PubMed

An inter-rater reliability study of a new "zonal" classification for reporting the location of retinal haemorrhages in childhood for clinical, legal and research purposes.

Fleck BW, Tandon A, Jones PA, Mulvihill AO, Minns RA.

Br J Ophthalmol. 2009 Oct 21. [Epub ahead of print]PMID: 19846410 [PubMed - as supplied by publisher]Related articles

Pain in neonates during screening for retinopathy of prematurity using binocular indirect ophthalmoscopy and wide-field digital retinal imaging: a randomised comparison.

Dhaliwal CA, Wright E, McIntosh N, Dhaliwal K, Fleck BW.

Arch Dis Child Fetal Neonatal Ed. 2009 Oct 8. [Epub ahead of print]PMID: 19815939 [PubMed - as supplied by publisher]Related articles

Feasibility of saccadic vector optokinetic perimetry: a method of automated static perimetry for children using eye tracking.

Murray IC, Fleck BW, Brash HM, Macrae ME, Tan LL, Minns RA.

Ophthalmology. 2009 Oct;116(10):2017-26. Epub 2009 Jun 27.PMID: 19560207 [PubMed - indexed for MEDLINE]Related articles

'The Epidemiology of Rhegmatogenous Retinal Detachment - Geographic Variation and Clinical Associations'

Mitry D, Charteris DG, Fleck BW, Campbell H, Singh J.

Br J Ophthalmol. 2009 Jun 9. [Epub ahead of print]PMID: 19515646 [PubMed - as supplied by publisher]Related articles

Rhegmatogenous retinal detachment in Scotland: research design and methodology.

Mitry D, Charteris DG, Yorston D, Fleck BW, Wright A, Campbell H, Singh J.

BMC Ophthalmol. 2009 Mar 24;9:2.PMID: 19317907 [PubMed - indexed for MEDLINE]Related articlesFree article

Digital image analysis of plus disease in retinopathy of prematurity.

Aslam T, Fleck B, Patton N, Trucco M, Azegrouz H.

Acta Ophthalmol. 2009 Jun;87(4):368-77. Epub 2009 Feb 6. Review.PMID: 19210329 [PubMed - indexed for MEDLINE]Related articles

Systematic review of digital imaging screening strategies for retinopathy of prematurity.

Fielder AR, Hildebrand PL, Ells A, Lorenz B, Trese MT, Capone A Jr, Gordon RA, Wilson C, Fleck BW, Chiang MF.

Pediatrics. 2009 Feb;123(2):e360-1; author reply e361. No abstract available. PMID: 19171594 [PubMed - indexed for MEDLINE]Related articles

Wide-field digital retinal imaging versus binocular indirect ophthalmoscopy for retinopathy of prematurity screening: a two-observer prospective, randomised comparison.

Dhaliwal C, Wright E, Graham C, McIntosh N, Fleck BW.

Br J Ophthalmol. 2009 Mar;93(3):355-9. Epub 2008 Nov 21.PMID: 19028742 [PubMed - indexed for MEDLINE]Related articles

Synthesis and structure-activity relationships of selective norepinephrine reuptake inhibitors (sNRI) with improved pharmaceutical characteristics.

Pontillo J, Wu D, Ching B, Hudson S, Genicot MJ, Gao Y, Ewing T, Fleck BA, Gogas K, Aparicio A, Wang H, Wen J, Wade WS.

Bioorg Med Chem Lett. 2008 Dec 1;18(23):6151-5. Epub 2008 Oct 7.PMID: 18954981 [PubMed - indexed for MEDLINE]Related articles

Characterization of thien-2-yl 1S,2R-milnacipran analogues as potent norepinephrine/serotonin transporter inhibitors for the treatment of neuropathic pain.

Dyck B, Tamiya J, Jovic F, Pick RR, Bradbury MJ, O'Brien J, Wen J, Johns M, Madan A, Fleck BA, Foster AC, Li B, Zhang M, Tran JA, Vickers T, Grey J, Saunders J, Chen C.

J Med Chem. 2008 Nov 27;51(22):7265-72.PMID: 18954038 [PubMed - indexed for MEDLINE]Related articles

Retinopathy of prematurity in small-for-gestational age infants compared with those of appropriate size for gestational age.

Dhaliwal CA, Fleck BW, Wright E, Graham C, McIntosh N.

