinol Metab. 2001 Jul;86(7):3284-91.PMID: 11443202 [PubMed - indexed for MEDLINE]Related articlesFree article

Cell biology. Chewing the fat--ACC and energy balance.

Ruderman N, Flier JS.

Science. 2001 Mar 30;291(5513):2558-9. No abstract available. PMID: 11286278 [PubMed - indexed for MEDLINE]Related articles

Obesity and the regulation of energy balance.

Spiegelman BM, Flier JS.

Cell. 2001 Feb 23;104(4):531-43. Review. No abstract available. PMID: 11239410 [PubMed - indexed for MEDLINE]Related articles