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Dissociation of antihyperglycaemic and adverse effects of partial perioxisome proliferator-activated receptor (PPAR-gamma) agonist balaglitazone.

Larsen PJ, Lykkegaard K, Larsen LK, Fleckner J, Sauerberg P, Wassermann K, Wulff EM.

Eur J Pharmacol. 2008 Oct 31;596(1-3):173-9. Epub 2008 Aug 16.PMID: 18761337 [PubMed - indexed for MEDLINE]Related articles

Adipocyte differentiation of 3T3-L1 preadipocytes is dependent on lipoxygenase activity during the initial stages of the differentiation process.

Madsen L, Petersen RK, Sørensen MB, Jørgensen C, Hallenborg P, Pridal L, Fleckner J, Amri EZ, Krieg P, Furstenberger G, Berge RK, Kristiansen K.

Biochem J. 2003 Nov 1;375(Pt 3):539-49.PMID: 18320708 [PubMed - indexed for MEDLINE]Related articlesFree article

Transcriptional program induced by factor VIIa-tissue factor, PAR1 and PAR2 in MDA-MB-231 cells.

Albrektsen T, Sørensen BB, Hjortø GM, Fleckner J, Rao LV, Petersen LC.

J Thromb Haemost. 2007 Aug;5(8):1588-97. Epub 2007 Apr 27.PMID: 17470200 [PubMed - indexed for MEDLINE]Related articles

Design of potent PPARalpha agonists.

Sauerberg P, Mogensen JP, Jeppesen L, Bury PS, Fleckner J, Olsen GS, Jeppesen CB, Wulff EM, Pihera P, Havranek M, Polivka Z, Pettersson I.

Bioorg Med Chem Lett. 2007 Jun 1;17(11):3198-202. Epub 2007 Mar 12.PMID: 17379517 [PubMed - indexed for MEDLINE]Related articles

Identification and synthesis of a novel selective partial PPARdelta agonist with full efficacy on lipid metabolism in vitro and in vivo.

Sauerberg P, Olsen GS, Jeppesen L, Mogensen JP, Pettersson I, Jeppesen CB, Daugaard JR, Galsgaard ED, Ynddal L, Fleckner J, Panajotova V, Polivka Z, Pihera P, Havranek M, Wulff EM.

J Med Chem. 2007 Apr 5;50(7):1495-503. Epub 2007 Mar 8.PMID: 17343371 [PubMed - indexed for MEDLINE]Related articles

The effect of neurogenin3 deficiency on pancreatic gene expression in embryonic mice.

Petri A, Ahnfelt-Rønne J, Frederiksen KS, Edwards DG, Madsen D, Serup P, Fleckner J, Heller RS.

J Mol Endocrinol. 2006 Oct;37(2):301-16.PMID: 17032746 [PubMed - indexed for MEDLINE]Related articlesFree article

Proteome profiling in the rat Harderian gland.

Yang JW, Afjehi-Sadat L, Gelpi E, Kunze M, Höger H, Fleckner J, Berger J, Lubec G.

J Proteome Res. 2006 Jul;5(7):1751-62.PMID: 16823983 [PubMed - indexed for MEDLINE]Related articles

Selective PPAR agonists for the treatment of type 2 diabetes.

Nehlin JO, Mogensen JP, Petterson I, Jeppesen L, Fleckner J, Wulff EM, Sauerberg P.

Ann N Y Acad Sci. 2006 May;1067:448-53. Review.PMID: 16804025 [PubMed - indexed for MEDLINE]Related articles

A case study of new textualism in state courts: Doe v. Marselle and the confidentiality of HIV-related information.

Fleckner J.

Conn Law Rev. 1997 Fall;30(1):295-324. No abstract available. PMID: 16086502 [PubMed - indexed for MEDLINE]Related articles

Sensory nerve inactivation by resiniferatoxin improves insulin sensitivity in male obese Zucker rats.

Moesgaard SG, Brand CL, Sturis J, Ahrén B, Wilken M, Fleckner J, Carr RD, Svendsen O, Hansen AJ, Gram DX.

Am J Physiol Endocrinol Metab. 2005 Jun;288(6):E1137-45.PMID: 15883192 [PubMed - indexed for MEDLINE]Related articlesFree article

Peroxisome proliferator-activated receptor expression and activation in normal human colonic epithelial cells and tubular adenomas.

Matthiessen MW, Pedersen G, Albrektsen T, Adamsen S, Fleckner J, Brynskov J.

Scand J Gastroenterol. 2005 Feb;40(2):198-205.PMID: 15764152 [PubMed - indexed for MEDLINE]Related articles

Structure-activity relationships of dimeric PPAR agonists.

Sauerberg P, Mogensen JP, Jeppesen L, Svensson LA, Fleckner J, Nehlin J, Wulff EM, Pettersson I.