Arch Dis Child Fetal Neonatal Ed. 2009 May;94(3):F193-5. Epub 2008 Sep 11.PMID: 18786959 [PubMed - indexed for MEDLINE]Related articles

Structure-activity relationship studies on a series of piperazinebenzylalcohols and their ketone and amine analogs as melanocortin-4 receptor ligands.

Marinkovic D, Tucci FC, Tran JA, Fleck BA, Wen J, Chen C.

Bioorg Med Chem Lett. 2008 Sep 1;18(17):4817-22. Epub 2008 Jul 25.PMID: 18682322 [PubMed - indexed for MEDLINE]Related articles

Structure-activity relationships of chiral selective norepinephrine reuptake inhibitors (sNRI) with increased oxidative stability.

Hudson S, Kiankarimi M, Eccles W, Dwight W, Mostofi YS, Genicot MJ, Fleck BA, Gogas K, Aparicio A, Wang H, Wen J, Wade WS.

Bioorg Med Chem Lett. 2008 Aug 15;18(16):4491-4. Epub 2008 Jul 17.PMID: 18672364 [PubMed - indexed for MEDLINE]Related articles

Synthesis and structure-activity relationships of selective norepinephrine reuptake inhibitors (sNRI) with a heterocyclic ring constraint.

Hudson S, Kiankarimi M, Eccles W, Mostofi YS, Genicot MJ, Dwight W, Fleck BA, Gogas K, Wade WS.

Bioorg Med Chem Lett. 2008 Aug 15;18(16):4495-8. Epub 2008 Jul 17.PMID: 18667309 [PubMed - indexed for MEDLINE]Related articles

Discovery of a potent, selective, and less flexible selective norepinephrine reuptake inhibitor (sNRI).

Wu D, Pontillo J, Ching B, Hudson S, Gao Y, Fleck BA, Gogas K, Wade WS.

Bioorg Med Chem Lett. 2008 Jul 15;18(14):4224-7. Epub 2008 May 20.PMID: 18550369 [PubMed - indexed for MEDLINE]Related articles

Studies on the structure-activity relationship of bicifadine analogs as monoamine transporter inhibitors.

Zhang M, Jovic F, Vickers T, Dyck B, Tamiya J, Grey J, Tran JA, Fleck BA, Pick R, Foster AC, Chen C.

Bioorg Med Chem Lett. 2008 Jul 1;18(13):3682-6. Epub 2008 May 23.PMID: 18539031 [PubMed - indexed for MEDLINE]Related articles

Studies on a series of milnacipran analogs containing a heteroaromatic group as potent norepinephrine and serotonin transporter inhibitors.

Vickers T, Dyck B, Tamiya J, Zhang M, Jovic F, Grey J, Fleck BA, Aparicio A, Johns M, Jin L, Tang H, Foster AC, Chen C.

Bioorg Med Chem Lett. 2008 Jun 1;18(11):3230-5. Epub 2008 Apr 25.PMID: 18468895 [PubMed - indexed for MEDLINE]Related articles

Incidence of retinopathy of prematurity in Lothian, Scotland, from 1990 to 2004.

Dhaliwal C, Fleck B, Wright E, Graham C, McIntosh N.

Arch Dis Child Fetal Neonatal Ed. 2008 Nov;93(6):F422-6. Epub 2008 May 7.PMID: 18463118 [PubMed - indexed for MEDLINE]Related articles

Identification of 1S,2R-milnacipran analogs as potent norepinephrine and serotonin transporter inhibitors.

Tamiya J, Dyck B, Zhang M, Phan K, Fleck BA, Aparicio A, Jovic F, Tran JA, Vickers T, Grey J, Foster AC, Chen C.

Bioorg Med Chem Lett. 2008 Jun 1;18(11):3328-32. Epub 2008 Apr 15.PMID: 18445525 [PubMed - indexed for MEDLINE]Related articles

Pharmacological and pharmacokinetic characterization of 2-piperazine-alpha-isopropyl benzylamine derivatives as melanocortin-4 receptor antagonists.

Chen C, Tucci FC, Jiang W, Tran JA, Fleck BA, Hoare SR, Wen J, Chen T, Johns M, Markison S, Foster AC, Marinkovic D, Chen CW, Arellano M, Harman J, Saunders J, Bozigian H, Marks D.

Bioorg Med Chem. 2008 May 15;16(10):5606-18. Epub 2008 Apr 1.PMID: 18417348 [PubMed - indexed for MEDLINE]Related articles

Design and synthesis of 3-arylpyrrolidine-2-carboxamide derivatives as melanocortin-4 receptor ligands.