Bioorg Med Chem Lett. 2005 Mar 1;15(5):1497-500.PMID: 15713415 [PubMed - indexed for MEDLINE]Related articles

Artifactual insulin release from differentiated embryonic stem cells.

Hansson M, Tonning A, Frandsen U, Petri A, Rajagopal J, Englund MC, Heller RS, Håkansson J, Fleckner J, Sköld HN, Melton D, Semb H, Serup P.

Diabetes. 2004 Oct;53(10):2603-9.PMID: 15448090 [PubMed - indexed for MEDLINE]Related articlesFree article

Association of aldose reductase gene Z+2 polymorphism with reduced susceptibility to diabetic nephropathy in Caucasian Type 1 diabetic patients.

Lajer M, Tarnow L, Fleckner J, Hansen BV, Edwards DG, Parving HH, Boel E.

Diabet Med. 2004 Aug;21(8):867-73.PMID: 15270790 [PubMed - indexed for MEDLINE]Related articles

Array-A-Lizer: a serial DNA microarray quality analyzer.

Petri A, Fleckner J, Matthiessen MW.

BMC Bioinformatics. 2004 Feb 9;5:12.PMID: 15018654 [PubMed - indexed for MEDLINE]Related articlesFree article

Prediction of PPAR-alpha ligand-mediated physiological changes using gene expression profiles.

Frederiksen KS, Wulff EM, Sauerberg P, Mogensen JP, Jeppesen L, Fleckner J.

J Lipid Res. 2004 Mar;45(3):592-601.PMID: 14999041 [PubMed - indexed for MEDLINE]Related articlesFree article

Mutational analysis of the UCP2 core promoter and relationships of variants with obesity.

Dalgaard LT, Andersen G, Larsen LH, Sørensen TI, Andersen T, Drivsholm T, Borch-Johnsen K, Fleckner J, Hansen T, Din N, Pedersen O.

Obes Res. 2003 Nov;11(11):1420-7.PMID: 14627764 [PubMed - indexed for MEDLINE]Related articles

Large dimeric ligands with favorable pharmacokinetic properties and peroxisome proliferator-activated receptor agonist activity in vitro and in vivo.

Sauerberg P, Bury PS, Mogensen JP, Deussen HJ, Pettersson I, Fleckner J, Nehlin J, Frederiksen KS, Albrektsen T, Din N, Svensson LA, Ynddal L, Wulff EM, Jeppesen L.

J Med Chem. 2003 Nov 6;46(23):4883-94.PMID: 14584939 [PubMed - indexed for MEDLINE]Related articles

Identification of hepatic transcriptional changes in insulin-resistant rats treated with peroxisome proliferator activated receptor-alpha agonists.

Frederiksen KS, Wulf EM, Wassermann K, Sauerberg P, Fleckner J.

J Mol Endocrinol. 2003 Jun;30(3):317-29.PMID: 12790802 [PubMed - indexed for MEDLINE]Related articlesFree article

Synthesis and biological and structural characterization of the dual-acting peroxisome proliferator-activated receptor alpha/gamma agonist ragaglitazar.

Ebdrup S, Pettersson I, Rasmussen HB, Deussen HJ, Frost Jensen A, Mortensen SB, Fleckner J, Pridal L, Nygaard L, Sauerberg P.

J Med Chem. 2003 Apr 10;46(8):1306-17.PMID: 12672231 [PubMed - indexed for MEDLINE]Related articles

Design and synthesis of novel PPARalpha/gamma/delta triple activators using a known PPARalpha/gamma dual activator as structural template.

Mogensen JP, Jeppesen L, Bury PS, Pettersson I, Fleckner J, Nehlin J, Frederiksen KS, Albrektsen T, Din N, Mortensen SB, Svensson LA, Wassermann K, Wulff EM, Ynddal L, Sauerberg P.

Bioorg Med Chem Lett. 2003 Jan 20;13(2):257-60.PMID: 12482434 [PubMed - indexed for MEDLINE]Related articles

Dual PPARalpha /gamma activation provides enhanced improvement of insulin sensitivity and glycemic control in ZDF rats.

Brand CL, Sturis J, Gotfredsen CF, Fleckner J, Fledelius C, Hansen BF, Andersen B, Ye JM, Sauerberg P, Wassermann K.

Am J Physiol Endocrinol Metab. 2003 Apr;284(4):E841-54. Epub 2002 Dec 10.PMID: 12475752 [PubMed - indexed for MEDLINE]Related articlesFree article

The gene encoding the Acyl-CoA-binding protein is activated by peroxisome proliferator-activated receptor gamma through an intronic response element functionally conserved between humans and rodents.

Helledie T, Grøntved L, Jensen SS, Kiilerich P, Rietveld L, Albrektsen T, Boysen MS, Nøhr J, Larsen LK, Fleckner J, Stunnenberg HG, Kristiansen K, Mandrup S.