Tran JA, Tucci FC, Arellano M, Jiang W, Chen CW, Marinkovic D, Fleck BA, Wen J, Foster AC, Chen C.

Bioorg Med Chem Lett. 2008 Mar 15;18(6):1931-8. Epub 2008 Feb 7.PMID: 18294847 [PubMed - indexed for MEDLINE]Related articles

Allosteric ligands for the corticotropin releasing factor type 1 receptor modulate conformational states involved in receptor activation.

Hoare SR, Fleck BA, Gross RS, Crowe PD, Williams JP, Grigoriadis DE.

Mol Pharmacol. 2008 May;73(5):1371-80. Epub 2008 Jan 31.PMID: 18239030 [PubMed - indexed for MEDLINE]Related articlesFree article

Pathogenesis of retinopathy of prematurity and possible preventive strategies.

Fleck BW, McIntosh N.

Early Hum Dev. 2008 Feb;84(2):83-8. Epub 2008 Jan 30. Review.PMID: 18234458 [PubMed - indexed for MEDLINE]Related articles

Studies on the structure-activity relationship of the basic amine of phenylpiperazines as melanocortin-4 receptor antagonists.

Tran JA, Arellano M, Fleck BA, Pontillo J, Marinkovic D, Tucci FC, Wen J, Saunders J, Chen C.

Med Chem. 2008 Jan;4(1):67-74.PMID: 18220971 [PubMed - indexed for MEDLINE]Related articles

Studies on the SAR and pharmacophore of milnacipran derivatives as monoamine transporter inhibitors.

Chen C, Dyck B, Fleck BA, Foster AC, Grey J, Jovic F, Mesleh M, Phan K, Tamiya J, Vickers T, Zhang M.

Bioorg Med Chem Lett. 2008 Feb 15;18(4):1346-9. Epub 2008 Jan 9.PMID: 18207394 [PubMed - indexed for MEDLINE]Related articles

Syntheses of tetrahydrothiophenes and tetrahydrofurans and studies of their derivatives as melanocortin-4 receptor ligands.

Tran JA, Chen CW, Tucci FC, Jiang W, Fleck BA, Chen C.

Bioorg Med Chem Lett. 2008 Feb 1;18(3):1124-30. Epub 2007 Dec 5.PMID: 18082401 [PubMed - indexed for MEDLINE]Related articles

Identification and characterization of pyrrolidine diastereoisomers as potent functional agonists and antagonists of the human melanocortin-4 receptor.

Chen C, Jiang W, Tran JA, Tucci FC, Fleck BA, Markison S, Wen J, Madan A, Hoare SR, Foster AC, Marinkovic D, Chen CW, Arellano M, Saunders J.

Bioorg Med Chem Lett. 2008 Jan 1;18(1):129-36. Epub 2007 Nov 4.PMID: 18032040 [PubMed - indexed for MEDLINE]Related articles

Design, synthesis, in vitro, and in vivo characterization of phenylpiperazines and pyridinylpiperazines as potent and selective antagonists of the melanocortin-4 receptor.

Tran JA, Jiang W, Tucci FC, Fleck BA, Wen J, Sai Y, Madan A, Chen TK, Markison S, Foster AC, Hoare SR, Marks D, Harman J, Chen CW, Arellano M, Marinkovic D, Bozigian H, Saunders J, Chen C.

J Med Chem. 2007 Dec 13;50(25):6356-66. Epub 2007 Nov 10.PMID: 17994683 [PubMed - indexed for MEDLINE]Related articles

Synthesis and characterization of trans-4-(4-chlorophenyl)pyrrolidine-3-carboxamides of piperazinecyclohexanes as ligands for the melanocortin-4 receptor.

Chen CW, Tran JA, Fleck BA, Tucci FC, Jiang W, Chen C.

Bioorg Med Chem Lett. 2007 Dec 15;17(24):6825-31. Epub 2007 Oct 17.PMID: 17964151 [PubMed - indexed for MEDLINE]Related articles

Synthesis and characterization of pyrrolidine derivatives as potent agonists of the human melanocortin-4 receptor.

Jiang W, Tran JA, Tucci FC, Fleck BA, Hoare SR, Markison S, Wen J, Chen CW, Marinkovic D, Arellano M, Foster AC, Chen C.