J Biol Chem. 2002 Jul 26;277(30):26821-30. Epub 2002 May 15.PMID: 12015306 [PubMed - indexed for MEDLINE]Related articlesFree article

Novel genes regulated by the insulin sensitizer rosiglitazone during adipocyte differentiation.

Albrektsen T, Frederiksen KS, Holmes WE, Boel E, Taylor K, Fleckner J.

Diabetes. 2002 Apr;51(4):1042-51.PMID: 11916924 [PubMed - indexed for MEDLINE]Related articlesFree article

Novel tricyclic-alpha-alkyloxyphenylpropionic acids: dual PPARalpha/gamma agonists with hypolipidemic and antidiabetic activity.

Sauerberg P, Pettersson I, Jeppesen L, Bury PS, Mogensen JP, Wassermann K, Brand CL, Sturis J, Wöldike HF, Fleckner J, Andersen AS, Mortensen SB, Svensson LA, Rasmussen HB, Lehmann SV, Polivka Z, Sindelar K, Panajotova V, Ynddal L, Wulff EM.

J Med Chem. 2002 Feb 14;45(4):789-804.PMID: 11831892 [PubMed - indexed for MEDLINE]Related articles

Identification of a novel integral plasma membrane protein induced during adipocyte differentiation.

Albrektsen T, Richter HE, Clausen JT, Fleckner J.

Biochem J. 2001 Oct 15;359(Pt 2):393-402.PMID: 11583587 [PubMed - indexed for MEDLINE]Related articlesFree article

Modulation of metabolism through transcriptional control has created new treatment opportunities for type 2 diabetes.

Boel E, Albrektsen T, Fleckner J, Selmer J.

Curr Pharm Biotechnol. 2000 Jul;1(1):63-71. Review.PMID: 11467362 [PubMed - indexed for MEDLINE]Related articles

The transcription factor Fos-related antigen 1 is induced by thiazolidinediones during differentiation of 3T3-L1 cells.

Albrektsen T, Fleckner J.

Mol Pharmacol. 2001 Mar;59(3):567-75.PMID: 11179452 [PubMed - indexed for MEDLINE]Related articlesFree article

U2AF65 recruits a novel human DEAD box protein required for the U2 snRNP-branchpoint interaction.

Fleckner J, Zhang M, Valcárcel J, Green MR.

Genes Dev. 1997 Jul 15;11(14):1864-72.PMID: 9242493 [PubMed - indexed for MEDLINE]Related articlesFree article

Assignment of the human tryptophanyl-tRNA synthetase gene (WARS) to chromosome 14q32.2 --> q32.32.

Børglum AD, Flint T, Tommerup N, Fleckner J, Justesen J, Kruse TA.

Cytogenet Cell Genet. 1996;73(1-2):99-103.PMID: 8646895 [PubMed - indexed for MEDLINE]Related articles

Transcriptional regulation of the interferon-gamma-inducible tryptophanyl-tRNA synthetase includes alternative splicing.

Tolstrup AB, Bejder A, Fleckner J, Justesen J.

J Biol Chem. 1995 Jan 6;270(1):397-403.PMID: 7814400 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential regulation of the human, interferon inducible tryptophanyl-tRNA synthetase by various cytokines in cell lines.

Fleckner J, Martensen PM, Tolstrup AB, Kjeldgaard NO, Justesen J.

Cytokine. 1995 Jan;7(1):70-7.PMID: 7749068 [PubMed - indexed for MEDLINE]Related articles

Are the tryptophanyl-tRNA synthetase and the peptide-chain-release factor from higher eukaryotes one and the same protein?

Frolova LYu, Fleckner J, Justesen J, Timms KM, Tate WP, Kisselev LL, Haenni AL.

Eur J Biochem. 1993 Mar 1;212(2):457-66.PMID: 8444184 [PubMed - indexed for MEDLINE]Related articlesFree article

Human interferon gamma potently induces the synthesis of a 55-kDa protein (gamma 2) highly homologous to rabbit peptide chain release factor and bovine tryptophanyl-tRNA synthetase.

Fleckner J, Rasmussen HH, Justesen J.

Proc Natl Acad Sci U S A. 1991 Dec 15;88(24):11520-4.PMID: 1763065 [PubMed - indexed for MEDLINE]Related articlesFree article

Interferon stimulates the expression of 2',5'-oligoadenylate synthetase and MHC class I antigens in insulin-producing cells.

Bonnevie-Nielsen V, Gerdes AM, Fleckner J, Petersen JS, Michelsen B, Dyrberg T.

J Interferon Res. 1991 Oct;11(5):255-60.PMID: 1723088 [PubMed - indexed for MEDLINE]Related articles