Bioorg Med Chem Lett. 2007 Dec 1;17(23):6546-52. Epub 2007 Oct 22.PMID: 17933528 [PubMed - indexed for MEDLINE]Related articles

Discovery of 1-[2-[(1S)-(3-dimethylaminopropionyl)amino-2-methylpropyl]-4-methylphenyl]-4-[(2R)-methyl-3-(4-chlorophenyl)-propionyl]piperazine as an orally active antagonist of the melanocortin-4 receptor for the potential treatment of cachexia.

Chen C, Jiang W, Tucci F, Tran JA, Fleck BA, Hoare SR, Joppa M, Markison S, Wen J, Sai Y, Johns M, Madan A, Chen T, Chen CW, Marinkovic D, Arellano M, Saunders J, Foster AC.

J Med Chem. 2007 Nov 1;50(22):5249-52. Epub 2007 Oct 5.PMID: 17918824 [PubMed - indexed for MEDLINE]Related articles

Pyrrolidinones as potent functional antagonists of the human melanocortin-4 receptor.

Jiang W, Tucci FC, Tran JA, Fleck BA, Wen J, Markison S, Marinkovic D, Chen CW, Arellano M, Hoare SR, Johns M, Foster AC, Saunders J, Chen C.

Bioorg Med Chem Lett. 2007 Oct 15;17(20):5610-3. Epub 2007 Aug 23.PMID: 17822895 [PubMed - indexed for MEDLINE]Related articles

Substituted NDP-MSH peptides paired with mutant melanocortin-4 receptors demonstrate the role of transmembrane 6 in receptor activation.

Fleck BA, Ling N, Chen C.

Biochemistry. 2007 Sep 18;46(37):10473-83. Epub 2007 Aug 23.PMID: 17713970 [PubMed - indexed for MEDLINE]Related articles

Amniotic membrane grafting for conjunctival and lid surface disease in the acute phase of toxic epidermal necrolysis.

Tandon A, Cackett P, Mulvihill A, Fleck B.

J AAPOS. 2007 Dec;11(6):612-3. Epub 2007 Jul 27.PMID: 17681814 [PubMed - indexed for MEDLINE]Related articles

Pyrrolidines as potent functional agonists of the human melanocortin-4 receptor.

Tran JA, Chen CW, Jiang W, Tucci FC, Fleck BA, Marinkovic D, Arellano M, Chen C.

Bioorg Med Chem Lett. 2007 Sep 15;17(18):5165-70. Epub 2007 Jul 4.PMID: 17629702 [PubMed - indexed for MEDLINE]Related articles

Pyrrolidinones as orally bioavailable antagonists of the human melanocortin-4 receptor with anti-cachectic activity.

Tran JA, Tucci FC, Jiang W, Marinkovic D, Chen CW, Arellano M, Markison S, Fleck BA, Wen J, White NS, Pontillo J, Saunders J, Marks D, Hoare SR, Madan A, Foster AC, Chen C.

Bioorg Med Chem. 2007 Aug 1;15(15):5166-76. Epub 2007 May 17.PMID: 17544282 [PubMed - indexed for MEDLINE]Related articles

Nystagmus secondary to drug exposure in utero.

Mulvihill AO, Cackett PD, George ND, Fleck BW.

Br J Ophthalmol. 2007 May;91(5):613-5. Epub 2006 Dec 13.PMID: 17166896 [PubMed - indexed for MEDLINE]Related articles

Lothian combined paediatric ophthalmology and rheumatology service.

Venkatesh P, Macrae M, Fleck BW.

Br J Ophthalmol. 2006 Dec;90(12):1549-50. No abstract available. PMID: 17114592 [PubMed - indexed for MEDLINE]Related articles

Kinetics of nonpeptide antagonist binding to the human gonadotropin-releasing hormone receptor: Implications for structure-activity relationships and insurmountable antagonism.

Sullivan SK, Hoare SR, Fleck BA, Zhu YF, Heise CE, Struthers RS, Crowe PD.

Biochem Pharmacol. 2006 Sep 28;72(7):838-49. Epub 2006 Aug 22.PMID: 16930559 [PubMed - indexed for MEDLINE]Related articles

Propionylpiperazines as human melanocortin-4 receptor ligands.

Chen CW, Tran JA, Jiang W, Tucci FC, Arellano M, Wen J, Fleck BA, Marinkovic D, White NS, Pontillo J, Saunders J, Madan A, Foster AC, Chen C.

Bioorg Med Chem Lett. 2006 Sep 15;16(18):4800-3. Epub 2006 Jul 7.PMID: 16824757 [PubMed - indexed for MEDLINE]Related articles

Arylpropionylpiperazines as antagonists of the human melanocortin-4 receptor.

Jiang W, Tucci FC, Chen CW, Arellano M, Tran JA, White NS, Marinkovic D, Pontillo J, Fleck BA, Wen J, Saunders J, Madan A, Foster AC, Chen C.

Bioorg Med Chem Lett. 2006 Sep 1;16(17):4674-8. Epub 2006 Jun 13.PMID: 16777413 [PubMed - indexed for MEDLINE]Related articles

Predicting hypoxia in cystic fibrosis patients during exposure to high altitudes.

Kamin W, Fleck B, Rose DM, Thews O, Thielen W.

J Cyst Fibros. 2006 Dec;5(4):223-8. Epub 2006 May 19.PMID: 16713400 [PubMed - indexed for MEDLINE]Related articles

Design, synthesis, and SAR studies on a series of 2-pyridinylpiperazines as potent antagonists of the melanocortin-4 receptor.

Tran JA, Pontillo J, Fleck BA, Marinkovic D, Arellano M, Tucci FC, Lanier M, Saunders J, Jiang W, Chen CW, Foster AC, Chen C.

Bioorg Med Chem Lett. 2006 Jul 15;16(14):3693-6. Epub 2006 May 11.PMID: 16697187 [PubMed - indexed for MEDLINE]Related articles

A cluster of deep bacterial infections following eye surgery associated with construction dust.

Gibb AP, Fleck BW, Kempton-Smith L.

J Hosp Infect. 2006 Jun;63(2):197-200. Epub 2006 Apr 4.PMID: 16600427 [PubMed - indexed for MEDLINE]Related articles

Low oxygen exposure does not cause pulmonary injury in the newborn rat.

White A, McColm JR, Wade J, Yaqoob Z, Sedowofia K, Fleck B, McIntosh N, Hislop A, Cunningham S.

Early Hum Dev. 2006 May;82(5):335-40. Epub 2005 Dec 15.PMID: 16343821 [PubMed - indexed for MEDLINE]Related articles

Molecular interactions of nonpeptide agonists and antagonists with the melanocortin-4 receptor.

Fleck BA, Chen C, Yang W, Huntley R, Markison S, Nickolls SA, Foster AC, Hoare SR.

Biochemistry. 2005 Nov 8;44(44):14494-508.PMID: 16262250 [PubMed - indexed for MEDLINE]Related articles

Structure-activity relationship studies on a series of cyclohexylpiperazines bearing a phanylacetamide as ligands of the human melanocortin-4 receptor.

Pontillo J, Tran JA, White NS, Arellano M, Fleck BA, Marinkovic D, Tucci FC, Saunders J, Foster AC, Chen C.

Bioorg Med Chem Lett. 2005 Dec 1;15(23):5237-40. Epub 2005 Sep 23.PMID: 16183282 [PubMed - indexed for MEDLINE]Related articles

High-throughput assessment of mitochondrial membrane potential in situ using fluorescence resonance energy transfer.

Dykens JA, Fleck B, Ghosh S, Lewis M, Velicelebi G, Ward MW.

Mitochondrion. 2002 May;1(5):461-73.PMID: 16120299 [PubMed]Related articles

Optimization of piperazinebenzylamines with a N-(1-methoxy-2-propyl) side chain as potent and selective antagonists of the human melanocortin-4 receptor.

Pontillo J, Marinkovic D, Tran JA, Arellano M, Fleck BA, Wen J, Tucci FC, Nelson J, Saunders J, Foster AC, Chen C.

Bioorg Med Chem Lett. 2005 Oct 15;15(20):4615-8.PMID: 16105734 [PubMed - indexed for MEDLINE]Related articles

Potent and orally active non-peptide antagonists of the human melanocortin-4 receptor based on a series of trans-2-disubstituted cyclohexylpiperazines.

Tucci FC, White NS, Markison S, Joppa M, Tran JA, Fleck BA, Madan A, Dyck BP, Parker J, Pontillo J, Arellano LM, Marinkovic D, Jiang W, Chen CW, Gogas KR, Goodfellow VS, Saunders J, Foster AC, Chen C.

Bioorg Med Chem Lett. 2005 Oct 1;15(19):4389-95.PMID: 16098742 [PubMed - indexed for MEDLINE]Related articles